Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1504 products of "Autophagy"
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CXCR4 antagonist 7
CAS:Compound PARA-B, a CXCR4 antagonist with IC50 = 9.3 nM, targets HIV, cancer, inflammatory diseases, and WHIM syndrome.Formula:C15H17N5O3Color and Shape:SolidMolecular weight:315.33(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formula:C32H28F3N5O4Purity:98%Color and Shape:SolidMolecular weight:603.59AGN 194078
CAS:AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).Formula:C22H23F2NO4Color and Shape:SolidMolecular weight:403.42CC214-1
CAS:CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.Formula:C20H21N7O2Purity:97.16%Color and Shape:SolidMolecular weight:391.43CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formula:C17H15FN2O4SColor and Shape:SolidMolecular weight:362.38AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Formula:C34H50N8Color and Shape:SolidMolecular weight:570.81ATG12-ATG3 inhibitor 1
CAS:ATG12-ATG3 Inhibitor 1 (compound 189) serves as a potent inhibitor of autophagy [1].Formula:C18H17NO3SColor and Shape:SolidMolecular weight:327.4Pentixafor
CAS:Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emissionFormula:C60H80N14O14Purity:98%Color and Shape:SolidMolecular weight:1221.36p38-α MAPK-IN-1
CAS:p38-α MAPK-IN-1 is a MAPK14 (p38-α) inhibitor with IC50 of 2300 nM and 5500 nM in EFC displacement assay and HTRF assay,respectively.Formula:C27H35N5O3Purity:99.93%Color and Shape:SolidMolecular weight:477.6Ref: TM-T12347
1mg84.00€5mg170.00€10mg266.00€25mg492.00€50mg737.00€100mg1,108.00€200mg1,485.00€1mL*10mM (DMSO)178.00€CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 is a potent small-molecule inhibitor of CXCL12/CXCR4 signaling that suppresses cell migration and metastasis in cancer models.Formula:C21H30N6Purity:100%Color and Shape:SolidMolecular weight:366.5AGN 194310
CAS:AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].Formula:C28H24O2SColor and Shape:SolidMolecular weight:424.55CXCR2 antagonist 2
CAS:CXCR2 antagonist 2 is a potent CXCR2 antagonist for cancer immunotherapy with an IC 50 value of 95 nM.Formula:C17H17FN2O4SColor and Shape:SolidMolecular weight:364.39(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9AZD0233
CAS:AZD0233, Oral CX3CR1 antagonist, modulates CX3CR1/CX3CL1 axis, improves cardiac function in DCM models.Formula:C19H29FN6O4SColor and Shape:SolidMolecular weight:456.54CXCR2-IN-2
CAS:CXCR2-IN-2, Selective CXCR2 antagonist (IC50=5.2 nM), BBB penetration, oral bioavailability, inhibits Gro-α-induced CD11b expression in blood.Formula:C18H23ClN2O5SColor and Shape:SolidMolecular weight:414.9AEW541 HCl
CAS:AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.Formula:C27H31Cl2N5OColor and Shape:SolidMolecular weight:512.47NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formula:C23H35Cl2N5OPurity:98%Color and Shape:SolidMolecular weight:468.46Ruxolitinib sulfate
CAS:Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.Formula:C17H20N6O4SColor and Shape:SolidMolecular weight:404.45AGN-195183
CAS:AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.Formula:C22H22ClF2NO4Color and Shape:SolidMolecular weight:437.86p38 MAPK-IN-1
CAS:p38 MAPK-IN-1 is a novel selective p38 MAPK inhibitor with high potency, which reduces inflammatory responses by inhibiting LPS-induced TNF-α production.Formula:C21H14F2N2OPurity:98%Color and Shape:SolidMolecular weight:348.35Gly-β-MCA
CAS:Gly-β-MCA is an orally bioactive, entero inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.Formula:C26H43NO6Purity:≥98.0%Color and Shape:SolidMolecular weight:465.626CEPN
CAS:6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.Formula:C23H18O5Color and Shape:SolidMolecular weight:374.39Cisd2 agonist 1
CAS:Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).Formula:C14H13FN2O3SPurity:99.06%Color and Shape:SolidMolecular weight:308.33Ref: TM-T78093
1mg71.00€5mg152.00€10mg236.00€25mg485.00€50mg802.00€100mg1,099.00€500mg2,205.00€1mL*10mM (DMSO)167.00€XIE62-1004
CAS:XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.Formula:C23H25NO3·HClColor and Shape:SolidMolecular weight:399.91AZ PFKFB3 26
CAS:AZ PFKFB3 26 is an effective and selective PFKFB3 inhibitor with an IC50 of 23 nM. The IC50s for PFKFB1 and PFKFB2 are 2.06 and 0.384 μM, respectively.
Formula:C24H26N4O2Purity:99.85%Color and Shape:SolidMolecular weight:402.49CXCR2-IN-1
CAS:CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.Formula:C19H20Cl2FN3O4SPurity:99.89%Color and Shape:SolidMolecular weight:476.35PHY34
CAS:PHY34 inhibits autophagy at nanomolar potency, with anti-tumor effects on HGSOC in vivo.Formula:C30H30O12Purity:98.71%Color and Shape:SolidMolecular weight:582.55Ref: TM-T37376
1mg164.00€2mg235.00€5mg369.00€10mg548.00€25mg879.00€50mg1,198.00€100mg1,596.00€500mg3,212.00€GDC-0349
CAS:GDC-0349 (RG-7603) is a potent and selective ATP-competitive inhibitor of mTOR, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.Formula:C24H32N6O3Purity:96.00% - 98.49%Color and Shape:SolidMolecular weight:452.55DC-LC3in-D5
CAS:DC-LC3in-D5 is a potent and selective covalent inhibitor of LC3A/B that disrupts autophagy by covalently binding to Lys49 on LC3B.Formula:C19H22Cl2N2O3Purity:99.79%Color and Shape:SolidMolecular weight:397.3Ref: TM-T61871
1mg94.00€5mg222.00€10mg356.00€25mg713.00€50mg1,108.00€100mg1,738.00€200mg2,332.00€1mL*10mM (DMSO)245.00€LRRK2-IN-19
CAS:LRRK2-IN-19 is a PROTAC-targeted protein ligand utilized in the synthesis of PROTAC JH-XII-03-02. JH-XII-03-02 acts as an effective and selective LRRK2 PROTAC degrader, which is applicable for research in Parkinson's disease.Formula:C19H22N6OColor and Shape:SolidMolecular weight:350.42HDAC10-IN-1
HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.Formula:C18H23N3O2Color and Shape:SolidMolecular weight:313.39(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formula:C23H31Cl2N7OColor and Shape:SolidMolecular weight:492.45CXCR2/CCR7 antagonist-1
CAS:CXCR2/CCR7 antagonist-1 (compound 6) is a potent dual antagonist of CXCR2 and CCR7, with IC50 values of 0.0046 μM and 0.0014 μM, respectively. It is valuable for research in tumor metastasis and autoimmune diseases.Formula:C23H27N3O5Color and Shape:SolidMolecular weight:425.48LRRK2-IN-4
CAS:LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Formula:C25H29ClF2N6O2Color and Shape:SolidMolecular weight:518.99LRRK2-IN-2
CAS:LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formula:C23H23Cl2F3N6O2Color and Shape:SolidMolecular weight:543.37Acetylpepstatin
CAS:Acetylpepstatin is an inhibitor of HIV-1 protease, HIV-2 protease, aspartyl protease.Formula:C33H61N5O11Purity:98%Color and Shape:SolidMolecular weight:703.875HDAC1-IN-8
CAS:HDAC1-IN-8 (compound 5c) is a potent and selective HDAC1 inhibitor, with IC50 values of 11.94 µM for HDAC1, 22.95 µM for HDAC6, and greater than 500 µM for HDAC8. It exhibits antiproliferative activity, induces cell cycle arrest in G1 and G2/M phases, and triggers autophagy (autophagy). Additionally, HDAC1-IN-8 demonstrates anticancer properties and holds potential for lung cancer research.Formula:C22H24N2O4Color and Shape:SolidMolecular weight:380.4374-FPBUA
CAS:4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Formula:C31H23FO7Color and Shape:SolidMolecular weight:526.51Autophagy-lysosome activator-1
Autophagy-lysosome Activator-1 (Compound F1) is an autophagy-lysosome stimulator that effectively induces the degradation of PD-L1 or VISTA in tumor cells.Formula:C17H18N4O2Color and Shape:SolidMolecular weight:310.35CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride, Inhibits SDF-1 (CXCL12) or I-TAC binding to CXCR7, used for tumor and inflammation research.Formula:C21H20ClFN6OPurity:99.84%Color and Shape:SolidMolecular weight:426.87SRI-31255
CAS:SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formula:C15H14N4Color and Shape:SolidMolecular weight:250.30ATG12-IN-1
CAS:ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.Formula:C23H15ClN4O2Color and Shape:SolidMolecular weight:414.84CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formula:C28H37N5O4SColor and Shape:SolidMolecular weight:539.69BRD5631
CAS:BRD5631 is an autophagy enhancer, enhances autophagy through an mTOR-independent pathway.Formula:C30H35N3O4Purity:98%Color and Shape:SolidMolecular weight:501.62SHS206
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).Formula:C14H7F6N3OColor and Shape:SolidMolecular weight:347.22UNC0638 hydrate
CAS:UNC0638 hydrate selectively inhibits G9a and GLP histone methyltransferases with IC50 values of 15 nM and 19 nM, respectively. It is effective in inhibiting invasion and migration of TNBC cells in vitro. Additionally, UNC0638 hydrate acts as an inhibitor of EHMT1/2 and induces the expression of fetal hemoglobin (HbF) in cultures of human erythroid progenitor cells. Furthermore, it exhibits antiviral activity against FMDV (foot-and-mouth disease virus) and VSV (vesicular stomatitis virus), demonstrating remarkable potency and selectivity across various epigenetic and non-epigenetic targets.Formula:C30H49N5O3Color and Shape:SolidMolecular weight:527.74ACT-777991
CAS:ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formula:C20H20F6N8O2SColor and Shape:SolidMolecular weight:550.48Autophagy activator-1
CAS:Autophagyactivator-1 (Compound B2) is an autophagy activator that induces autophagy by downregulating key members of the HSP70 family and activating the unfolded protein response.
Formula:C25H32O8Color and Shape:SolidMolecular weight:460.517PARL-IN-1
PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.Formula:C40H58N6O7Color and Shape:SolidMolecular weight:734.92QW24
CAS:QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.Formula:C27H28N2O4Color and Shape:SolidMolecular weight:444.52
