Trk receptor
Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.
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Amitriptyline hydrochloride
CAS:549-18-8
Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and …
Formula:
C20H24ClN
Purity:
97% - 99.94%
Color and Shape:
Crystals White To Off-White Powder
Molecular weight:
313.86
Ref: TM-T0678
| 1g | 57.00 € | ||
| 500mg | 49.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
CE-245677
CAS:717899-97-3
CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s …
Formula:
C24H22Cl2N6O3
Purity:
98.99%
Color and Shape:
Solid
Molecular weight:
513.38
Ref: TM-T14921
| 1mg | 61.00 € | ||
| 2mg | 85.00 € | ||
| 5mg | 118.00 € | ||
| 10mg | 185.00 € | ||
| 25mg | 308.00 € | ||
| 50mg | 423.00 € | ||
| 100mg | 627.00 € | ||
| 1mL*10mM (DMSO) | 135.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Tepotinib
CAS:1100598-32-0
Tepotinib (EMD-1214063) is a selective, orally, and ATP-competitive c-MET tyrosine kinase inhibitor. Tepotinib has antitumor …
Formula:
C29H28N6O2
Purity:
98% - 99.81%
Color and Shape:
Solid
Molecular weight:
492.57
Ref: TM-T6121
| 1mg | 50.00 € | ||
| 2mg | 65.00 € | ||
| 5mg | 109.00 € | ||
| 10mg | 192.00 € | ||
| 25mg | 411.00 € | ||
| 50mg | 534.00 € | ||
| 100mg | 634.00 € | ||
| 500mg | 1,352.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
N-Acetyl-5-hydroxytryptamine
CAS:1210-83-9
N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.
Formula:
C12H14N2O2
Purity:
98.03% - 99.91%
Color and Shape:
Solid
Molecular weight:
218.25
Ref: TM-T1354
| 10mg | 38.00 € | ||
| 25mg | 57.00 € | ||
| 50mg | 77.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, …
Purity:
98%
Ref: TM-T81740
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
GNF-8625 monopyridin-N-piperazine hydrochloride
CAS:2412055-62-8
GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.
Formula:
C25H27ClFN7
Purity:
99.44%
Color and Shape:
Solid
Molecular weight:
479.98
Ref: TM-T40034
| 1mg | 93.00 € | ||
| 5mg | 197.00 € | ||
| 10mg | 316.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 …
Formula:
C29H35F2N7O6S
Purity:
98%
Color and Shape:
Liquid
Molecular weight:
647.69
Ref: TM-T79126
| 5mg | To inquire | ||
| 50mg | To inquire |
Estimated delivery in United States, on Tuesday 7 Jan 2025
PF-06737007
CAS:1863905-38-7
PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, …
Formula:
C25H28F4N2O6
Purity:
98%
Color and Shape:
Solid
Molecular weight:
528.49
Ref: TM-T17170
| 2mg | 50.00 € |
Estimated delivery in United States, on Tuesday 7 Jan 2025
Sitravatinib
CAS:1123837-84-2
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, …
Formula:
C33H29F2N5O4S
Purity:
98.9% - 99.74%
Color and Shape:
Solid
Molecular weight:
629.68
Ref: TM-T4349
| 5mg | 51.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 134.00 € | ||
| 50mg | 206.00 € | ||
| 100mg | 330.00 € | ||
| 200mg | 523.00 € | ||
| 500mg | 829.00 € | ||
| 1mL*10mM (DMSO) | 72.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Belizatinib
CAS:1357920-84-3
Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type …
Formula:
C33H44FN5O3
Purity:
99.33% - 99.48%
Color and Shape:
Solid
Molecular weight:
577.73
Ref: TM-T4257
| 1mg | 42.00 € | ||
| 2mg | 56.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 139.00 € | ||
| 25mg | 268.00 € | ||
| 50mg | 371.00 € | ||
| 100mg | 517.00 € | ||
| 1mL*10mM (DMSO) | 111.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
LM22B-10
CAS:342777-54-2
LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and …
Formula:
C27H33ClN2O4
Purity:
98.19%
Color and Shape:
Solid
Molecular weight:
485.01
Ref: TM-T4496
| 1mg | 39.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 132.00 € | ||
| 25mg | 272.00 € | ||
| 50mg | 429.00 € | ||
| 100mg | 682.00 € | ||
| 1mL*10mM (DMSO) | 132.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
LOXO-195
CAS:1350884-56-8
(6RS)-LOXO-195 (BAY 2731954) is a potent and selective Trk tyrosine kinase inhibitor.
Formula:
C20H21FN6O
Purity:
97.92%
Color and Shape:
Solid
Molecular weight:
380.42
Ref: TM-T9496
| 2mg | 35.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 78.00 € | ||
| 25mg | 142.00 € | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
GNF-5837
CAS:1033769-28-6
GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).
Formula:
C28H21F4N5O2
Purity:
96.17% - 99.29%
Color and Shape:
Solid
Molecular weight:
535.49
Ref: TM-T6097
| 5mg | 50.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 122.00 € | ||
| 50mg | 185.00 € | ||
| 100mg | 305.00 € | ||
| 200mg | 398.00 € | ||
| 500mg | 643.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
DS-1205
CAS:1855860-24-0
DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 …
Formula:
C41H42FN5O7
Purity:
99.28%
Color and Shape:
Solid
Molecular weight:
735.8
Ref: TM-T9123
| 1mg | 104.00 € | ||
| 5mg | 252.00 € | ||
| 10mg | 367.00 € | ||
| 25mg | 683.00 € | ||
| 50mg | 913.00 € | ||
| 1mL*10mM (DMSO) | 281.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
GW 441756
CAS:504433-23-2
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of …
Formula:
C17H13N3O
Purity:
98.43% - ≥95%
Color and Shape:
Solid
Molecular weight:
275.3
Ref: TM-T6052
| 5mg | 55.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 149.00 € | ||
| 50mg | 220.00 € | ||
| 100mg | 335.00 € | ||
| 500mg | 789.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Tyrphostin AG 879
CAS:148741-30-4
Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher …
Formula:
C18H24N2OS
Purity:
99.05%
Color and Shape:
Solid
Molecular weight:
316.46
Ref: TM-T6712
| 5mg | 50.00 € | ||
| 10mg | 73.00 € | ||
| 25mg | 152.00 € | ||
| 50mg | 245.00 € | ||
| 100mg | 418.00 € | ||
| 1mL*10mM (DMSO) | 53.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Entrectinib
CAS:1108743-60-7
Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective …
Formula:
C31H34F2N6O2
Purity:
98.03% - 99.61%
Color and Shape:
Solid
Molecular weight:
560.64
Ref: TM-T3678
| 2mg | 41.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 109.00 € | ||
| 50mg | 165.00 € | ||
| 100mg | 276.00 € | ||
| 500mg | 677.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Selitrectinib
CAS:2097002-61-2
Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.
Formula:
C20H21FN6O
Purity:
99.55% - ≥95%
Color and Shape:
Solid
Molecular weight:
380.42
Ref: TM-T7435
| 1mg | 40.00 € | ||
| 5mg | 86.00 € | ||
| 10mg | 118.00 € | ||
| 25mg | 223.00 € | ||
| 50mg | 331.00 € | ||
| 100mg | 440.00 € | ||
| 1mL*10mM (DMSO) | 93.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
Repotrectinib
CAS:1802220-02-5
Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, …
Formula:
C18H18FN5O2
Purity:
100% - 99.86%
Color and Shape:
Solid
Molecular weight:
355.37
Ref: TM-T4071
| 1mg | 49.00 € | ||
| 2mg | 69.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 166.00 € | ||
| 25mg | 290.00 € | ||
| 50mg | 463.00 € | ||
| 100mg | 673.00 € | ||
| 1mL*10mM (DMSO) | 100.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
ONO-7475
CAS:1646839-59-9
ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase
Formula:
C32H26N4O6
Purity:
98.74%
Color and Shape:
Solid
Molecular weight:
562.57
Ref: TM-T8327
| 1mg | 62.00 € | ||
| 5mg | 135.00 € | ||
| 10mg | 209.00 € | ||
| 25mg | 353.00 € | ||
| 50mg | 525.00 € | ||
| 100mg | 738.00 € | ||
| 1mL*10mM (DMSO) | 167.00 € |
Estimated delivery in United States, on Monday 13 Jan 2025
