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FLT

FLT

FLT (Fms-like tyrosine kinase) inhibitors are compounds that target FLT receptors, which are involved in the regulation of angiogenesis through the VEGF (vascular endothelial growth factor) pathway. FLT receptors play a crucial role in the development of new blood vessels in tumors. Inhibiting FLT receptors can effectively reduce angiogenesis and tumor growth, making these inhibitors important in cancer therapy. At CymitQuimica, we offer a selection of high-quality FLT inhibitors to support your research in oncology, vascular biology, and angiogenesis.

Found 92 products of "FLT"

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  • HPK1-IN-2
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    HPK1-IN-2

    CAS:
    <p>HPK1-IN-2 is a strong, oral HPK1 inhibitor (IC50&lt;0.05 μM), also blocking Lck, Flt3 kinases, with anticancer properties.</p>
    Formula:C19H20N6OS
    Purity:97.31%
    Color and Shape:Solid
    Molecular weight:380.47

    Ref: TM-T9017

  • (E/Z)-Zotiraciclib
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    (E/Z)-Zotiraciclib

    CAS:
    <p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>
    Formula:C23H24N4O
    Purity:97.75% - 99.92%
    Color and Shape:Solid
    Molecular weight:372.46

    Ref: TM-T21503

  • Crenolanib
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    Crenolanib

    CAS:
    <p>Crenolanib (ARO 002) is an orally bioavailable type III tyrosine kinases inhibitor of PDGFRα/β and FLT3 (IC50s: 11, 3.2, and 4 nM).</p>
    Formula:C26H29N5O2
    Purity:98.40% - 99.73%
    Color and Shape:Solid
    Molecular weight:443.54

    Ref: TM-T2677

  • 5'-Fluoroindirubinoxime
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    5'-Fluoroindirubinoxime

    CAS:
    <p>5'-Fluoroindirubinoxime (5'-FIO) is a potent FLT3 inhibitor( IC50 : 15 nM).</p>
    Formula:C16H10FN3O2
    Purity:>99.99%
    Color and Shape:Solid
    Molecular weight:295.27

    Ref: TM-T8317

  • UNC2025 2HCl (1429881-91-3(free base))
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    UNC2025 2HCl (1429881-91-3(free base))

    <p>UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.</p>
    Formula:C28H42Cl2N6O
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:549.62

    Ref: TM-T4419

  • SGI-7079
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    SGI-7079

    CAS:
    <p>SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.</p>
    Formula:C26H26FN7
    Purity:95.51% - 99.26%
    Color and Shape:Solid
    Molecular weight:455.53

    Ref: TM-T6982

  • SB1317 hydrochloride (1204918-72-8(free base))
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    SB1317 hydrochloride (1204918-72-8(free base))

    <p>SB1317 hydrochloride (1204918-72-8(free base)) (TG-02 hydrochloride) is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM).</p>
    Formula:C23H25ClN4O
    Purity:99.84%
    Color and Shape:Solid
    Molecular weight:408.92

    Ref: TM-T4227

  • AMG 925
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    AMG 925

    CAS:
    <p>AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.</p>
    Formula:C26H29N7O2
    Purity:99.75%
    Color and Shape:Solid
    Molecular weight:471.55

    Ref: TM-T6756

  • UNC2541
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    UNC2541

    CAS:
    <p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>
    Formula:C24H34FN7O2
    Purity:98.33%
    Color and Shape:Solid
    Molecular weight:471.57

    Ref: TM-T17205

  • Pacritinib
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    Pacritinib

    CAS:
    <p>Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).</p>
    Formula:C28H32N4O3
    Purity:99.25% - 99.49%
    Color and Shape:Solid
    Molecular weight:472.58

    Ref: TM-T6020

  • TG-46
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    TG-46

    CAS:
    <p>TG-46 (TG46) inhibits JAK2, FLT3, RET, JAK3 and can be used to study glaucoma.</p>
    Formula:C26H34N6O3S
    Purity:98.82% - 99.81%
    Color and Shape:Solid
    Molecular weight:510.65

    Ref: TM-T20743

  • FLT3-IN-6
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    FLT3-IN-6

    CAS:
    <p>FLT3-IN-6 is a potent and selective inhibitor of FLT3-ITD (FLT3 mutation) with an IC50 of 1.336 nM.</p>
    Formula:C23H25N5O3
    Color and Shape:Solid
    Molecular weight:419.48

    Ref: TM-T11300

  • JNJ-47117096 hydrochloride
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    JNJ-47117096 hydrochloride

    CAS:
    <p>JNJ-47117096 hydrochloride is potent and selective MELK inhibitor, with an IC50 of 23 nM, also effectively inhibits Flt3, with an IC50 of 18 nM.</p>
    Formula:C21H23ClN4O2
    Color and Shape:Solid
    Molecular weight:398.89

    Ref: TM-T11725

  • FLT3-IN-12
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    FLT3-IN-12

    CAS:
    <p>FLT3-IN-12: potent, selective oral FLT3 inhibitor; FLT3-WT IC50: 1.48 nM, FLT3-D835Y: 2.87 nM; &gt;1000x selective over c-KIT; anti-AML, IC50: 0.75 nM MV4-11.</p>
    Formula:C21H23F3N6O
    Color and Shape:Solid
    Molecular weight:432.44

    Ref: TM-T62412

  • FLT3-IN-15
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    FLT3-IN-15

    CAS:
    <p>FLT3-IN-15 is an orally active and potent FLT3 inhibitor, capable of acting on FLT3 (IC50: 0.87 nM) and FLT3/D835Y (IC50: 0.32 nM).</p>
    Formula:C22H23ClFN5O2
    Color and Shape:Solid
    Molecular weight:443.91

    Ref: TM-T62607

  • PDGFRα/FLT3-ITD-IN-2
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    PDGFRα/FLT3-ITD-IN-2

    CAS:
    <p>PDGFRα/FLT3-ITD-IN-2 is a potent inhibitor of PDGFRα (IC50&gt;20 μM) and FLT3 (IC50: 0.004 μM).</p>
    Formula:C28H41N9O
    Color and Shape:Solid
    Molecular weight:519.68

    Ref: TM-T63629

  • FLT3-IN-18
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    FLT3-IN-18

    CAS:
    <p>FLT3-IN-18: potent, selective FLT3 inhibitor, IC50 0.003 μM, induces apoptosis, G1 arrest, blocks FLT3/STAT5, potential in AML research.</p>
    Formula:C26H36N8O
    Color and Shape:Solid
    Molecular weight:476.62

    Ref: TM-T73142

  • FLT3/D835Y-IN-1
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    FLT3/D835Y-IN-1

    CAS:
    <p>FLT3/D835Y-IN-1, an oral FLT3 inhibitor (IC50: FLT3 - 0.26 nM, D835Y - 0.18 nM), shows anticancer potential in AML research.</p>
    Formula:C22H21N5O3
    Color and Shape:Solid
    Molecular weight:403.43

    Ref: TM-T61977

  • AGL 2043
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    AGL 2043

    CAS:
    <p>AGL 2043 is a potent, reversible, ATP-competitive inhibitor of type III receptor tyrosine kinases.</p>
    Formula:C15H12N4S
    Color and Shape:Solid
    Molecular weight:280.35

    Ref: TM-T26576

  • MDK5466
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    MDK5466

    CAS:
    <p>MDK5466 is an Flt3 inhibitor that acts by preventing glutamate-induced cell death.</p>
    Formula:C21H23N3OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:365.49

    Ref: TM-T24438