DNA/RNA Synthesis
Inhibitors of DNA and RNA synthesis are compounds that interfere with the replication and transcription processes in cells, thereby preventing the production of essential genetic material. These inhibitors can target various enzymes and proteins involved in nucleic acid synthesis, making them valuable tools for studying the mechanisms of replication, transcription, and translation. They are also used in developing treatments for infections and cancer. At CymitQuimica, we offer a broad spectrum of DNA/RNA synthesis inhibitors to support your research in molecular biology, virology, and therapeutic development.
Found 706 products of "DNA/RNA Synthesis"
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DDD85646
CAS:<p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>Formula:C21H24Cl2N6O2SPurity:97.8% - 99.76%Color and Shape:SolidMolecular weight:495.43RAD51-IN-4
CAS:<p>RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.</p>Formula:C31H34FN5O5S2Color and Shape:SolidMolecular weight:639.76Balapiravir hydrochloride
CAS:<p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>Formula:C21H31ClN6O8Color and Shape:SolidMolecular weight:530.96G4/HDAC-IN-1
<p>G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.</p>Formula:C36H49ClFN7O4Color and Shape:SolidMolecular weight:698.2712R-LOX-IN-1
CAS:<p>12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.</p>Formula:C15H11NO2Color and Shape:SolidMolecular weight:237.258-NH2-ATP tetrasodium
CAS:<p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>Formula:C10H13N6Na4O13P3Color and Shape:SolidMolecular weight:610.12FAICAR
CAS:<p>FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.</p>Formula:C10H15N4O9PColor and Shape:SolidMolecular weight:366.22KY386
CAS:<p>KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.</p>Formula:C21H19N5O2SColor and Shape:SolidMolecular weight:405.47WRN inhibitor 5
CAS:<p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Formula:C23H20N2O6SColor and Shape:SolidMolecular weight:452.48Emzadirib
CAS:<p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>Formula:C27H40N4O6S2Purity:99.79% - 99.9%Color and Shape:SolidMolecular weight:580.76MC-VC-PAB-Cyclohexanediamine-Thailanstatin A
CAS:<p>MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a spliceostatin analog and a drug-linker conjugate for antibody-drug conjugates (ADC), comprising the cytotoxic</p>Formula:C63H91N9O16Purity:98%Color and Shape:SolidMolecular weight:1230.45WRN inhibitor 4
CAS:<p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>Formula:C16H14N2O5SColor and Shape:SolidMolecular weight:346.36NVS-SM2
CAS:<p>NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.</p>Formula:C23H30N6OColor and Shape:SolidMolecular weight:406.523-Cyanovinylcarbazole phosphoramidite
CAS:<p>3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.</p>Formula:C50H53N4O6PColor and Shape:SolidMolecular weight:836.95LNA-Adenosine
CAS:<p>LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.</p>Formula:C11H13N5O4Purity:99.15%Color and Shape:SolidMolecular weight:279.25Thymectacin
CAS:<p>Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.</p>Formula:C21H25BrN3O9PPurity:97.05% - 99.49%Color and Shape:SolidMolecular weight:574.32SMN-C3
CAS:<p>SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).</p>Formula:C24H28N6OPurity:99.01% - 99.05%Color and Shape:SolidMolecular weight:416.52DHX9-IN-2
CAS:<p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>Formula:C18H16ClN3O3S2Purity:98%Color and Shape:SolidMolecular weight:421.92Sorivudine
CAS:<p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>Formula:C11H13BrN2O6Purity:99.74%Color and Shape:SolidMolecular weight:349.13CeMMEC1
CAS:<p>CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).</p>Formula:C19H16N2O4Purity:98.9% - 99.92%Color and Shape:SolidMolecular weight:336.34Lomibuvir
CAS:<p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>Formula:C25H35NO4SPurity:99.83%Color and Shape:SolidMolecular weight:445.61Adafosbuvir
CAS:<p>Adafosbuvir has antiviral activity.</p>Formula:C22H29FN3O10PColor and Shape:SolidMolecular weight:545.457PCNA-IN-1
CAS:<p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>Formula:C19H18I3NO3Color and Shape:SolidMolecular weight:689.065TREX1-IN-4
CAS:<p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>Formula:C24H19ClN6O4Color and Shape:SolidMolecular weight:490.898DNA ligase-IN-2
CAS:<p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is >64 μg/mL.</p>Formula:C13H8FN3O3Color and Shape:SolidMolecular weight:273.2194,5'-Dimethylangelicin-NHS
<p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity & photosensitivity.</p>Formula:C21H19NO7SColor and Shape:SolidMolecular weight:429.44HPH-15
CAS:<p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>Formula:C19H31N3S4Color and Shape:SolidMolecular weight:429.73(E)-Antiviral agent 67
CAS:<p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>Formula:C19H19N3OColor and Shape:SolidMolecular weight:305.374RAD51-IN-5
CAS:<p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>Formula:C26H38N4O5S2Color and Shape:SolidMolecular weight:550.73EFdA-TP tetrasodium
CAS:<p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>Formula:C12H11FN5Na4O12P3Purity:98%Color and Shape:SolidMolecular weight:621.12ddCTP trisodium
<p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>Formula:C9H13N3Na3O12P3Color and Shape:SolidMolecular weight:517.1TREX1-IN-3
CAS:<p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>Formula:C24H19ClN6O4Color and Shape:SolidMolecular weight:490.898DHX9-IN-9
CAS:<p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>Formula:C21H21ClFN5O3S2Color and Shape:SolidMolecular weight:510KWR095
CAS:<p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>Formula:C33H31ClF3N9O4Color and Shape:SolidMolecular weight:710.105NSC 641396
CAS:<p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>Formula:C18H13NO3Color and Shape:SolidMolecular weight:291.301Metesind Glucuronate
CAS:<p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>Formula:C29H34N4O10SColor and Shape:SolidMolecular weight:630.67Antitumor agent-74
<p>Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.</p>Formula:C26H23FN6Color and Shape:SolidMolecular weight:438.5WRN inhibitor 13
CAS:<p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>Formula:C16H20N2O5SColor and Shape:SolidMolecular weight:352.405DNA polymerase-IN-6
CAS:<p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>Formula:C26H28ClFN8O4Color and Shape:SolidMolecular weight:571.0035-Iminodaunorubicin hydrochloride
CAS:<p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>Formula:C27H31ClN2O9Color and Shape:SolidMolecular weight:563.00RAD51-IN-7
CAS:<p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>Formula:C25H31N5O4S2Color and Shape:SolidMolecular weight:529.67T-2513 hydrochloride
CAS:<p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>Formula:C25H28ClN3O5Color and Shape:SolidMolecular weight:485.96RAD51-IN-8
<p>RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.</p>Formula:C16H14Cl2FN3O2Color and Shape:SolidMolecular weight:370.21CYP2C19-IN-1
<p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>Formula:C26H26N2O6SColor and Shape:SolidMolecular weight:494.56BAY-364
CAS:<p>BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+</p>Formula:C23H19N3O4Color and Shape:SolidMolecular weight:401.41UMPK ligand 1
CAS:<p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>Formula:C15H22N4O5SColor and Shape:SolidMolecular weight:370.424Plevitrexed
CAS:<p>Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor & reduced folate carrier, treats gastric cancer.</p>Formula:C26H25FN8O4Purity:98%Color and Shape:SolidMolecular weight:532.53Methyl 3-oxodecanoate
CAS:<p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>Formula:C11H20O3Color and Shape:SolidMolecular weight:200.275Zorubicin
CAS:<p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>Formula:C34H35N3O10Color and Shape:SolidMolecular weight:645.66Dencatistat
CAS:<p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>Formula:C24H27N7O5SPurity:98.85%Color and Shape:SolidMolecular weight:525.58(R)-CSN5i-3
CAS:<p>(R)-CSN5i-3 is CSN5i-3 of the R configuration.</p>Formula:C28H29F2N5O2Purity:99.76% - 99.97%Color and Shape:SolidMolecular weight:505.56DIDS
CAS:<p>DIDS inhibits anion exchangers reversibly then irreversibly and blocks RAD51.</p>Formula:C16H10N2O6S4Purity:98%Color and Shape:SolidMolecular weight:454.52Epolactaene
CAS:<p>Epolactaene: neuritogenic, inhibits mammalian DNA polymerases & human DNA topoisomerase II.</p>Formula:C21H27NO6Color and Shape:SolidMolecular weight:389.445-Methylcytosine hydrochloride
CAS:<p>5-Methylcytosine hydrochloride plays a critical role in regulating gene expression, promoting genomic imprinting, and inhibiting transposon factors. It is also closely associated with translation fidelity and tRNA recognition.</p>Formula:C5H8ClN3OColor and Shape:SolidMolecular weight:161.59Antiviral agent 67
CAS:<p>Antiviralagent 67 (compound PC6) is an inhibitor of DENVNS5 (RNA-dependent RNA polymerase) with a Ki value of 1.12 nM.</p>Formula:C19H19N3OColor and Shape:SolidMolecular weight:305.374DHX9-IN-19
CAS:<p>DHX9-IN-19 (compound 3) is an orally active inhibitor of DHX9, playing a significant role in cancer research.</p>Formula:C20H21ClN4O4S2Color and Shape:SolidMolecular weight:480.988L-2'-Fd4C
CAS:<p>L-2'-Fd4C is an L-nucleoside analogue with both anti-human immunodeficiency virus (HIV) and anti-hepatitis B virus (HBV) activity [1].</p>Formula:C9H10FN3O3Color and Shape:SolidMolecular weight:227.19Ladirubicin
CAS:<p>Ladirubicin, as an anthracyclines analog is the leading compound of alkylcyclines.</p>Formula:C29H31NO11SColor and Shape:SolidMolecular weight:601.62Pol I-IN-1
<p>Pol I-IN-1 is a powerful inhibitor of RNA polymerase I (Pol I), specifically targeting the large catalytic subunit RPA194, demonstrating an inhibition</p>Formula:C23H22N4O2Color and Shape:SolidMolecular weight:386.45Polθ-IN-8
CAS:<p>Polθ-IN-8 (example 77) is a DNA polymerase θ (Polθ) inhibitor with an IC50 for Polθ ATPase activity of less than 100 nM. Polθ-IN-8 is useful for researching diseases related to Polθ activity, such as cancer.</p>Formula:C22H22ClN7O3SColor and Shape:SolidMolecular weight:499.97CB 30900
CAS:<p>CB30900 is a novel and effective thymidylate synthase inhibitor.</p>Formula:C31H32FN5O9Color and Shape:SolidMolecular weight:637.61DENV-IN-6
CAS:<p>DENV-IN-6, a potent anti-DENV (I-IV) and HIV-1 IIIB inhibitor with EC50 ranging 6.8-17.5 μM for DENV and EC50 0.0181 μM for HIV-1.</p>Formula:C23H26ClFN4OSColor and Shape:SolidMolecular weight:461APE1-IN-3
CAS:<p>APE1-IN-3 (Compound 1), an APE1 inhibitor, is utilized in cancer research.</p>Formula:C17H16O4Color and Shape:SolidMolecular weight:284.31GTSE1-IN-1
CAS:<p>GTSE1-IN-1 (compound Y18), an orally active GTSE1 inhibitor, exhibits notable anticancer properties. It effectively represses the proliferation of cancer cells by downregulating GTSE1 transcription and expression, which leads to DNA damage and promotes persistent cell cycle arrest and cellular senescence. Moreover, GTSE1-IN-1 substantially reduces the adhesion, migration, and invasion of colorectal cancer HCT116 cells and non-small cell lung cancer A549 cells in vitro.</p>Formula:C21H24FN7Color and Shape:SolidMolecular weight:393.46WRN inhibitor 11
CAS:<p>WRN inhibitor 11 (Example 17) is an orally effective inhibitor of WRN helicase, with an IC50 of 63 nM.</p>Formula:C34H35ClF3N9O5Color and Shape:SolidMolecular weight:742.152-CEES
CAS:<p>2-CEES is a mustard gas analogue that only forms DNA monoadducts. It induces centromere amplification in both human and mouse cells and can lead to chromosome instability.</p>Formula:C4H9ClSColor and Shape:SolidMolecular weight:124.632D-G23
CAS:<p>D-G23 is a selective RAD52 inhibitor. It disrupts RAD52-mediated DNA repair pathways and suppresses the growth of cancer cells deficient in BRCA1 and BRCA2. D-G23 shows promise for research into homologous recombination-related cancers caused by BRCA1/2 mutations, such as hereditary breast and ovarian cancers.</p>Formula:C19H22N4O3Color and Shape:SolidMolecular weight:354.403MTH1 activator-1
CAS:<p>MTH1 activator-1 is an MTH1 activator that enhances endogenous MTH1 activity and significantly reduces 8-oxo-dG levels in cellular DNA. It is useful for investigating the upregulation of oxidative damage repair in nucleotide pools and examining biological effects, as well as for studies aiming to delay or prevent tumorigenesis.</p>Formula:C29H23F3N4O2Color and Shape:SolidMolecular weight:516.514NRTT-IN-1
CAS:<p>NRTT-IN-1 (Compound 1) is an inhibitor of the nucleoside reverse transcriptase translocation (NRTT), effectively blocking HIV DNA synthesis and viral replication.</p>Formula:C28H24FN5O5Color and Shape:SolidMolecular weight:529.51912(S)-HETE
CAS:<p>Enpatoran hydrochloride (M5049 hydrochloride) is a TLR7/8 inhibitor with antiviral activity that is used in the study of autoimmune diseases.</p>Formula:C20H32O3Color and Shape:SolidMolecular weight:320.47Polθ-IN-5
CAS:<p>Polθ-IN-5 (Compound 139) is an inhibitor of DNA polymerase theta (Polθ) that exhibits antitumor activity.</p>Formula:C23H18ClF2N7O3SColor and Shape:SolidMolecular weight:545.95Werner syndrome RecQ helicase-IN-2
CAS:<p>Werner syndrome RecQ helicase-IN-2 is a potent Werner syndrome RecQ DNA helicase (WRN) inhibitor, useful in research on colorectal and gastric cancers.</p>Formula:C32H34F3N9O5Purity:99.02%Color and Shape:SolidMolecular weight:681.67WRN inhibitor 12
CAS:<p>WRN inhibitor 12 (compound 5) serves as an inhibitor for the WRN helicase.</p>Formula:C33H33ClF3N9O5Color and Shape:SolidMolecular weight:728.12Uridine 3',5'-diphosphate
CAS:<p>Uridine 3′,5′-diphosphate (3′,5′-UDP; Compound pUp) serves as a competitive RNase inhibitor [1].</p>Formula:C9H14N2O12P2Color and Shape:SolidMolecular weight:404.16Bersiporocin
CAS:<p>Bersiporocin is a novel prolyl-tRNA synthetase (PRS) inhibitor that exerts antifibrotic effects through downregulation of collagen synthesis in IPF.</p>Formula:C15H19Cl2N3OPurity:98.88% - 99.79%Color and Shape:SolidMolecular weight:328.24ATIC-IN-2
CAS:<p>ATIC-IN-2 (Compound 1) is a competitive inhibitor of the bifunctional enzyme AICAR Tfase/IMPCH (ATIC), binding to inosine monophosphate cyclohydrolase (IMPCH) with a Ki of 0.13 μM.</p>Formula:C4H4N4O3SColor and Shape:SolidMolecular weight:188.165Polθ-IN-6
CAS:<p>Polθ-IN-6 (Compound 89) is an inhibitor of DNA polymerase theta (Polθ) and exhibits antitumor activity.</p>Formula:C25H23N3O3SColor and Shape:SolidMolecular weight:445.53GSK_WRN4
CAS:<p>GSK_WRN4 is a WRN helicase inhibitor with anti-cancer activity, inhibiting MSI tumor cell growth by inducing DNA double-strand breaks, useful in cancer research</p>Formula:C16H20N2O4SPurity:99.95%Color and Shape:SolidMolecular weight:336.41AB25583
CAS:<p>AB25583 is a small molecule inhibitor of Polθ helicase (Polθ-hel) with an IC50 of 6 nM. It selectively kills cells deficient in BRCA1/2 and synergizes with Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. AB25583 can be utilized in tumor research.</p>Formula:C22H17ClN4O3SColor and Shape:SolidMolecular weight:452.912'-(2-Nitrobenzyl)-ATP
CAS:<p>2'-(2-Nitrobenzyl)-ATP is an analog of rATP. It acts as a transcription terminator by inhibiting the elongation of RNA chains by T7 RNA polymerase.</p>Formula:C17H21N6O15P3Color and Shape:SolidMolecular weight:642.30RAD51-IN-6
CAS:<p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>Formula:C27H40N3O5PSColor and Shape:SolidMolecular weight:549.66Polθ-IN-7
CAS:<p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>Formula:C28H35F3N6O2Color and Shape:SolidMolecular weight:544.612KL-50
CAS:<p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>Formula:C7H7FN6O2Color and Shape:SolidMolecular weight:226.17N-Nitrosonornicotine
CAS:<p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>Formula:C9H11N3OColor and Shape:SolidMolecular weight:177.2WRN inhibitor 7
CAS:<p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>Formula:C27H23N3O6Color and Shape:SolidMolecular weight:485.49And1 degrader 1
CAS:<p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>Formula:C26H27Cl2N3OColor and Shape:SolidMolecular weight:468.42LN-439A
CAS:<p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>Formula:C24H26FN3O4Color and Shape:SolidMolecular weight:439.482,5-Di-tert-butyl-1,4-benzoquinone
CAS:<p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>Formula:C14H20O2Color and Shape:SolidMolecular weight:220.31Xanthosine-5'-Triphosphate trisodium
CAS:<p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>Formula:C10H12N4Na3O15P3Color and Shape:SolidMolecular weight:590.111RECTAS-2.0
CAS:<p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G>A mutation, intended for research in Fabry disease.</p>Formula:C18H17ClN4O4Color and Shape:SolidMolecular weight:388.805GR 122222X
CAS:<p>GR 122222X is an inhibitor of topoisomerase II.</p>Formula:C26H35N5O11SPurity:98%Color and Shape:SolidMolecular weight:625.65GHP-88309
CAS:<p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>Formula:C16H11FN2OColor and Shape:SolidMolecular weight:266.27VPC-80051
CAS:<p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>Formula:C16H13F2N3OColor and Shape:SolidMolecular weight:301.291iPAF1C
CAS:<p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>Formula:C27H26BrFN4OColor and Shape:SolidMolecular weight:521.42PolQi1
CAS:<p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>Formula:C18H14ClF5N4O2Purity:98.97%Color and Shape:SolidMolecular weight:448.77(Rac)-Plevitrexed
CAS:<p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>Formula:C26H25FN8O4Purity:98%Color and Shape:SolidMolecular weight:532.535-Fluorouridine 5'-phosphate
CAS:<p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>Formula:C9H12FN2O9PColor and Shape:SolidMolecular weight:342.172CTPS1-IN-1
CAS:<p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>Formula:C21H22N6O4S2Purity:99.46%Color and Shape:SolidMolecular weight:486.57HRO761
CAS:<p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>Formula:C31H31ClF3N9O5Purity:98.74% - 99.62%Color and Shape:SolidMolecular weight:702.08SR 11302
CAS:<p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>Formula:C26H32O2Purity:98.65%Color and Shape:SolidMolecular weight:376.53
