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CaSR

CaSR

The calcium-sensing receptor (CaSR) is a GPCR that plays a vital role in maintaining calcium homeostasis by regulating parathyroid hormone secretion and calcium reabsorption in the kidneys. CaSR is also involved in various other physiological processes, including bone metabolism and vascular function. Modulators of CaSR are used in the treatment of conditions such as hyperparathyroidism, osteoporosis, and cardiovascular diseases. At CymitQuimica, we provide a selection of high-quality CaSR modulators to support your research in calcium metabolism, endocrinology, and bone health.

Found 32 products of "CaSR"

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  • Calhex 231 hydrochloride
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    Calhex 231 hydrochloride

    CAS:
    <p>Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .</p>
    Formula:C25H28Cl2N2O
    Purity:99.36%
    Color and Shape:Solid
    Molecular weight:443.41

    Ref: TM-T10666

  • Tecalcet Hydrochloride
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    Tecalcet Hydrochloride

    CAS:
    <p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>
    Formula:C18H23Cl2NO
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:340.29

    Ref: TM-T13918

  • GSK3004774
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    GSK3004774

    CAS:
    <p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>
    Formula:C32H40N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:528.68

    Ref: TM-T11493

  • (Rac)-Upacicalcet
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    (Rac)-Upacicalcet

    CAS:
    <p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>
    Formula:C11H14ClN3O6S
    Color and Shape:Solid
    Molecular weight:351.76

    Ref: TM-T61232

  • NPS-2143
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    NPS-2143

    CAS:
    <p>NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.</p>
    Formula:C24H25ClN2O2
    Purity:99.56%
    Color and Shape:Solid
    Molecular weight:408.92

    Ref: TM-T1730

  • Ronacaleret HCl
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    Ronacaleret HCl

    CAS:
    <p>Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.</p>
    Formula:C25H32ClF2NO4
    Purity:99.97%
    Color and Shape:Solid
    Molecular weight:483.98

    Ref: TM-T34385

  • Encaleret
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    Encaleret

    CAS:
    <p>Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.</p>
    Formula:C29H33ClFNO4
    Color and Shape:Solid
    Molecular weight:514.03

    Ref: TM-T31624

  • CaSR antagonist-1
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    CaSR antagonist-1

    CAS:
    <p>CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigation</p>
    Formula:C29H24FN3O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:497.58

    Ref: TM-T79023

  • Calindol hydrochloride
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    Calindol hydrochloride

    CAS:
    <p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>
    Formula:C21H21ClN2
    Purity:99.47%
    Color and Shape:Solid
    Molecular weight:336.86

    Ref: TM-T21758

  • H-Glu-Thr-OH
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    H-Glu-Thr-OH

    CAS:
    <p>H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).</p>
    Formula:C9H16N2O6
    Color and Shape:Solid
    Molecular weight:248.23

    Ref: TM-T201727

  • TAK-075
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    TAK-075

    CAS:
    <p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>
    Formula:C36H46N4O4S
    Color and Shape:Solid
    Molecular weight:630.84

    Ref: TM-T206506

  • SB-423562
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    SB-423562

    CAS:
    <p>SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.</p>
    Formula:C26H32N2O4
    Purity:99.22%
    Color and Shape:Solid
    Molecular weight:436.54

    Ref: TM-T12846