Cannabinoid Receptor
Cannabinoid receptors are GPCRs that mediate the effects of endogenous cannabinoids (endocannabinoids) and phytocannabinoids, such as those found in cannabis. The two main types of cannabinoid receptors, CB1 and CB2, are involved in regulating a wide range of physiological processes, including pain perception, appetite, mood, and immune function. Cannabinoid receptor modulators have therapeutic potential in treating conditions such as chronic pain, epilepsy, and multiple sclerosis. At CymitQuimica, we offer a wide range of high-quality cannabinoid receptor modulators to support your research in neuropharmacology, pain management, and immunology.
Found 196 products of "Cannabinoid Receptor"
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O-2050
CAS:<p>O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.</p>Formula:C23H31NO4SPurity:98%Color and Shape:SolidMolecular weight:417.56GW405833 hydrochloride
CAS:<p>GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].</p>Formula:C23H25Cl3N2O3Color and Shape:SolidMolecular weight:483.822-Linoleoyl Glycerol
CAS:<p>2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.</p>Formula:C21H38O4Color and Shape:SolidMolecular weight:354.531CB1 inverse agonist 1
CAS:<p>MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.</p>Formula:C25H18Cl3N3O3Purity:99.92%Color and Shape:SolidMolecular weight:514.79Hemopressin(rat) TFA
CAS:<p>Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.</p>Formula:C55H78F3N13O14Color and Shape:SolidMolecular weight:1202.28CB-25
CAS:<p>CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cells</p>Formula:C25H41NO3Purity:98%Color and Shape:SolidMolecular weight:403.6γ-Linolenoyl monoethanolamide
CAS:<p>γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].</p>Formula:C20H35NO2Color and Shape:SolidMolecular weight:321.505Tedalinab
CAS:<p>Tedalinab is an effective and selective cannabinoid receptor 2 agonist.</p>Formula:C19H21F2N3OPurity:98%Color and Shape:SolidMolecular weight:345.39Prostaglandin E2-1-glyceryl ester
CAS:<p>Prostaglandin E2-1-glyceryl ester, a member of the Prostaglandin Glycerol Ester family, serves as an endocannabinoid ligand targeting the CB1 receptor. This compound triggers a swift and transient surge in intracellular free calcium levels [1] [2].</p>Formula:C23H38O7Color and Shape:SolidMolecular weight:426.55PSB-SB1202
CAS:<p>PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].</p>Formula:C23H26O4Color and Shape:SolidMolecular weight:366.45CB2R-IN-1
CAS:<p>CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).</p>Formula:C23H27F3N4O6S3Purity:98%Color and Shape:SolidMolecular weight:608.67CB-52
CAS:<p>CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].</p>Formula:C26H43NO3Color and Shape:SolidMolecular weight:417.62URB447
CAS:<p>URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].</p>Formula:C25H21ClN2OColor and Shape:SolidMolecular weight:400.9Isopropyl dodec-11-enylfluorophosphonate
CAS:<p>Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibits</p>Formula:C15H30FO2PPurity:98%Color and Shape:SolidMolecular weight:292.37Amauromine
CAS:<p>Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.</p>Formula:C32H36N4O2Color and Shape:SolidMolecular weight:508.65PSNCBAM-1
CAS:<p>PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.</p>Formula:C22H21ClN4OPurity:99.86%Color and Shape:SolidMolecular weight:392.88PF 514273
CAS:<p>PF 514273 is a CB1 receptor antagonist.</p>Formula:C21H17Cl2F2N3O2Purity:98%Color and Shape:SolidMolecular weight:452.28GSK494581A
CAS:<p>GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.</p>Formula:C27H28F2N2O4SPurity:98%Color and Shape:SolidMolecular weight:514.58GP 1a
CAS:<p>GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.</p>Formula:C23H22Cl2N4OPurity:99.79%Color and Shape:SolidMolecular weight:441.35GW 833972A
CAS:<p>GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.</p>Formula:C18H14Cl2F3N5OPurity:99.93%Color and Shape:SoildMolecular weight:444.24MDA7
CAS:<p>MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.</p>Formula:C22H25NO2Color and Shape:SolidMolecular weight:335.439MDMB-FUBICA
CAS:<p>MDMB-FUBICA is a potent agonist of the cannabinoid receptors and exhibits psychoactive properties. It can be utilized in e-cigarettes.</p>Formula:C23H25FN2O3Color and Shape:SolidMolecular weight:396.455BNS808
CAS:<p>BNS808 is an orally active, selective CB1R antagonist with an IC50 of 0.8 nM, demonstrating significant selectivity for CB2R and minimal brain penetration. It is being studied for the treatment of obesity and related metabolic complications, such as metabolic dysfunction-associated steatotic liver disease (MASLD). BNS808 reduces drug exposure to the central nervous system, enhancing safety, and minimizes drug interactions through high plasma protein binding.</p>Formula:C25H20Cl3N3O3SColor and Shape:SolidMolecular weight:548.869CB1/2 receptor-1
CAS:<p>CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.</p>Formula:C33H48O2Color and Shape:SolidMolecular weight:476.73BAY 38-7271
CAS:<p>BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).</p>Formula:C20H21F3O5SPurity:98%Color and Shape:SolidMolecular weight:430.44GAT564
<p>GAT564, an allosteric CB1R modulator, shows EC50s of 87 nM (cAMP) & 320 nM (β-arrestin2) and lowers IOP effectively in glaucoma mice.</p>Formula:C20H16N2O2SColor and Shape:SolidMolecular weight:348.42Bzo-poxizid
CAS:<p>Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.</p>Formula:C20H21N3O2Color and Shape:SolidMolecular weight:335.40HU-308
CAS:<p>HU-308, a synthetic cannabinoid analogue, is a highly selective agonist of the CB2 receptor. It demonstrates an affinity for the CB2 receptor that is over 440 times greater than its affinity for the CB1 receptor, which are predominantly found in immune cells. This compound plays a crucial role in modulating the immunosuppressive effects of the endocannabinoid system (ECS). Additionally, HU-308 possesses anti-inflammatory and neuroprotective properties, and it regulates the function of microglia. Its potential applications include research into neuroinflammation and retinal diseases.</p>Formula:C27H42O3Color and Shape:SolidMolecular weight:414.62CB1/2 agonist 1
<p>Potent CB1/2 agonist 1; crosses blood-brain barrier; anti-inflammatory, analgesic; for multiple sclerosis research.</p>Formula:C21H24BrFN2O2Color and Shape:SolidMolecular weight:435.33TM38837
CAS:<p>CB1 antagonist 4 is an inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. It can reduce body weight, improve plasma inflammatory markers, and enhance glucose homeostasis [1].</p>Formula:C27H20Cl2F3N7OColor and Shape:SolidMolecular weight:586.40CB2 receptor antagonist 1
CAS:<p>Compound 29 is a potent, CB2-selective antagonist/reverse agonist. Derivatives 23 & 24 offer antinociception; 24 activates cannabinoid/TRPV1 receptors.</p>Formula:C28H47NO3Color and Shape:SolidMolecular weight:445.68Taranabant
CAS:<p>Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.</p>Formula:C27H25ClF3N3O2Purity:99.06% - 99.06%Color and Shape:SolidMolecular weight:515.96CBR Agonist-2
<p>CBR Agonist-2: CB1 receptor agonist, EC50 - 960 nM, Ki - 970 nM, useful for hCB1R-related disease research.</p>Formula:C27H27FN4OColor and Shape:SolidMolecular weight:442.53CBR Agonist-1
<p>CBR Agonist-1 targets CB1R and CB2R with Ki of 0.18 μM and 1.22 μM, useful for studying cannabinoid-related diseases.</p>Formula:C27H27FN4OColor and Shape:SolidMolecular weight:442.53HU 433
CAS:<p>HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.</p>Formula:C27H42O3Color and Shape:SolidMolecular weight:414.621'-Naphthoyl-2-methylindole
CAS:<p>1'-Naphthoyl-2-methylindole (Compound 88) acts as a cannabinoid mimic and an inhibitor of Win 55212-2, displaying a 34% inhibition of [3H]Win 55212-2 binding to cannabinoid receptors at a concentration of 3 μM.</p>Formula:C20H15NOColor and Shape:SolidMolecular weight:285.34FDU-PB-22
CAS:<p>FDU-PB-22, a novel synthetic cannabinoid, undergoes rapid metabolism in human liver microsomes (HLM) with a half-life of 12.4 minutes.</p>Formula:C26H18FNO2Color and Shape:SolidMolecular weight:395.43MDA77
CAS:<p>MDA77 is a CB2 agonist with an EC50 value of 5.82 nM and exhibits no activity towards CB1.</p>Formula:C21H23N3O3Color and Shape:SolidMolecular weight:365.43O-1269
CAS:<p>O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.</p>Formula:C22H22Cl3N3OColor and Shape:SolidMolecular weight:450.79AB-FUBINACA 3-fluorobenzyl isomer
CAS:<p>AB-FUBINACA 3-fluorobenzyl isomer is a synthetic cannabinoid and an indazole derivative, exhibiting high affinity for central CB1 receptors (Ki= 0.9 nM) and possessing anticonvulsant activity.</p>Formula:C20H21FN4O2Color and Shape:SolidMolecular weight:368.41AM8936
<p>AM8936: potent CB1 agonist, EC50 rCB1=8.6nM/hCB1=1.4nM, Ki rat CB1=0.55nM; potential for CNS, metabolic, pain, glaucoma research.</p>Formula:C25H33NO3Color and Shape:SolidMolecular weight:395.53(Rac)-Zevaquenabant
CAS:<p>(Rac)-Zevaquenabant ((Rac)-MRI-1867, compound 6b) is a potent and selective antagonist of cannabinoid receptor type 1 (CB1R) and inducible nitric oxide synthase (iNOS), with a binding affinity (Ki) of 5.7 nM for CB1R. It holds promise as an investigative tool in liver fibrosis research due to these characteristics.</p>Formula:C25H21ClF3N5O2SColor and Shape:SolidMolecular weight:547.98WIN 55,212-2 Mesylate
CAS:<p>WIN 55,212-2 Mesylate ((R)-(+)-WIN 55212) is a potent aminoalkylindole cannabinoid (CB) receptor agonist with Kis of 62.3 and 3.3 nM for human recombinant CB1 and CB2 receptors, respectively. Cannabinoid analogue WIN 55,212-2 Mesylate exhibited a novel anticancer effect against human tumors.</p>Formula:C28H30N2O6SPurity:98% - 99.71%Color and Shape:White To Off-White SolidMolecular weight:522.61AM-2232
CAS:<p>AM-2232 (UNII-40KCH8YIKP) is a potent and unselective agonist of the cannabinoid receptors.</p>Formula:C24H20N2OPurity:99.37%Color and Shape:SolidMolecular weight:352.432-Arachidonoylglycerol
CAS:<p>In the central nervous system, 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand</p>Formula:C23H38O4Purity:95%Color and Shape:LiquidMolecular weight:378.55Ref: TM-T14011
Discontinued productAEF0117
CAS:<p>AEF0117 is a signaling inhibitor of CB1-SSi that inhibits cannabinoid self-administration and can be used to study cannabis withdrawal.</p>Formula:C29H40O3Purity:99.58%Color and Shape:SolidMolecular weight:436.63
