ALK
ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.
Found 147 products for "ALK".
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ALK/ROS1-IN-5
ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.Formula:C32H28F2N4O3Color and Shape:SolidMolecular weight:554.586EW-7195
CAS:EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.Formula:C23H18N8Purity:99.98%Color and Shape:White SolidMolecular weight:406.44Ref: TM-T38752
1mg124.00€2mg177.00€5mg295.00€1mL*10mM (DMSO)326.00€10mg507.00€25mg1,009.00€50mg1,648.00€100mg2,602.00€LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formula:C25H26Cl4N6Purity:98.21%Color and Shape:SolidMolecular weight:552.33Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurity:98.73% - 98.87%Color and Shape:SolidMolecular weight:486.8Ref: TM-T8399
5mg34.00€1mL*10mM (DMSO)35.00€10mg50.00€25mg78.00€50mg94.00€100mg131.00€200mg162.00€500mg215.00€A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formula:C18H14N4Purity:98.82% - ≥95%Color and Shape:SolidMolecular weight:286.33Ref: TM-T2098
1mg40.00€2mg52.00€5mg86.00€1mL*10mM (DMSO)95.00€10mg118.00€25mg200.00€50mg280.00€100mg394.00€200mg580.00€DMH-1
CAS:DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.Formula:C24H20N4OPurity:98% - 99.92%Color and Shape:SolidMolecular weight:380.44Brigatinib
CAS:Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.Formula:C29H39ClN7O2PPurity:97.18% - >99.99%Color and Shape:White SolidMolecular weight:584.09Ref: TM-T3621
2mg34.00€5mg48.00€1mL*10mM (DMSO)62.00€10mg63.00€25mg92.00€50mg108.00€100mg158.00€200mg227.00€500mg385.00€Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formula:C30H34N4O2Purity:98% - 99.94%Color and Shape:White SolidMolecular weight:482.62Ref: TM-T1936
2mg44.00€5mg65.00€1mL*10mM (DMSO)70.00€10mg82.00€50mg100.00€100mg159.00€200mg245.00€500mg414.00€LDN-214117
CAS:LDN-214117 is a potent and selective ALK2 inhibitor.Formula:C25H29N3O3Purity:98% - 99.83%Color and Shape:SolidMolecular weight:419.52CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formula:C28H30N4O2Purity:98.96%Color and Shape:White SolidMolecular weight:454.56Ref: TM-T9224
1mg124.00€5mg271.00€1mL*10mM (DMSO)324.00€10mg408.00€25mg672.00€50mg945.00€100mg1,279.00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formula:C17H13N5Purity:99.10% - 99.86%Color and Shape:Gray SolidMolecular weight:287.32Ref: TM-T6337
1mg34.00€2mg46.00€5mg63.00€1mL*10mM (DMSO)69.00€10mg80.00€25mg116.00€50mg169.00€100mg241.00€500mg597.00€LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formula:C25H22N6Purity:98% - 99.86%Color and Shape:SolidMolecular weight:406.485-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Formula:C12H9N3SPurity:97%Color and Shape:Yellow SolidMolecular weight:227.29Ref: TM-T50042
2mg43.00€5mg60.00€1mL*10mM (DMSO)60.00€10mg90.00€25mg138.00€50mg200.00€100mg301.00€200mg432.00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurity:99.13% - 99.97%Color and Shape:Cyan SolidMolecular weight:448.95CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formula:C30H38ClN7O3Purity:98.86% - 99.98%Color and Shape:White SolidMolecular weight:580.12Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg39.00€5mg56.00€1mL*10mM (DMSO)65.00€10mg84.00€25mg105.00€50mg159.00€100mg268.00€500mg655.00€BIBF0775
CAS:BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).Formula:C31H34N4O2Purity:99.45% - 99.79%Color and Shape:SolidMolecular weight:494.63Ref: TM-T5197
1mg40.00€1mL*10mM (DMSO)90.00€5mg92.00€10mg128.00€25mg205.00€50mg288.00€100mg414.00€200mg578.00€Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formula:C23H26Cl2FN5O3Color and Shape:SolidMolecular weight:510.39ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Formula:C22H16N4OPurity:99.30% - ≥95%Color and Shape:SolidMolecular weight:352.39ALK5-IN-10
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formula:C22H18BrN7Purity:99.93%Color and Shape:SolidMolecular weight:460.33Ref: TM-T9837
1mg93.00€5mg182.00€1mL*10mM (DMSO)215.00€10mg269.00€25mg429.00€50mg610.00€100mg820.00€200mg1,099.00€
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