OX Receptor
Orexin receptors (OX1 and OX2) are GPCRs that bind to orexins, neuropeptides involved in regulating wakefulness, appetite, and energy homeostasis. Dysregulation of orexin signaling is linked to sleep disorders such as narcolepsy, as well as metabolic conditions like obesity. Orexin receptor modulators are being investigated for their therapeutic potential in treating sleep disorders, anxiety, and addiction. At CymitQuimica, we offer a range of high-quality orexin receptor modulators to support your research in sleep biology, metabolism, and neuropharmacology.
Found 42 products for "OX Receptor".
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EMPA
CAS:EMPA is a selective, high-affinity and reversible antagonist of orexin OX2 receptor(human and rat OX2-HEK293 membranes with KD values of 1.1 and 1.4 nMFormula:C23H26N4O4SPurity:99.11%Color and Shape:SolidMolecular weight:454.54Ref: TM-T11186
1mg49.00€2mg69.00€5mg92.00€1mL*10mM (DMSO)104.00€10mg142.00€25mg250.00€50mg375.00€100mg563.00€200mg795.00€Filorexant
CAS:Filorexant (MK-6096) is an orally bioavailable effective and selective reversible antagonist of OX1 and OX2 receptor with (Ki <3 nM).Formula:C24H25FN4O2Purity:98.88%Color and Shape:SolidMolecular weight:420.48YNT-185
CAS:YNT-185 is a nonpeptide, selective agonist of the orexin type-2 receptor (OX2R), demonstrating EC50 values of 0.028 μM and 2.75 μM for OX2R and OX1R,Formula:C33H37N5O5SPurity:99.67%Color and Shape:SolidMolecular weight:615.74Seltorexant
CAS:Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.Formula:C21H22FN7OPurity:99.79% - >99.99%Color and Shape:White SolidMolecular weight:407.44Ref: TM-T12877L
1mg34.00€2mg49.00€5mg74.00€1mL*10mM (DMSO)82.00€10mg98.00€25mg144.00€50mg260.00€100mg358.00€500mg822.00€Orexin A (human, rat, mouse) (TFA)
Endogenous orexin receptor agonist with Ki of 20 nM (OX1) and 38 nM (OX2), promotes feeding, may regulate sleep-wake cycle.Formula:C154H244N47F3O46S4Purity:98%Color and Shape:SolidMolecular weight:3675.12Orexin B, human
CAS:Orexin B, human agonizes Orexin receptors (OX1 Ki=420 nM, OX2 Ki=36 nM), promotes feeding in rats, and is a neuropeptide.Formula:C123H212N44O35SPurity:98%Color and Shape:SolidMolecular weight:2899.34Orexin A (human, rat, mouse)
CAS:Orexin A, a 33 AA neuropeptide in humans, rats, mice, influences various processes, studied in pancreatic function and as an OX1R antagonist.Formula:C152H243N47O44S4Purity:98%Color and Shape:SolidMolecular weight:3561.1OXA(17-33)
CAS:Potent and selective peptide orexin OX1 receptor agonist (EC50 values are 8.29 and 187 nM for OX1 and OX2 receptors respectively). Truncated form of orexin A.Formula:C79H125N23O22Purity:98%Color and Shape:SolidMolecular weight:1749Orexin B, rat, mouse
CAS:Orexin B, rat, mouse is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Formula:C126H215N45O34SPurity:98%Color and Shape:SolidMolecular weight:2936.45[Ala11,D-Leu15]-Orexin B(human)
CAS:OX2 receptor agonist with 400x selectivity vs OX1. EC50: 0.13 nM (OX2), 52 nM (OX1).Formula:C120H206N44O35SPurity:98%Color and Shape:SolidMolecular weight:2857.28ZL-1101
ZL-1101 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134.Color and Shape:Odour Liquid[Ala11,D-Leu15]-Orexin B acetate
[Ala11,D-Leu15]-Orexin B acetate is a selective agonist of orexin-2 receptor (OX2) with an EC50 of 0.13 nM, showing 400-fold selectivity over OX1 (52 nM).Formula:C122H210N44O37SPurity:98.18%Color and Shape:SolidMolecular weight:2917.31Orexin B, rat, mouse TFA
Orexin B, rat/mouse TFA, activates OX1-R & OX2-R receptors, influencing food intake, energy, and sleep regulation.Formula:C128H216F3N45O36SColor and Shape:SolidMolecular weight:3050.42Suntinorexton
CAS:Suntinorexton (TAK 861) is an orexin type 2 receptor (OX2R) agonist used in the study of neurologic disorders.Formula:C23H28F2N2O4SPurity:99.89%Color and Shape:White SolidMolecular weight:466.54Ref: TM-T39807
1mg158.00€5mg385.00€1mL*10mM (DMSO)395.00€10mg625.00€25mg954.00€50mg1,288.00€100mg1,738.00€200mg2,332.00€Xenopus orexin B
CAS:Xenopus orexin B, a neuropeptide identified as an endogenous ligand for an orphan G-protein-coupled receptor, acts as a potent agonist of OX2R [1].Formula:C130H219N45O40S2Color and Shape:SolidMolecular weight:3116.54SB-408124
CAS:SB408124: Non-peptide, OX1 receptor antagonist, Ki 57 nM (whole cell) and 27 nM (membrane), 50x more selective than OX2.Formula:C19H18F2N4OPurity:99.75% - 99.81%Color and Shape:SolidMolecular weight:356.37OXA(17-33) TFA
OXA(17-33) TFA: Potent OX1 agonist, ~23x more selective for OX1 (EC50=8.29nM) than OX2 (187nM).Formula:C81H126F3N23O24Color and Shape:SolidMolecular weight:1863Orexin A (human, rat, mouse) acetate
Orexin A (human, rat, mouse) acetate (Hypocretin-1 (human, rat, mouse) acetate) is an excitatory neuropeptide with analgesic properties.Formula:C154H247N47O46S4Color and Shape:SolidMolecular weight:3621.15SB-674042
CAS:SB-674042 is a nonpeptide dual antagonist of the appetite peptides OX1 and OX2 receptors.SB-674042 is used in the treatment of depression.Formula:C24H21FN4O2SPurity:99.82% - 99.9%Color and Shape:SolidMolecular weight:448.51TCS 1102
CAS:TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).Formula:C27H26N4O2SPurity:99.35% - 99.52%Color and Shape:SolidMolecular weight:470.59SB-649868
CAS:SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).Formula:C26H24FN3O3SPurity:99.53%Color and Shape:SolidMolecular weight:477.55Ref: TM-T5498
2mg34.00€5mg71.00€1mL*10mM (DMSO)86.00€10mg110.00€25mg225.00€50mg366.00€100mg587.00€200mg788.00€Orexin 2 Receptor Agonist
CAS:Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.Formula:C32H34N4O5SPurity:98.26% - 99.43%Color and Shape:SolidMolecular weight:586.7Ref: TM-T3177
2mg39.00€5mg60.00€10mg75.00€1mL*10mM (DMSO)77.00€25mg130.00€50mg220.00€100mg323.00€200mg447.00€PF3274167
CAS:PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.Formula:C19H19ClFN5O3Purity:99.67% - 99.88%Color and Shape:White SolidMolecular weight:419.84MK-3697
CAS:MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).Formula:C23H21N5O3SPurity:97.69% - 98.15%Color and Shape:SolidMolecular weight:447.51Ref: TM-T1913
1mg49.00€2mg65.00€5mg90.00€1mL*10mM (DMSO)100.00€10mg113.00€25mg200.00€50mg333.00€100mg477.00€TCS-OX2-29
CAS:TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.Formula:C23H31N3O3Purity:99.81%Color and Shape:SolidMolecular weight:397.51Orexin B, rat, mouse Acetate
Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.Formula:C128H219N45O36SPurity:94.61%Color and Shape:SolidMolecular weight:2996.45OXA (17-33) acetate
OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).Formula:C79H125N23O22Purity:98.84%Color and Shape:SolidMolecular weight:1748.98SB-334867 free base
CAS:SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.Formula:C17H13N5O2Purity:99.67% - >99.99%Color and Shape:SolidMolecular weight:319.32Ref: TM-T6140
2mg39.00€5mg66.00€1mL*10mM (DMSO)73.00€10mg94.00€25mg152.00€50mg215.00€100mg319.00€200mg475.00€IPSU
CAS:IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.Formula:C23H27N5O2Purity:97.05%Color and Shape:SolidMolecular weight:405.49Ref: TM-T5503
2mg49.00€5mg81.00€1mL*10mM (DMSO)87.00€10mg92.00€25mg190.00€50mg284.00€100mg409.00€200mg627.00€DORA-22
CAS:DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memoryFormula:C23H22F2N4O2Purity:97.67%Color and Shape:SolidMolecular weight:424.44Ref: TM-T5500
1mg124.00€2mg178.00€5mg269.00€1mL*10mM (DMSO)314.00€10mg408.00€25mg672.00€50mg945.00€100mg1,279.00€MK-1064
CAS:MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).Formula:C24H20ClN5O3Purity:99.19% - 99.82%Color and Shape:White SolidMolecular weight:461.9L-368,899 hydrochloride
CAS:L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.Formula:C26H43ClN4O5S2Purity:99.59%Color and Shape:SolidMolecular weight:591.23Ref: TM-T11794
2mg105.00€5mg147.00€1mL*10mM (DMSO)200.00€10mg230.00€25mg439.00€50mg685.00€100mg964.00€ACT-462206
CAS:ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.Formula:C20H24N2O4SPurity:99.87%Color and Shape:SolidMolecular weight:388.48Ref: TM-T26559
1mg42.00€1mL*10mM (DMSO)87.00€5mg88.00€10mg130.00€25mg264.00€50mg423.00€100mg670.00€500mg1,341.00€GSK1059865
CAS:GSK1059865 is a potent antagonist of the orexin 1 receptor.Formula:C20H23BrFN3O2Purity:99.72%Color and Shape:SolidMolecular weight:436.32Ref: TM-T11477
1mg69.00€5mg147.00€1mL*10mM (DMSO)164.00€10mg230.00€25mg386.00€50mg582.00€100mg873.00€CVN766
CAS:CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and >10 μM for OX2R. CVN766 can be used to study schizophrenia [1].Formula:C20H21F3N8OColor and Shape:SolidMolecular weight:446.43RTIOXA-43
CAS:RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.Formula:C37H37N5O5SPurity:99.17%Color and Shape:White SolidMolecular weight:663.79Ref: TM-T87345
1mg193.00€5mg485.00€1mL*10mM (DMSO)707.00€10mg782.00€25mg1,558.00€50mg2,502.00€100mg3,385.00€OX2R agonist 1
CAS:OX2R agonist 1 is an OX2R activator with an EC50 of less than 100 nM. It is utilized in research related to narcolepsy and cataplexy.Formula:C21H28F2N2O5SColor and Shape:SolidMolecular weight:458.52Tebideutorexant
CAS:Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.Formula:C23H16D2F4N4O2Purity:98.89%Color and Shape:White SolidMolecular weight:460.42Alixorexton
CAS:Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.Formula:C21H30N2O5SColor and Shape:SolidMolecular weight:422.538Rocavorexant
CAS:Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.Formula:C18H19F3N8OColor and Shape:SolidMolecular weight:420.392YNT-3708
CAS:YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.Formula:C35H36N4O6SColor and Shape:SolidMolecular weight:640.749(S)-YNT-3708
CAS:(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.Formula:C35H36N4O6SColor and Shape:SolidMolecular weight:640.749
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