Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1483 products of "Autophagy"
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TOMATIDINE HYDROCHLORIDE
CAS:Tomatidine hydrochloride (Tomatidine HCl) is a steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway.Formula:C27H46ClNO2Purity:99.75% - ≥95%Color and Shape:SolidMolecular weight:452.11Triptonide
CAS:<p>Triptonide treats autoimmune diseases, has antileukemic/tumor effects, is anti-inflammatory, and boosts IL-37.</p>Formula:C20H22O6Purity:99.11% - 99.64%Color and Shape:White Crystalline PowderMolecular weight:358.39Leonurine hydrochloride
CAS:Leonurine hydrochloride (SCM-198 hydrochloride) , a major alkaloid compound extracted from Leonurus japonicas Houtt.Formula:C14H22ClN3O5Purity:99.07%Color and Shape:SolidMolecular weight:347.79Rhoifolin
CAS:Rhoifolin (Apigenin 7-O-neohesperidoside) is extracted from Turpinia arguya Seem dried leaves.Formula:C27H30O14Purity:98.11% - 98.58%Color and Shape:SolidMolecular weight:578.52palovarotene
CAS:<p>Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).</p>Formula:C27H30N2O2Purity:97.88% - 98.05%Color and Shape:SolidMolecular weight:414.54C646
CAS:<p>C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).</p>Formula:C24H19N3O6Purity:98% - 99.21%Color and Shape:SolidMolecular weight:445.42SB 239063
CAS:<p>SB 239063 (SB239063) is a potent and selective p38 MAPKα/β inhibitor with IC50 of 44 nM, showing no activity against the γ- and δ-kinase isoforms.</p>Formula:C20H21FN4O2Purity:99.42% - 99.81%Color and Shape:SolidMolecular weight:368.4Silmitasertib
CAS:Silmitasertib (CX-4945) is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).Formula:C19H12ClN3O2Purity:98% - 99.90%Color and Shape:SolidMolecular weight:349.77Scriptaid
CAS:Scriptaid (GCK1026) is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.Formula:C18H18N2O4Purity:96.74% - 99.45%Color and Shape:SolidMolecular weight:326.354E1rcat
CAS:<p>4E1RCat is a dual inhibitor of eIF4E:eIF4 g and eIF4E:4E-BP1 interaction. And it inhibits the binding of eIF4 g to eIF4E with IC50 of 3.2 μM.</p>Formula:C28H18N2O6Purity:99.47%Color and Shape:SolidMolecular weight:478.45Hemin
CAS:Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer.Formula:C34H32ClFeN4O4Purity:97.169% - 99.59%Color and Shape:Dark Purple Crystalline PowderMolecular weight:651.94β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Formula:C15H14O3Purity:99.76% - 99.88%Color and Shape:SolidMolecular weight:242.27DAPT
CAS:DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active.Formula:C23H26F2N2O4Purity:98.06% - 99.81%Color and Shape:White SolidMolecular weight:432.46Ginsenoside Rb1
CAS:Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.Formula:C54H92O23Purity:99.12% - 99.76%Color and Shape:SolidMolecular weight:1109.29SB225002
CAS:SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.Formula:C13H10BrN3O4Purity:98.16% - 99.85%Color and Shape:SolidMolecular weight:352.14FC131 TFA (606968-52-9 free base)
CAS:FC131 TFA (606968-52-9 free base) (FC131 TFA) is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hivFormula:C38H48F3N11O8Purity:99.39% - 99.67%Color and Shape:SolidMolecular weight:843.85ATI-2341 acetate(1337878-62-2 free base)
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13.Formula:C106H182N26O27S2Purity:97.14%Color and Shape:SolidMolecular weight:2316.87MSX-122
CAS:MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).Formula:C16H16N6Purity:98.31% - 98.94%Color and Shape:SolidMolecular weight:292.34Acacetin
CAS:Acacetin (5,7-Dihydroxy-4'-methoxyflavone) is an O-methylated flavone found in various plants, shows antinociceptive, anti-inflammatory, and antioxidantFormula:C16H12O5Purity:96.26% - ≥95%Color and Shape:Pale-Yellow NeedlesMolecular weight:284.26Danirixin
CAS:<p>Danirixin (GSK1325756) is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).</p>Formula:C19H21ClFN3O4SPurity:99.78% - >99.99%Color and Shape:SolidMolecular weight:441.9Navarixin
CAS:Navarixin (MK-7123)(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophilFormula:C21H23N3O5Purity:98% - 99.51%Color and Shape:SolidMolecular weight:397.42PD 169316
CAS:PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor.Formula:C20H13FN4O2Purity:98.65%Color and Shape:SolidMolecular weight:360.34AMD 3465 hexahydrobromide
CAS:AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.Formula:C24H44Br6N6Purity:99.39%Color and Shape:SolidMolecular weight:896.07SB-265610
CAS:<p>SB-265610 (GSK-CXCR2) is a nonpeptide and allosteric CXCR2 antagonist.</p>Formula:C14H9BrN6OPurity:99.5%Color and Shape:SolidMolecular weight:357.16ML339
CAS:<p>ML339 a selective inhibitor of CXCR6(IC50 = 140 nM) with no response when screened against CXCR5 and CXCR4.</p>Formula:C26H32ClN3O5Purity:99.9%Color and Shape:SolidMolecular weight:502AMD-070 hydrochloride
CAS:AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.Formula:C21H28ClN5Purity:98.38% - 98.57%Color and Shape:SolidMolecular weight:385.93CTCE 9908 acetate
CTCE 9908 acetate is an antagonist of CXCR4 and inhibits migration in CXCR4-expressing ovarian cancer cells.Formula:C88H151N27O25Purity:98.47%Color and Shape:SolidMolecular weight:1987.31MSX-127
CAS:MSX-127 elicites positive response in peptide CXCR4.Formula:C16H24N2O4Purity:98.43%Color and Shape:SolidMolecular weight:308.37WZ811
CAS:<p>WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).</p>Formula:C18H18N4Purity:99.42% - ≥95%Color and Shape:SolidMolecular weight:290.36USL311
CAS:USL311 blocks CXCR4/SDF-1 interaction, inhibits tumor cell growth and migration.Formula:C24H34N6OPurity:98.46% - 99.56%Color and Shape:SolidMolecular weight:422.57TAK-779
CAS:TAK-779 (Takeda 779) is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).Formula:C33H39ClN2O2Purity:99.21%Color and Shape:SolidMolecular weight:531.13Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purity:98% - 99.5%Color and Shape:SolidMolecular weight:855.02JMS-17-2
CAS:JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).Formula:C25H26ClN3OPurity:98.7% - 99.44%Color and Shape:SolidMolecular weight:419.95TC14012 acetate
TC14012 acetate is a serum-stable derivative of T140 which is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM.Formula:C92H144N34O21S2Purity:98.33% - 99.71%Color and Shape:SolidMolecular weight:2126.47MSX-130
CAS:MSX-130 is CXCR4 Antagonist.Formula:C36H26N4Purity:99.19%Color and Shape:SolidMolecular weight:514.62SRT3109
CAS:SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.Formula:C18H23F2N5O4S2Purity:99.65% - 99.92%Color and Shape:SolidMolecular weight:475.53Plerixafor
CAS:Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.Formula:C28H54N8Purity:99.17% - >99.99%Color and Shape:SolidMolecular weight:502.78AZD-5069
CAS:AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).Formula:C18H22F2N4O5S2Purity:98.38% - 98.63%Color and Shape:SolidMolecular weight:476.52Plerixafor octahydrochloride
CAS:Plerixafor octahydrochloride mobilizes HSCs by blocking SDF-1alpha/CXCR4 interaction, facilitating their release into circulation.Formula:C28H62Cl8N8Purity:98.01% - 99.79%Color and Shape:SolidMolecular weight:794.46SX-682
CAS:SX-682 is an orally available allosteric inhibitor of CXCR1 and CXCR2.Cost-effective and quality-assured.Formula:C19H14BF4N3O4SPurity:98.19% - 99.61%Color and Shape:SolidMolecular weight:467.2Isobavachalcone
CAS:<p>Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in</p>Formula:C20H20O4Purity:98% - 99.76%Color and Shape:SolidMolecular weight:324.37HG-10-102-01
CAS:HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).Formula:C17H20ClN5O3Purity:99.59%Color and Shape:SolidMolecular weight:377.83Lucanthone
CAS:<p>Lucanthone (Lucanthonum) is an inhibitor of Apurinic endonuclease-1 (APE-1).</p>Formula:C20H24N2OSPurity:99.92%Color and Shape:Yellow Crystals From Alcohol SolidMolecular weight:340.48Pennogenin 3-O-β-chacotrioside
CAS:Pennogenin 3-O-beta-chacotrioside from Paris polyphylla fights colorectal cancer, boosting autophagy proteins LC3 and Beclin-1.Formula:C45H72O17Purity:99.69% - 99.77%Color and Shape:SolidMolecular weight:885.04RITA
CAS:RITA (NSC-652287) forms DNA-DNA/protein cross-links without DNA breaks; disrupts p53/Mdm2 like nutlin-3.Formula:C14H12O3S2Purity:98.49% - 99.55%Color and Shape:SolidMolecular weight:292.374EGI-1
CAS:4EGI-1, a competitive eIF4E/eIF4 g interaction inhibitor, binds to eIF4E(KD=25 μM).Formula:C18H12Cl2N4O4SPurity:96.8% - 99.12%Color and Shape:SolidMolecular weight:451.28Bortezomib
CAS:Bortezomib (LDP 341) is a 20S proteasome inhibitor (Ki=0.6 nM) that is reversible and selective.Formula:C19H25BN4O4Purity:97.79% - >99.99%Color and Shape:Yellow SolidMolecular weight:384.24CZC-25146 hydrochloride
CAS:<p>CZC-25146 is a selective LRRK2 inhibitor with IC50 of 4.76 nM/6.87 nM for wild type LRRK2 and G2019S LRRK2, respectively.</p>Formula:C22H26ClFN6O4SPurity:98.76%Color and Shape:SolidMolecular weight:525Danshensu
CAS:<p>Danshensu (Dan shen suan A) is an active ingredient of Salvia miltiorrhiza with wide cardiovascular benefit.</p>Formula:C9H10O5Purity:98.4% - 99.74%Color and Shape:SolidMolecular weight:198.17SKF-96365 hydrochloride
CAS:SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal YFormula:C22H27ClN2O3Purity:99.47% - 99.92%Color and Shape:SolidMolecular weight:402.91
