GRK
G protein-coupled receptor kinases (GRKs) are a family of enzymes that phosphorylate activated GPCRs, leading to receptor desensitization and regulation of receptor signaling. GRKs play critical roles in controlling the intensity and duration of GPCR signaling, making them important in the regulation of various physiological processes, including cardiovascular function, immune response, and neurotransmission. GRK inhibitors and activators are studied for their potential therapeutic applications in heart failure, cancer, and neurological disorders. At CymitQuimica, we provide a range of high-quality GRK modulators to support your research in signal transduction, receptor regulation, and therapeutic development.
Found 43 products for "GRK".
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GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formula:C19H16FN5O2Purity:98.98% - 99.51%Color and Shape:SolidMolecular weight:365.36Ref: TM-T3513
1mg39.00€2mg50.00€1mL*10mM (DMSO)62.00€5mg70.00€10mg94.00€25mg161.00€50mg290.00€100mg538.00€500mg1,161.00€GRK6-IN-2
CAS:GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.Formula:C21H21FN6Purity:99.65%Color and Shape:SolidMolecular weight:376.43GRK6-IN-3
CAS:GRK6-IN-3 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 1.03 μM [1].Formula:C17H20N4O2Molecular weight:312.3663GRK5-IN-3
CAS:GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).Formula:C23H21N7O3Color and Shape:SolidMolecular weight:443.46CCG-273220
CAS:CCG-273220 covalently inhibits GRK5 at Cys474 with 220 nM IC50; more selective over GRK2.Formula:C26H24ClFN4O3Color and Shape:SolidMolecular weight:494.95GSK466317A
CAS:GSK466317A is a GRK2 inhibitor.Formula:C21H16ClF3N4O2Purity:98%Color and Shape:SolidMolecular weight:448.83CCG-271423
CAS:CCG-271423: potent GRK5 inhibitor (IC50: 0.0021 μM), less on GRK2 (IC50: 44 μM); lowers Ca2+ events and heart cell contractility.Formula:C28H26N4O3Color and Shape:SolidMolecular weight:466.53CCG-224406
CAS:CCG-22440 is a Highly Selective and Potent Inhibitor of G Protein-Coupled Receptor Kinase 2.Formula:C29H27FN6O5Color and Shape:SolidMolecular weight:558.56GRK5-IN-4
CAS:GRK5-IN-4: potent, selective covalent inhibitor of GRK5 (IC50=1.1 μM), 90x more specific than GRK2, useful for heart failure research.Formula:C26H25N7O3Color and Shape:SolidMolecular weight:483.52CCG-273463
CAS:CCG-273463: Potent GRK5 inhibitor (IC50: 9 nM), used for researching heart failure, hypertrophy, cancer.Formula:C26H25BrN4O3Color and Shape:SolidMolecular weight:521.41GSK317354A
CAS:GSK317354A is a GRK2 inhibitor.Formula:C25H18F4N6OColor and Shape:SolidMolecular weight:494.44GSK299115A
CAS:GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.Formula:C20H16Cl2N4O2Purity:99.69%Color and Shape:SolidMolecular weight:415.27Ref: TM-T27471
1mg303.00€5mg732.00€1mL*10mM (DMSO)895.00€10mg1,018.00€25mg1,513.00€50mg2,035.00€100mg2,673.00€KR-39038
CAS:KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.Formula:C24H32ClFN6OColor and Shape:SolidMolecular weight:475.00Ro 32-0432 hydrochloride
CAS:Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formula:C28H28N4O2Purity:98%Color and Shape:Red SolidMolecular weight:452.55GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Formula:C27H32N8O3SColor and Shape:SolidMolecular weight:548.66DS-1558
CAS:DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDFFormula:C21H21F3O4Color and Shape:SolidMolecular weight:394.38GRK5-IN-5
CAS:GRK5-IN-5 (Compound 4a) is a selective inhibitor of G protein-coupled receptor kinase 5 (GRK5) with an IC50 value of 0.03 μM. It shows an IC50 of 2.2 μM for GRK2 and 0.036 μM for GRK6. GRK5-IN-5 exhibits potent anti-hypertrophic activity in cardiac muscle and inhibits the proliferation of non-cardiac cells. It blocks pathological cardiac remodeling by inhibiting the abnormal upregulation of hypertrophic marker genes Nppa and Nppb. GRK5-IN-5 is useful for research in myocardial hypertrophy.Formula:C30H27FN4O5Molecular weight:542.57LAS195319
CAS:LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Formula:C29H26N10O3SColor and Shape:SolidMolecular weight:594.65CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H25FN4O4Purity:98%Color and Shape:SolidMolecular weight:452.48GRK6-IN-5
CAS:GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.Formula:C23H21N3O2Color and Shape:SolidMolecular weight:371.4317
