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ALK

ALK

ALK inhibitors are compounds that specifically target and inhibit Anaplastic Lymphoma Kinase (ALK), a receptor tyrosine kinase involved in the development and progression of certain cancers, including non-small cell lung cancer and neuroblastoma. By inhibiting ALK, these compounds block signaling pathways that promote tumor cell growth and survival. At CymitQuimica, we offer ALK inhibitors to support your research in oncology, targeted cancer therapies, and signal transduction.

Found 158 products for "ALK".

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  • ALK5 Inhibitor II (hydrochloride)
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    ALK5 Inhibitor II (hydrochloride)

    CAS:
    ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).
    Formula:C17H13N5·HCl
    Purity:98%
    Color and Shape:Solid
    Molecular weight:323.8

    Ref: TM-T22560

  • 2-Keto Crizotinib
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    2-Keto Crizotinib

    CAS:
    2-Keto Crizotinib is an active lactam metabolite of crizotinib.
    Formula:C21H20Cl2FN5O2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:464.32

    Ref: TM-T19510

  • ALK2-IN-6
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    ALK2-IN-6

    CAS:
    ALK2-IN-6 is a potent and selective ALK2 inhibitor with an IC50 of 9 nM. ALK2-IN-6 exhibits excellent brain permeability and effectively suppresses bone morphogenetic protein signaling across various preclinical cancer models for the treatment of diffuse intrinsic pontine glioma.
    Formula:C26H31N3O3
    Purity:99.97%
    Color and Shape:Gray Solid
    Molecular weight:433.54

    Ref: TM-T212603

  • Entrectinib-D8
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    Entrectinib-D8

    CAS:
    Entrectinib-D8 is the deuterated form of Entrectinib. Entrectinib (T3678) (NMS-E628) is an orally bioavailable inhibitor that effectively crosses the blood-brain barrier and exhibits central nervous system activity. It targets TrkA/B/C, ROS1, and ALK with IC50 values of 1, 3, 5, 12, and 7 nM, respectively. Entrectinib (T3678) induces apoptosis and cell cycle arrest in cancer cells, demonstrates antitumor properties, and alleviates bleomycin-induced pulmonary fibrosis in mice.
    Formula:C31H34F2N6O2
    Molecular weight:568.69

    Ref: TM-TMID-0768

  • FDA-Approved Kinase Inhibitor Library
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    FDA-Approved Kinase Inhibitor Library

    A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
    Color and Shape:Liquid

    Ref: TM-L1610

  • Kinase Inhibitor Library
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    Kinase Inhibitor Library

    A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;
    Color and Shape:Odour Solid

    Ref: TM-L1600

  • Zilurgisertib fumarate
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    Zilurgisertib fumarate

    CAS:
    Zilurgisertib fumarate is a selective ALK2 inhibitor that modulates iron metabolism and improves anemia by inhibiting SMAD phosphorylation and hepcidin production.
    Formula:C30H38N4O3·xC4H4O4
    Purity:99.96%
    Color and Shape:Yellow Solid
    Molecular weight:502.66 (free base)

    Ref: TM-T84860

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    PROTAC ALK degrader-3

    PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.
    Formula:C50H60ClN9O7S
    Color and Shape:Solid
    Molecular weight:966.59

    Ref: TM-T201107

  • TL13-112
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    TL13-112

    CAS:
    TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
    Formula:C49H60ClN9O10S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1002.57

    Ref: TM-T13929

  • ALK-IN-12
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    ALK-IN-12

    CAS:
    ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.
    Formula:C24H30ClN6O2P
    Color and Shape:Solid
    Molecular weight:500.97

    Ref: TM-T38584

  • ALK protein ligand-1
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    ALK protein ligand-1

    CAS:
    ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.
    Formula:C24H29ClN6O3S
    Color and Shape:Solid
    Molecular weight:517.043

    Ref: TM-T204887

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    Entrectinib-D4

    Entrectinib-D4 is the deuterium-labeled isotope of Paquinimod. Entrectinib (T3678) is an orally active inhibitor of TrkA/B/C, ROS1, and ALK, capable of crossing the blood-brain barrier and possessing central nervous system activity, with IC50 values of 1, 3, 5, 12, and 7 nM, respectively. It induces apoptosis and cell cycle arrest in cancer cells, exhibits antitumor efficacy, and mitigates bleomycin-induced pulmonary fibrosis in mice.

    Ref: TM-TMID-0624

  • CymitQuimica logo
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    ALK/ROS1-IN-3

    ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.
    Formula:C32H32N4O2
    Color and Shape:Solid
    Molecular weight:504.25253

    Ref: TM-T208757

  • ALK-IN-13
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    ALK-IN-13

    CAS:
    ALK-IN-13 is an ALK inhibitor.
    Formula:C29H39ClN7O2P
    Color and Shape:Solid
    Molecular weight:584.1

    Ref: TM-T38583

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    Ceritinib-amide-C3-acid

    CAS:
    Ceritinib-amide-C3-acid is a ligand-linker conjugate of a target protein. It consists of the protein ligand Ceritinib and a linker used for connecting an E3 ligase ligand. Ceritinib-amide-C3-acid is useful in the synthesis of [TD-004].
    Formula:C33H42ClN5O6S
    Molecular weight:672.24

    Ref: TM-T217158

  • TL13-12
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    TL13-12

    CAS:
    TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).
    Formula:C45H53ClN10O10S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:961.49

    Ref: TM-T13930

  • TL13-110
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    TL13-110

    CAS:
    Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).
    Formula:C49H62ClN9O9S
    Color and Shape:Solid
    Molecular weight:988.59

    Ref: TM-T37083

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    ALK-IN-29

    ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.
    Formula:C29H32FN3O
    Color and Shape:Solid
    Molecular weight:457.58

    Ref: TM-T201303

  • ALKBH5-IN-5
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    ALKBH5-IN-5

    CAS:
    ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.
    Formula:C13H13NO3
    Purity:99.54%
    Color and Shape:Solid
    Molecular weight:231.25

    Ref: TM-T203011

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    Lys-PEG3-BA

    CAS:
    Lys-PEG3-BA is a PROTAC degrader targeting EML4-ALK/EGFR, with DC50 values of 1.32 μM for H3122 cells (expressing EML4-ALK fusion protein) and 19.66 μM for H1975 cells (with EGFRL858R/T790M mutations). In vitro studies show that Lys-PEG3-BA can inhibit the proliferation of non-small cell lung cancer cells by modulating the ubiquitin-proteasome system. Lys-PEG3-BA is applicable for research related to non-small cell lung cancer.
    Formula:C38H57ClN9O7P
    Molecular weight:818.35

    Ref: TM-T217126