Entrectinib
CAS: 1108743-60-7
Ref. TM-T3678
| 2mg | 41.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 109.00 € | ||
| 50mg | 165.00 € | ||
| 100mg | 276.00 € | ||
| 500mg | 677.00 € | ||
| 1ml*10 (DMSO) | 68.00 € |
Product Information
- RXDX-101, NMS-E628
Entrectinib (RXDX-101) is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C-ros oncogene 1 (ROS1; IC50: 0.2 nM). Entrectinib blocks proliferation of ALK-dependent cell lines, including those with C1156Y or L1196M resistance mutations, and inhibits ALK-dependent signaling. It has been shown to inhibit the growth of a non-small cell lung Y cell line bearing an EML4-ALK rearrangement. In mice bearing various ROS1, Trk, or ALK-driven xenografts, Entrectinib has been shown to induce tumor regression.
Chemical properties
Technical inquiry about: TM-T3678 Entrectinib
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