OX Receptor

Orexin B, human-13C6,15N (Human orexin B-13C6,15N) TFA is a variant of Orexin B, human, labeled with 13C and 15N isotopes. This compound acts as an agonist of the orexin receptors (Orexin Receptor, OX Receptor), with Ki values of 420 nM for OXR1 and 36 nM for OXR2. Orexin B, human plays a role in the regulation of appetite, wakefulness, cardiovascular function, and neuroendocrine activity.

Orexin A-13C18,15N3 (human, rat, mouse) ((Hypocretin-1-13C18,15N3 (human, rat, mouse)) TFA) is a compound labeled with 13C and 15N, and it is a form of Orexin A (human, rat, mouse). Orexin A, also known as Hypocretin-1, is a 33 amino acid excitatory neuropeptide involved in various central and peripheral processes. It binds to and activates two G protein-coupled receptors: the Orexin-1 receptor (OX1R) and Orexin-2 receptor (OX2R), playing a crucial role in regulating feeding behavior. Orexin A is also an active molecule with potent antinociceptive and anti-hyperalgesic properties.

SB-674042 is a nonpeptide dual antagonist of the appetite peptides OX1 and OX2 receptors.SB-674042 is used in the treatment of depression.

MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).

TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays >250-fold selectivity for OX2 over OX1.

Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.

OXA (17-33) acetate is a more potent agonist of orexin-1 receptor (OX1, EC50 = 8.29 nM)) over OX2 (EC50 = 187 nM).

TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).

SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).

SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.

IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.

Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.

DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory

MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).

PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.

ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.

L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.

INBRX-106 is a human monoclonal antibody (mAb) targeting TNFRSF4/OX40/CD134. It is a novel hexavalent OX40 agonist.

BAT6026 is a human monoclonal antibody (mAb) that targets TNFRSF4/OX40/CD134. It notably reduces Treg cells within tumors and increases CD8+ T cells.

YH-002 is a human IgG1 monoclonal antibody (mAb) that specifically targets TNFRSF4/OX40/CD134. It binds to OX40 by mimicking the function of OX40L.