FLT
FLT (Fms-like tyrosine kinase) inhibitors are compounds that target FLT receptors, which are involved in the regulation of angiogenesis through the VEGF (vascular endothelial growth factor) pathway. FLT receptors play a crucial role in the development of new blood vessels in tumors. Inhibiting FLT receptors can effectively reduce angiogenesis and tumor growth, making these inhibitors important in cancer therapy. At CymitQuimica, we offer a selection of high-quality FLT inhibitors to support your research in oncology, vascular biology, and angiogenesis.
Found 86 products of "FLT"
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FLT3-IN-3
CAS:FLT3-IN-3 is an effective FLT3 inhibitor, and the IC50s of FLT3 WT and FLT3 D835Y are 13 and 8 nM, respectively.Formula:C27H38N8OPurity:99.25%Color and Shape:SolidMolecular weight:490.64Ref: TM-T11298
1mg107.00€5mg259.00€10mg432.00€25mg715.00€50mg1,008.00€100mg1,359.00€500mg2,717.00€1mL*10mM (DMSO)278.00€MRX-2843
CAS:MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).Formula:C29H40N6OPurity:98.59% - 99.63%Color and Shape:SolidMolecular weight:488.67Ref: TM-T16144
1mg62.00€5mg138.00€10mg215.00€25mg430.00€50mg622.00€100mg887.00€1mL*10mM (DMSO)148.00€FLT3-IN-23
FLT3-IN-23 (compound 15), a potent inhibitor of FMS-like tyrosine kinase 3 (FLT3), exhibits an IC 50 value of 7.42 nM and demonstrates antiproliferative effectsColor and Shape:Odour SolidHSK205
HSK205 is a dual FLT3 and haspin inhibitor, exhibiting potent antitumor activity [1], with an IC50 of 0.187 nM for FLT3.Color and Shape:Odour SolidFLT3/CHK1-IN-1
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantlyColor and Shape:Odour SolidIRAK1/4/pan-FLT3 Kinase-IN-1
CAS:IRAK1/4/pan-FLT3 Kinase-IN-1 (Compound 31) is a potent inhibitor of IRAK1, IRAK4, and FLT3 kinases, demonstrating IC50 values of 5 nM for IRAK1, 0.6 nM for IRAK4, and less than 0.5 nM for FLT3. It exhibits favorable pharmacokinetic properties and holds promise for research in acute myeloid leukemia, with survival extension effects comparable to Gilteritinib.Formula:C21H26FN5O2Color and Shape:SolidMolecular weight:399.46Emirodatamab
CAS:Emirodatamab (AMG-427) is an anti-FLT3/CD3 bispecific T-cell engager with an extended half-life. It can induce high cytotoxicity in primary AML progenitor cells and enhance FLT-3 expression. Combining Emirodatamab with anti-PD-1 antibodies increases T-cell dependent cytotoxicity (TDCC). This compound is under investigation for use in relapsed or refractory AML.PROTAC FLT-3 degrader 3
PROTACFLT-3degrader 3 (compound 35) is a PROTAC degrader of FLT. It exhibits antiproliferative activity, with an IC50 value of 7.55 nM in MV4-11 cells.Formula:C48H44Cl2N10O6Molecular weight:926.28223PF15 TFA
PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM.Formula:C46H50F3N13O8Purity:98%Color and Shape:SolidMolecular weight:969.97PROTAC FLT3/GSPT1/IKZF1/3 degrader-1
PROTACFLT3/GSPT1/IKZF1/3 degrader-1 is an FLT3 PROTAC degrader with DC50 = 1.2 nM. It functions as a molecular glue to degrade its brain substrates and exhibits antiproliferative activity against resistant acute myeloid leukemia (AML) cells, showing potential applications in AML research.Color and Shape:Odour SolidFLT3-IN-24
FLT3-IN-24 (compound 24) is a potent and selective inhibitor of FLT3 kinase, with an IC50 of 7.94 nM. It also exhibits anti-proliferative effects on cells.Formula:C23H20N6O2SMolecular weight:444.13685FLT3/HDAC-IN-2
Compound 25h, also known as FLT3/HDAC-IN-2, is a dual inhibitor of FLT3/HDAC. It exhibits antiproliferative activity against MOLM-13 cells and is used in the study of acute myeloid leukemia.Color and Shape:Odour Solid2-Butenamide
CAS:2-Butenamide, FLT3 inhibitor. Affordable Excellence: Reliable Quality You Can TrustFormula:C4H7NOColor and Shape:SolidMolecular weight:85.1JAK3-IN-14
CAS:JAK3-IN-14 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively.Formula:C18H13N3OPurity:98.29%Color and Shape:SoildMolecular weight:287.32Ref: TM-T67754
1mg167.00€5mg409.00€10mg595.00€25mg888.00€50mg1,234.00€100mg1,665.00€1mL*10mM (DMSO)358.00€Pacritinib citrate
CAS:Pacritinib (SB1518) citrate effectively inhibits wild-type JAK2 (IC 50 =23 nM) and the JAK2 V617F mutant (IC 50 =19 nM). It also targets FLT3 (IC 50 =22 nM) and the FLT3 D835Y mutant (IC 50 =6 nM). This compound is utilized in the study of acute myeloid leukemia (AML) and myelofibrosis (MF) [1] [2] [3].Formula:C34H40N4O10Color and Shape:SolidMolecular weight:664.7PF15
CAS:PF15, a PROTAC for FLT3-ITD, degrades FLT3 kinase. DC50: 76.7 nM; hinders FLT3-ITD+ cell growth; potential in leukemia.Formula:C44H49N13O6Purity:98%Color and Shape:SolidMolecular weight:855.943-Hydroxy Midostaurin
CAS:3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM inFormula:C35H30N4O5Purity:98%Color and Shape:SolidMolecular weight:586.648FLT3-IN-10
CAS:FLT3-IN-10, a potent FLT3 inhibitor, may treat FLT3-mutated AML.Formula:C15H11FN2OPurity:99.8%Color and Shape:SolidMolecular weight:254.26Ref: TM-T9856
2mg35.00€5mg56.00€10mg96.00€25mg172.00€50mg254.00€100mg360.00€200mg490.00€1mL*10mM (DMSO)54.00€FLT3-ITD-IN-2
FLT3-ITD-IN-2 (Compound A1) is an inhibitor of the FLT3-ITD kinase, exhibiting an IC50 of 2.12 nM. It effectively suppresses the proliferation of the FLT3-dependent human AML cell line MOLM-13, with an IC50 of 25.65 nM. FLT3-ITD-IN-2 demonstrates antitumor activity against acute myeloid leukemia.Formula:C39H50N8O6Color and Shape:SolidMolecular weight:726.86FLT3 Ligand-Linker Conjugate 1
CAS:FLT3 Ligand-Linker Conjugate 1 consists of an FLT3 ligand and a PROTAC linker that can recruit E3 ligase VHL. This conjugate is useful for synthesizing PROTAC RSS0680, a bifunctional compound designed for targeted protein degradation of kinases.Formula:C29H34N6O4S2Color and Shape:SolidMolecular weight:594.748FLT3-IN-22
FLT3-IN-22 (compound 22f) is a potent inhibitor of FLT3, demonstrating IC50 values of 0.941 nM for FLT3 and 0.199 nM for the FLT3/D835Y mutant.Formula:C24H22N6O2Color and Shape:SolidMolecular weight:426.47FLT3-IN-20
FLT3-IN-20 (compound 34f) is a potent FLT3 inhibitor, demonstrating IC50 values of 1 nM for FLT3-D835Y and 4 nM for FLT3-ITD.Formula:C28H33N7O2SColor and Shape:SolidMolecular weight:531.67Anti-FLT1 Antibody (6K171)
Anti-FLT1 Antibody (6K171) is a Mouse antibody targeting FLT1. Anti-FLT1 Antibody (6K171) can be used in ELISA,ICC/IF.Color and Shape:Odour LiquidAnti-VEGFR1/FLT-1 Antibody (9F18)
Anti-VEGFR1/FLT-1 Antibody (9F18) is a Rabbit antibody targeting VEGFR1/FLT-1. Anti-VEGFR1/FLT-1 Antibody (9F18) can be used in ELISA.Color and Shape:Odour LiquidAnti-FLT1 Antibody (6S618)
Anti-FLT1 Antibody (6S618) is an antibody targeting FLT1. Anti-FLT1 Antibody (6S618) can be used in ELISA, IHC.Color and Shape:Odour LiquidAnti-FLT1 Antibody (3W705)
Anti-FLT1 Antibody (3W705) is an antibody targeting FLT1. Anti-FLT1 Antibody (3W705) can be used in ELISA, WB, IHC, FCM.Color and Shape:Odour LiquidFLT3-IN-16
CAS:FLT3-IN-16 is a potent FLT3 inhibitor (IC50 = 1.1 μM) for acute myeloid leukemia research.Formula:C15H15N3O2SPurity:99.21%Color and Shape:SolidMolecular weight:301.36Ref: TM-T9843
2mg34.00€5mg52.00€10mg86.00€25mg172.00€50mg260.00€100mg369.00€200mg487.00€1mL*10mM (DMSO)58.00€BPR1K871
CAS:BPR1K871, a preclinical development candidate for anti-cancer therapy [1], is a potent, selective dual inhibitor targeting FLT3 and AURKA, with IC50 values ofFormula:C25H28ClN7O2SColor and Shape:SolidMolecular weight:526.05FLT1 Protein, Human, Recombinant (aa 1-328, His)
FLT1 Protein, Human, Recombinant (aa 1-328, His) is expressed in HEK293 mammalian cells with His tag.Purity:97.5%Color and Shape:Lyophilized PowderMolecular weight:35.6 kDa (predicted)VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.Ref: TM-TMPK-00451
5µg91.00€10µg150.00€20µg239.00€50µg471.00€100µg779.00€200µg1,410.00€500µg3,018.00€FLT1 Protein, Human, Recombinant (hFc)
FLT1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.Color and Shape:Lyophilized PowderMolecular weight:61.1 kDa (predicted)Ref: TM-TMPY-00119
5µg85.00€10µg119.00€20µg192.00€50µg388.00€100µg655.00€200µg1,151.00€500µg2,777.00€VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi)
VEGFR1/FLT-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag.Color and Shape:Lyophilized PowderMolecular weight:85.1 kDa (predicted). Due to glycosylation, the protein migrates to 100-120 kDa based on Tris-Bis PAGE result.FLT1 Protein, Human, Recombinant (aa 1-756, His)
FLT1 Protein, Human, Recombinant (aa 1-756, His) is expressed in HEK293 mammalian cells with His tag.Color and Shape:Lyophilized PowderMolecular weight:83.7 kDa (predicted); 110-120 kDa (reducing condition, due to glycosylation)Ref: TM-TMPY-02108
1mg3,278.00€5µg65.00€10µg94.00€20µg153.00€50µg291.00€100µg554.00€200µg827.00€500µg1,598.00€FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated
FLT1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag.Color and Shape:Lyophilized PowderMolecular weight:85.45 kDa (predicted); 113.32 kDa (reducing conditions)UNC2025 2HCl (1429881-91-3(free base))
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.Formula:C28H42Cl2N6OPurity:99.71%Color and Shape:SolidMolecular weight:549.62Ref: TM-T4419
1mg52.00€2mg77.00€5mg95.00€10mg163.00€25mg306.00€50mg538.00€100mg767.00€1mL*10mM (DMSO)163.00€Fostamatinib Disodium
CAS:Fostamatinib Disodium (R788 Disodium) is an orally available Syk kinase inhibitor with potential anti-inflammatory and immunomodulating activities.Formula:C23H24FN6O9P·2NaPurity:96.13% - 99.09%Color and Shape:SolidMolecular weight:624.42Ref: TM-T2605
1mg44.00€2mg52.00€5mg84.00€10mg117.00€25mg210.00€50mg354.00€100mg530.00€500mg1,153.00€1mL*10mM (DMSO)110.00€5'-Fluoroindirubinoxime
CAS:5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).Formula:C16H10FN3O2Purity:>99.99%Color and Shape:SolidMolecular weight:295.27INE963
CAS:INE963: Potent against Pf 3D7 (EC50=6nM), clears parasites in <24h; effective on P. falciparum/vivax isolates (EC50=0.01-7nM).Formula:C19H26N6O2SPurity:99.08% - 99.45%Color and Shape:SolidMolecular weight:402.51FLT3-IN-2
CAS:FLT3-IN-2 is an FLT3 inhibitor (IC50<1 μM).Formula:C21H16ClF3N4Purity:97.57% - 98.53%Color and Shape:SolidMolecular weight:416.83Ref: TM-T1938
1mg40.00€2mg52.00€5mg82.00€10mg113.00€25mg200.00€50mg333.00€100mg477.00€1mL*10mM (DMSO)93.00€TCS 359
CAS:TCS 359 (FLT3 Inhibitor) is a potent FLT3 inhibitor with IC50 of 42 nM.Formula:C18H20N2O4SPurity:99.31%Color and Shape:SolidMolecular weight:360.43Pacritinib
CAS:Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).Formula:C28H32N4O3Purity:99.25% - 99.49%Color and Shape:SolidMolecular weight:472.58HPK1-IN-2
CAS:HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50<0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.Formula:C19H20N6OSPurity:97.31%Color and Shape:SolidMolecular weight:380.47Ref: TM-T9017
1mg73.00€5mg136.00€10mg219.00€25mg365.00€50mg520.00€100mg692.00€200mg888.00€1mL*10mM (DMSO)161.00€UNC2541
CAS:UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.Formula:C24H34FN7O2Purity:98.33%Color and Shape:SolidMolecular weight:471.57BPR1J-097
CAS:BPR1J-097) is a novel FLT-3 inhibitor(IC50: 11±7 nM) with promising in vivo anti-tumor activities. It also inhibits FLT-3 D835Y (IC50: 3 nM).Formula:C27H28N6O3SPurity:99.3%Color and Shape:SolidMolecular weight:516.61BPR1J-097 hydrochloride (1327167-19-0(free base))
BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.
Formula:C27H29ClN6O3SPurity:98% - 98.54%Color and Shape:SolidMolecular weight:553.07UNC2025
CAS:UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor.Formula:C28H40N6OPurity:99.53% - 99.74%Color and Shape:SolidMolecular weight:476.664SC-203
CAS:4SC-203 is a multi-kinase inhibitor with potential anti-tumor activity.Cost-effective and quality-assured.Formula:C33H38N8O4SPurity:99.52% - 99.84%Color and Shape:SolidMolecular weight:642.77TAK-659 hydrochloride
CAS:TAK-659 hydrochloride (TAK-659) is a potent and selective inhibitor of spleen tyrosine kinase (SYK) with an IC50 value of 3.2 nM.Formula:C17H22ClFN6OPurity:99.28% - 99.82%Color and Shape:SolidMolecular weight:380.85Gilteritinib hemifumarate
CAS:Gilteritinib hemifumarate (ASP2215 hemifumarate) is a potent ATP-competitive dual FLT3 (IC50: 0.29 nM) and AXL (IC50: 0.73 nM) inhibitor for the treatment of
Formula:C29H44N8O3C4H4O4Purity:99.78%Color and Shape:SolidMolecular weight:610.75KRN383
CAS:KRN383 inhibits ITD cell growth at ≤2.9 nM, erases ITD tumors in mice at 80 mg/kg dose, and may suit various treatment plans.Formula:C17H17N3O4Color and Shape:SolidMolecular weight:327.33
