Gamma-secretase
Gamma-Secretase inhibitors are compounds that target the gamma-secretase enzyme complex, which is involved in the cleavage of amyloid precursor protein (APP) to produce beta-amyloid peptides. These peptides can aggregate to form amyloid plaques, a hallmark of Alzheimer's disease. By inhibiting gamma-secretase, these compounds aim to reduce the production of beta-amyloid and its accumulation in the brain, making them a key focus in Alzheimer's disease research. At CymitQuimica, we offer gamma-secretase inhibitors to support your research in amyloid biology, Alzheimer's therapy, and neurodegenerative diseases.
Found 60 products of "Gamma-secretase"
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Jagged-1 (188-204) TFA(219127-21-6 free base)
Jagged-1 (188-204) TFA, a JAG-1 skin protein fragment, induces epidermal maturation and keratinocyte stratification.Formula:C95H128F3N25O28S3Purity:99.48%Color and Shape:SolidMolecular weight:2221.37JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Formula:C23H24N2O3Purity:99.61%Color and Shape:SolidMolecular weight:376.45MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formula:C21H21ClF2NaO4SColor and Shape:SolidMolecular weight:465.89γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Formula:C24H25ClN4OSPurity:98%Color and Shape:SolidMolecular weight:453FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formula:C25H30N2O5Purity:99.81% - ≥98%Color and Shape:SolidMolecular weight:438.52Ref: TM-T3075
1mg34.00€2mg49.00€5mg71.00€10mg94.00€25mg168.00€50mg295.00€100mg513.00€500mg1,125.00€1mL*10mM (DMSO)78.00€LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purity:97.07%Color and Shape:SolidMolecular weight:409.48Ref: TM-T9015
1mg35.00€5mg80.00€10mg112.00€25mg197.00€50mg290.00€100mg420.00€200mg590.00€1mL*10mM (DMSO)87.00€IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C15H15NO5S2Purity:97.96% - 98.38%Color and Shape:SolidMolecular weight:353.41RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formula:C25H28F3N7Purity:99.50%Color and Shape:SolidMolecular weight:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Formula:C20H14D3FO2SColor and Shape:SolidMolecular weight:343.43Dilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Purity:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Color and Shape:LiquidTarextumab
CAS:Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.Purity:95%Color and Shape:LiquidMolecular weight:~150 kDaCIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFormula:C17H20ClN3O2SPurity:99.02%Color and Shape:SolidMolecular weight:365.88γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formula:C24H24N4OSPurity:99.75% - 99.96%Color and Shape:SolidMolecular weight:416.54ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formula:C19H20BrClN2O3SPurity:99.69%Color and Shape:SolidMolecular weight:471.8Ref: TM-T11178L
1mg154.00€5mg370.00€10mg583.00€25mg858.00€50mg1,170.00€100mg1,575.00€1mL*10mM (DMSO)424.00€γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Formula:C23H19FN4O2Purity:98%Color and Shape:SolidMolecular weight:402.42tCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Formula:C24H44O2Purity:98%Color and Shape:SolidMolecular weight:364.61γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Formula:C25H22F4N6O2Purity:98%Color and Shape:SolidMolecular weight:514.47LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Formula:C26H23F2N3O4Purity:98%Color and Shape:SolidMolecular weight:479.48ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Formula:C19H20BrClN2O3SPurity:98%Color and Shape:SolidMolecular weight:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Formula:C22H29N5O8Purity:98.80%Color and Shape:SolidMolecular weight:491.49Ref: TM-T12770
1mg152.00€5mg364.00€10mg565.00€25mg1,044.00€50mg1,773.00€100mg2,602.00€1mL*10mM (DMSO)394.00€
