Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
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HhAntag
CAS:496794-70-8
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the …
Formula:
C24H23ClN4O3
Purity:
95.73%
Color and Shape:
Solid
Molecular weight:
450.92
Ref: TM-T3460
| 1mg | 69.00 € | ||
| 2mg | 97.00 € | ||
| 5mg | 160.00 € | ||
| 10mg | 274.00 € | ||
| 25mg | 472.00 € | ||
| 50mg | 707.00 € | ||
| 100mg | 1,103.00 € | ||
| 1mL*10mM (DMSO) | 170.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
Vismodegib
CAS:879085-55-9
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: …
Formula:
C19H14Cl2N2O3S
Purity:
98% - 99.99%
Color and Shape:
Solid
Molecular weight:
421.3
Ref: TM-T2590
| 5mg | 46.00 € | ||
| 10mg | 58.00 € | ||
| 50mg | 73.00 € | ||
| 100mg | 93.00 € | ||
| 200mg | 108.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
SANT-1
CAS:304909-07-7
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects …
Formula:
C23H27N5
Purity:
100% - 99.98%
Color and Shape:
Solid
Molecular weight:
373.49
Ref: TM-T2450
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 126.00 € | ||
| 50mg | 197.00 € | ||
| 100mg | 350.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
Sonidegib
CAS:956697-53-3
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM …
Formula:
C26H26F3N3O3
Purity:
98% - 99.97%
Color and Shape:
Solid
Molecular weight:
485.5
Ref: TM-T1926
| 5mg | 59.00 € | ||
| 10mg | 84.00 € | ||
| 25mg | 116.00 € | ||
| 50mg | 161.00 € | ||
| 100mg | 260.00 € | ||
| 1mL*10mM (DMSO) | 64.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
Taladegib
CAS:1258861-20-9
Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.
Formula:
C26H24F4N6O
Purity:
100% - 99.39%
Color and Shape:
Solid
Molecular weight:
512.5
Ref: TM-T2666
| 2mg | 42.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 95.00 € | ||
| 25mg | 148.00 € | ||
| 50mg | 229.00 € | ||
| 100mg | 340.00 € | ||
| 200mg | 472.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
Ciliobrevin A
CAS:302803-72-1
Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
Formula:
C17H9Cl2N3O2
Purity:
97.10% - 99.22%
Color and Shape:
Solid
Molecular weight:
358.18
Ref: TM-T3156
| 2mg | 42.00 € | ||
| 5mg | 59.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 168.00 € | ||
| 50mg | 235.00 € | ||
| 100mg | 331.00 € | ||
| 200mg | 492.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Monday 10 Mar 2025
SMANT hydrochloride
CAS:1177600-74-6
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.
Formula:
C16H24BrClN2O
Purity:
100%
Color and Shape:
Solid
Molecular weight:
375.73
Ref: TM-T23370
| 5mg | 39.00 € | ||
| 10mg | 58.00 € | ||
| 25mg | 105.00 € | ||
| 50mg | 178.00 € | ||
| 100mg | 305.00 € | ||
| 200mg | 442.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
AZD8542
CAS:1126366-36-6
AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.
Formula:
C25H24N4O2
Purity:
99.96%
Color and Shape:
Solid
Molecular weight:
412.48
Ref: TM-T26723
| 1mg | 316.00 € | ||
| 5mg | 750.00 € | ||
| 10mg | 1,064.00 € | ||
| 25mg | 1,586.00 € | ||
| 50mg | 2,072.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
SMO-IN-2
CAS:1822355-27-0
SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 …
Formula:
C25H25F4N5O2
Purity:
98.64%
Color and Shape:
Liquid
Molecular weight:
503.49
Ref: TM-T63429
| 1mg | 156.00 € | ||
| 5mg | 359.00 € | ||
| 10mg | 540.00 € | ||
| 25mg | 882.00 € | ||
| 50mg | 1,188.00 € | ||
| 100mg | 1,596.00 € |
Estimated delivery in United States, on Monday 21 Apr 2025
RU-SKI 43
CAS:1043797-53-0
RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits …
Formula:
C22H30N2O2S
Purity:
99.78%
Color and Shape:
Solid
Molecular weight:
386.55
Ref: TM-T12797
| 1mg | 49.00 € | ||
| 5mg | 108.00 € | ||
| 10mg | 155.00 € | ||
| 25mg | 356.00 € | ||
| 50mg | 530.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Monday 5 May 2025
TAK-441
CAS:1186231-83-3
TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.
Formula:
C28H31F3N4O6
Purity:
98.79%
Color and Shape:
Solid
Molecular weight:
576.56
Ref: TM-T21325
| 1mg | 99.00 € | ||
| 5mg | 235.00 € | ||
| 10mg | 354.00 € | ||
| 25mg | 635.00 € | ||
| 50mg | 944.00 € |
Estimated delivery in United States, on Monday 5 May 2025
CUR61414
CAS:334998-36-6
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds …
Formula:
C31H42N4O5
Purity:
97.34% - 98.00%
Color and Shape:
Solid
Molecular weight:
550.69
Ref: TM-T15019
| 1mg | 52.00 € | ||
| 5mg | 111.00 € | ||
| 10mg | 180.00 € | ||
| 25mg | 359.00 € | ||
| 50mg | 550.00 € | ||
| 100mg | 787.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Monday 5 May 2025
Hh-Ag1.5
CAS:612542-14-0
Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates …
Formula:
C28H26ClF2N3OS
Purity:
98.61%
Color and Shape:
Solid
Molecular weight:
526.04
Ref: TM-T24754
| 1mg | 127.00 € | ||
| 5mg | 305.00 € | ||
| 10mg | 472.00 € | ||
| 25mg | 782.00 € | ||
| 50mg | 1,103.00 € | ||
| 100mg | 1,539.00 € | ||
| 1mL*10mM (DMSO) | 354.00 € |
Estimated delivery in United States, on Monday 5 May 2025
SAG 21k
CAS:946002-48-8
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain …
Formula:
C29H28ClF2N3O2S
Purity:
99.51%
Color and Shape:
Liquid
Molecular weight:
556.07
Ref: TM-T35559
| 1mg | 115.00 € | ||
| 5mg | 274.00 € | ||
| 10mg | 411.00 € | ||
| 25mg | 700.00 € | ||
| 50mg | 938.00 € | ||
| 100mg | 1,378.00 € |
Estimated delivery in United States, on Monday 5 May 2025
GSA-10
CAS:300833-95-8
GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.
Formula:
C26H30N2O5
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
450.53
Ref: TM-T22814
| 1mg | 133.00 € | ||
| 5mg | 250.00 € | ||
| 10mg | 369.00 € | ||
| 25mg | 625.00 € | ||
| 50mg | 905.00 € | ||
| 100mg | 1,293.00 € |
Estimated delivery in United States, on Monday 5 May 2025
