Trk receptor
Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.
Found 53 products of "Trk receptor"
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N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.
Formula:C12H14N2O2Purity:98.31% - 99.91%Color and Shape:SolidMolecular weight:218.25CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.
Formula:C24H22Cl2N6O3Purity:98.99% - 99.23%Color and Shape:SolidMolecular weight:513.38Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurity:97% - 99.94%Color and Shape:Crystals White To Off-White PowderMolecular weight:313.86CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Color and Shape:Odour LiquidAnti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Color and Shape:Odour LiquidGNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formula:C25H27ClFN7Purity:98.97%Color and Shape:SolidMolecular weight:479.98TrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formula:C16H13N3O5Molecular weight:327.08552Protein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].
Formula:C29H35F2N7O6SPurity:98%Color and Shape:SolidMolecular weight:647.69Adimanebart
CAS:Amdokitug is a human-derived IgG1λ monoclonal antibody that acts as an inhibitor of MUSK.Color and Shape:LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formula:C25H28F4N2O6Purity:98%Color and Shape:SolidMolecular weight:528.49GNF-5837
CAS:GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).Formula:C28H21F4N5O2Purity:97.26% - 98.08%Color and Shape:SolidMolecular weight:535.49Ref: TM-T6097
5mg48.00€10mg80.00€25mg117.00€50mg178.00€100mg295.00€200mg384.00€500mg622.00€1mL*10mM (DMSO)52.00€Cyclotraxin B acetate(1203586-72-4 free base)
Cyclotraxin B acetate is an antagonist of TrkB receptors; inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM).Formula:C50H77N13O19S3Purity:99.42%Color and Shape:SolidMolecular weight:1260.42LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).
Formula:C15H21N3O6Purity:99.56%Color and Shape:SolidMolecular weight:339.34Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formula:C21H22F2N6O2Purity:99.15% - >99.99%Color and Shape:SolidMolecular weight:428.44Ref: TM-T5995
1mg37.00€5mg74.00€10mg90.00€25mg157.00€50mg236.00€100mg356.00€500mg820.00€1mL*10mM (DMSO)81.00€Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formula:C26H21F3N4O4Purity:99.67% - 99.75%Color and Shape:SolidMolecular weight:510.46Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formula:C20H21FN6OPurity:99.55% - ≥95%Color and Shape:SolidMolecular weight:380.42Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg42.00€5mg59.00€10mg88.00€25mg111.00€50mg168.00€100mg283.00€500mg692.00€1mL*10mM (DMSO)69.00€CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formula:C32H31N3O5SPurity:99.92%Color and Shape:SolidMolecular weight:569.67Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFormula:C26H29Cl4FN6O3Purity:98.73%Color and Shape:SolidMolecular weight:634.36Ref: TM-T22324
1mg59.00€5mg127.00€10mg188.00€25mg404.00€50mg645.00€100mg938.00€200mg1,264.00€1mL*10mM (DMSO)170.00€Belizatinib
CAS:Belizatinib (TSR-011) is an effective, oral and dual inhibitor of ALK (IC50: 0.7 nM, wild-type recombinant ALK) and TRKA, TRKB, and TRKC.Formula:C33H44FN5O3Purity:99.33% - 99.44%Color and Shape:SolidMolecular weight:577.73Ref: TM-T4257
1mg40.00€2mg54.00€5mg93.00€10mg133.00€25mg259.00€50mg358.00€100mg500.00€1mL*10mM (DMSO)105.00€
