Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1483 products of "Autophagy"
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Esmolol hydrochloride
CAS:Esmolol is a cardioselective beta-blocker used in parenteral forms in the treatment of arrhythmias and severe hypertension.Formula:C16H25NO4·HClPurity:98.72% - 99.48%Color and Shape:White SolidMolecular weight:331.15Erlotinib mesylate
CAS:<p>Erlotinib: reversible inhibitor binding to ATP site of epidermal growth factor receptor.</p>Formula:C23H27N3O7SPurity:98%Color and Shape:SolidMolecular weight:489.54PBA-1105
CAS:PBA-1105, an autophagy-targeting chimeric molecule (AUTOTAC), facilitates the self-oligomerization of p62. Additionally, PBA-1105 enhances the autophagic flux of Ub-conjugated aggregates.Formula:C39H48N2O6Color and Shape:SolidMolecular weight:640.81Gavilimomab
CAS:Gavilimomab(ABX-CBL) is a murine-derived IgM monoclonal antibody against CD147 antigen used in immunosuppressive treatments for glucocorticoid-resistant GVHD).Purity:95%Color and Shape:LiquidResveratrol analog 2
CAS:Resveratrol analog 2 mimics Resveratrol, a natural antioxidant with anti-inflammatory, cardioprotective, and anticancer benefits.Formula:C16H13FO3Purity:98%Color and Shape:SolidMolecular weight:272.27Seriniquinone
CAS:Seriniquinone is a selective agent of anticancer that acts by inducing cell death via autophagocytosis and targeting the cancer-protective protein dermcidin.Formula:C20H8O4SPurity:98%Color and Shape:SolidMolecular weight:344.34TAMRA alkyne, 6-isomer
CAS:<p>TAMRA alkyne, 6-isomer: a xanthene dye linker with orange emission, used for DNA/RNA labeling, reacts via Click Chemistry.</p>Formula:C28H25N3O4Color and Shape:SolidMolecular weight:467.52SU11274
CAS:SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.Formula:C28H30ClN5O4SPurity:98.62% - 99.53%Color and Shape:Orange PowderMolecular weight:568.09Paroxetine hydrochloride hemihydrate
CAS:<p>Paroxetine hydrochloride hemihydrate (Paxil) is an effective and selective serotonin reuptake inhibitor (SSRI).</p>Formula:C38H44Cl2F2N2O7Purity:99.949%Color and Shape:SolidMolecular weight:749.67SR12418
CAS:SR12418 is a specific synthetic ligand for REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. inhibits IL-17A expression in EL4 cells.Formula:C31H30FNO3Purity:99.96%Color and Shape:SolidMolecular weight:483.57VUF10132
CAS:<p>VUF10132 is a full inverse CXCR3 N3.35A agonist.</p>Formula:C19H13BrCl4N2O2Purity:98%Color and Shape:SolidMolecular weight:523.03IZCZ-3
CAS:IZCZ-3,antitumor activity. is a potent c-MYC transcription inhibitor.Formula:C46H49N7OPurity:98%Color and Shape:SolidMolecular weight:715.93YOK-2204
CAS:<p>YOK-2204 is a ligand for the p62-ZZ domain and activates p62-dependent selective autophagy. It is also applicable in the design of AUTOTACs.</p>Formula:C28H35NO4Color and Shape:SolidMolecular weight:449.58(R)-Hydroxychloroquine
CAS:(R)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine is an agent of synthetic antimalarial.Formula:C18H26ClN3OPurity:98%Color and Shape:SolidMolecular weight:335.87AL 8697
CAS:<p>AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases.</p>Formula:C21H21F3N4OPurity:99.55% - 99.89%Color and Shape:SolidMolecular weight:402.41LS2265
CAS:LS2265, a fenofibrate derivative with a taurine modification, effectively induces the proliferation of peroxisomes in rat liver cells.Formula:C19H20ClNO6SPurity:98%Color and Shape:SolidMolecular weight:425.88AGN 205327
CAS:AGN 205327 is a potent synthetic RAR agonist,showing selective RAR activation without RXR inhibition for retinoid research.Formula:C24H26N2O3Purity:99.45% - 99.71%Color and Shape:SolidMolecular weight:390.47OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Formula:C25H24F3N3O6S2Color and Shape:SolidMolecular weight:583.6YM-155 hydrochloride
CAS:Sepantronium hydrochloride (YM-155 hydrochloride) is a novel survivin suppressant that inhibits survivin promoter with an IC 50 of 0.54 nM[1].Formula:C20H19ClN4O3Color and Shape:SolidMolecular weight:398.85ATG7-IN-3
CAS:<p>ATG7-IN-3, or compound 18, is an ATG7 inhibitor with a 0.048 μM IC50, blocking autophagy and LC3B puncta in H4 cells.</p>Formula:C11H16N6O5S2Purity:99.88%Color and Shape:SolidMolecular weight:376.41Evogliptin
CAS:Evogliptin (DA-1229) is an oral DPP4 inhibitor effective in reducing blood sugar and liver inflammation.Formula:C19H26F3N3O3Color and Shape:SolidMolecular weight:401.42IT1t
CAS:IT1t inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. is a potent CXCR4 antagonist.Formula:C21H34N4S2Purity:98%Color and Shape:SolidMolecular weight:406.65MPM-1
MPM-1, a marine mimic, induces rapid necrotic-like death in cancer cells, disrupts autophagy, and causes lysosomal swelling.Formula:C34H44F6N4O7Color and Shape:SolidMolecular weight:734.73PX20606 trans racemate
CAS:PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).Formula:C29H22Cl3NO4Purity:98%Color and Shape:SolidMolecular weight:554.85Autophagy inducer 4
CAS:Autophagy inducer 4, a Magnolol-based Mannich derivative, is an anticancer agent that blocks cancer cell migration & is 76x more toxic to T47D cells.Formula:C32H37NO6Color and Shape:SolidMolecular weight:531.64(Rac)-BL-918
CAS:(Rac)-BL-918 is the racemic form of BL-918. BL-918 is an effective activator of UNC-51-like kinase 1 (ULK1) (EC₅₀ = 24.14 nM), Parkinson's disease.Formula:C23H15F8N3OSPurity:97.03%Color and Shape:SolidMolecular weight:533.44eIF4A3-IN-2
CAS:eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 inhibitor with an IC50 of 110 nM.Formula:C25H19Br2ClN4O2Purity:98%Color and Shape:SolidMolecular weight:602.71KRH-1636
CAS:KRH-1636: potent, selective CXCR4 antagonist; orally active; inhibits X4 HIV-1 by blocking viral entry and membrane fusion.Formula:C32H37N7O2Color and Shape:SolidMolecular weight:551.68(S)-Hydroxychloroquine
CAS:(S)-Hydroxychloroquine is the enantiomer of Hydroxychloroquine. Hydroxychloroquine shows efficiently inhibits SARS-CoV-2 infection in vitro.Formula:C18H26ClN3OPurity:98%Color and Shape:SolidMolecular weight:335.87MRT-68601 HCl
CAS:MRT-68601 HCl, a potent TBK1 (TANK-binding kinase-1), inhibits the formation of autophagosomes in lung cancer cells.Formula:C25H34N6O2Purity:98%Color and Shape:SolidMolecular weight:450.58TN-14003
CAS:TN-14003 is a synthetic antagonist 14-mer peptide inhibiting metastasis in an animal model.Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42SX-517
CAS:SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects, inhibits CXCL-1-induced Ca²⁺ flux.Formula:C19H16BFN2O3SColor and Shape:SolidMolecular weight:382.22TUN-92046
CAS:<p>TUN-92046 is a permeable alpha-ketoglutarate analog that blocks harmful autophagy in cardiomyopathy.</p>Formula:C7H10O5Purity:95.48% - 98.58%Color and Shape:SolidMolecular weight:174.15VUF5834
CAS:VUF5834 is a full inverse agonist of CXCR3 N3.35A.Formula:C31H41N5O2Purity:98%Color and Shape:SolidMolecular weight:515.69SA72
CAS:SA72 is a highly selective inhibitor of fatty acid amide hydrolase (FAAH).Formula:C21H26N2O6Purity:98%Color and Shape:SolidMolecular weight:402.44Elliptinium acetate
CAS:Elliptinium acetate (NSC 264137), a cytotoxic DNA intercalator for cancer research, targets L1210 cells.Formula:C20H20N2O3Color and Shape:SolidMolecular weight:336.38Aliskiren fumarate
CAS:Oral renin inhibitor Aliskiren fumarate treats hypertension; IC50: 1.5 nM. Useful for cardiovascular and cancer cachexia research.Formula:C34H57N3O10Color and Shape:SolidMolecular weight:667.83rac-NBI-74330
CAS:rac-NBI-74330 is an effective and selective CXCR3 antagonist.Formula:C32H27F4N5O3Purity:99.6%Color and Shape:SolidMolecular weight:605.58FAAH inhibitor 1
CAS:FAAH inhibitor 1 (Benzothiazole analog 3) is an effective FAAH inhibitor with an IC50 of 18 nM.Formula:C24H23N3O3S3Purity:99.6%Color and Shape:SolidMolecular weight:497.65ALLO-1
CAS:ALLO-1, vital for autophagy, aids in engulfing paternal organelles by binding to worm LC3, LGG-1, via its LIR motif.Formula:C17H15ClN2O2Purity:98%Color and Shape:SolidMolecular weight:314.77AS1708727
CAS:AS1708727 inhibits Foxo1, reducing blood sugar and triglycerides by altering gene expression.Formula:C24H24Cl2N2O2Color and Shape:SolidMolecular weight:443.37Sulfosuccinimidyl oleate
CAS:Sulfosuccinimidyl oleate (Sulfo-N-succinimidyl oleate) (Sulfo-N-succinimidyl oleate) is a long chain fatty acid that inhibits fatty acid transport into cells.Formula:C22H37NO7SPurity:98%Color and Shape:SolidMolecular weight:459.6Ipsalazide
CAS:<p>Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.</p>Formula:C16H11N3Na2O6Purity:99.43%Color and Shape:SolidMolecular weight:387.25CC214-2
CAS:CC214-2: strong dual mTORC1/2 inhibitor, blocks autophagy, may shorten TB duration.Formula:C20H25N5O3Color and Shape:SolidMolecular weight:383.44CXCR3 Antagonist 6c
CAS:CXCR3 antagonist 6c blocks CXCR3 and inhibits Ca2+ movement and T-cell migration (IC50: 0.06 µM & 100 nM) with selectivity over 14 other GPCRs.Formula:C30H32Cl3N5O3Color and Shape:SolidMolecular weight:616.97ATG7-IN-2
CAS:ATG7-IN-2 inhibits ATG7 protein with 0.089 μM IC50 and suppresses autophagy marker LC3B.Formula:C11H16N6O7SColor and Shape:SolidMolecular weight:376.35HF51116
CAS:HF51116 blocks XCR4, hinders SDF-1α cell effects & HIV-1; potential for HIV, stem cells, cancer spread.Formula:C29H46N8OColor and Shape:SolidMolecular weight:522.73AC-55649
CAS:<p>AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9.</p>Formula:C21H26O2Purity:99.98%Color and Shape:SolidMolecular weight:310.43STK683963
CAS:STK683963 activates ATG4B, mediates redox regulation, and aids cancer research.Formula:C12H8FN3O2SColor and Shape:SolidMolecular weight:277.27Obatoclax
CAS:Obatoclax (GX15-070), a pan-BCL-2 inhibitor (Ki 220 nM) induces autophagy, degrades cyclin D1, and has anti-cancer/antiparasitic properties.Formula:C20H19N3OPurity:99.44%Color and Shape:SolidMolecular weight:317.38
