GRK
G protein-coupled receptor kinases (GRKs) are a family of enzymes that phosphorylate activated GPCRs, leading to receptor desensitization and regulation of receptor signaling. GRKs play critical roles in controlling the intensity and duration of GPCR signaling, making them important in the regulation of various physiological processes, including cardiovascular function, immune response, and neurotransmission. GRK inhibitors and activators are studied for their potential therapeutic applications in heart failure, cancer, and neurological disorders. At CymitQuimica, we provide a range of high-quality GRK modulators to support your research in signal transduction, receptor regulation, and therapeutic development.
Found 33 products of "GRK"
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CCG-271423
CAS:CCG-271423: potent GRK5 inhibitor (IC50: 0.0021 μM), less on GRK2 (IC50: 44 μM); lowers Ca2+ events and heart cell contractility.Formula:C28H26N4O3Color and Shape:SolidMolecular weight:466.53CCG-224406
CAS:CCG-22440 is a Highly Selective and Potent Inhibitor of G Protein-Coupled Receptor Kinase 2.Formula:C29H27FN6O5Color and Shape:SolidMolecular weight:558.56GRK5-IN-4
CAS:GRK5-IN-4: potent, selective covalent inhibitor of GRK5 (IC50=1.1 μM), 90x more specific than GRK2, useful for heart failure research.Formula:C26H25N7O3Color and Shape:SolidMolecular weight:483.52CCG-273463
CAS:CCG-273463: Potent GRK5 inhibitor (IC50: 9 nM), used for researching heart failure, hypertrophy, cancer.Formula:C26H25BrN4O3Color and Shape:SolidMolecular weight:521.41GRK5-IN-3
CAS:GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).Formula:C23H21N7O3Color and Shape:SolidMolecular weight:443.46GSK299115A
CAS:GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.Formula:C20H16Cl2N4O2Purity:99.81%Color and Shape:SolidMolecular weight:415.27Ref: TM-T27471
1mg319.00€5mg772.00€10mg1,074.00€25mg1,596.00€50mg2,147.00€100mg2,822.00€1mL*10mM (DMSO)945.00€DS-1558
CAS:DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDFFormula:C21H21F3O4Color and Shape:SolidMolecular weight:394.38Ro 32-0432 hydrochloride
CAS:Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formula:C28H28N4O2Purity:98%Color and Shape:SolidMolecular weight:452.55GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Formula:C27H32N8O3SColor and Shape:SolidMolecular weight:548.66GRK6-IN-4
CAS:GRK6-IN-4 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 value of 1.56 μM. GRK6-IN-4 is applicable for research related to hematological malignancies, inflammatory diseases, and autoimmune disorders.Formula:C15H15N5Color and Shape:SolidMolecular weight:265.313CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:452.48GRK6-IN-5
CAS:GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.Formula:C23H21N3O2Color and Shape:SolidMolecular weight:371.432LAS195319
CAS:LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Formula:C29H26N10O3SColor and Shape:SolidMolecular weight:594.65
