Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1424 products of "Autophagy"
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Autocamtide 2, amide
<p>Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.</p>Formula:C65H119N23O19Purity:98%Color and Shape:SolidMolecular weight:1526.79Biotin-16-UTP
CAS:<p>Biotin-16-UTP serves as an efficient substrate for RNA polymerase, capable of substituting UTP in vitro transcription reactions to facilitate RNA labeling [1].</p>Formula:C32H48Li4N7O19P3SColor and Shape:SolidMolecular weight:987.51Salinomycin sodium salt
CAS:<p>Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.</p>Formula:C42H69NaO11Purity:98.76% - 99.11%Color and Shape:White Or Light Yellow Crystalline Powder With Special SmelMolecular weight:772.98DOTA-CXCR4-L
<p>DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancer</p>Formula:C58H78N16O14Purity:98%Color and Shape:SolidMolecular weight:1223.34E70K
<p>E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuate</p>Formula:C108H178N34O28Purity:98%Color and Shape:SolidMolecular weight:2400.78Nictide
CAS:<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Formula:C123H193N45O28Color and Shape:SolidMolecular weight:2750.13N6-Isopentenyladenosine
CAS:<p>N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.</p>Formula:C15H21N5O4Purity:97.13% - 99.69%Color and Shape:SolidMolecular weight:335.36CXM102
<p>CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.</p>Formula:C28H27NO3Color and Shape:SolidMolecular weight:425.52TRAF6 peptide
CAS:<p>TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.</p>Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64SQA1
CAS:<p>SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.</p>Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98LC3in-C42
<p>LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.</p>Color and Shape:Odour SolidVUF-11222
CAS:<p>VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).</p>Formula:C25H31BrINPurity:99.82%Color and Shape:SolidMolecular weight:552.33Cabergoline
CAS:<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Formula:C26H37N5O2Purity:97.69% - 99.86%Color and Shape:White Crystalline SolidMolecular weight:451.6PHTPP-1304
CAS:<p>PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.</p>Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Polyphemusin II-Derived Peptide
CAS:<p>T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.</p>Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42MRL828
<p>MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.</p>Formula:C46H51FN14O5SColor and Shape:SolidMolecular weight:930.38716SG31
<p>SG31 is a potent activator of autophagy, exerting its effects through the AMPK/ULK1-dependent pathway.</p>Formula:C26H37N6O8PColor and Shape:SolidMolecular weight:592.58cGMP-HTL
<p>cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.</p>Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Peptide R
CAS:<p>Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.</p>Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1Zn-DPA-maytansinoid conjugate 1
<p>Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.</p>Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83Tigecycline mesylate
CAS:<p>Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.</p>Formula:C30H43N5O11SPurity:98%Color and Shape:SolidMolecular weight:681.75Fe-TMPyP
CAS:<p>Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.</p>Formula:C44H36Cl5FeN8Color and Shape:SolidMolecular weight:909.92Microcolin H
CAS:<p>Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].</p>Formula:C38H63N5O9Color and Shape:SolidMolecular weight:733.93MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53Hoechst 33342 analog trihydrochloride
CAS:<p>Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating the</p>Formula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05vMIP-II (1-21) TFA
<p>vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.</p>Color and Shape:Odour SolidClionamine B
CAS:<p>Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.</p>Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.65Acridine homodimer
CAS:<p>Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.</p>Formula:C38H42Cl2N6O2Color and Shape:SolidMolecular weight:685.69ITIC-4F
CAS:<p>ITIC-4F: a postfullerene IDTT electron acceptor for high-efficiency PSCs, relevant in binary, ternary, and tandem setups.</p>Formula:C94H78F4N4O2S4Purity:98%Color and Shape:SolidMolecular weight:1499.92Desethylamiodarone hydrochloride
CAS:<p>Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.</p>Formula:C23H26ClI2NO3Purity:98%Color and Shape:SolidMolecular weight:653.72G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Formula:C27H31IN2O3Color and Shape:SolidMolecular weight:558.45NAMPT degrader-1
<p>Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.</p>Formula:C56H68ClN9O5S2Color and Shape:SolidMolecular weight:1046.78RK-682 (calcium salt)
CAS:<p>RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.</p>Formula:C42H74CaO10Color and Shape:SolidMolecular weight:779.122TSPO Ligand-Linker Conjugates 1
<p>TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.</p>Formula:C32H55N3O10SColor and Shape:SolidMolecular weight:673.86p62-ZZ Ligand-Linker Conjugate 1
CAS:<p>p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.</p>Formula:C31H42N2O6Color and Shape:SolidMolecular weight:538.68Autophagy agonist-1
<p>Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.</p>Formula:C33H41N3O5Color and Shape:SolidMolecular weight:559.7Tetramethylrhodamine-dUTP
<p>Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .</p>Formula:C43H52N6O19P3Color and Shape:SolidMolecular weight:1049.82Balixafortide TFA (1051366-32-5 free base)
<p>Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.</p>Formula:C82H113N22F3O23S2Purity:98%Color and Shape:SolidMolecular weight:1896.05LC3B recruiter 2
CAS:<p>LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.</p>Formula:C10H9ClN2O2Color and Shape:SolidMolecular weight:224.644Cy5.5-SE (DIPEA)
<p>Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.</p>Formula:C53H66N4O16S4Color and Shape:SolidMolecular weight:1143.37Corydalmine hydrochloride
CAS:<p>Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.</p>Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86DB1113
CAS:<p>DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.</p>Formula:C59H68F3N13O6SColor and Shape:SolidMolecular weight:1144.31AZD4721
CAS:<p>AZD4721, an oral CXCR2 antagonist, may be researched for treating inflammation.</p>Formula:C19H25FN4O5S2Color and Shape:SolidMolecular weight:472.55Cy3-dCTP
<p>Cy3-dCTP, a fluorescent cyanine-dye-labeled nucleotide triphosphate, serves as a DNA imaging probe.</p>Formula:C43H51Li4N6O20P3S2Color and Shape:SolidMolecular weight:1156.71Beclin1-Bcl-2 interaction inhibitor 1
<p>Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].</p>Color and Shape:Odour SolidYTK-105
CAS:<p>YTK-105 is a ligand targeting autophagy that binds to p62.</p>Formula:C16H19NO2Purity:98.31%Color and Shape:SoildMolecular weight:257.33Erlotinib-13C6
CAS:<p>Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.</p>Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397AUTAC1
CAS:<p>AUTAC1 is a MetAP2-targeted autophagy-mediated degradator (AUTAC) that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.</p>Formula:C44H63FN8O11SPurity:99.45% - 99.45%Color and Shape:SolidMolecular weight:931.08Cyanine 5 Tyramide methyl indole
<p>Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.</p>Formula:C40H47N3O8S2Color and Shape:SolidMolecular weight:761.95
