Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
Found 44 products of "Hedgehog/Smoothened"
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ALLO-2
CAS:<p>ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.</p>Formula:C18H12F3N5OPurity:99.19%Color and Shape:SolidMolecular weight:371.32GANT 58
CAS:<p>GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).</p>Formula:C24H16N4SPurity:99.53%Color and Shape:SolidMolecular weight:392.48Dynarrestin
CAS:<p>Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.</p>Formula:C22H23F2N3O2SPurity:99.64%Color and Shape:SolidMolecular weight:431.5SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Formula:C28H30Cl3N3OSPurity:>99.99%Color and Shape:SoildMolecular weight:562.98HPP-9
<p>HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BET</p>Formula:C49H52N6O11Color and Shape:SolidMolecular weight:900.97HSP70-IN-3
<p>HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.</p>Formula:C48H78N6O7SColor and Shape:SolidMolecular weight:883.23CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Formula:C31H43ClN4O5Purity:94.05%Color and Shape:SolidMolecular weight:587.15HL2-m5
CAS:<p>HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.</p>Formula:C70H101N15O24S3Color and Shape:SolidMolecular weight:1632.83GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Color and Shape:Odour SolidGI-560192
CAS:<p>GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.</p>Formula:C20H16N2O2Purity:99.53%Color and Shape:SoildMolecular weight:316.35SANT 2
CAS:<p>SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.</p>Formula:C26H26ClN3O4Purity:99.23%Color and Shape:SolidMolecular weight:479.96JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Formula:C19H18N4OSPurity:98.93% - 99.89%Color and Shape:SolidMolecular weight:350.44SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Formula:C28H28ClN3OSPurity:97.37% - 98.88%Color and Shape:SolidMolecular weight:490.06HhAntag
CAS:<p>HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity</p>Formula:C24H23ClN4O3Purity:95.73%Color and Shape:SolidMolecular weight:450.92MRT-81
CAS:<p>MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.</p>Formula:C31H29N3O5SPurity:99.72%Color and Shape:SolidMolecular weight:555.64Glasdegib
CAS:<p>Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.</p>Formula:C21H22N6OPurity:98.72%Color and Shape:SolidMolecular weight:374.44SAG hydrochloride (912545-86-9(free base))
CAS:<p>SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.</p>Formula:C28H29Cl2N3OSPurity:99.19% - 99.77%Color and Shape:SolidMolecular weight:526.52MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Formula:C24H23N3O5SPurity:99.73%Color and Shape:SolidMolecular weight:465.52HPI 1
CAS:<p>HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.</p>Formula:C27H29NO6Purity:97.6%Color and Shape:SolidMolecular weight:463.52SANT-1
CAS:<p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>Formula:C23H27N5Purity:99.98% - >99.99%Color and Shape:SolidMolecular weight:373.49
