CaSR
The calcium-sensing receptor (CaSR) is a GPCR that plays a vital role in maintaining calcium homeostasis by regulating parathyroid hormone secretion and calcium reabsorption in the kidneys. CaSR is also involved in various other physiological processes, including bone metabolism and vascular function. Modulators of CaSR are used in the treatment of conditions such as hyperparathyroidism, osteoporosis, and cardiovascular diseases. At CymitQuimica, we provide a selection of high-quality CaSR modulators to support your research in calcium metabolism, endocrinology, and bone health.
Found 34 products of "CaSR"
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γ-L-Glutamyl-L-alanine
CAS:γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).Formula:C8H14N2O5Purity:99.49%Color and Shape:SolidMolecular weight:218.21Poly-D-lysine hydrobromide (MW 30000-70000)
CAS:Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.Formula:(C6H14N2O2)x·xHBrColor and Shape:SolidMolecular weight:227.102NPS-2143
CAS:NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.Formula:C24H25ClN2O2Purity:99.56%Color and Shape:SolidMolecular weight:408.92(Rac)-Upacicalcet
CAS:(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.Formula:C11H14ClN3O6SColor and Shape:SolidMolecular weight:351.76Calhex 231 hydrochloride
CAS:Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .Formula:C25H28Cl2N2OPurity:99.36%Color and Shape:SolidMolecular weight:443.41Tecalcet Hydrochloride
CAS:Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.
Formula:C18H23Cl2NOPurity:99.97%Color and Shape:SolidMolecular weight:340.29GSK3004774
CAS:GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.Formula:C32H40N4O3Purity:98%Color and Shape:SolidMolecular weight:528.68Ronacaleret HCl
CAS:Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.Formula:C25H32ClF2NO4Purity:99.97%Color and Shape:SolidMolecular weight:483.98CaSR antagonist-1
CAS:CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigationFormula:C29H24FN3O2SPurity:98%Color and Shape:SolidMolecular weight:497.58Encaleret
CAS:Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.Formula:C29H33ClFNO4Color and Shape:SolidMolecular weight:514.03Calindol hydrochloride
CAS:Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.Formula:C21H21ClN2Purity:99.47%Color and Shape:SolidMolecular weight:336.86H-Glu-Thr-OH
CAS:H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).Formula:C9H16N2O6Color and Shape:SolidMolecular weight:248.23TAK-075
CAS:TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.Formula:C36H46N4O4SColor and Shape:SolidMolecular weight:630.84SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Formula:C26H32N2O4Purity:99.22%Color and Shape:SolidMolecular weight:436.54Ref: TM-T12846
1mg37.00€5mg80.00€10mg119.00€25mg210.00€50mg319.00€100mg442.00€200mg605.00€1mL*10mM (DMSO)89.00€
