Trk receptor
Trk receptor inhibitors target the Tropomyosin receptor kinases (Trk), a family of receptor tyrosine kinases that play a significant role in the development and function of the nervous system. Trk receptors are involved in neurotrophin signaling, which is essential for the survival, differentiation, and growth of neurons. Dysregulation of Trk signaling is associated with neurological disorders and certain cancers. At CymitQuimica, we offer Trk receptor inhibitors to support your research in neurobiology, oncology, and neurodegenerative diseases.
Found 59 products of "Trk receptor"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
GNF-5837
CAS:<p>GNF-5837 is a specific, and orally bioavailable pan-TRK inhibitor for TrkA/TrkB (IC50: 8/12 nM).</p>Formula:C28H21F4N5O2Purity:97.26% - 98.08%Color and Shape:SolidMolecular weight:535.49DS-1205
CAS:<p>DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.</p>Formula:C41H42FN5O7Purity:99.75%Color and Shape:SolidMolecular weight:735.8GW 441756
CAS:<p>GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.</p>Formula:C17H13N3OPurity:97.73% - 99.8%Color and Shape:SolidMolecular weight:275.3Tyrphostin AG 879
CAS:<p>Tyrphostin AG 879 (AG 879) effectively inhibits HER2/ErbB2 (IC50: 1 μM), 100- and 500-fold higher selective to ErbB2 than EGFR and PDGFR.</p>Formula:C18H24N2OSPurity:99.05%Color and Shape:SolidMolecular weight:316.46Sitravatinib
CAS:<p>Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and</p>Formula:C33H29F2N5O4SPurity:98.9% - 99.85%Color and Shape:SolidMolecular weight:629.68LM22B-10
CAS:<p>LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.</p>Formula:C27H33ClN2O4Purity:98.18%Color and Shape:SolidMolecular weight:485.01Larotrectinib
CAS:<p>Larotrectinib (LOXO-101) is an orally administered inhibitor of the TRK kinase and is highly selective only for the TRK family of receptors(IC50s = 2-20 nM).</p>Formula:C21H22F2N6O2Purity:99.15% - >99.99%Color and Shape:SolidMolecular weight:428.44CH7057288
CAS:<p>CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.</p>Formula:C32H31N3O5SPurity:99.92%Color and Shape:SolidMolecular weight:569.67Larotrectinib sulfate
CAS:<p>Larotrectinib sulfate (LOXO-101 sulfate) is an oral active and specific ATP-competitive inhibitor of tropomyosin receptor kinases (TRK).</p>Formula:C21H22F2N6O2·H2O4SPurity:98.62% - 99.76%Color and Shape:SolidMolecular weight:526.51Repotrectinib
CAS:<p>Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor, with IC50 of 1.01/5.3/1.08/1.26 nM for WT ALK, SRC, ALK L1196M and ALK G1202R, respectively.</p>Formula:C18H18FN5O2Purity:99.92% - >99.99%Color and Shape:SolidMolecular weight:355.377,8-Dihydroxyflavone
CAS:<p>7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone and exist in Tridax procumbens, Godmania aesculifolia, and primula tree leaves.</p>Formula:C15H10O4Purity:98.48% - 99.81%Color and Shape:SolidMolecular weight:254.24Frunevetmab
CAS:<p>Frunevetmab (NV-02) is a feline-adapted monoclonal antibody targeting NGF (nerve growth factor), with a Kd value of 20 pM. Feline osteoarthritis (OA).</p>Purity:95% - 95%Color and Shape:LiquidFasinumab
CAS:<p>Fasinumab (anti-NGF mAb) is in Phase III trials for acute sciatica & knee OA. It significantly improves pain & function vs. placebo.</p>Purity:95%Color and Shape:LiquidFulranumab
CAS:<p>Fulranumab (AMG-403) is a humanised monoclonal antibody targeting NGF, analgesic effects, and can be used for the study of chronic pain.</p>Purity:95%Color and Shape:LiquidTanezumab
CAS:<p>Tanezumab (RN-624) is a humanised monoclonal antibody targeting NGF，pain conditions, including osteoarthritis, knee arthritis, and neuropathic pain.</p>Purity:95%Color and Shape:LiquidBMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Formula:C23H24FN9OPurity:99.69% - 99.94%Color and Shape:SolidMolecular weight:461.49Protein kinase inhibitor 5
CAS:<p>Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].</p>Formula:C29H31F2N7OPurity:98%Color and Shape:SolidMolecular weight:531.6Tavilermide
CAS:<p>Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.</p>Formula:C24H32N6O11Purity:98.98%Color and Shape:SolidMolecular weight:580.54TrkA-IN-1
CAS:<p>TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.</p>Formula:C25H20N4OPurity:98%Color and Shape:SolidMolecular weight:392.45Paltimatrectinib
CAS:<p>Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.</p>Formula:C20H15F5N6Purity:99.96%Color and Shape:SolidMolecular weight:434.37
