Trk receptor
Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.
Found 59 products for "Trk receptor".
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Amitriptyline hydrochloride
CAS:Amitriptyline hydrochloride (Annoyltin) is the hydrochloride salt of the tricyclic dibenzocycloheptadiene amitriptyline with antidepressant and antinociceptiveFormula:C20H24ClNPurity:99.39% - 99.94%Color and Shape:SolidMolecular weight:313.86N-Acetyl-5-hydroxytryptamine
CAS:N-Acetyl-5-hydroxytryptamine, or Normelatonin, is melatonin's precursor, made from serotonin, and activates TrkB receptor.Formula:C12H14N2O2Purity:98.31% - 99.91%Color and Shape:Yellow SolidMolecular weight:218.25CE-245677
CAS:CE-245677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases. With a cellular IC50s of 4.7 and 1 nM.Formula:C24H22Cl2N6O3Purity:98.99% - 99.23%Color and Shape:SolidMolecular weight:513.38Ref: TM-T14921
1mg58.00€2mg82.00€5mg113.00€1mL*10mM (DMSO)129.00€10mg177.00€25mg296.00€50mg409.00€100mg605.00€CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Color and Shape:Odour LiquidProtein kinase inhibitor 5 sulfate hydrate
Protein kinase inhibitor 5 sulfate hydrate, a potent TRK-A inhibitor, exhibits an IC50 of 1.8 nM and impairs cell viability [1].Formula:C29H35F2N7O6SPurity:98%Color and Shape:SolidMolecular weight:647.69Anti-TrkB/NTRK2 Antibody
Anti-TrkB/NTRK2 Antibody is a potent monoclonal antibody targeting the TrkB/NTRK2 receptor. Anti-TrkB/NTRK2 Antibody demonstrates significant receptor engagement activity in vitro and facilitates the measurable protection of neuronal integrity while improving cognitive performance in various preclinical models of neurodegeneration.Color and Shape:Odour LiquidTRK-IN-31 hydrochloride
TRK-IN-31 hydrochloride is an orally active TRK inhibitor with an IC50 of 1.8 nM. It demonstrates excellent antiproliferative activity in Ba/F3-MPRIP-TRKAG667C cells and selectively inhibits TRK kinase activity. Additionally, TRK-IN-31 hydrochloride significantly suppresses tumor growth in a Ba/F3-MPRIP-TRKAG667C subcutaneous mouse model.Anti-MUSK Antibody
Anti-MUSK Antibody serves as a functional therapeutic tool specifically designed to enable the precise detection and neutralization of the muscle-specific kinase which plays a pivotal role in the maintenance of the neuromuscular junction structural integrity during strictly monitored laboratory observation periods and molecular investigations to evaluate the pathological consequences of receptor tyrosine kinase inhibition in advanced neuroscience and immunology research models to facilitate the study of neuromuscular disorders.GNF-8625 monopyridin-N-piperazine hydrochloride
CAS:GNF-8625 monopyridin-N-piperazine hydrochloride is a protomyosin receptor kinase (TRK) inhibitor.Formula:C25H27ClFN7Purity:98.97%Color and Shape:SolidMolecular weight:479.98TrkA-IN-6
TrkA-IN-6 (compound R48) is a hydrazone-based, selective inhibitor of the tropomyosin receptor kinase A (TrkA). It exhibits greater cytotoxicity towards U87 GBM cells compared to Temozolomide, with an IC50 of 68.99 μM.Formula:C16H13N3O5Color and Shape:SolidMolecular weight:327.08552Anti-NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Color and Shape:Odour LiquidAnti-NGF Antibody (5D767)
Anti-NGF Antibody (5D767) is a Rabbit IgG monoclonal antibody targeting Human NGF.Color and Shape:Odour LiquidPF-06737007
CAS:PF-06737007 is an effective inhibitor of pan-Trk in cell-based assays (IC50s: 7.7 nM, 15 nM, and 3.9 nM for TrkA, TrkB, and TrkC, respectively).Formula:C25H28F4N2O6Purity:98%Color and Shape:SolidMolecular weight:528.49Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Formula:C26H21F3N4O4Purity:99.67% - 99.75%Color and Shape:SolidMolecular weight:510.46Selitrectinib
CAS:Selitrectinib (LOXO-195) is a potent and selective inhibitor of the receptor tyrosine kinases(TRK).Cost-effective and quality-assured.Formula:C20H21FN6OPurity:99.57% - ≥95%Color and Shape:SolidMolecular weight:380.42DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purity:99.75%Color and Shape:SolidMolecular weight:735.8LM22A-4
CAS:LM22A-4: BDNF mimetic, TrkB agonist, IC50=47 nM (fluorescence anisotropy).Formula:C15H21N3O6Purity:99.56%Color and Shape:SolidMolecular weight:339.34CH7057288
CAS:CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.Formula:C32H31N3O5SPurity:99.92%Color and Shape:SolidMolecular weight:569.67Larotrectinib
CAS:Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).Formula:C21H22F2N6O2Purity:99.15% - >99.99%Color and Shape:SolidMolecular weight:428.44Ref: TM-T5995
1mg37.00€5mg74.00€1mL*10mM (DMSO)81.00€10mg90.00€25mg157.00€50mg236.00€100mg356.00€500mg820.00€Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purity:98.03% - 99.61%Color and Shape:SolidMolecular weight:560.64Ref: TM-T3678
2mg39.00€5mg56.00€1mL*10mM (DMSO)65.00€10mg84.00€25mg105.00€50mg159.00€100mg268.00€500mg655.00€
