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DHFR

DHFR

Dihydrofolate reductase (DHFR) is an enzyme that plays a crucial role in the folate cycle, which is essential for DNA synthesis, repair, and methylation. DHFR inhibitors are widely used as chemotherapeutic agents in the treatment of cancer and autoimmune diseases due to their ability to inhibit cell proliferation. At CymitQuimica, we provide a variety of DHFR inhibitors to support your research in cancer therapy, immunology, and molecular biology.

Found 32 products of "DHFR"

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  • (Rac)-Managlinat dialanetil
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    (Rac)-Managlinat dialanetil

    CAS:
    <p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>
    Formula:C21H33N4O6PS
    Purity:98.52%
    Color and Shape:Solid
    Molecular weight:500.55

    Ref: TM-T16009

  • DHFR-IN-5
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    DHFR-IN-5

    CAS:
    <p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>
    Formula:C18H24N4O4
    Color and Shape:Solid
    Molecular weight:360.41

    Ref: TM-T73328

  • 10-Deazaaminopterin
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    10-Deazaaminopterin

    CAS:
    <p>10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.</p>
    Formula:C20H21N7O5
    Color and Shape:Solid
    Molecular weight:439.42

    Ref: TM-T24961

  • Clociguanil
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    Clociguanil

    CAS:
    <p>Clociguanil has antimalarial activity.</p>
    Formula:C12H15Cl2N5O
    Color and Shape:Solid
    Molecular weight:316.19

    Ref: TM-T27043

  • Epiroprim
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    Epiroprim

    CAS:
    <p>Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus and Streptococcus.</p>
    Formula:C19H23N5O2
    Purity:99.68% - >99.99%
    Color and Shape:Solid
    Molecular weight:353.42

    Ref: TM-T25381

  • Piritrexim
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    Piritrexim

    CAS:
    <p>Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma</p>
    Formula:C17H19N5O2
    Purity:98.50% - >99.99%
    Color and Shape:Solid
    Molecular weight:325.37

    Ref: TM-T24644

  • Talotrexin ammonium
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    Talotrexin ammonium

    CAS:
    <p>Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.</p>
    Formula:C27H30N10O6
    Purity:97.49%
    Color and Shape:Solid
    Molecular weight:590.59

    Ref: TM-T64295

  • Methotrexate-γ-aspartate
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    Methotrexate-γ-aspartate

    CAS:
    <p>Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.</p>
    Formula:C24H27N9O8
    Purity:98%
    Color and Shape:Solid
    Molecular weight:569.53

    Ref: TM-T24457

  • Phototrexate
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    Phototrexate

    CAS:
    <p>Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).</p>
    Formula:C20H19N7O5
    Color and Shape:Solid
    Molecular weight:437.41

    Ref: TM-T41148

  • 4′-DTMP
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    4′-DTMP

    CAS:
    <p>4′-DTMP (4-Demethyltrimethoprim) is a DHFR inhibitor with antimicrobial activity against Escherichia coli.</p>
    Formula:C13H16N4O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:276.29

    Ref: TM-T78238

  • Brodimoprim
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    Brodimoprim

    CAS:
    <p>Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).</p>
    Formula:C13H15BrN4O2
    Purity:98% - 98.33%
    Color and Shape:Solid
    Molecular weight:339.19

    Ref: TM-T19858

  • DHFR-IN-4
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    DHFR-IN-4

    CAS:
    <p>DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.</p>
    Formula:C18H21N5O2S
    Purity:99.41%
    Color and Shape:Solid
    Molecular weight:371.46

    Ref: TM-T61486