Hedgehog/Smoothened
The Hedgehog/Smoothened signaling pathway is a crucial GPCR-related pathway involved in embryonic development, tissue regeneration, and stem cell maintenance. Smoothened (SMO) is a key transmembrane protein that transduces signals from the Hedgehog (Hh) ligands to activate downstream signaling cascades. Dysregulation of the Hedgehog/Smoothened pathway is implicated in various cancers and developmental disorders, making it a significant target for therapeutic intervention. At CymitQuimica, we offer a range of high-quality modulators for the Hedgehog/Smoothened pathway to support your research in developmental biology, oncology, and regenerative medicine.
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Dynarrestin
CAS:2222768-84-3
Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.
Formula:
C22H23F2N3O2S
Purity:
99.49%
Color and Shape:
Solid
Molecular weight:
431.5
Ref: TM-T15183
| 2mg | 62.00 € | ||
| 5mg | 90.00 € | ||
| 10mg | 156.00 € | ||
| 25mg | 255.00 € | ||
| 50mg | 392.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
GANT 58
CAS:64048-12-0
GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 …
Formula:
C24H16N4S
Purity:
99.53%
Color and Shape:
Solid
Molecular weight:
392.48
Ref: TM-T15370
| 5mg | 47.00 € | ||
| 10mg | 70.00 € | ||
| 25mg | 116.00 € | ||
| 50mg | 185.00 € | ||
| 100mg | 299.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
ALLO-2
CAS:1357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in …
Formula:
C18H12F3N5O
Purity:
98.67%
Color and Shape:
Solid
Molecular weight:
371.32
Ref: TM-T14188
| 1mg | 62.00 € | ||
| 5mg | 136.00 € | ||
| 10mg | 204.00 € | ||
| 25mg | 340.00 € | ||
| 50mg | 483.00 € | ||
| 100mg | 634.00 € | ||
| 200mg | 872.00 € | ||
| 1mL*10mM (DMSO) | 150.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Naftifine hydrochloride
CAS:65473-14-5
Naftifine HCl: synthetic antifungal; inhibits squalene epoxidase, disrupting fungal cell sterol synthesis.
Formula:
C21H22ClN
Purity:
98.75% - 99.84%
Color and Shape:
Solid
Molecular weight:
323.86
Ref: TM-T1543
| 1g | 105.00 € | ||
| 100mg | 41.00 € | ||
| 500mg | 90.00 € | ||
| 1mL*10mM (DMSO) | 35.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Tolnaftate
CAS:2398-96-1
Tolnaftate (NP-27) is a synthetic antifungal agent.
Formula:
C19H17NOS
Purity:
98.85%
Color and Shape:
White Powder
Molecular weight:
307.41
Ref: TM-T1094
| 1g | 55.00 € | ||
| 1mL*10mM (DMSO) | 55.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
Ellagic acid
CAS:476-66-4
Ellagic acid (Gallogen), a thickened tetracyclic natural product, is a potent CK2 inhibitor. Ellagic acid …
Formula:
C14H6O8
Purity:
97.11% - 99.76%
Color and Shape:
Cream Colored Needles From Pyridine 1992)
Molecular weight:
302.19
Ref: TM-T0465
| 1g | 69.00 € | ||
| 5g | 143.00 € | ||
| 500mg | 49.00 € |
Estimated delivery in United States, on Wednesday 4 Dec 2024
CUR61414 hydrochloride
CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces …
Formula:
C31H43ClN4O5
Purity:
95.22%
Color and Shape:
Liquid
Molecular weight:
587.15
Ref: TM-T15019L
| 1mg | 251.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
SAG dihydrochloride
CAS:2702366-44-5
SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.
Formula:
C28H30Cl3N3OS
Purity:
100%
Color and Shape:
Soild
Molecular weight:
562.98
Ref: TM-T40465
| 1mg | 64.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 150.00 € | ||
| 25mg | 245.00 € | ||
| 50mg | 370.00 € | ||
| 100mg | 554.00 € | ||
| 1mL*10mM (DMSO) | 225.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
SANT 2
CAS:329196-48-7
SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.
Formula:
C26H26ClN3O4
Purity:
99.23%
Color and Shape:
Solid
Molecular weight:
479.96
Ref: TM-T23307
| 2mg | 34.00 € | ||
| 5mg | 46.00 € | ||
| 1mL*10mM (DMSO) | 56.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
SAG hydrochloride (912545-86-9(free base))
CAS:2095432-58-7
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.
Formula:
C28H29Cl2N3OS
Purity:
98% - 99.19%
Color and Shape:
Solid
Molecular weight:
526.52
Ref: TM-T4211
| 1mg | 51.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 151.00 € | ||
| 25mg | 271.00 € | ||
| 50mg | 372.00 € | ||
| 100mg | 557.00 € | ||
| 1mL*10mM (DMSO) | 110.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
GANT 61
CAS:500579-04-4
GANT 61 (GANT61) is an inhibitor for Gli1 and Gli2.
Formula:
C27H35N5
Purity:
100% - ≥95%
Color and Shape:
Solid
Molecular weight:
429.6
Ref: TM-T3070
| 2mg | 39.00 € | ||
| 5mg | 56.00 € | ||
| 10mg | 87.00 € | ||
| 25mg | 163.00 € | ||
| 50mg | 300.00 € | ||
| 100mg | 421.00 € | ||
| 500mg | 975.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Purmorphamine
CAS:483367-10-8
Purmorphamine (Shh Signaling Antagonist VI), which directly binds and activates Smoothened, blocks BODIPY-cyclopamine binding to …
Formula:
C31H32N6O2
Purity:
98.11% - 99.48%
Color and Shape:
Light Tan Solid
Molecular weight:
520.62
Ref: TM-T1810
| 2mg | 55.00 € | ||
| 5mg | 87.00 € | ||
| 10mg | 139.00 € | ||
| 50mg | 277.00 € | ||
| 1mL*10mM (DMSO) | 88.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Cyclopamine
CAS:4449-51-8
Cyclopamine (11-Deoxojervine), a Smoothened (Smo) antagonist (IC50: 46 nM in TM3Hh12 cells), belongs to the …
Formula:
C27H41NO2
Purity:
98.31% - 99.66%
Color and Shape:
White Crystalline Solid
Molecular weight:
411.62
Ref: TM-T2825
| 5mg | 52.00 € | ||
| 10mg | 80.00 € | ||
| 25mg | 131.00 € | ||
| 50mg | 209.00 € | ||
| 100mg | 334.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
SAG
CAS:912545-86-9
SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.
Formula:
C28H28ClN3OS
Purity:
98.16% - 98.88%
Color and Shape:
Solid
Molecular weight:
490.06
Ref: TM-T1779
| 1mg | 51.00 € | ||
| 2mg | 70.00 € | ||
| 5mg | 94.00 € | ||
| 10mg | 149.00 € | ||
| 25mg | 269.00 € | ||
| 50mg | 368.00 € | ||
| 100mg | 547.00 € | ||
| 200mg | 783.00 € | ||
| 500mg | 1,160.00 € | ||
| 1mL*10mM (DMSO) | 96.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
MRT-10
CAS:330829-30-6
MRT-10 is a Smoothened (Smo) receptor antagonist.
Formula:
C24H23N3O5S
Purity:
99.47%
Color and Shape:
Solid
Molecular weight:
465.52
Ref: TM-T23027
| 1mg | 45.00 € | ||
| 2mg | 61.00 € | ||
| 5mg | 93.00 € | ||
| 10mg | 130.00 € | ||
| 25mg | 256.00 € | ||
| 50mg | 364.00 € | ||
| 100mg | 510.00 € | ||
| 200mg | 693.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Glasdegib
CAS:1095173-27-5
Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of …
Formula:
C21H22N6O
Purity:
98.00%
Color and Shape:
Solid
Molecular weight:
374.44
Ref: TM-T6514
| 1mg | 42.00 € | ||
| 5mg | 96.00 € | ||
| 10mg | 143.00 € | ||
| 25mg | 296.00 € | ||
| 50mg | 500.00 € | ||
| 100mg | 723.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
JK184
CAS:315703-52-7
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
Formula:
C19H18N4OS
Purity:
99.09% - 99.89%
Color and Shape:
Solid
Molecular weight:
350.44
Ref: TM-T3588
| 2mg | 35.00 € | ||
| 5mg | 52.00 € | ||
| 10mg | 84.00 € | ||
| 25mg | 153.00 € | ||
| 50mg | 256.00 € | ||
| 100mg | 411.00 € | ||
| 500mg | 911.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
HPI 1
CAS:599150-20-6
HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 …
Formula:
C27H29NO6
Purity:
94.4%
Color and Shape:
Solid
Molecular weight:
463.52
Ref: TM-T22089
| 1mg | 46.00 € | ||
| 2mg | 59.00 € | ||
| 5mg | 90.00 € | ||
| 10mg | 132.00 € | ||
| 25mg | 214.00 € | ||
| 50mg | 319.00 € | ||
| 100mg | 462.00 € | ||
| 500mg | 1,003.00 € | ||
| 1mL*10mM (DMSO) | 106.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Jervine
CAS:469-59-0
Jervine inhibits Smoothened, blocking Hedgehog signaling and GLI1 transcription activation.
Formula:
C27H39NO3
Purity:
98.73% - 99.86%
Color and Shape:
Needles From Methanol + Water Solid
Molecular weight:
425.6
Ref: TM-T3363
| 5mg | 74.00 € | ||
| 10mg | 123.00 € | ||
| 25mg | 259.00 € | ||
| 50mg | 493.00 € | ||
| 100mg | 707.00 € | ||
| 500mg | 1,416.00 € | ||
| 1mL*10mM (DMSO) | 75.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
HhAntag
CAS:496794-70-8
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the …
Formula:
C24H23ClN4O3
Purity:
95.73%
Color and Shape:
Solid
Molecular weight:
450.92
Ref: TM-T3460
| 1mg | 68.00 € | ||
| 2mg | 96.00 € | ||
| 5mg | 159.00 € | ||
| 10mg | 273.00 € | ||
| 25mg | 469.00 € | ||
| 50mg | 703.00 € | ||
| 100mg | 1,094.00 € | ||
| 1mL*10mM (DMSO) | 169.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
