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Hedgehog/Smoothened

Hedgehog/Smoothened

The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.

Found 44 products of "Hedgehog/Smoothened"

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  • Sonidegib
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    Sonidegib

    CAS:
    <p>Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.</p>
    Formula:C26H26F3N3O3
    Purity:98% - 99.97%
    Color and Shape:Solid
    Molecular weight:485.5

    Ref: TM-T1926

  • MRT-10
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    MRT-10

    CAS:
    <p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>
    Formula:C24H23N3O5S
    Purity:99.73%
    Color and Shape:Solid
    Molecular weight:465.52

    Ref: TM-T23027

  • SANT-1
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    SANT-1

    CAS:
    <p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>
    Formula:C23H27N5
    Purity:99.98% - >99.99%
    Color and Shape:Solid
    Molecular weight:373.49

    Ref: TM-T2450

  • Neurodazine
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    Neurodazine

    CAS:
    <p>Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.</p>
    Formula:C27H21ClN2O3
    Purity:98.01%
    Color and Shape:Solid
    Molecular weight:456.92

    Ref: TM-T16287

  • RUSKI-201
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    RUSKI-201

    CAS:
    <p>RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.</p>
    Formula:C20H27N3OS
    Color and Shape:Solid
    Molecular weight:357.51

    Ref: TM-T34451

  • SANT-2
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    SANT-2

    CAS:
    <p>SANT-2 is a potent inhibitor of Shh signaling pathway.</p>
    Formula:C23H20ClN3O4
    Color and Shape:Solid
    Molecular weight:437.88

    Ref: TM-T69189

  • Hedgehog Antagonist VIII
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    Hedgehog Antagonist VIII

    CAS:
    <p>Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.</p>
    Formula:C23H15ClF4N4O2
    Color and Shape:Solid
    Molecular weight:490.84

    Ref: TM-T35537

  • RUSKI-201 dihydrochloride
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    RUSKI-201 dihydrochloride

    CAS:
    <p>RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.</p>
    Formula:C20H29Cl2N3OS
    Color and Shape:Solid
    Molecular weight:430.43

    Ref: TM-T62388

  • SMANT hydrochloride
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    SMANT hydrochloride

    CAS:
    <p>SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.</p>
    Formula:C16H24BrClN2O
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:375.73

    Ref: TM-T23370

  • 3-epi-Vitamin D3
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    3-epi-Vitamin D3

    CAS:
    <p>3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM in</p>
    Formula:C27H44O
    Color and Shape:Solid
    Molecular weight:384.64

    Ref: TM-T72726

  • SMO-IN-3
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    SMO-IN-3

    CAS:
    <p>SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.</p>
    Formula:C27H25F4N3O2
    Color and Shape:Solid
    Molecular weight:499.5

    Ref: TM-T63387

  • MS-0022
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    MS-0022

    CAS:
    <p>MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.</p>
    Formula:C21H16BrN3O
    Color and Shape:Solid
    Molecular weight:406.28

    Ref: TM-T68861

  • Hedgehog IN-3
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    Hedgehog IN-3

    CAS:
    <p>Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].</p>
    Formula:C18H13ClF3N5O
    Color and Shape:Solid
    Molecular weight:407.78

    Ref: TM-T75148

  • AZD8542
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    AZD8542

    CAS:
    <p>AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.</p>
    Formula:C25H24N4O2
    Purity:99.96%
    Color and Shape:Solid
    Molecular weight:412.48

    Ref: TM-T26723

  • SMO-IN-2
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    SMO-IN-2

    CAS:
    <p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>
    Formula:C25H25F4N5O2
    Purity:98.64%
    Color and Shape:Solid
    Molecular weight:503.49

    Ref: TM-T63429

  • GSA-10
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    GSA-10

    CAS:
    <p>GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.</p>
    Formula:C26H30N2O5
    Purity:99.71%
    Color and Shape:Solid
    Molecular weight:450.53

    Ref: TM-T22814

  • Robotnikinin
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    Robotnikinin

    CAS:
    <p>Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.</p>
    Formula:C25H27ClN2O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:454.95

    Ref: TM-T26110

  • Hh-Ag1.5
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    Hh-Ag1.5

    CAS:
    <p>Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.</p>
    Formula:C28H26ClF2N3OS
    Purity:99.8%
    Color and Shape:Solid
    Molecular weight:526.04

    Ref: TM-T24754

  • Hedgehog IN-2
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    Hedgehog IN-2

    CAS:
    <p>Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of &lt;0.003 μM in C3H10T1/2 cells [1].</p>
    Formula:C24H22N4O2
    Color and Shape:Solid
    Molecular weight:398.46

    Ref: TM-T79055

  • TAK-441
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    TAK-441

    CAS:
    <p>TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA &amp; tumor growth.</p>
    Formula:C28H31F3N4O6
    Purity:99.82%
    Color and Shape:Solid
    Molecular weight:576.56

    Ref: TM-T21325