HIV Protease
HIV Protease inhibitors are a class of antiretroviral drugs that specifically target the protease enzyme of the Human Immunodeficiency Virus (HIV). By inhibiting this enzyme, these compounds prevent the virus from processing its polyproteins into mature, functional proteins, thereby blocking the production of new infectious virions. HIV Protease inhibitors are a cornerstone of highly active antiretroviral therapy (HAART) used to manage HIV/AIDS. At CymitQuimica, we provide a variety of HIV Protease inhibitors to support your research in HIV treatment, drug resistance, and virology.
Found 476 products for "HIV Protease".
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BMS-818251
CAS:BMS-818251 is a potent small-molecule inhibitor that targets HIV-1 entry, with an EC50 value of 0.019 nM. It exhibits over 10 times greater efficacy on the cross-subtype panels of the 208-HIV-1 strain compared to BMS-626529. BMS-818251 enhances potency through interactions with gp120 residues in the conserved β20-β21 hairpin.Formula:C29H26N6O5SColor and Shape:SolidMolecular weight:570.619HIV-1 inhibitor-44
HIV-1 inhibitor-44 (compound 11l) is an HIV-1 reverse transcriptase inhibitor that exhibits activity against wild-type HIV-1 strains (EC50: 0.209 μM).Formula:C23H26N2O4SColor and Shape:SolidMolecular weight:426.53DPC 684
CAS:DPC 684 is a potent and selective HIV-1 protease inhibitor with an IC90 of 5.7-40 nM and a Ki of 0.021 nM. It competitively inhibits HIV-1 protease, preventing viral polyprotein cleavage. Compared to cellular proteases, DPC 684 shows high selectivity for retroviral proteases. The compound exhibits low protein binding and offers broad-spectrum inhibition against various wild-type and mutant HIV-1 proteases, with an IC90 of 1.9-6.3 nM. DPC 684 is significant for HIV research.Formula:C35H48FN5O5SColor and Shape:SolidMolecular weight:669.85GS-9822
CAS:GS-9822 is a new LEDGIN inhibitor targeting LEDGF/p75 to alter HIV integration, showing a block-and-lock effect in cells.Formula:C36H39ClN4O4SColor and Shape:SolidMolecular weight:659.24HIV-1 protease-IN-15
CAS:HIV-1protease-IN-15 (Compound 27) is an orally active selective inhibitor of HIV-1 protease (HIV-1protease) with a pIC50 of 9.347. It inhibits the maturation of HIV proteins, effectively blocking viral replication. HIV-1protease-IN-15 shows potential for research into HIV-1 infection.Formula:C27H36F3N3O4SColor and Shape:SolidMolecular weight:555.65Telinavir
CAS:Telinavir (SC-52151) is a potent and selective inhibitor of HIV protease. It effectively inhibits both HIV-1 and HIV-2, as well as lymphotropic, monocytotropic strains, and wild isolates of simian immunodeficiency viruses, with an EC50 of 26 ng/mL (43 nM). Telinavir shows high protein binding in human plasma and a low distribution rate in red blood cells.Formula:C33H44N6O5Color and Shape:SolidMolecular weight:604.74HIV-1 inhibitor-61
CAS:HIV-1 Inhibitor-61 (2c) serves as a potent inhibitor of HIV-1 reverse transcriptase, exhibiting an EC50 value of 0.07 nM in NL4-3 wt MT-4 cells [1].Formula:C24H24F2N2O2SColor and Shape:SolidMolecular weight:442.52HIV-1 inhibitor-14
HIV-1 inhibitor-14: potent, broad HIV-1 RT inhibitor. IC50=0.14μM. Effective against wild-type and resistant strains, EC50=5.79-28.3nM.Formula:C29H32N6O4SColor and Shape:SolidMolecular weight:560.67ZLM-66
ZLM-66: Doravirine analog, HIV-1 NNRTI inhibitor, IC50: 41nM, EC50: HIV-1 13nM, cIAP1 0.32nM; useful in AIDS research.Color and Shape:SolidLamivudine, (+/-)-trans-
CAS:Lamivudine, a drug for HIV-1 and HBV, inhibits reverse transcriptase and resembles zalcitabine.Formula:C8H11N3O3SPurity:98%Color and Shape:SolidMolecular weight:229.26NNRT-IN-2
CAS:NNRT-IN-2 (compound 7w) is an orally administered non-nucleoside reverse transcriptase inhibitor (NNRTI) that effectively suppresses both wild-type HIV-1 and various mutant strains. It inhibits HIV-1 reverse transcriptase with an EC 50 value of 22 nM. Additionally, NNRT-IN-2 exhibits insensitivity to CYP and hERG, demonstrating favorable safety and pharmacokinetic profiles [1].Formula:C19H14F3N5O3Color and Shape:SolidMolecular weight:417.34HIV-1 inhibitor-18
HIV-1 inhibitor-18 blocks HIV-1 capsid, effective on NL4-3 strain (EC50: 5.14 μM), slightly toxic (MT-4CC50>9.51).Formula:C27H31N3O6SColor and Shape:SolidMolecular weight:525.62HIV-1 inhibitor-41
HIV-1 inhibitor-41 (B23): Oral non-nucleoside reverse transcriptase blocker, EC50 of 50 nM (E138K), 20.8 nM (WT), low hERG/CYP impact, non-toxic.Formula:C16H15F2N3OSColor and Shape:SolidMolecular weight:335.37GSK3739936
CAS:GSK3739936 inhibits HIV-1 integrase (IC50: 11.1 nM, EC50: 1.7 nM), weak on CYP (IC50 >24.3 μM), rapid absorption, moderate clearance, high oral availability.Formula:C34H43FN2O4Color and Shape:SolidMolecular weight:562.71HIV-IN-3
HIV-IN-3 (Compound 22a) is a potent inhibitor of HIV (IC50: 1.5 μM). HIV-IN-3 has potential for the study of HIV-related diseases.Formula:C21H32ClN7O3Color and Shape:SolidMolecular weight:465.98HIV-1 inhibitor-82
CAS:HIV-1inhibitor-82 (Compound L14) is a small molecule inhibitor of HIV-1 entry with oral bioavailability, exhibiting an IC50 value of 0.39 μM. It holds potential for research in combating HIV-1 infection.Formula:C37H37ClN2O6S2Color and Shape:SolidMolecular weight:705.28HIV-1 protease-IN-6
HIV-1 protease-IN-6 (17d) strongly inhibits HIV-1 protease (IC50: 21 pM, Ki: 4.7 pM) and effectively targets DRV-resistant mutants.Formula:C27H31FN2O6SColor and Shape:SolidMolecular weight:530.61HIV-1 inhibitor-13
HIV-1 inhibitor-13: oral NNRTI, IC50=0.14μM for HIV-1 RT, effective on resistant strains (EC50=2.85-18nM).Formula:C30H32N6O3Color and Shape:SolidMolecular weight:524.61HIV-1 inhibitor-8
HIV-1 inhibitor-8: potent oral NNRTI, low toxicity, IC50: 0.081 μM, effective on multiple strains, EC50: 4.44-54.5 nM.Formula:C25H21N5OSColor and Shape:SolidMolecular weight:439.53HIV-1 inhibitor-17
HIV-1 inhibitor-18 blocks HIV-1 capsid, acts on NL4-3 strain (EC50: 2.57 μM), has low cytotoxicity (MT-4 CC50: >8.55).Formula:C32H32N4O5SColor and Shape:SolidMolecular weight:584.69ATPase-IN-6
CAS:ATPase-IN-6 is an inhibitor of H+/K+-ATPase (ATPase) and a derivative of imidazopyridine. It exhibits significant antiviral activity against various viruses, such as HIV-1 and SARS-CoV-2. ATPase-IN-6 is applicable in antiviral infection research.Formula:C29H25N3O4SColor and Shape:SolidMolecular weight:511.59BI 224436
CAS:BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.Formula:C27H26N2O4Color and Shape:SolidMolecular weight:442.51Emtricitabine triphosphate
CAS:Emtricitabine triphosphate is an active metabolite of Emtricitabine, a drug for HIV/HBV that inhibits reverse transcriptase.Formula:C8H13FN3O12P3SColor and Shape:SolidMolecular weight:487.19HIV-1 inhibitor-52
CAS:HIV-1 inhibitor-52: potent, broad-spectrum with EC50s 1.6-6.4 nM against various HIV-1 strains.Formula:C46H72FNO5SColor and Shape:SolidMolecular weight:770.13L 702007
CAS:L 702007 is an inhibitor of HIV-1 reverse transcriptase.Formula:C18H25N3O2Purity:98%Color and Shape:SolidMolecular weight:315.41ML67-33
CAS:ML67-33 selectively activates K2P channels; EC50: 36.3 μM (cell-free), 9.7 μM (HEK293). Reversible TREK-1 modulation.Formula:C18H17Cl2N5Purity:98%Color and Shape:SolidMolecular weight:374.27
