Autophagy
Autophagy inhibitors target the cellular process of autophagy, which involves the degradation and recycling of cellular components through lysosomes. Autophagy is a critical mechanism for maintaining cellular homeostasis, but its dysregulation is implicated in various diseases, including cancer, neurodegeneration, and infections. Inhibitors of autophagy can block this process, making them valuable tools for studying the role of autophagy in disease and developing therapeutic strategies. At CymitQuimica, we offer autophagy inhibitors to support your research in cell biology, oncology, and neurodegenerative diseases.
Found 1503 products of "Autophagy"
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LC3B recruiter 2
CAS:LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.Formula:C10H9ClN2O2Color and Shape:SolidMolecular weight:224.644MLCK inhibitor peptide 18
CAS:Myosin light chain kinase inhibitor; IC50=50 nM; 4000x more selective over CaM kinase II; no PKA inhibition; cell-permeable.Formula:C60H105N23O11Purity:98%Color and Shape:SolidMolecular weight:1324.64Autophagy agonist-1
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.Formula:C33H41N3O5Color and Shape:SolidMolecular weight:559.7ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formula:C25H30N2OSColor and Shape:SolidMolecular weight:406.58N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Formula:C15H21N5O4Purity:97.13% - 99.69%Color and Shape:SolidMolecular weight:335.36BVT173187
CAS:BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Formula:C14H10Cl3NO2Color and Shape:SolidMolecular weight:330.59SQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formula:C22H26N4O5Color and Shape:SolidMolecular weight:426.47DB1113
CAS:DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Formula:C59H68F3N13O6SColor and Shape:SolidMolecular weight:1144.31TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Formula:C145H238N34O44Color and Shape:SolidMolecular weight:3161.64Ch55-O-C3-NH2
CAS:Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR.Formula:C27H35NO4Purity:98%Color and Shape:SolidMolecular weight:437.57(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.
Formula:C30H39N5O6Molecular weight:565.29003CXCR4-IN-3
CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).
LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Color and Shape:Odour SolidAutophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Formula:C24H30F2N2Molecular weight:384.23771Fumagilin-105
CAS:Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.Formula:C46H60N2O9Color and Shape:SolidMolecular weight:784.98(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.Formula:C29H36N8O6Molecular weight:592.27578VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formula:C25H31BrINPurity:99.82%Color and Shape:SolidMolecular weight:552.33Atorvastatin Sodium
CAS:Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors onFormula:C33H34FN2NaO5Purity:99.88% - >99.99%Color and Shape:SolidMolecular weight:580.63Acetazolamide
CAS:Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.
Formula:C4H6N4O3S2Purity:99.61% - 99.94%Color and Shape:Crystals From Water 1992)Molecular weight:222.25p62-ZZ Ligand-Linker Conjugate 1
CAS:p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.Formula:C31H42N2O6Color and Shape:SolidMolecular weight:538.68YTK-105
CAS:YTK-105 is a ligand targeting autophagy that binds to p62.Formula:C16H19NO2Purity:98.31%Color and Shape:SoildMolecular weight:257.33Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formula:C39H59N13O8S2Color and Shape:SolidMolecular weight:902.1CXM102
CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.Formula:C28H27NO3Color and Shape:SolidMolecular weight:425.52BOLD-100 free base
CAS:BOLD-100 (NKP-1339/IT-139) is a ruthenium anticancer agent that inhibits GRP78 and disrupts ER homeostasis, affecting lysosome function and autophagy.Formula:C14H12Cl4N4RuColor and Shape:SolidMolecular weight:479.15PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formula:C27H31NO4SPurity:99.02%Color and Shape:SolidMolecular weight:465.6Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Formula:C22H23N3O4Color and Shape:SolidMolecular weight:399.397Nictide
CAS:Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.Formula:C123H193N45O28Color and Shape:SolidMolecular weight:2750.13FDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Formula:C22H24N6OPurity:98.73% - 99.55%Color and Shape:SoildMolecular weight:388.47Ref: TM-T77809
1mg66.00€5mg142.00€10mg215.00€25mg358.00€50mg517.00€100mg707.00€1mL*10mM (DMSO)158.00€HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Color and Shape:Odour SolidcGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Formula:C31H51ClN7O14PSColor and Shape:SolidMolecular weight:844.27Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Color and Shape:Odour SolidSalinomycin sodium salt
CAS:Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.Formula:C42H69NaO11Purity:98.76% - 99.11%Color and Shape:White Or Light Yellow Crystalline Powder With Special SmelMolecular weight:772.98PHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Formula:C51H50F6N4O7Color and Shape:SolidMolecular weight:944.96Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Formula:C20H24ClNO4Color and Shape:SolidMolecular weight:377.86Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formula:C21H20ClNO5Purity:97.74% - 99.99%Color and Shape:SolidMolecular weight:401.84Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Formula:C115H145ClN18O31S2Zn2Color and Shape:SolidMolecular weight:2505.83STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFormula:C19H10N2O3·C2H4O2Purity:99.75%Color and Shape:SolidMolecular weight:374.35Tigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formula:C30H43N5O11SPurity:98%Color and Shape:SolidMolecular weight:681.75Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Formula:C53H66N4O16S4Color and Shape:SolidMolecular weight:1143.37Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Formula:C44H36Cl5FeN8Color and Shape:SolidMolecular weight:909.92Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFormula:C32H38Cl3N7Color and Shape:SolidMolecular weight:627.05Insecticidal agent 364
CAS:Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.
Formula:C23H18N4O3SPurity:99.81%Color and Shape:SolidMolecular weight:430.48Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formula:C90H141N33O18S2Color and Shape:SolidMolecular weight:2037.42Biotin-11-dCTP
Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .Formula:C28H43Li3N7O16P3SColor and Shape:SolidMolecular weight:879.49Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Formula:C27H45NO3Color and Shape:SolidMolecular weight:431.65MRT 67307 dihydrochloride
CAS:MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.
Formula:C26H38Cl2N6O2Purity:99.75%Color and Shape:SoildMolecular weight:537.53Balixafortide TFA (1051366-32-5 free base)
Balixafortide TFA is a selective CXCR4 antagonist with IC50 < 10nM, over 1000x preference for CXCR4, and blocks β-arrestin and calcium flux.Formula:C82H113N22F3O23S2Purity:98%Color and Shape:SolidMolecular weight:1896.05SHP2-IN-35
SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.Formula:C34H32FeO6Color and Shape:SolidMolecular weight:592.46Balixafortide
CAS:Balixafortide (POL6326), a potent CXCR4 blocker with IC50 < 10 nM, mobilizes HSPCs and is anti-cancer, 1000x more selective than CXCR7.Formula:C84H118N24O21S2Purity:98%Color and Shape:SolidMolecular weight:1864.14ABX-IL8
ABX-IL8 is a humanized antibody targeting IL-8, capable of interfering with tube formation in human umbilical vein endothelial cells.Purity:>95%Color and Shape:LiquidMolecular weight:143.94 kDa
