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Gamma-secretase

Gamma-secretase

Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.

Found 59 products of "Gamma-secretase"

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  • tCFA15
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    tCFA15

    CAS:
    <p>tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.</p>
    Formula:C24H44O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:364.61

    Ref: TM-T13917

  • RR-11a analog
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    RR-11a analog

    CAS:
    <p>RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).</p>
    Formula:C22H29N5O8
    Purity:98.80%
    Color and Shape:Solid
    Molecular weight:491.49

    Ref: TM-T12770

  • γ-Secretase modulator 11
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    γ-Secretase modulator 11

    CAS:
    <p>5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency and</p>
    Formula:C28H22F2N4O2
    Color and Shape:Solid
    Molecular weight:484.5

    Ref: TM-T63216

  • LY-411575 isomer 1
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    LY-411575 isomer 1

    CAS:
    <p>LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.</p>
    Formula:C26H23F2N3O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:479.48

    Ref: TM-T11903

  • Aβ42-IN-1 free base
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    Aβ42-IN-1 free base

    CAS:
    <p>Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091</p>
    Formula:C29H26N4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:462.54

    Ref: TM-T10443

  • RR-11a
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    RR-11a

    CAS:
    <p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>
    Formula:C24H28N6O10
    Purity:98%
    Color and Shape:Solid
    Molecular weight:560.51

    Ref: TM-T12769

  • BMS-983970
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    BMS-983970

    CAS:
    <p>BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.</p>
    Formula:C26H26F4N4O3
    Color and Shape:Solid
    Molecular weight:518.5

    Ref: TM-T14683

  • BT-GSI
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    BT-GSI

    <p>BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma &amp; anti-resorptive for multiple myeloma/bone disease research.</p>
    Formula:C26H46BrN5O10P2
    Color and Shape:Solid
    Molecular weight:730.52

    Ref: TM-T73485

  • Yhhu-3792 hydrochloride
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    Yhhu-3792 hydrochloride

    CAS:
    <p>Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].</p>
    Formula:C24H25ClN4O2
    Color and Shape:Solid
    Molecular weight:436.93

    Ref: TM-T84890

  • BMS-932481
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    BMS-932481

    CAS:
    <p>BMS-932481 is a γ-secretase modulator.</p>
    Formula:C24H24FN7O
    Color and Shape:Solid
    Molecular weight:445.49

    Ref: TM-T26864

  • GSM-1
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    GSM-1

    CAS:
    <p>GSM-1 is a modulator of γ-Secretase.</p>
    Formula:C26H31ClF3NO2
    Color and Shape:Solid
    Molecular weight:481.98

    Ref: TM-T24116

  • Gossypolone
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    Gossypolone

    CAS:
    <p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>
    Formula:C30H26O10
    Purity:96.66%
    Color and Shape:Solid
    Molecular weight:546.52

    Ref: TM-T31987

  • γ-Secretase modulator 11 hydrochloride
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    γ-Secretase modulator 11 hydrochloride

    CAS:
    <p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>
    Formula:C28H23ClF2N4O2
    Color and Shape:Solid
    Molecular weight:520.96

    Ref: TM-T63638

  • PF-06648671
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    PF-06648671

    CAS:
    <p>PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.</p>
    Formula:C25H23ClF4N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:538.92

    Ref: TM-T24621

  • DAPM
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    DAPM

    CAS:
    <p>DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.</p>
    Formula:C20H20F2N2O4
    Purity:99.76%
    Color and Shape:Solid
    Molecular weight:390.38

    Ref: TM-T86161

  • CymitQuimica logo
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    BPN-15606 besylate

    <p>BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).</p>
    Formula:C29H29FN6O4S
    Color and Shape:Solid
    Molecular weight:576.64

    Ref: TM-T64081

  • Notch inhibitor 1
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    Notch inhibitor 1

    CAS:
    <p>Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.</p>
    Formula:C26H25F7N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:574.49

    Ref: TM-T16341

  • Aβ42-IN-1
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    Aβ42-IN-1

    CAS:
    <p>Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).</p>
    Formula:C29H27ClN4O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:499

    Ref: TM-T10211

  • HDAC6-IN-9
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    HDAC6-IN-9

    CAS:
    <p>HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.</p>
    Formula:C19H16N2O3
    Purity:98.84%
    Color and Shape:Solid
    Molecular weight:320.34

    Ref: TM-T60856