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Hedgehog/Smoothened

The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.

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products per page. 35 products on this category.

BrandProduct dataPurityPrice rangeEstimated delivery
Targetmol logo
ALLO-2
REF: TM-T14188CAS: 1357350-60-7 		99.19%64.00 €~2,664.00 €Fri 11 Apr 25
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Ellagic acid
REF: TM-T0465CAS: 476-66-4 		97.11% - 99.75%47.00 €~142.00 €Fri 11 Apr 25
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Dynarrestin
REF: TM-T15183CAS: 2222768-84-3 		99.49%62.00 €~483.00 €Fri 11 Apr 25
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GANT 58
REF: TM-T15370CAS: 64048-12-0 		99.53%38.00 €~303.00 €Fri 11 Apr 25
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Naftifine hydrochloride
REF: TM-T1543CAS: 65473-14-5 		98.75% - 99.84%35.00 €~107.00 €Fri 11 Apr 25
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Tolnaftate
REF: TM-T1094CAS: 2398-96-1 		98.85%35.00 €~54.00 €Fri 11 Apr 25
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SAG dihydrochloride
REF: TM-T40465CAS: 2702366-44-5 		100%65.00 €~563.00 €Mon 14 Apr 25
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CUR61414 hydrochloride
REF: TM-T15019L		95.22%255.00 €Mon 14 Apr 25
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SANT 2
REF: TM-T23307CAS: 329196-48-7 		99.23%34.00 €~57.00 €Mon 14 Apr 25
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MRT-81
REF: TM-T9532CAS: 1263132-08-6 		98.31%48.00 €~2,133.00 €Mon 21 Apr 25
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SAG hydrochloride (912545-86-9(free base))
REF: TM-T4211CAS: 2095432-58-7 		99.19% - 99.77%51.00 €~563.00 €Mon 21 Apr 25
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GANT 61
REF: TM-T3070CAS: 500579-04-4 		100% - ≥95%39.00 €~998.00 €Mon 21 Apr 25
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Purmorphamine
REF: TM-T1810CAS: 483367-10-8 		97.19% - 99.48%56.00 €~283.00 €Mon 21 Apr 25
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Cyclopamine
REF: TM-T2825CAS: 4449-51-8 		98.31% - 99.66%52.00 €~339.00 €Mon 21 Apr 25
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SAG
REF: TM-T1779CAS: 912545-86-9 		98.16% - 98.88%51.00 €~1,188.00 €Mon 21 Apr 25
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MRT-10
REF: TM-T23027CAS: 330829-30-6 		99.47%47.00 €~1,733.00 €Mon 21 Apr 25
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Glasdegib
REF: TM-T6514CAS: 1095173-27-5 		98.72%43.00 €~740.00 €Mon 21 Apr 25
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JK184
REF: TM-T3588CAS: 315703-52-7 		99.09% - 99.89%35.00 €~933.00 €Mon 21 Apr 25
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HPI 1
REF: TM-T22089CAS: 599150-20-6 		94.4%47.00 €~1,026.00 €Mon 21 Apr 25
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Jervine
REF: TM-T3363CAS: 469-59-0 		99.20% - 99.86%70.00 €~1,444.00 €Mon 21 Apr 25
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ALLO-2
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ALLO-2

CAS:1357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in …
Formula:
C18H12F3N5O
Purity:
99.19%
Color and Shape:
Solid
Molecular weight:
371.32

Ref: TM-T14188

1mg64.00 €
5mg140.00 €
10mg212.00 €
25mg353.00 €
50mg500.00 €
100mg658.00 €
200mg905.00 €
1mL*10mM (DMSO)156.00 €
Estimated delivery in United States, on Friday 11 Apr 2025
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Ellagic acid
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Ellagic acid

CAS:476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid …
Formula:
C14H6O8
Purity:
97.11% - 99.75%
Color and Shape:
Cream Colored Needles From Pyridine 1992)
Molecular weight:
302.19

Ref: TM-T0465

1g69.00 €
5g142.00 €
500mg52.00 €
Estimated delivery in United States, on Friday 11 Apr 2025
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Dynarrestin
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Dynarrestin

CAS:2222768-84-3
Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.
Formula:
C22H23F2N3O2S
Purity:
99.49%
Color and Shape:
Solid
Molecular weight:
431.5

Ref: TM-T15183

2mg62.00 €
5mg89.00 €
10mg156.00 €
25mg255.00 €
50mg391.00 €
Estimated delivery in United States, on Friday 11 Apr 2025
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GANT 58
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GANT 58

CAS:64048-12-0
GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 …
Formula:
C24H16N4S
Purity:
99.53%
Color and Shape:
Solid
Molecular weight:
392.48

Ref: TM-T15370

5mg48.00 €
10mg70.00 €
25mg117.00 €
50mg187.00 €
100mg303.00 €
1mL*10mM (DMSO)52.00 €
Estimated delivery in United States, on Friday 11 Apr 2025
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Naftifine hydrochloride
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Naftifine hydrochloride

CAS:65473-14-5
Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.
Formula:
C21H22ClN
Purity:
98.75% - 99.84%
Color and Shape:
Solid
Molecular weight:
323.86

Ref: TM-T1543

1g107.00 €
100mg42.00 €
500mg92.00 €
1mL*10mM (DMSO)35.00 €
Estimated delivery in United States, on Friday 11 Apr 2025
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Tolnaftate
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Tolnaftate

CAS:2398-96-1
Tolnaftate (NP-27) is a synthetic antifungal agent.
Formula:
C19H17NOS
Purity:
98.85%
Color and Shape:
White Powder
Molecular weight:
307.41

Ref: TM-T1094

1g35.00 €
1mL*10mM (DMSO)35.00 €
Estimated delivery in United States, on Friday 11 Apr 2025
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SAG dihydrochloride
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SAG dihydrochloride

CAS:2702366-44-5
SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.
Formula:
C28H30Cl3N3OS
Purity:
100%
Color and Shape:
Soild
Molecular weight:
562.98

Ref: TM-T40465

1mg65.00 €
5mg96.00 €
10mg153.00 €
25mg249.00 €
50mg376.00 €
100mg563.00 €
1mL*10mM (DMSO)227.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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CUR61414 hydrochloride
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CUR61414 hydrochloride

CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces …
Formula:
C31H43ClN4O5
Purity:
95.22%
Color and Shape:
Liquid
Molecular weight:
587.15

Ref: TM-T15019L

1mg255.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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SANT 2
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SANT 2

CAS:329196-48-7
SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.
Formula:
C26H26ClN3O4
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
479.96

Ref: TM-T23307

2mg34.00 €
5mg47.00 €
1mL*10mM (DMSO)57.00 €
Estimated delivery in United States, on Monday 14 Apr 2025
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MRT-81
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MRT-81

CAS:1263132-08-6
MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway …
Formula:
C31H29N3O5S
Purity:
98.31%
Color and Shape:
Solid
Molecular weight:
555.64

Ref: TM-T9532

1mg48.00 €
5mg97.00 €
10mg145.00 €
25mg255.00 €
50mg368.00 €
100mg505.00 €
200mg692.00 €
1mL*10mM (DMSO)116.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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SAG hydrochloride (912545-86-9(free base))
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SAG hydrochloride (912545-86-9(free base))

CAS:2095432-58-7
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
Formula:
C28H29Cl2N3OS
Purity:
99.19% - 99.77%
Color and Shape:
Solid
Molecular weight:
526.52

Ref: TM-T4211

1mg51.00 €
5mg96.00 €
10mg153.00 €
25mg274.00 €
50mg376.00 €
100mg563.00 €
1mL*10mM (DMSO)111.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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GANT 61
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GANT 61

CAS:500579-04-4
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.
Formula:
C27H35N5
Purity:
100% - ≥95%
Color and Shape:
Solid
Molecular weight:
429.6

Ref: TM-T3070

2mg39.00 €
5mg57.00 €
10mg88.00 €
25mg166.00 €
50mg306.00 €
100mg430.00 €
500mg998.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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Purmorphamine
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Purmorphamine

CAS:483367-10-8
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to …
Formula:
C31H32N6O2
Purity:
97.19% - 99.48%
Color and Shape:
Light Tan Solid
Molecular weight:
520.62

Ref: TM-T1810

2mg56.00 €
5mg88.00 €
10mg141.00 €
50mg283.00 €
1mL*10mM (DMSO)88.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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Cyclopamine
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Cyclopamine

CAS:4449-51-8
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the …
Formula:
C27H41NO2
Purity:
98.31% - 99.66%
Color and Shape:
White Crystalline Solid
Molecular weight:
411.62

Ref: TM-T2825

5mg52.00 €
10mg81.00 €
25mg134.00 €
50mg212.00 €
100mg339.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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SAG
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SAG

CAS:912545-86-9
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.
Formula:
C28H28ClN3OS
Purity:
98.16% - 98.88%
Color and Shape:
Solid
Molecular weight:
490.06

Ref: TM-T1779

1mg51.00 €
2mg71.00 €
5mg96.00 €
10mg153.00 €
25mg274.00 €
50mg376.00 €
100mg557.00 €
200mg797.00 €
500mg1,188.00 €
1mL*10mM (DMSO)97.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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MRT-10
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MRT-10

CAS:330829-30-6
MRT-10 is a Smoothened (Smo) receptor antagonist.
Formula:
C24H23N3O5S
Purity:
99.47%
Color and Shape:
Solid
Molecular weight:
465.52

Ref: TM-T23027

1mg47.00 €
2mg63.00 €
5mg96.00 €
10mg135.00 €
25mg265.00 €
50mg378.00 €
100mg530.00 €
200mg720.00 €
1mL*10mM (DMSO)87.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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Glasdegib
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Glasdegib

CAS:1095173-27-5
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of …
Formula:
C21H22N6O
Purity:
98.72%
Color and Shape:
Solid
Molecular weight:
374.44

Ref: TM-T6514

1mg43.00 €
5mg87.00 €
10mg145.00 €
25mg303.00 €
50mg512.00 €
100mg740.00 €
1mL*10mM (DMSO)96.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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discount label
JK184
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JK184

CAS:315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
Formula:
C19H18N4OS
Purity:
99.09% - 99.89%
Color and Shape:
Solid
Molecular weight:
350.44

Ref: TM-T3588

2mg35.00 €
5mg52.00 €
10mg85.00 €
25mg155.00 €
50mg259.00 €
100mg416.00 €
500mg933.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
+ info
discount label
HPI 1
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HPI 1

CAS:599150-20-6
HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 …
Formula:
C27H29NO6
Purity:
94.4%
Color and Shape:
Solid
Molecular weight:
463.52

Ref: TM-T22089

1mg47.00 €
2mg60.00 €
5mg92.00 €
10mg135.00 €
25mg217.00 €
50mg324.00 €
100mg472.00 €
500mg1,026.00 €
1mL*10mM (DMSO)107.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
+ info
discount label
Jervine
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Jervine

CAS:469-59-0
Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.
Formula:
C27H39NO3
Purity:
99.20% - 99.86%
Color and Shape:
Needles From Methanol + Water Solid
Molecular weight:
425.6

Ref: TM-T3363

5mg70.00 €
10mg119.00 €
25mg259.00 €
50mg499.00 €
100mg715.00 €
500mg1,444.00 €
1mL*10mM (DMSO)74.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
+ info
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