ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 158 products for "ALK".
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ALK5-IN-84
ALK5-IN-84 (Compound 23) is an ALK5 inhibitor with a pKi value of 9.35 for hALK5. Administered via inhalation, ALK5-IN-84 exhibits significant ALK5 inhibitory activity. This compound holds potential for research in developing inhalable ALK5 inhibitors.Formula:C20H20ClFN6OMolecular weight:414.86EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formula:C23H18N8Purity:99.98%Color and Shape:White SolidMolecular weight:406.4426LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formula:C25H26Cl4N6Purity:98.21%Color and Shape:SolidMolecular weight:552.326Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formula:C23H26Cl2FN5O3Color and Shape:SolidMolecular weight:510.39Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurity:98.73% - 98.87%Color and Shape:SolidMolecular weight:486.798LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.Formula:C25H29N3O3Purity:98% - 99.83%Color and Shape:SolidMolecular weight:419.5161CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purity:97.76%Color and Shape:White SolidMolecular weight:428.5261LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.4824BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Formula:C31H34N4O2Purity:99.45% - 99.79%Color and Shape:SolidMolecular weight:494.6273AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13% - 99.97%Color and Shape:Cyan SolidMolecular weight:448.948A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formula:C18H14N4Purity:98.82% - ≥95%Color and Shape:SolidMolecular weight:286.3306Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formula:C30H34N4O2Purity:98% - 99.94%Color and Shape:White SolidMolecular weight:482.6166GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purity:98.89% - >99.99%Color and Shape:Yellow SolidMolecular weight:532.57Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.67%Color and Shape:SolidMolecular weight:560.64NVP-TAE 684
CAS:NVP-TAE 684 (TAE684) is a excellently effective and specific ALK inhibitor(IC50=3 nM).Formula:C30H40ClN7O3SPurity:98% - 99.82%Color and Shape:White SolidMolecular weight:614.2CEP-28122
CAS:CEP-28122 is a highly potent and selective orally active ALK inhibitor.Formula:C28H35ClN6O3Purity:99.87% - >99.99%Color and Shape:SolidMolecular weight:539.069R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurity:99.61%Color and Shape:SolidMolecular weight:363.39ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formula:C22H18BrN7Purity:99.93%Color and Shape:SolidMolecular weight:460.329SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Formula:C25H26N4O3Purity:99.72%Color and Shape:SolidMolecular weight:430.4989Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Formula:C22H18FN7Purity:98.85% - 99.81%Color and Shape:White SolidMolecular weight:399.4236
