Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1Erlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397PHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98Fe-TMPyP
CAS:<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formula:C44H36Cl5FeN8Color and Shape:SolidMolecular weight:909.92Hoechst 33342 analog trihydrochloride
CAS:<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05Elaiophylin
CAS:<p>Elaiophylin exhibits anti-Plasmodium falciparum and anti-Trypanosoma brucei activity; IC50: 0.36 μM & 0.45 μM, respectively.</p>Formula:C54H88O18Purity:98%Color and Shape:SolidMolecular weight:1025.27Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Color and Shape:Odour SolidMRT67307
CAS:<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>Formula:C26H36N6O2Purity:99.25% - 99.84%Color and Shape:SolidMolecular weight:464.6Clionamine B
CAS:<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.65NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formula:C56H68ClN9O5S2Color and Shape:SolidMolecular weight:1046.78MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53ML-SA5
CAS:<p>ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes.Cost-effective and quality-assured.</p>Formula:C19H24ClN3O4S2Purity:99.16% - >99.99%Color and Shape:SoildMolecular weight:457.99Tigecycline mesylate
CAS:<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formula:C30H43N5O11SPurity:98%Color and Shape:SolidMolecular weight:681.75Desethylamiodarone hydrochloride
CAS:<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72SJFα
CAS:<p>SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.</p>Formula:C59H67F2N7O11SPurity:95.25%Color and Shape:SolidMolecular weight:1120.27
