HIV Protease
HIV Protease inhibitors are a class of antiretroviral drugs that specifically target the protease enzyme of the Human Immunodeficiency Virus (HIV). By inhibiting this enzyme, these compounds prevent the virus from processing its polyproteins into mature, functional proteins, thereby blocking the production of new infectious virions. HIV Protease inhibitors are a cornerstone of highly active antiretroviral therapy (HAART) used to manage HIV/AIDS. At CymitQuimica, we provide a variety of HIV Protease inhibitors to support your research in HIV treatment, drug resistance, and virology.
Found 505 products of "HIV Protease"
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Salvianan A
CAS:1,6,11-Trimethyl-1,2-dihydrofuro[2',3':1,2]phenanthro[4,3-d]oxazole (compound 1) serves as an effective anti-HIV-1 agent [1].Formula:C20H17NO2Color and Shape:SolidMolecular weight:303.35NNRT-IN-6
NNRT-IN-6 (Compound 13a) is a non-nucleoside reverse transcriptase inhibitor (NNRT) used to inhibit HIV-1 reverse transcriptase (HIV-1RT), with an IC50 of 0.41 μM. It effectively suppresses both wild-type HIV-1 and mutants L100I, K103N, Y181C, Y188L, E138K, F227L/V106A, and RES056, with an EC50 range of 6.2-250 nM.Formula:C32H31N9O3SColor and Shape:SolidMolecular weight:621.71HIV-1 inhibitor-78
HIV-1inhibitor-78 (compound 15f) is a potent and broad-spectrum non-nucleoside reverse transcriptase inhibitor, with an EC50 value of 3 nM against wild-type HIV-1. It is useful for research on HIV infections.Formula:C32H34N6O4SColor and Shape:SolidMolecular weight:598.72HIV protease-IN-1
CAS:HIV protease-IN-1 (compound 1·succinate), a potent non-peptidic inhibitor of HIV protease, is utilized for AIDS research [1].Formula:C39H40ClF7N10O7Color and Shape:SolidMolecular weight:929.24HIV-IN-2
CAS:HIV-IN-2 (Compound 100) is a potent inhibitor of HIV, showing potential for research into HIV infection [1].Formula:C34H27ClF7N9O3SColor and Shape:SolidMolecular weight:810.14HIV gp120 (318-327)
CAS:HIVgp120 (318-327) is a short sequence (rgpgrafvti) from the envelope peptide of the HIV-1 IIIB strain, corresponding to the conserved C-terminal region of the glycoprotein. It is part of the HIV vaccine V3 peptide epitope, also known as the I10 peptide. However, HIVgp120 (318-327) lacks the A2 anchor residues needed for epitope-specific CTL recognition but possesses structural features that allow mixed A2 binding.Formula:C48H80N16O12Color and Shape:SolidMolecular weight:1073.25Pol (476-484), HIV-1 RT Epitope
CAS:Pol (476-484), HIV-1 RT Epitope is a biologically active peptide and represents the dominant HLA A*0201-restricted epitope within HIV-1 reverse transcriptase (Formula:C46H78N12O12Color and Shape:SolidMolecular weight:991.182-Bromoaldisine
CAS:2-Bromoaldisine, a pyrrole alkaloid isolated from Stylissa carter, is known to inhibit HIV-1 infection and suppress the Raf/MEK/MAPK pathway.Formula:C8H7BrN2O2Color and Shape:SolidMolecular weight:243.06NNRT-IN-9
NNRT-IN-9 (Compound EG28) is a non-nucleoside reverse transcriptase inhibitor (NNRT). It demonstrates strong antiviral and resistance-fighting activity against wild-type (WT) and various clinically relevant mutant strains (E138K and K103N + Y181C) of HIV-1, with EC50 values of 55 nM, 67 nM, and 3910 nM, respectively. NNRT-IN-9 is applicable in acquired immunodeficiency syndrome (AIDS) research.Color and Shape:Odour Solid[(Cys(Bzl)84,Glu(OBzl)85)]CD4 (81-92)
CAS:[(Cys(Bzl)84, Glu(OBzl)85)]CD4 (81-92) is a selective HIV-1 inhibitor that blocks the interaction between HIV-1 and CD4 molecules, thereby inhibiting viral infection and cell fusion. At a concentration of 25 μM, it can completely prevent fusion formation [1].Formula:C76H108N14O26SColor and Shape:SolidMolecular weight:1665.81Epicoccone B
CAS:Epicoccone B from C. globosum has DPPH scavenging (IC50=10.8μM) and α-glucosidase inhibition (IC50=27.3μM), also anti-HIV.Formula:C9H8O5Color and Shape:SolidMolecular weight:196.16QYL-685
CAS:QYL-685 is a methylenecyclopropane nucleoside analog.Formula:C20H24N7O5PColor and Shape:SolidMolecular weight:473.42Lenacapavir sodium
CAS:Lenacapavir, also known as GS-6207, is an HIV-1 capsid inhibitor. It demonstrates an average EC50 of 50 pM (ranging from 20-160 pM) against 23 clinical isolates of HIV-1 from diverse subtypes, with tests performed in peripheral blood mononuclear cells (PBMCs). In vitro, Lenacapavir exhibits picomolar potency and shows no cross-resistance with existing antiretroviral compounds. Furthermore, Lenacapavir displays significant antiviral activity in individuals with HIV-1, regardless of prior treatment history, with no pre-existing resistance detected.Formula:C39H31ClF10N7NaO5S2Color and Shape:SolidMolecular weight:990.26Capsid assembly inhibitor
CAS:Capsid assembly inhibitor is a 12-mer peptide that binds to the Gag capsid (CA) domain, effectively inhibiting the assembly of both immature and mature-like HIV-1 capsid particles in vitro.Formula:C69H96N12O22Color and Shape:SolidMolecular weight:1445.57HIV-1 inhibitor-80
HIV-1inhibitor-80 (compound M44) is an HIV-1 inhibitor with an EC50 of 5-148 nM. It demonstrates excellent metabolic stability and low cytotoxicity in human plasma and liver microsomes.Formula:C26H19N7OColor and Shape:SolidMolecular weight:445.475HIV-1 protease-IN-14
HIV-1protease-IN-14 (compound 5ae) is an effective inhibitor of HIV-1protease, exhibiting Ki values of 0.28 nM and 56.9 nM against WTHIV-1PR and R41THIV-1PR, respectively. This compound also demonstrates low cytotoxicity.Color and Shape:Odour SolidAI 3-16787
CAS:AI 3-16787 is an HIV-1 integrase inhibitor exhibiting inhibitory activity against strand transfer in the presence of Mn²⁺.Formula:C21H24O4Purity:99.01%Color and Shape:SolidMolecular weight:340.41NF279
CAS:P2X1 antagonistFormula:C49H36N6Na6O23S6Purity:98%Color and Shape:SolidMolecular weight:1407.17VIR-165
VIR-165, a derivative of VIRIP (353-372 of alpha1-antitrypsin), blocks several HIV-1 strains.Formula:C109H158N22O25S2Purity:98%Color and Shape:SolidMolecular weight:2240.7CI-39
CAS:CI-39, an NNRTI with EC50 of 3.40 µM, inhibits HIV-1 reverse transcriptase and RNase H, with CC50 >30 µM.Formula:C19H18N2O4Color and Shape:SolidMolecular weight:338.36Tenofovir-C3-O-C12-trimethylsilylacetylene ammonium
CAS:Tenofovir-C3-O-C12 has a longer half-life, potent anti-HIV effects, and better pharmacokinetics than tenofovir.Formula:C29H55N6O5PSiColor and Shape:SolidMolecular weight:626.855Peptide T
CAS:Peptide T, an HIV-1 derived octapeptide, may inhibit gp120 binding to CD4 and cytokines, and affect VIP receptors.Formula:C35H55N9O16Purity:98%Color and Shape:SolidMolecular weight:857.86BNM-III-170
CAS:BNM-III-170 is able to inhibit HIV-1 viral entry into target cells.Formula:C25H26ClF7N6O6Color and Shape:SolidMolecular weight:674.96MPG, HIV related
CAS:MPG: 27-amino acid peptide from HIV-1 gp41 & SV40 T antigen, delivers nucleic acids into cells efficiently.Formula:C126H201N35O33SPurity:98%Color and Shape:SolidMolecular weight:2766.22(2S,5S)-Censavudine
(2S,5S)-Censavudine, a potent HIV inhibitor and nucleoside reverse transcriptase blocker.Formula:C12H12N2O4Color and Shape:SolidMolecular weight:248.23Globotriaosylceramides (porcine)
CAS:Globotriaosylceramides, cell membrane glycosphingolipids, act as Shiga toxin receptors and accumulate in Fabry disease, resisting HIV by blocking gp120.Formula:C60H113NO18Color and Shape:SolidMolecular weight:1136.553KRH-3955 Salt
CAS:KRH-3955, a CXCR4 antagonist, is an orally bioavailable and extremely potent inhibitor of HIV-1 infection.Formula:C40H63N7O18Purity:98%Color and Shape:SolidMolecular weight:929.96BMS-955176 TFA
CAS:GSK3532795: Oral HIV-1 maturation inhibitor, broad virus coverage, EC50: 15 nM, good preclinical pharmacokinetics.Formula:C44H64N2O8SPurity:98%Color and Shape:SolidMolecular weight:781.06Elvucitabine
CAS:Elvucitabine, a reverse transcriptase inhibitor, is used potentially for the treatment of HBV infection and HIV infection.Formula:C9H10FN3O3Color and Shape:SolidMolecular weight:227.19AL-470
CAS:AL-470 demonstrates significant antiviral efficacy, exhibiting EC50 values of 0.27 µM against HIV-1, 0.63 µM against HIV-2, and 0.35 µM against EV-A71, asFormula:C67H57N7O23Color and Shape:SolidMolecular weight:1328.2Hypoglaunine D
CAS:Hypoglaunine D, an anti-HIV analogue of Triptonine B, inhibits HIV in H9 cells with an EC50 of 22 μg/ml.Formula:C41H47NO19Color and Shape:SolidMolecular weight:857.81L 754394
CAS:L 754394 is an effective and specific inhibitor of the HIV-1 protease.Formula:C38H47N5O5Color and Shape:SolidMolecular weight:653.81(-)-Rabdosiin
CAS:(-)-Rabdosiin, identified as a novel phenolic marker in Symphytum officinale L., exhibits antioxidant, neuroprotective, and anti-HIV activities [1].Formula:C36H30O16Color and Shape:SolidMolecular weight:718.61HIV-1 protease-IN-10
HIV-1 protease-IN-10 (Compound 2), exhibiting HIV-1 latency reversing activity (IC50: 0.22 μM), selectively binds to the PKCδ C1b domain (IC50: 0.69 μM) andFormula:C23H40O5Purity:98%Color and Shape:SolidMolecular weight:396.56Aureothin
CAS:Aureothin: a nitroaryl polyketide with antitumor, antifungal & insecticidal properties; inhibits NADH:oxidoreductase (IC50s: 0.07-22 nmol/mg).Formula:C22H23NO6Color and Shape:SolidMolecular weight:397.42HIV-IN-9
HIV-IN-9 (Compound 2b) is an HIV inhibitor with an IC50 value of 6.65 μg/mL, demonstrating high binding affinity for HIV-RT.Color and Shape:Odour SolidSchineolignin B
Schineolignin B is a useful organic compound for research related to life sciences and the catalog number is T126011.Formula:C22H30O5Color and Shape:SolidMolecular weight:374.477Enfuvirtide
CAS:Enfuvirtide is an anti-HIV-1 fusion peptide that inhibits HIV p24 antigen and Gag gene expression in macrophages.Formula:C204H301N51O64Purity:98%Color and Shape:White To Off-White Amorphous SolidMolecular weight:4491.95PNU-142721
CAS:PNU-142721, reverse transcriptase inhibitor, is used to treat human immunodeficiency virus (HIV) infection.Formula:C13H11ClN4OSColor and Shape:SolidMolecular weight:306.77TAT peptide
TAT peptide, a CPP, delivers molecules into cells by traversing membrane barriers using aa49-57 of TAT protein.Formula:C65H124N34O15Purity:98%Color and Shape:SolidMolecular weight:1621.91Lopinavir Metabolite M-1
CAS:Lopinavir Metabolite M-1, derived from Lopinavir, inhibits HIV protease (Ki=0.7 pM) and shows antiviral activity in vitro.Formula:C37H46N4O6Color and Shape:SolidMolecular weight:642.78GLR-19
CAS:GLR-19 is an anti-HIV peptide with demonstrated antiviral activity against HSV-2 [1] [2].Formula:C102H194N40O20Purity:98%Color and Shape:SolidMolecular weight:2300.89Peritassine A
CAS:Peritassine A, an alkaloid derived from Tripterygium wilfordii Hook. f., exhibits anti-HIV properties.Formula:C38H47NO18Color and Shape:SolidMolecular weight:805.783KRL74
CAS:KRL74 is a cyclic peptide inhibitor that interferes with the interaction between the p6 domain of the HIV Gag protein and the UEV domain of the human TSG101 protein (p6/UEV), with an IC50 of 5.44 μM and a Kd of 11.9 μM. It also inhibits the budding of HIV from host cells, exhibiting an IC50 of 2 μM in virus-like particle (VLP) budding assays.Formula:C50H61ClN10O9Color and Shape:SolidMolecular weight:981.53ICeD-2
ICeD-2 triggers death in HIV-1 infected cells, requires HIV protease, inhibits DPP8/9, and stabilizes DPP9 in PBMCs.Formula:C20H29N3OColor and Shape:SolidMolecular weight:327.46Carbovir triphosphate
CAS:Carbovir triphosphate (CBV-TP), a phosphorylated metabolite, serves as a research tool for studying human immunodeficiency virus (HIV) [1].Formula:C11H16N5O11P3Color and Shape:SolidMolecular weight:487.19Morin 3-O-β-D-glucopyranoside
CAS:Morin 3-O-β-D-glucopyranoside, a natural flavonoid, exhibits antifungal, anticancer, and antioxidant properties.Formula:C21H20O12Color and Shape:SolidMolecular weight:464.38HIV-1 inhibitor-12
HIV-1 inhibitor-12: potent at inhibiting HIV-1 capsid protein polymerization with 9 nM IC50.Formula:C42H36ClF10N7O5S2Color and Shape:SolidMolecular weight:1008.35Tenofovir-C3-O-C15-CF3 ammonium
CAS:Tenofovir-C3-O-C15-CF3 (ammonium) has a longer half-life and stronger anti-HIV action, improving pharmacokinetics in vivo.Formula:C28H52F3N6O5PColor and Shape:SolidMolecular weight:640.73
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