Antibacterial

Antitubercular Agent-38, a derivative of Benzothiazinones (BTZs), demonstrates potent antituberculosis activity while maintaining low cardiac toxicity and

JSF-4898 is an orally bioactive inhibitor of Mycobacterium tuberculosis MenG enzyme. It exhibits a minimum inhibitory concentration (MIC) of 0.78 μM against Mycobacterium tuberculosis H37Rv. Additionally, JSF-4898 enhances the efficacy of rifampicin in a subacute infection model of Mycobacterium tuberculosis in mice.

Arginomycin is a nucleoside antibiotic (antibiotic) that inhibits the growth of Gram-positive bacteria and fungi in vitro.

Plantaricin A, an antimicrobial peptide extracted from Lactobacillus plantarum, exhibits efficacy against bacteria [1].

Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.

DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates

Ecteinascidin-Analog-1, a tetrahydroisoquinoline, is key for synthesizing ecteinascidin analogs with antitumor and antimicrobial properties.

Collinin, a coumarin in Z. schinifolium, combats M. tuberculosis and inhibits NO production, platelet aggregation, and tumor growth in mice.

Antibacterial Agent 156 (Compound 57), a bactericidal that selectively targets C.

CJ-21,058 is an effective SecA inhibitor with an IC50 of 15 µg/mL. It inhibits the ATP-dependent translocation of precursor proteins across bacterial cell membranes. Additionally, CJ-21,058 exhibits antibacterial activity against Gram-positive bacteria.

Cafamycin is a bioactive chemical.

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.

'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).

Pyrindamycin B is an antibiotic,and actives against gram-positive and gram-negative bacterias

KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2, with an IC50 value of 8.3 nM. KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems, leading to significant bacterial resistance to carbapenem antibiotics.

Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].

Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.

Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.

Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial

Psoracorylifol C is a useful organic compound for research related to life sciences and the catalog number is T124015.

Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.

Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.

JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.

Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.

Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.

Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.

Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].

Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.

β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.

Dicresulene diammonium is an impurity found in Policresulen, which is an organic acid possessing hemostatic, antimicrobial, and antiviral properties[1][2].

Atrovenetin is an antibiotic found in Penicillium species (antibiotic). It exhibits inhibitory activity against Bacillus subtilis and Staphylococcus aureus. Atrovenetin is also a potent antioxidant.

Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.

LF11 displays antimicrobial activity.

Wychimicin C, a spirotetronate polyketide, combats MRSA and Enterococcus (IC50: 0.125-0.5 µg/mL), from Actinocrispum MI503-AF4.

Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1].

Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25

Kapurimycin A3 is an antitumor antibiotics.

Himastatin, an antitumor antibiotic from S. hygroscopicus, is a dimeric cyclohexadepsipeptide with piperazic acid and a unique aromatic core.

Dalbavancin HCl (MDL-63397 HCl), a semi-synthetic antibiotic, targets Gram-positive bacteria with low MICs for S. aureus and B. anthracis.

Lugdunin is an antibiotic peptide that disrupts membrane potential in bacteria, demonstrating activity against Gram-positive species including S.

3′-Omethyl-5′-hydroxydiplacone (compound 2), a C-6-geranylflavonoid isolated from the ethanol extract of Paulownia tomentosa fruits, exhibits antibacterial

SPR741, a cationic peptide from polymyxin B, is being developed to treat serious Gram-negative infections.

2-Phenoxyphenol has antibacterial against Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, Burkholderia pseudomallei, etc.

Loloatin B 10 is a bioactive chemical.

JH-LPH-28, a sulfonyl piperazine, inhibits LpxH with strong antibiotic activity, MIC of 0.83 μg/mL.

BAL30072: Antibiotic effective against MDR Acinetobacter (4 μg/mL) and P. aeruginosa (8 μg/mL); a monocyclic beta-lactam.

Anti gram-positive/negative bacteria agent 1 is an antibiotic linked with a synthetic MECAM-based siderophore, serving as a conjugate aimed at combating gram-

Trimethoprim hydrochloride: oral, broad-spectrum antibiotic, DHFR inhibitor, treats UTIs, shigellosis, pneumocystis pneumonia, may block Influenza A with zinc.

NR-NO2 is a prospective therapeutic agent with targeted delivery and image-guided capability for use in antitumor studies, also demonstrating antibacterial

Dienone B is a cytotoxic secondary metabolite from tyrosine as isolated from the sponges Verongia aerophoba & Aplysina aerophoba.

Deethylindanomycin, a polyether antibiotic from S. setonii, combats Gram-positive bacteria and in vitro coccidia; ionophore selective for K+ ions.

Tomopenem is a penem antibiotic.

Antibacterial agent 60 is a potent compound that effectively reduces the minimum inhibitory concentration (MIC) of Ceftazidime, an antibacterial agent.

Setomimycin is an antibiotic against Gram positive bacteria, including mycobacteria.

Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.

Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing

Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria.

N-Hydroxypipecolic acid potassium is a metabolite of plant and a systemic acquired resistance (SAR) regulator.

Altromycin E is a new pluramycin-like antibiotic.

Kapurimycin A1 is an antitumor antibiotic produced by Streptomyces.

Compound 1h (Antibacterial agent 108) is a potent antibacterial agent, demonstrating a minimum inhibitory concentration (MIC) of 3 μM against both MRSA and

Cloxacillin Sodium: chlorinated Oxacillin derivative, semi-synthetic, treats beta-lactamase staph infections.

Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.

Maximin H1, an antimicrobial peptide sourced from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits efficacy against several

NXL-101, an oral/IV antibiotic for Gram-positive bacteria like MRSA, was discontinued by Novexel in 2008.

Ilicicolin F is a useful organic compound for research related to life sciences. The catalog number is T125283 and the CAS number is 22738-98-3.

Dihydrotetrodecamycin, a fungal metabolite extracted from S. nashvillensis, exhibits antibacterial properties. It demonstrates activity against the fish-pathogenic bacterium P. piscicida.

TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial

2-Benzylaniline is a potential Cytochrome P450 2B6 inhibitor with an IC50 value of 4.36 μM.

AA45 boosts Ceftazidime's efficacy by lowering its MIC value, showcasing strong antibacterial properties.

Altromycin F is a new pluramycin-like antibiotic.

Almurtide: Muramyl dipeptide derivative with anti-inflammatory, anti-tumor properties, protects mice from Pseudomonas and Candida infections.

Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.

ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.

Actinoidin A is a glycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.

Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.

Pacidamycin I is an antimicrobial nucleoside antibiotics. Pacidamycin I inhibits translocase I, a key enzyme in peptidoglycan assembly.

Efrotomycin: an oral antibiotic from Streptomyces Lactamdurans; minimal effect on Salmonella in pigs.

Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.

Apigravin, a potent antibacterial compound, demonstrates activity against Bacillus subtilis, exhibiting a minimum inhibitory concentration (MIC) value of 61 μM

Umirolimus, a sirolimus derivative, boosts anti-inflammatory/antiproliferative effects & offers better pharmacokinetics.

cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.

Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-

Aurein 2.4, an antibiotic antimicrobial peptide, exhibits activity against Gram-positive bacteria [1] [2].

XT-2 peptide, an antimicrobial agent sourced from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.

Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.

NOSO-502: Bacterial translation inhibitor, active against Enterobacteriaceae, safe and effective antibacterial.

Mycothiol detoxifies, links foreign compounds, and acts as microbes' glutathione.

Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.

Choline Iodide has antibacterial activity against Leishmania panamensis and inhibitor of Acetylcholinesterase, degenerative neurological diseases.

AA58 enhances Ceftazidime efficacy by lowering its MIC.

Glicophenone, an antibacterial agent, demonstrates minimum inhibitory concentrations (MICs) of 32 μg/mL against multiple strains, including MRSA OM481, MRSA

Adenoregulin (Dermaseptin b2), an antimicrobial peptide antibiotic, exhibits efficacy against both Gram-negative and Gram-positive bacteria, as well as yeast

DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.