PKA
Protein kinase A (PKA) is a key enzyme in the GPCR signaling cascade, activated by cyclic AMP (cAMP) in response to various extracellular signals. PKA regulates a wide range of cellular processes, including metabolism, gene expression, and cell growth. Dysregulation of PKA activity is associated with various diseases, including cancer, metabolic disorders, and cardiovascular conditions. PKA modulators are valuable tools in research aimed at understanding GPCR signaling pathways and developing new therapeutic strategies. At CymitQuimica, we provide a selection of high-quality PKA modulators to support your research in signal transduction, cellular regulation, and disease mechanisms.
Found 60 products of "PKA"
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H-8 hydrochloride
CAS:H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Formula:C12H17Cl2N3O2SPurity:99.93%Color and Shape:White To Off-White Crystalline SolidMolecular weight:338.256-Bn-cAMP
CAS:6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.Formula:C17H18N5O6PColor and Shape:SolidMolecular weight:419.338-Chloro-cAMP sodium
CAS:8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.Formula:C10H10ClN5NaO6PColor and Shape:SolidMolecular weight:385.638-MA-cAMP
CAS:8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.Formula:C11H15N6O6PColor and Shape:SolidMolecular weight:358.25BGC201531
CAS:BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.Formula:C26H28N2O6SPurity:98.51% - 99.33%Color and Shape:SolidMolecular weight:496.58Rp-cAMPS triethylammonium salt
CAS:Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Formula:C16H27N6O5PSPurity:98%Color and Shape:SolidMolecular weight:446.46FMP-API-1
CAS:FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).Formula:C13H14N2O2Color and Shape:SolidMolecular weight:230.262Protein kinase inhibitor 7
CAS:Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Formula:C12H15N3O2SMolecular weight:265.338-Br-cGMP-AM
CAS:8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.Formula:C13H15BrN5O9PColor and Shape:SolidMolecular weight:496.16PET-cGMP
CAS:PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.
Formula:C18H16N5O7PColor and Shape:SolidMolecular weight:445.323
