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DNA/RNA Synthesis

DNA/RNA Synthesis

Inhibitors of DNA and RNA synthesis are compounds that interfere with the replication and transcription processes in cells, thereby preventing the production of essential genetic material. These inhibitors can target various enzymes and proteins involved in nucleic acid synthesis, making them valuable tools for studying the mechanisms of replication, transcription, and translation. They are also used in developing treatments for infections and cancer. At CymitQuimica, we offer a broad spectrum of DNA/RNA synthesis inhibitors to support your research in molecular biology, virology, and therapeutic development.

Found 706 products of "DNA/RNA Synthesis"

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  • DDD85646
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    DDD85646

    CAS:
    <p>DDD85646 is an inhibitor of T. brucei N-myristoyltransferase with a Ki of 1.44 nM, an IC50 of 2 nM and an EC50 of 2 nM. The IC50 of hNMT is 4 nM.</p>
    Formula:C21H24Cl2N6O2S
    Purity:97.8% - 99.76%
    Color and Shape:Solid
    Molecular weight:495.43

    Ref: TM-T27135

  • RAD51-IN-4
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    RAD51-IN-4

    CAS:
    <p>RAD51-IN-4, a potent RAD51 inhibitor, may be useful in researching mitochondrial defect-related conditions.</p>
    Formula:C31H34FN5O5S2
    Color and Shape:Solid
    Molecular weight:639.76

    Ref: TM-T73107

  • Balapiravir hydrochloride
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    Balapiravir hydrochloride

    CAS:
    <p>Balapiravir HCl, an NS5B inhibitor, is used potentially for the treatment of HCV infection.</p>
    Formula:C21H31ClN6O8
    Color and Shape:Solid
    Molecular weight:530.96

    Ref: TM-T26736

  • G4/HDAC-IN-1
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    G4/HDAC-IN-1

    <p>G4/HDAC-IN-1, a G4/HDAC dual inhibitor, IC50 1.1 µM, blocks TNBC growth, useful in cancer research.</p>
    Formula:C36H49ClFN7O4
    Color and Shape:Solid
    Molecular weight:698.27

    Ref: TM-T72946

  • 12R-LOX-IN-1
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    12R-LOX-IN-1

    CAS:
    <p>12R-LOX-IN-1 (Compound 4a), with an IC50 of 28.25 µM, is an inhibitor of 12R-LOX.</p>
    Formula:C15H11NO2
    Color and Shape:Solid
    Molecular weight:237.25

    Ref: TM-T83457

  • 8-NH2-ATP tetrasodium
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    8-NH2-ATP tetrasodium

    CAS:
    <p>8-NH2-ATP tetrasodium, an inactive ATP variant, originates from 8-NH2-Ado tetrasodium, which triggers the apoptosis-associated cleavage of poly (ADP-ribose) polymerase [1] [2].</p>
    Formula:C10H13N6Na4O13P3
    Color and Shape:Solid
    Molecular weight:610.12

    Ref: TM-T84731

  • FAICAR
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    FAICAR

    CAS:
    <p>FAICAR (5-Formamidoimidazole-4-carboxamide ribotide), a purine nucleotide, plays a crucial role in metabolic processes.</p>
    Formula:C10H15N4O9P
    Color and Shape:Solid
    Molecular weight:366.22

    Ref: TM-T84746

  • KY386
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    KY386

    CAS:
    <p>KY386 is a potent and selective DHX33 helicase inhibitor with an IC50 value of 19 nM.</p>
    Formula:C21H19N5O2S
    Color and Shape:Solid
    Molecular weight:405.47

    Ref: TM-T81967

  • WRN inhibitor 5
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    WRN inhibitor 5

    CAS:
    <p>WRN Inhibitor 5 (Example 157), a cyclic vinyl sulfone-based compound, serves as an inhibitor of Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>
    Formula:C23H20N2O6S
    Color and Shape:Solid
    Molecular weight:452.48

    Ref: TM-T80772

  • Emzadirib
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    Emzadirib

    CAS:
    <p>Emzadirib (RAD51-IN-2) is a potent RAD51 inhibitor with potential anticancer activity for the study of DNA damage repair.</p>
    Formula:C27H40N4O6S2
    Purity:99.79% - 99.9%
    Color and Shape:Solid
    Molecular weight:580.76

    Ref: TM-T12682

  • MC-VC-PAB-Cyclohexanediamine-Thailanstatin A
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    MC-VC-PAB-Cyclohexanediamine-Thailanstatin A

    CAS:
    <p>MC-VC-PAB-Cyclohexanediamine-Thailanstatin A is a spliceostatin analog and a drug-linker conjugate for antibody-drug conjugates (ADC), comprising the cytotoxic</p>
    Formula:C63H91N9O16
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1230.45

    Ref: TM-T79085

  • WRN inhibitor 4
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    WRN inhibitor 4

    CAS:
    <p>WRN Inhibitor 4 (Example 107), a cyclic vinyl sulfone-based compound, serves as an inhibitor of the Werner Syndrome ATP-dependent helicase enzyme (WRN).</p>
    Formula:C16H14N2O5S
    Color and Shape:Solid
    Molecular weight:346.36

    Ref: TM-T80773

  • NVS-SM2
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    NVS-SM2

    CAS:
    <p>NVS-SM2 boosts SMN2 splicing, enhances exon 7 inclusion, and raises SMN protein levels orally.</p>
    Formula:C23H30N6O
    Color and Shape:Solid
    Molecular weight:406.52

    Ref: TM-T33764

  • 3-Cyanovinylcarbazole phosphoramidite
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    3-Cyanovinylcarbazole phosphoramidite

    CAS:
    <p>3-Cyanovinylcarbazole phosphoramidite: an antiviral, hinders viral DNA synthesis, modifies ribonucleotides.</p>
    Formula:C50H53N4O6P
    Color and Shape:Solid
    Molecular weight:836.95

    Ref: TM-T74188

  • LNA-Adenosine
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    LNA-Adenosine

    CAS:
    <p>LNA-Adenosine (LNA-A) is a nucleoside analogue that acts as a ligand for adenosine A3 receptors.</p>
    Formula:C11H13N5O4
    Purity:99.15%
    Color and Shape:Solid
    Molecular weight:279.25

    Ref: TM-T32826

  • Thymectacin
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    Thymectacin

    CAS:
    <p>Thymectacin (NB 1011) is a selective thymidine synthase (TS) inhibitor with anticancer activity for the study of colon cancer and solid tumors.</p>
    Formula:C21H25BrN3O9P
    Purity:97.05% - 99.49%
    Color and Shape:Solid
    Molecular weight:574.32

    Ref: TM-T24881

  • SMN-C3
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    SMN-C3

    CAS:
    <p>SMN-C3 (MV8T2MCK57) is an orally active modulator of SMN2 splicing, and has the potential to treat spinal muscular atrophy (SMA).</p>
    Formula:C24H28N6O
    Purity:99.01% - 99.05%
    Color and Shape:Solid
    Molecular weight:416.52

    Ref: TM-T12935

  • DHX9-IN-2
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    DHX9-IN-2

    CAS:
    <p>DHX9-IN-2 is an inhibitor targeting ATP-dependent RNA de-helicase A (DHX9) with anticancer and antitumor activity for cancer research.</p>
    Formula:C18H16ClN3O3S2
    Purity:98%
    Color and Shape:Solid
    Molecular weight:421.92

    Ref: TM-T82568

  • Sorivudine
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    Sorivudine

    CAS:
    <p>Sorivudine (BV-araU) is an antiviral blocking DNA synthesis in viruses like varicella, HSV-1, and Epstein-Barr.</p>
    Formula:C11H13BrN2O6
    Purity:99.74%
    Color and Shape:Solid
    Molecular weight:349.13

    Ref: TM-T16911

  • CeMMEC1
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    CeMMEC1

    CAS:
    <p>CeMMEC1 is an inhibitor of BRD4, and also has a great affinity for TAF1(IC50=0.9 μM).</p>
    Formula:C19H16N2O4
    Purity:98.9% - 99.92%
    Color and Shape:Solid
    Molecular weight:336.34

    Ref: TM-T4345

  • Lomibuvir
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    Lomibuvir

    CAS:
    <p>Lomibuvir (VCH-222, VX-222) is an allosteric inhibitor of HCV NS5B with Kd 17 nM, blocks RNA elongation, EC50 5.2 nM for 1b/Con1.</p>
    Formula:C25H35NO4S
    Purity:99.83%
    Color and Shape:Solid
    Molecular weight:445.61

    Ref: TM-T6729

  • Adafosbuvir
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    Adafosbuvir

    CAS:
    <p>Adafosbuvir has antiviral activity.</p>
    Formula:C22H29FN3O10P
    Color and Shape:Solid
    Molecular weight:545.457

    Ref: TM-T26560

  • PCNA-IN-1
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    PCNA-IN-1

    CAS:
    <p>PCNA-IN-1 (Compound 11) is an inhibitor of the PCNA/PIP-box interaction, with an IC50 greater than 50 μM. It is applicable in cancer research.</p>
    Formula:C19H18I3NO3
    Color and Shape:Solid
    Molecular weight:689.065

    Ref: TM-T204170

  • TREX1-IN-4
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    TREX1-IN-4

    CAS:
    <p>TREX1-IN-4 (Compound 96) is an inhibitor of TREX1 and TREX2, exhibiting an IC50 of less than 0.1 μM for TREX1 and an IC50 of less than 1 μM for TREX2. It has an EC50 ranging from 0.1 to 10 μM in HCT116 cells. TREX1-IN-4 is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898

    Ref: TM-T205208

  • DNA ligase-IN-2
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    DNA ligase-IN-2

    CAS:
    <p>DNA ligase-IN-2 (compound 2) acts as a potent LigA inhibitor, effectively hindering the DNA-independent spontaneous adenylation activity of full-length LigA and the truncated enzyme LigA:AD with an IC50 of 29 nM. It also significantly suppresses the in vitro growth of Staphylococcus aureus, showing MIC values of 1 μg/mL for S. aureus ATCC 29213 and S. aureus ATCC 700699, while the MIC for Escherichia coli (E. coli) ATCC 25922 is &gt;64 μg/mL.</p>
    Formula:C13H8FN3O3
    Color and Shape:Solid
    Molecular weight:273.219

    Ref: TM-T204415

  • CymitQuimica logo
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    4,5'-Dimethylangelicin-NHS

    <p>NHS-modified coumarin, 4,5'-Dimethylangelicin-NHS, shows photochemical activity &amp; photosensitivity.</p>
    Formula:C21H19NO7S
    Color and Shape:Solid
    Molecular weight:429.44

    Ref: TM-T62365

  • HPH-15
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    HPH-15

    CAS:
    <p>HPH-15 is an anti-cell migration compound that inhibits cell movement by binding to hnRNP U or suppressing TGF-β. Additionally, it prevents epithelial-to-mesenchymal transition (EMT). HPH-15 holds potential for research in areas such as anti-tumor metastasis and anti-fibrosis.</p>
    Formula:C19H31N3S4
    Color and Shape:Solid
    Molecular weight:429.73

    Ref: TM-T205327

  • (E)-Antiviral agent 67
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    (E)-Antiviral agent 67

    CAS:
    <p>(E)-Antiviral agent 67 (compound PC6) is a pyrazolone-based antiviral compound that exhibits inhibitory activity against RNA-dependent RNA polymerase.</p>
    Formula:C19H19N3O
    Color and Shape:Solid
    Molecular weight:305.374

    Ref: TM-T206106

  • RAD51-IN-5
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    RAD51-IN-5

    CAS:
    <p>RAD51-IN-5 blocks RAD51; may aid mitochondrial disorder research. (WO2021164746A1, cmpd 3)</p>
    Formula:C26H38N4O5S2
    Color and Shape:Solid
    Molecular weight:550.73

    Ref: TM-T63892

  • EFdA-TP tetrasodium
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    EFdA-TP tetrasodium

    CAS:
    <p>EFdA-TP tetrasodium is a potent HIV-1 inhibitor that blocks DNA synthesis as an ICT or DCT.</p>
    Formula:C12H11FN5Na4O12P3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:621.12

    Ref: TM-T72461

  • CymitQuimica logo
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    ddCTP trisodium

    <p>ddCTP trisodium, an HIV reverse transcriptase target, aids AIDS research and DNA sequencing as a ddNTP.</p>
    Formula:C9H13N3Na3O12P3
    Color and Shape:Solid
    Molecular weight:517.1

    Ref: TM-T63602

  • TREX1-IN-3
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    TREX1-IN-3

    CAS:
    <p>TREX1-IN-3 (Compound 95) is an inhibitor of TREX1 and TREX2, with an IC50 of less than 0.1 μM for TREX1 and less than 1 μM for TREX2, as well as an EC50 of less than 1 μM for HCT116 cells. It is applicable for research in the field of cancer.</p>
    Formula:C24H19ClN6O4
    Color and Shape:Solid
    Molecular weight:490.898

    Ref: TM-T205254

  • DHX9-IN-9
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    DHX9-IN-9

    CAS:
    <p>DHX9-IN-9 (509) acts as an inhibitor of the RNA helicase DHX9, demonstrating an EC50 of 0.0177 μM in DHX9 cellular target engagement, primarily utilized in cancer research [1].</p>
    Formula:C21H21ClFN5O3S2
    Color and Shape:Solid
    Molecular weight:510

    Ref: TM-T86205

  • KWR095
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    KWR095

    CAS:
    <p>KWR095 is an orally active inhibitor of WRN, demonstrating an IC50 of 0.032 μM against WRN ATPase. It disrupts the double-stranded helicase activity of WRN and inhibits tumor cell proliferation, exhibiting antitumor properties.</p>
    Formula:C33H31ClF3N9O4
    Color and Shape:Solid
    Molecular weight:710.105

    Ref: TM-T205595

  • NSC 641396
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    NSC 641396

    CAS:
    <p>NSC 641396 is a ribonucleotide reductase (RNR) inhibitor with an IC50 value of 1.2 μM. Additionally, it acts as an inhibitor of protein arginine N-methyltransferase 9 (PRMT9) and exhibits antitumor properties.</p>
    Formula:C18H13NO3
    Color and Shape:Solid
    Molecular weight:291.301

    Ref: TM-T204449

  • Metesind Glucuronate
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    Metesind Glucuronate

    CAS:
    <p>Metesind Glucuronate is an antineoplastic. It also is a specific thymidylate synthase inhibitor.</p>
    Formula:C29H34N4O10S
    Color and Shape:Solid
    Molecular weight:630.67

    Ref: TM-T24454

  • CymitQuimica logo
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    Antitumor agent-74

    <p>Antitumor agent-74, a quinazoline derivative, inhibits DNA, arrests cell cycle, and induces apoptosis with agent-75.</p>
    Formula:C26H23FN6
    Color and Shape:Solid
    Molecular weight:438.5

    Ref: TM-T62509

  • WRN inhibitor 13
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    WRN inhibitor 13

    CAS:
    <p>WRN inhibitor 13 is an inhibitor of the WRN helicase with a pIC50 value ranging from 6 to 7.</p>
    Formula:C16H20N2O5S
    Color and Shape:Solid
    Molecular weight:352.405

    Ref: TM-T204389

  • DNA polymerase-IN-6
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    DNA polymerase-IN-6

    CAS:
    <p>DNA polymerase-IN-6 (Compound 27) exhibits inhibitory activity against DNA polymerase, with EC50 values of 0.33 µM for HCMV, 1.9 µM for HSV-1, 0.76 µM for HSV-2, and 0.066 µM for EBV.</p>
    Formula:C26H28ClFN8O4
    Color and Shape:Solid
    Molecular weight:571.003

    Ref: TM-T204284

  • 5-Iminodaunorubicin hydrochloride
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    5-Iminodaunorubicin hydrochloride

    CAS:
    <p>5-Iminodaunorubicin HCl: quinone-modified anthracycline with antitumor properties, induces DNA breaks in cancer cells.</p>
    Formula:C27H31ClN2O9
    Color and Shape:Solid
    Molecular weight:563.00

    Ref: TM-T72115

  • RAD51-IN-7
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    RAD51-IN-7

    CAS:
    <p>RAD51-IN-7 inhibits RAD51 gene, with potential for mitochondrial disorders. (From WO2021164746A1, cmpd 71)</p>
    Formula:C25H31N5O4S2
    Color and Shape:Solid
    Molecular weight:529.67

    Ref: TM-T63728

  • T-2513 hydrochloride
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    T-2513 hydrochloride

    CAS:
    <p>T-2513 hydrochloride: selective topoisomerase I inhibitor, binds DNA complex, halts DNA/RNA synthesis, causes cell death.</p>
    Formula:C25H28ClN3O5
    Color and Shape:Solid
    Molecular weight:485.96

    Ref: TM-T63225

  • CymitQuimica logo
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    RAD51-IN-8

    <p>RAD51-IN-8 inhibits RAD51-BRCA2 interaction and H4A4 with EC50 of 19 μM; a micromolar PPI inhibitor.</p>
    Formula:C16H14Cl2FN3O2
    Color and Shape:Solid
    Molecular weight:370.21

    Ref: TM-T61469

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    CYP2C19-IN-1

    <p>CYP2C19-IN-1: potent CYP2C19 inhibitor, non-genotoxic, non-hepatotoxic, blocks RdRP (Ki: 6.16 μM), useful for ZIKV research.</p>
    Formula:C26H26N2O6S
    Color and Shape:Solid
    Molecular weight:494.56

    Ref: TM-T63337

  • BAY-364
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    BAY-364

    CAS:
    <p>BAY-364 (BAY-299N) functions as an inhibitor targeting the second bromine domain in TAF1, demonstrating inhibitory effects on TAF1 in Kasumi-1 cells, CD34+</p>
    Formula:C23H19N3O4
    Color and Shape:Solid
    Molecular weight:401.41

    Ref: TM-T73451

  • UMPK ligand 1
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    UMPK ligand 1

    CAS:
    <p>UMPK ligand 1 (ZINC07785412) serves as a ligand for uridine monophosphate kinase (UMPK).</p>
    Formula:C15H22N4O5S
    Color and Shape:Solid
    Molecular weight:370.424

    Ref: TM-T204579

  • Plevitrexed
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    Plevitrexed

    CAS:
    <p>Plevitrexed, an oral TS inhibitor (Ki: 0.44 nM), targets α-folate receptor &amp; reduced folate carrier, treats gastric cancer.</p>
    Formula:C26H25FN8O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.53

    Ref: TM-T12635L

  • Methyl 3-oxodecanoate
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    Methyl 3-oxodecanoate

    CAS:
    <p>Methyl 3-oxodecanoate exhibits virulence factor activity against human pathogens and shows effects on Synechococcus elongatus (a species of fluorescent algae) as well as on culture supernatant. Additionally, Methyl 3-oxodecanoate inhibits DNA synthesis by suppressing protein synthesis at the translation initiation level.</p>
    Formula:C11H20O3
    Color and Shape:Solid
    Molecular weight:200.275

    Ref: TM-T206384

  • Zorubicin
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    Zorubicin

    CAS:
    <p>Zorubicin, a Daunorubicin derivative, targets topoisomerase II, inhibits DNA polymerase, and researches acute leukemia, sarcomas.</p>
    Formula:C34H35N3O10
    Color and Shape:Solid
    Molecular weight:645.66

    Ref: TM-T69130

  • Dencatistat
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    Dencatistat

    CAS:
    <p>Dencatistat is a highly selective and oral cytidine triphosphate synthase 1 CTPS1 inhibitor specific.CTPS1-IN-2 for B-cell, T-cell lymphomas and solid tumors.</p>
    Formula:C24H27N7O5S
    Purity:98.85%
    Color and Shape:Solid
    Molecular weight:525.58

    Ref: TM-T86106