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DNA/RNA Synthesis

DNA/RNA Synthesis

Inhibitors of DNA and RNA synthesis are compounds that interfere with the replication and transcription processes in cells, thereby preventing the production of essential genetic material. These inhibitors can target various enzymes and proteins involved in nucleic acid synthesis, making them valuable tools for studying the mechanisms of replication, transcription, and translation. They are also used in developing treatments for infections and cancer. At CymitQuimica, we offer a broad spectrum of DNA/RNA synthesis inhibitors to support your research in molecular biology, virology, and therapeutic development.

Found 706 products of "DNA/RNA Synthesis"

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  • RAD51-IN-6
    Targetmol
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    RAD51-IN-6

    CAS:
    <p>RAD51-IN-6, a potent RAD51 gene inhibitor, may help research mitochondrial disorders. (WO2021164746A1, cmpd 23)</p>
    Formula:C27H40N3O5PS
    Color and Shape:Solid
    Molecular weight:549.66

    Ref: TM-T63883

  • Polθ-IN-7
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    Polθ-IN-7

    CAS:
    <p>Polθ-IN-7 (example 12) is an inhibitor of DNA polymerase θ (Polθ) with a Ki of 1.27 nM.</p>
    Formula:C28H35F3N6O2
    Color and Shape:Solid
    Molecular weight:544.612

    Ref: TM-T204135

  • KL-50
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    KL-50

    CAS:
    <p>KL-50, a selective toxin, effectively targets tumors deficient in the DNA repair protein O6-methylguanine-DNA-methyltransferase (MGMT), which corrects O6-alkylguanine lesions. This compound induces both DNA damage response pathways and cell cycle arrest in MGMT-deficient cells, regardless of mismatch repair (MMR) status. KL-50 shows promise in the study of brain tumors lacking MGMT.</p>
    Formula:C7H7FN6O2
    Color and Shape:Solid
    Molecular weight:226.17

    Ref: TM-T200136

  • N-Nitrosonornicotine
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    N-Nitrosonornicotine

    CAS:
    <p>N-Nitrosonornicotine, a tobacco-specific nitrosamine, exhibits carcinogenic and mutagenic properties, and is capable of inducing micronuclei in C3A cells. Additionally, N-Nitrosonornicotine can form DNA adducts.</p>
    Formula:C9H11N3O
    Color and Shape:Solid
    Molecular weight:177.2

    Ref: TM-T201694

  • WRN inhibitor 7
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    WRN inhibitor 7

    CAS:
    <p>WRN inhibitor 7 (Compound h6), a potent inhibitor of Werner syndrome helicase, demonstrates effective suppression of WRN's helicase and ATPase activities with IC50 values of 9.8 μM and 15.8 μM, respectively. This compound is utilized in the study of microsatellite instable (MSI) cancers [1].</p>
    Formula:C27H23N3O6
    Color and Shape:Solid
    Molecular weight:485.49

    Ref: TM-T87635

  • And1 degrader 1
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    And1 degrader 1

    CAS:
    <p>And1 degrader 1 (Compound A15) is a degrader of acidic nucleoplasmic DNA-binding protein 1 (And1) that notably induces degradation of And1 in NSCLC cells. When combined with Olaparib (1 μM), And1 degrader 1 at a concentration of 5 μM effectively inhibits proliferation in A549 and H460 cells. This compound is applicable in cancer research studies.</p>
    Formula:C26H27Cl2N3O
    Color and Shape:Solid
    Molecular weight:468.42

    Ref: TM-T200443

  • LN-439A
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    LN-439A

    CAS:
    <p>LN-439A (compound LN-439A) is a novel BAP1 inhibitor that suppresses the growth of basal-like breast cancer by degrading KLF5.</p>
    Formula:C24H26FN3O4
    Color and Shape:Solid
    Molecular weight:439.48

    Ref: TM-T200435

  • 2,5-Di-tert-butyl-1,4-benzoquinone
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    2,5-Di-tert-butyl-1,4-benzoquinone

    CAS:
    <p>2,5-Di-tert-butyl-1,4-benzoquinone is a potent antibacterial agent found primarily in marine Streptomyces sp. VITVSK1, effective against emerging antibiotic resistance. Additionally, it serves as a powerful inhibitor of RNA polymerase.</p>
    Formula:C14H20O2
    Color and Shape:Solid
    Molecular weight:220.31

    Ref: TM-T201504

  • Xanthosine-5'-Triphosphate trisodium
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    Xanthosine-5'-Triphosphate trisodium

    CAS:
    <p>Xanthosine-5'-Triphosphate (5'-XTP) trisodium is a nucleotide formed through the deamination of purine bases. It serves as a substrate for inosine triphosphate pyrophosphatase (ITPase).</p>
    Formula:C10H12N4Na3O15P3
    Color and Shape:Solid
    Molecular weight:590.111

    Ref: TM-TXB-00592

  • RECTAS-2.0
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    RECTAS-2.0

    CAS:
    <p>RECTAS-2.0 is a small molecule designed to correct RNA mis-splicing caused by the GLA c.639+919G&gt;A mutation, intended for research in Fabry disease.</p>
    Formula:C18H17ClN4O4
    Color and Shape:Solid
    Molecular weight:388.805

    Ref: TM-T206725

  • GR 122222X
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    GR 122222X

    CAS:
    <p>GR 122222X is an inhibitor of topoisomerase II.</p>
    Formula:C26H35N5O11S
    Purity:98%
    Color and Shape:Solid
    Molecular weight:625.65

    Ref: TM-T24100

  • GHP-88309
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    GHP-88309

    CAS:
    <p>GHP-88309 is an orally active, broad-spectrum anti-paramyxovirus agent that targets viral polymerase, interrupting viral RNA synthesis. It effectively inhibits respiratory syncytial virus (RSV), measles virus (MeV), and canine distemper virus (CDV) with an EC50 of 0.06-1.2 μM. In mouse models, GHP-88309 demonstrates significant anti-infective activity.</p>
    Formula:C16H11FN2O
    Color and Shape:Solid
    Molecular weight:266.27

    Ref: TM-T204819

  • VPC-80051
    Targetmol
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    VPC-80051

    CAS:
    <p>VPC-80051 is an hnRNP A1 splicing activity inhibitor that directly interacts with the hnRNP A1 RBD and reduces AR-V7 messenger levels in the 22Rv1 CRPC cell line. VPC-80051 is applicable in prostate cancer research.</p>
    Formula:C16H13F2N3O
    Color and Shape:Solid
    Molecular weight:301.291

    Ref: TM-T204737

  • iPAF1C
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    iPAF1C

    CAS:
    <p>iPAF1C is a powerful inhibitor of the polymerase-associated factor 1 complex (PAF1C) and exhibits anti-HIV activity [1].</p>
    Formula:C27H26BrFN4O
    Color and Shape:Solid
    Molecular weight:521.42

    Ref: TM-T86731

  • PolQi1
    Targetmol
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    PolQi1

    CAS:
    <p>PolQi1 is a highly efficient and selective Polϴ (DNA polymerase theta) inhibitor with an IC50 of 2 nM, showing potential for cancer therapy.</p>
    Formula:C18H14ClF5N4O2
    Purity:98.97%
    Color and Shape:Solid
    Molecular weight:448.77

    Ref: TM-T89335

  • (Rac)-Plevitrexed
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    (Rac)-Plevitrexed

    CAS:
    <p>(Rac)-Plevitrexed is a racemate of Plevitrexed. Plevitrexed is an orally active and potent inhibitor of thymidylate synthase (TS).</p>
    Formula:C26H25FN8O4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:532.53

    Ref: TM-T12674

  • 5-Fluorouridine 5'-phosphate
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    5-Fluorouridine 5'-phosphate

    CAS:
    <p>5-Fluorouridine 5'-phosphate acts as an ODCase (uridine 5'-monophosphate decarboxylase) inhibitor, exhibiting a Ki value of 98 µM for human ODCase and 645 µM for Methanococcus jannaschii ODCase. This compound also shows inhibitory activity on leukemia and lymphoma cell lines, making it useful for cancer research studies.</p>
    Formula:C9H12FN2O9P
    Color and Shape:Solid
    Molecular weight:342.172

    Ref: TM-T205644

  • CTPS1-IN-1
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    CTPS1-IN-1

    CAS:
    <p>CTPS1-IN-1 is a cytidine-5′ triphosphate synthase 1 (CTPS1) inhibitor with potential antitumor activity and can be used to study autoimmune diseases.</p>
    Formula:C21H22N6O4S2
    Purity:99.46%
    Color and Shape:Solid
    Molecular weight:486.57

    Ref: TM-T86105

  • HRO761
    Targetmol
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    HRO761

    CAS:
    <p>HRO761 is a potent Werne r syndrome RecQ DNA deconjugase (WRN) inhibitor that can be used to study cancers such as colon and stomach cancer.</p>
    Formula:C31H31ClF3N9O5
    Purity:98.74% - 99.62%
    Color and Shape:Solid
    Molecular weight:702.08

    Ref: TM-T72107

  • SR 11302
    Targetmol
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    SR 11302

    CAS:
    <p>SR 11302 is an inhibitor of activator protein-1 (AP-1).</p>
    Formula:C26H32O2
    Purity:98.65%
    Color and Shape:Solid
    Molecular weight:376.53

    Ref: TM-T23384