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Dopamine Receptor

Dopamine Receptor

Dopamine receptors are a group of GPCRs that respond to the neurotransmitter dopamine, playing a key role in the regulation of movement, motivation, reward, and several cognitive functions. These receptors are divided into D1-like and D2-like families, each with distinct functions and pharmacological profiles. Dopamine receptor modulators are widely studied for their applications in treating Parkinson's disease, schizophrenia, addiction, and other neuropsychiatric disorders. At CymitQuimica, we offer a wide range of high-quality dopamine receptor modulators to support your research in neuroscience, mental health, and GPCR signaling.

Found 435 products of "Dopamine Receptor"

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  • LY3154207
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    LY3154207

    CAS:
    LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.
    Formula:C24H29Cl2NO3
    Color and Shape:Solid
    Molecular weight:450.4

    Ref: TM-T11912

  • D1R antagonist 1
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    D1R antagonist 1

    CAS:
    Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].
    Formula:C22H26BrNO4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:448.35

    Ref: TM-T78735

  • Cendifensine
    Targetmol
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    Cendifensine

    CAS:
    Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).
    Formula:C14H17Cl2NO
    Color and Shape:Solid
    Molecular weight:286.197

    Ref: TM-T206480

  • CymitQuimica logo
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    PD-147693

    CAS:
    PD-147693 (compound II) is an active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, and it exhibits antipsychotic activity similar to CI-1007.
    Formula:C24H27NO
    Molecular weight:345.477

    Ref: TM-T204694

  • CymitQuimica logo
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    D4R antagonis-2

    Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.
    Formula:C21H23ClF2N2O2
    Color and Shape:Solid
    Molecular weight:408.87

    Ref: TM-T62054

  • NMDAR antagonist 5
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    NMDAR antagonist 5

    CAS:
    NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.
    Formula:C17H21N3
    Color and Shape:Solid
    Molecular weight:267.369

    Ref: TM-T206943

  • Dopamine D4 receptor ligand 3
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    Dopamine D4 receptor ligand 3

    CAS:
    Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.
    Formula:C28H31N3O5
    Color and Shape:Solid
    Molecular weight:489.56

    Ref: TM-T207369

  • U91356
    Targetmol
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    U91356

    CAS:
    U91356 is an agonist of the dopamine receptors.
    Formula:C13H17N3O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:231.29

    Ref: TM-T13240

  • RG-15
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    RG-15

    CAS:
    RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.
    Formula:C25H32Cl2F3N5O2S
    Color and Shape:Solid
    Molecular weight:594.52

    Ref: TM-T206486

  • Dinoxyline
    Targetmol
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    Dinoxyline

    CAS:
    <p>Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.</p>
    Formula:C15H13NO3
    Color and Shape:Solid
    Molecular weight:255.27

    Ref: TM-T201856

  • Disulergine
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    Disulergine

    CAS:
    Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.
    Formula:C17H24N4O2S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:348.46

    Ref: TM-T24003

  • CymitQuimica logo
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    Dopamine D3 receptor ligand-1

    Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:
    Formula:C27H29N5O
    Color and Shape:Solid
    Molecular weight:439.55

    Ref: TM-T62528

  • 6-Chloro-5-(2-chloroethyl)indolin-2-one
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    6-Chloro-5-(2-chloroethyl)indolin-2-one

    CAS:
    6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.
    Formula:C10H9Cl2NO
    Color and Shape:Solid
    Molecular weight:230.09

    Ref: TM-T64862

    ne
    Discontinued
    Discontinued product
  • 3-Hydroxybenzylamine
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    3-Hydroxybenzylamine

    CAS:
    <p>3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.</p>
    Formula:C7H9NO
    Color and Shape:Solid
    Molecular weight:123.155

    Ref: TM-T124305

    ne
    Discontinued
    Discontinued product
  • GR 218,231
    Targetmol
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    GR 218,231

    CAS:
    GR 218,231 is a selective antagonist of D3 dopamine receptor.
    Formula:C24H33NO3S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:415.59

    Ref: TM-T27431

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    Discontinued product