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Aurora Kinase

Aurora Kinase

Aurora kinase inhibitors target the Aurora kinases, a family of serine/threonine kinases that play a critical role in the regulation of mitosis. These kinases are essential for proper chromosome alignment, segregation, and cytokinesis during cell division. Abnormal Aurora kinase activity can lead to uncontrolled cell proliferation and cancer. By inhibiting Aurora kinases, these compounds can induce cell cycle arrest and apoptosis in cancer cells, making them valuable tools in cancer research and therapy. At CymitQuimica, we offer a wide range of high-quality Aurora kinase inhibitors to support your research in cell cycle regulation, mitosis, and oncology.

Found 94 products of "Aurora Kinase"

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  • TC-A 2317 hydrochloride
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    TC-A 2317 hydrochloride

    CAS:
    <p>TC-A 2317 HCl inhibits Aurora A kinase (Ki 1.2 nM) over Aurora B (Ki 101 nM), displaying antitumor effects.</p>
    Formula:C19H29ClN6O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:392.93

    Ref: TM-T23426

  • CCT129202
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    CCT129202

    CAS:
    <p>CCT129202 is an ATP-competitive pan-Aurora inhibitor for Aurora A, Aurora B and Aurora C with IC50 of 0.042 μM, 0.198 μM and 0.227 μM, respectively.</p>
    Formula:C23H25ClN8OS
    Purity:98.14%
    Color and Shape:Solid
    Molecular weight:497.02

    Ref: TM-T6435

  • LY3295668
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    LY3295668

    CAS:
    <p>LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.</p>
    Formula:C24H26ClF2N5O2
    Purity:99.68%
    Color and Shape:Solid
    Molecular weight:489.95

    Ref: TM-T15815

  • Aurora A inhibitor 1
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    Aurora A inhibitor 1

    CAS:
    <p>Aurora A inhibitor 1: potent, selective, targets cancer-linked Aurora A overexpression, potential for cancer research. (WO2021147974A1, 49)</p>
    Formula:C25H28ClF2N5O2
    Color and Shape:Solid
    Molecular weight:503.97

    Ref: TM-T63436

  • Aurora inhibitor 1
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    Aurora inhibitor 1

    CAS:
    <p>Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).</p>
    Formula:C23H25N9S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:459.57

    Ref: TM-T10412

  • Glycyl H-1152 hydrochloride
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    Glycyl H-1152 hydrochloride

    CAS:
    <p>Glycyl-H-1152 is a potent ROCK-II inhibitor (IC50=11.8 nM) with high selectivity over CaMKII, PKG, Aurora A, PKA, and PKC. Better than Y-27632 and HA-1077.</p>
    Formula:C18H26Cl2N4O3S
    Color and Shape:Solid
    Molecular weight:449.39

    Ref: TM-T35459

  • TY-011
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    TY-011

    CAS:
    <p>TY-011 is an inhibitor of Aurora A/B kinases. This compound induces DNA damage and cell apoptosis (Apoptosis) in human gastric cancer cells by promoting abnormal microtubule-kinetochore attachments, effectively suppressing cancer cell proliferation. The IC50 values for TY-011 in human gastric cancer cell lines range from 0.11-4.49 μM. It is utilized in research focused on gastric cancer.</p>
    Formula:C18H16ClN5
    Color and Shape:Solid
    Molecular weight:337.81

    Ref: TM-T89833

  • Aurora B inhibitor 1
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    Aurora B inhibitor 1

    CAS:
    <p>Aurora B inhibitor 1 is an Aurora B (Aurora-1) inhibitor (Ki &lt;0.010 uM) with potential anticancer activity for cancer research.</p>
    Formula:C25H26ClF2N7O2
    Purity:98.37%
    Color and Shape:Solid
    Molecular weight:529.97

    Ref: TM-T12010

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    Aurora/LIM kinase-IN-1

    <p>Aurora/LIM kinase-IN-1 (Compound F114) is a dual inhibitor targeting aurora and lim kinases, potentially useful in GBM cancer treatment efforts.</p>
    Formula:C16H20N6O
    Color and Shape:Solid
    Molecular weight:312.37

    Ref: TM-T60783

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    Hesperadin hydrochloride

    <p>Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.</p>
    Formula:C29H33ClN4O3S
    Color and Shape:Solid
    Molecular weight:553.12

    Ref: TM-T63905

  • BRD-7880
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    BRD-7880

    CAS:
    <p>BRD-7880 is a potent and highly specific inhibitor of aurora kinases B and C.</p>
    Formula:C32H38N4O7
    Color and Shape:Solid
    Molecular weight:590.67

    Ref: TM-T70600

  • 6K465
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    6K465

    CAS:
    <p>6K465 is a potent Aurora A kinase inhibitor that reduces c-MYC and N-MYC oncoproteins, showing antiproliferative effects in SCLC and breast cancer cell lines.</p>
    Formula:C26H33ClFN9O
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:542.05

    Ref: TM-T85508

  • BET/Aurora kinase-IN-1
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    BET/Aurora kinase-IN-1

    CAS:
    <p>BET/Aurora kinase-IN-1 (Compound 38) is a dual inhibitor of BET and Aurora kinases. It exhibits antiproliferative activity against various tumor cell lines and demonstrates significant antitumor efficacy in xenograft models of renal cell carcinoma and colon cancer, with tumor growth inhibition (TGI) rates of 45.99% and 53.06%, respectively.</p>
    Formula:C25H30FN7O
    Color and Shape:Solid
    Molecular weight:463.55

    Ref: TM-T205073

  • SCH-1473759
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    SCH-1473759

    CAS:
    <p>SCH-1473759 is an inhibitor of the aurora (IC50s: 4 and 13 nM for Aurora A and B, respectively).</p>
    Formula:C20H26N8OS
    Purity:98%
    Color and Shape:Solid
    Molecular weight:426.54

    Ref: TM-T16862