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OX Receptor

OX Receptor

Orexin receptors (OX1 and OX2) are GPCRs that bind to orexins, neuropeptides involved in regulating wakefulness, appetite, and energy homeostasis. Dysregulation of orexin signaling is linked to sleep disorders such as narcolepsy, as well as metabolic conditions like obesity. Orexin receptor modulators are being investigated for their therapeutic potential in treating sleep disorders, anxiety, and addiction. At CymitQuimica, we offer a range of high-quality orexin receptor modulators to support your research in sleep biology, metabolism, and neuropharmacology.

Found 40 products of "OX Receptor"

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  • SB-649868
    Targetmol
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    SB-649868

    CAS:
    <p>SB-649868 (GSK649868) is a potent and selective orally active antagonist of orexin(pKi =9.4 and 9.5 at the OX1 and OX2 receptor, respectively).</p>
    Formula:C26H24FN3O3S
    Purity:99.53%
    Color and Shape:Solid
    Molecular weight:477.55

    Ref: TM-T5498

  • Orexin 2 Receptor Agonist
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    Orexin 2 Receptor Agonist

    CAS:
    <p>Orexin 2 Receptor Agonist (OX2R) is an effective (EC50: 23 nM) and OX2R-selective (OX1R/OX2R EC50 ratio: 70) agonist.</p>
    Formula:C32H34N4O5S
    Purity:98.26% - 99.43%
    Color and Shape:Solid
    Molecular weight:586.7

    Ref: TM-T3177

  • MK-1064
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    MK-1064

    CAS:
    <p>MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA).</p>
    Formula:C24H20ClN5O3
    Purity:99.19% - 99.82%
    Color and Shape:Solid
    Molecular weight:461.9

    Ref: TM-T3722

  • DORA-22
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    DORA-22

    CAS:
    <p>DORA-22 is a dual orexin receptor antagonist, improves mild stress-induced insomnia with minimal effect on memory</p>
    Formula:C23H22F2N4O2
    Purity:97.67%
    Color and Shape:Solid
    Molecular weight:424.44

    Ref: TM-T5500

  • IPSU
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    IPSU

    CAS:
    <p>IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors.</p>
    Formula:C23H27N5O2
    Purity:97.05%
    Color and Shape:Solid
    Molecular weight:405.49

    Ref: TM-T5503

  • PF3274167
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    PF3274167

    CAS:
    <p>PF3274167 (Cligosiban) is a potent and selective, high-affinity nonpeptide oxytocin receptor antagonist.</p>
    Formula:C19H19ClFN5O3
    Purity:99.67% - 99.88%
    Color and Shape:Solid
    Molecular weight:419.84

    Ref: TM-T3347

  • SB-334867 free base
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    SB-334867 free base

    CAS:
    <p>SB-334867 free base (SB334867A free base) is a selective orexin-1 (OX1) receptor antagonist.</p>
    Formula:C17H13N5O2
    Purity:99.67% - >99.99%
    Color and Shape:Solid
    Molecular weight:319.32

    Ref: TM-T6140

  • MK-3697
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    MK-3697

    CAS:
    <p>MK-3697, an isonicotinamide small molecule, acts as a potent and selective Orexin 2 receptor antagonist (Ki: 0.95 nM).</p>
    Formula:C23H21N5O3S
    Purity:97.69% - 98.15%
    Color and Shape:Solid
    Molecular weight:447.51

    Ref: TM-T1913

  • TCS-OX2-29
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    TCS-OX2-29

    CAS:
    <p>TCS-OX2-29 is a potent and selective OX2 receptor antagonist (IC50: 40 nM). It displays &gt;250-fold selectivity for OX2 over OX1.</p>
    Formula:C23H31N3O3
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:397.51

    Ref: TM-T4965

  • Orexin B, rat, mouse Acetate
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    Orexin B, rat, mouse Acetate

    <p>Orexin B, rat, mouse Acetate (Rat orexin B) is an endogenous agonist at Orexin receptor with Kis of 420 and 36 nM for OX1 and OX2, respectively.</p>
    Formula:C128H219N45O36S
    Purity:94.61%
    Color and Shape:Solid
    Molecular weight:2996.45

    Ref: TM-TP1045L

  • TCS 1102
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    TCS 1102

    CAS:
    <p>TCS 1102 is an effective, dual orexin receptor antagonist (Ki: 0.2/3 nM for OX2/1 receptors).</p>
    Formula:C27H26N4O2S
    Purity:99.35% - 99.52%
    Color and Shape:Solid
    Molecular weight:470.59

    Ref: TM-T2710

  • L-368,899 hydrochloride
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    L-368,899 hydrochloride

    CAS:
    <p>L-368,899 hydrochloride is an OXTR antagonist that prevents oxytocin-induced antiabnormal pain and anti-nausea, and may be used in the study of depression.</p>
    Formula:C26H43ClN4O5S2
    Purity:99.59%
    Color and Shape:Solid
    Molecular weight:591.23

    Ref: TM-T11794

  • ACT-462206
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    ACT-462206

    CAS:
    <p>ACT-462206 is a Orexin 1/Orexin 2 receptor antagonist.ACT-462206 is highly potent and can be used to study sleep and anxiety.</p>
    Formula:C20H24N2O4S
    Purity:99.45%
    Color and Shape:Solid
    Molecular weight:388.48

    Ref: TM-T26559

  • Tebideutorexant
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    Tebideutorexant

    CAS:
    <p>Tebideutorexant, an orexin-1 receptor antagonist, shows anti-panic effects in rodents and humans, providing a tool for stress response and psychiatric research.</p>
    Formula:C23H16D2F4N4O2
    Purity:98.89%
    Color and Shape:Solid
    Molecular weight:460.42

    Ref: TM-T70332

  • Alixorexton
    Targetmol
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    Alixorexton

    CAS:
    <p>Alixorexton is an agonist of the orexin-2 receptor (orexin-2 receptor) and is utilized in obesity research.</p>
    Formula:C21H30N2O5S
    Color and Shape:Solid
    Molecular weight:422.538

    Ref: TM-T205053

  • YNT-3708
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    YNT-3708

    CAS:
    <p>YNT-3708 is an orexin receptor (OXR) agonist, exhibiting EC50 values of 14.6 nM for OX1R and 277 nM for OX2R.</p>
    Formula:C35H36N4O6S
    Color and Shape:Solid
    Molecular weight:640.749

    Ref: TM-T206764

  • (S)-YNT-3708
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    (S)-YNT-3708

    CAS:
    <p>(S)-YNT-3708 is the S-isomer of YNT-3708, demonstrating relatively low activity against OX1R and OX2R receptors, with EC50 values of 3595 nM and 1661 nM, respectively.</p>
    Formula:C35H36N4O6S
    Color and Shape:Solid
    Molecular weight:640.749

    Ref: TM-T206866

  • Rocavorexant
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    Rocavorexant

    CAS:
    <p>Rocavorexant is an antagonist of the orexin-1 receptor (orexin-1 receptor), exhibiting a pIC50 value of 9.1 for human OX1 and a pIC50 of 6.0 for human OX2.</p>
    Formula:C18H19F3N8O
    Color and Shape:Solid
    Molecular weight:420.392

    Ref: TM-T206374

  • RTIOXA-43
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    RTIOXA-43

    CAS:
    <p>RTIOXA-43 is an OX2R/OX1R (orexin receptor) dual agonist that increases wakefulnesand is commonly used in studies related to narcolepsy and neural signaling.</p>
    Formula:C37H37N5O5S
    Purity:99.17%
    Color and Shape:Solid
    Molecular weight:663.79

    Ref: TM-T87345

  • CVN766
    Targetmol
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    CVN766

    CAS:
    <p>CVN766 is an orally active orexin 1 receptor antagonist with blood-brain permeability, demonstrating IC50 values of 8 nM for OX1R and &gt;10 μM for OX2R. CVN766 can be used to study schizophrenia [1].</p>
    Formula:C20H21F3N8O
    Color and Shape:Solid
    Molecular weight:446.43

    Ref: TM-T86110