Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
Found 49 products for "Hedgehog/Smoothened".
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SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Formula:C28H29Cl2N3OSPurity:99.19% - 99.97%Color and Shape:White SolidMolecular weight:526.52Ref: TM-T4211
1mg49.00€2mg65.00€5mg90.00€1mL*10mM (DMSO)105.00€10mg114.00€25mg222.00€50mg334.00€100mg502.00€200mg717.00€MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formula:C31H29N3O5SPurity:99.72%Color and Shape:SolidMolecular weight:555.64HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formula:C27H29NO6Purity:97.6%Color and Shape:SolidMolecular weight:463.52Ref: TM-T22089
1mg44.00€2mg57.00€1mL*10mM (DMSO)88.00€5mg96.00€10mg128.00€25mg207.00€50mg308.00€100mg447.00€500mg973.00€SAG
CAS:SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.Formula:C28H28ClN3OSPurity:97.37% - 98.88%Color and Shape:SolidMolecular weight:490.06Ref: TM-T1779
1mg46.00€2mg58.00€5mg86.00€1mL*10mM (DMSO)87.00€10mg114.00€25mg221.00€50mg305.00€100mg452.00€200mg647.00€Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Formula:C27H21ClN2O3Purity:98.03%Color and Shape:SolidMolecular weight:456.925-LOX inhibitor
CAS:5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Formula:C22H27N5O2Purity:98.52%Color and Shape:SolidMolecular weight:393.48Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Formula:C23H15ClF4N4O2Color and Shape:SolidMolecular weight:490.84SMO-IN-3
CAS:SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Formula:C27H25F4N3O2Color and Shape:SolidMolecular weight:499.53-epi-Vitamin D3
CAS:3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFormula:C27H44OColor and Shape:SolidMolecular weight:384.64RUSKI-201
CAS:RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Formula:C20H27N3OSColor and Shape:SolidMolecular weight:357.51Hedgehog IN-3
CAS:Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Formula:C18H13ClF3N5OColor and Shape:SolidMolecular weight:407.78SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formula:C16H24BrClN2OPurity:99.81%Color and Shape:White SolidMolecular weight:375.73MS-0022
CAS:MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Formula:C21H16BrN3OColor and Shape:SolidMolecular weight:406.28RUSKI-201 dihydrochloride
CAS:RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Formula:C20H29Cl2N3OSColor and Shape:SolidMolecular weight:430.43M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Formula:C23H29N3O2Color and Shape:SolidMolecular weight:379.5LEQ-506
CAS:LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Formula:C27H29N5OColor and Shape:SolidMolecular weight:439.55SANT-2
CAS:SANT-2 is a potent inhibitor of Shh signaling pathway.Formula:C23H20ClN3O4Color and Shape:SolidMolecular weight:437.88SMO-IN-2
CAS:SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.Formula:C25H25F4N5O2Purity:98.76%Color and Shape:White SolidMolecular weight:503.49AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formula:C25H24N4O2Purity:99.95%Color and Shape:SolidMolecular weight:412.48Hh-Ag1.5
CAS:Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formula:C28H26ClF2N3OSPurity:99.8%Color and Shape:White SolidMolecular weight:526.04Ref: TM-T24754
1mg120.00€5mg289.00€1mL*10mM (DMSO)334.00€10mg447.00€25mg740.00€50mg1,044.00€100mg1,459.00€
