Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
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Vismodegib
CAS:879085-55-9
Vismodegib (GDC-0449) is a hedgehog pathway inhibitor (IC50: 3 nM). It also inhibits P-gp (IC50: …
Formula:
C19H14Cl2N2O3S
Purity:
98% - 99.99%
Color and Shape:
Solid
Molecular weight:
421.3
Ref: TM-T2590
| 5mg | 45.00 € | ||
| 10mg | 57.00 € | ||
| 50mg | 72.00 € | ||
| 100mg | 92.00 € | ||
| 200mg | 106.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SANT-1
CAS:304909-07-7
SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects …
Formula:
C23H27N5
Purity:
100% - 99.98%
Color and Shape:
Solid
Molecular weight:
373.49
Ref: TM-T2450
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 83.00 € | ||
| 25mg | 123.00 € | ||
| 50mg | 193.00 € | ||
| 100mg | 343.00 € | ||
| 1mL*10mM (DMSO) | 57.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Sonidegib
CAS:956697-53-3
Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM …
Formula:
C26H26F3N3O3
Purity:
98% - 99.97%
Color and Shape:
Solid
Molecular weight:
485.5
Ref: TM-T1926
| 5mg | 59.00 € | ||
| 10mg | 82.00 € | ||
| 25mg | 114.00 € | ||
| 50mg | 159.00 € | ||
| 100mg | 255.00 € | ||
| 1mL*10mM (DMSO) | 64.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Taladegib
CAS:1258861-20-9
Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.
Formula:
C26H24F4N6O
Purity:
100% - 99.39%
Color and Shape:
Solid
Molecular weight:
512.5
Ref: TM-T2666
| 2mg | 41.00 € | ||
| 5mg | 60.00 € | ||
| 10mg | 93.00 € | ||
| 25mg | 145.00 € | ||
| 50mg | 223.00 € | ||
| 100mg | 331.00 € | ||
| 200mg | 459.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Ciliobrevin A
CAS:302803-72-1
Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.
Formula:
C17H9Cl2N3O2
Purity:
97.10% - 99.22%
Color and Shape:
Solid
Molecular weight:
358.18
Ref: TM-T3156
| 2mg | 46.00 € | ||
| 5mg | 62.00 € | ||
| 10mg | 84.00 € | ||
| 25mg | 172.00 € | ||
| 50mg | 298.00 € | ||
| 100mg | 513.00 € | ||
| 200mg | 655.00 € | ||
| 500mg | 1,017.00 € | ||
| 1mL*10mM (DMSO) | 69.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SMANT hydrochloride
CAS:1177600-74-6
SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.
Formula:
C16H24BrClN2O
Purity:
100%
Color and Shape:
Solid
Molecular weight:
375.73
Ref: TM-T23370
| 5mg | 38.00 € | ||
| 10mg | 56.00 € | ||
| 25mg | 102.00 € | ||
| 50mg | 172.00 € | ||
| 100mg | 295.00 € | ||
| 200mg | 426.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
AZD8542
CAS:1126366-36-6
AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.
Formula:
C25H24N4O2
Purity:
99.96%
Color and Shape:
Solid
Molecular weight:
412.48
Ref: TM-T26723
| 1mg | 311.00 € | ||
| 5mg | 737.00 € | ||
| 10mg | 1,044.00 € | ||
| 25mg | 1,549.00 € | ||
| 50mg | 2,038.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
SMO-IN-2
CAS:1822355-27-0
SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 …
Formula:
C25H25F4N5O2
Purity:
98.64%
Color and Shape:
Liquid
Molecular weight:
503.49
Ref: TM-T63429
| 1mg | 152.00 € | ||
| 5mg | 351.00 € | ||
| 10mg | 528.00 € | ||
| 25mg | 861.00 € | ||
| 50mg | 1,160.00 € | ||
| 100mg | 1,559.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
RU-SKI 43
CAS:1043797-53-0
RU-SKI 43: Potent, selective Hhat inhibitor, IC50 850 nM. Anticancer; potential lung adenocarcinoma treatment. Inhibits …
Formula:
C22H30N2O2S
Purity:
99.78%
Color and Shape:
Solid
Molecular weight:
386.55
Ref: TM-T12797
| 1mg | 49.00 € | ||
| 5mg | 107.00 € | ||
| 10mg | 152.00 € | ||
| 25mg | 348.00 € | ||
| 50mg | 517.00 € | ||
| 1mL*10mM (DMSO) | 116.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
TAK-441
CAS:1186231-83-3
TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.
Formula:
C28H31F3N4O6
Purity:
98.79%
Color and Shape:
Solid
Molecular weight:
576.56
Ref: TM-T21325
| 1mg | 96.00 € | ||
| 5mg | 230.00 € | ||
| 10mg | 346.00 € | ||
| 25mg | 620.00 € | ||
| 50mg | 922.00 € | ||
| 100mg | 1,383.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
CUR61414
CAS:334998-36-6
CUR61414 is a cell-permeable inhibitor of Hedgehog signaling pathway (IC50 =100-200 nM) and selectively binds …
Formula:
C31H42N4O5
Purity:
97.34% - 98.00%
Color and Shape:
Solid
Molecular weight:
550.69
Ref: TM-T15019
| 1mg | 52.00 € | ||
| 5mg | 110.00 € | ||
| 10mg | 176.00 € | ||
| 25mg | 352.00 € | ||
| 50mg | 538.00 € | ||
| 100mg | 769.00 € | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
Hh-Ag1.5
CAS:612542-14-0
Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates …
Formula:
C28H26ClF2N3OS
Purity:
98.61%
Color and Shape:
Solid
Molecular weight:
526.04
Ref: TM-T24754
| 1mg | 122.00 € | ||
| 5mg | 295.00 € | ||
| 10mg | 454.00 € | ||
| 25mg | 753.00 € | ||
| 50mg | 1,061.00 € | ||
| 100mg | 1,481.00 € | ||
| 1mL*10mM (DMSO) | 341.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
SAG 21k
CAS:946002-48-8
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain …
Formula:
C29H28ClF2N3O2S
Purity:
99.51%
Color and Shape:
Liquid
Molecular weight:
556.07
Ref: TM-T35559
| 1mg | 113.00 € | ||
| 5mg | 268.00 € | ||
| 10mg | 402.00 € | ||
| 25mg | 684.00 € | ||
| 50mg | 915.00 € | ||
| 100mg | 1,344.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
GSA-10
CAS:300833-95-8
GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.
Formula:
C26H30N2O5
Purity:
≥98%
Color and Shape:
Solid
Molecular weight:
450.53
Ref: TM-T22814
| 1mg | 130.00 € | ||
| 5mg | 244.00 € | ||
| 10mg | 360.00 € | ||
| 25mg | 611.00 € | ||
| 50mg | 884.00 € | ||
| 100mg | 1,262.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
