Antibacterial

<p>FASN-IN-6 (compound 44), a potent fatty acid biosynthesis (FAB) inhibitor, serves as an antibacterial agent, exhibiting minimum inhibitory concentrations (MICs</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>

<p>RvD4, derived from docosahexaenoic acid, reduces neutrophil infiltration and promotes phagocytosis/clearance by human cells.</p>

<p>BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs; IC50s: 108 nM and 427 nM for B.</p>

<p>C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.</p>

<p>MMV1578877 is an inhibitor of Mycobacterium ulcerans with an IC50 of 0.37 μM. It is applicable in research related to Buruli ulcer (BU).</p>

<p>dmDNA31: a rifamycin antibiotic, inhibits bacterial RNA polymerase, strongly kills Staphylococcus aureus.</p>

<p>Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>Psoracorylifol B is a natural product that can be used as a reference standard.</p>

<p>Halocyamine B, isolated from Halocynthia roretzi, is an antibiotic peptide.</p>

<p>JH-LPH-28, a sulfonyl piperazine, inhibits LpxH with strong antibiotic activity, MIC of 0.83 μg/mL.</p>

<p>Gramicidin B is a nonribosomal peptide with antibiotic properties [1].</p>

<p>Lankacidins is an antitumor antibiotic of the macrolide tetraenes family from Streptomyces.</p>

<p>Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Lacto-N-fucopentaose I is a milk oligosaccharide.</p>

<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>

<p>Amicetin, a potent antibiotic, is effective against gram-positive bacteria by inhibiting protein synthesis [1] [2] [3].</p>

<p>Massarigenin C from M. flavorosea inhibits neuraminidase (IC50=4.15μM) and α-glucosidase (IC50=1.25mM), reduces blood glucose in mice.</p>

<p>Pyrrole (1H-pyrrole) is a fungicides.</p>

<p>Ceftaroline: a cephalosporin antibiotic effective against MRSA, drug-resistant S. pneumoniae, and Gram-negatives; used for cSSSIs and CABP research.</p>

<p>Pseudomonic acid D is a topical antibiotic agent used against superficial skin infections such as impetigo or folliculitis.</p>

<p>Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.</p>

<p>Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.</p>

<p>NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.</p>

<p>Pyrrolnitrin: broad-spectrum antibiotic from Pseudomonas pyrrocinia; effective against fungi, yeast, and gram-positive bacteria.</p>

<p>Viomycin sulfate hydrate is an effective antimycobacterial antibiotic (antibiotic). It rapidly inhibits the elongation of polypeptide chains when added to purified endogenous polypeptide-synthesizing Escherichia coli polypeptide systems.</p>

<p>Dehydrolycopene, a major SGA in tomatoes' green fruits, leaves, and flowers, targets bacteria, fungi, insects, and animals.</p>

<p>Cefsulodin, a β-lactam antibiotic, targets E. coli's penicillin-binding proteins, aiding with cell wall synthesis disruption.</p>

<p>XT-4, an antimicrobial peptide originating from the skin secretions of Xenopus tropicalis, exhibits potent activity against E.</p>

<p>ACH-702 is an agent of anti-tubercular. ACH-702 is an effective, bactericidal compound with activity against many antibiotic-resistant pathogens.</p>

<p>broad spectrum antibiotic</p>

<p>Brilliant green: dye for silk/wool, inhibits mold, parasites, fungus, and kills Gram-positive bacteria.</p>

<p>Kirromycin, an antibiotic from Streptomyces, blocks protein synthesis and stunts B. brevis growth by hindering elongation factor Tu in E. coli.</p>

<p>Antibacterial agent 39 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.</p>

<p>DNA Gyrase-IN-9 (compound 4j), an antibacterial agent, selectively targets DNA gyrase.</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).</p>

<p>Aurein 2.5, an antimicrobial peptide with antibiotic properties, exhibits both antibacterial and antifungal activities [1] [2].</p>

<p>Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.</p>

<p>Candicidin, a heptaene macrolide from S. griseus or A. levoris, treats candidiasis topically. Mainly candicidin D.</p>

<p>Antibacterial Agent 33 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Sitafloxacin: potent broad-spectrum oral fluoroquinolone effective against resistant strains.</p>

<p>Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.</p>

<p>Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.</p>

<p>Cafamycin is a bioactive chemical.</p>

<p>Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.</p>

<p>Streptolydigin inhibits RNA synthesis by binding to RNA polymerase and does not inhibit eukaryotic RNA polymerases.</p>

<p>1-Ethylnaphthalene exhibits antibacterial activity and can be used in biochemical experiments and drug synthesis.</p>

<p>P-113 is a peptide with antimicrobial activity.</p>

<p>Oxiran-2-ylmethanol exhibits antibacterial activity against Escherichia coli and can be used in related research in the field of life sciences.</p>

<p>Avibactam Tetrabutylammonium is a non-β-lactam β-lactamase inhibitor that inhibits TEM-1, P99, and KPC-2 β-lactamases covalent and reversible.</p>

<p>Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting</p>

<p>LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37.</p>

<p>Aerocavin is an antibiotic (antibiotic) that exhibits activity against both Gram-positive and Gram-negative bacteria in vitro [in vitro].</p>

<p>Myristoyl glutamic acid sodium, a surfactant in amino acid cleansers, has mild antibacterial properties and cleanses the skin surface of excess oil and dirt.</p>

<p>Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial</p>

<p>Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.</p>

<p>Cephabacin M4 is a new cephem antibiotic isolated from bacterial.</p>

<p>LL-37, Human TFA (154947-66-7 free base) is a 37-residue amphipathic helical peptide, the sole human cathelicidin antimicrobial peptide, antibacterial.</p>

<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>

<p>Benzylpenicillin, a penicillin derivative, treats infections using sodium or potassium salts. Effective against gram-positive bacteria and gram-negative cocci.</p>

<p>Altromycin D is a new pluramycin-like antibiotic.</p>

<p>Dodicin hydrochloride, an effective disinfectant, demonstrates broad antimicrobial activity [1].</p>

<p>SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.</p>

<p>"Benanomicin A, from Actinomycetes, is antifungal and antiviral, effective against pathogens like C. albicans and HIV-1 (MICs 3.13-50 μg/ml)."</p>

<p>Vinclozolin (Ornalin) is a fungicide with anti-androgenic activity, commonly used in agriculture.</p>

<p>Bafilomycin B1, a Streptomyces-derived macrolide, inhibits E. coli ATPase and fights Gram-positive bacteria and fungi.</p>

<p>Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.</p>

<p>Polymyxin B2 is an antibiotic primarily utilized for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.</p>

<p>Galloyl-bis-HHDP glucose (HeT), an ellagitannin, exhibits phytoprotective effects against Pseudomonas viridiflava [1].</p>

<p>Linopristin is a streptogramin B class antibiotic. It is one of the components of the antibiotic combination NXL103.</p>

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>Latamoxef is an oxacephem antibiotic and is a member of the cephalosporins.</p>

<p>Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.</p>

<p>3-Aminoisonicotinohydrazide exhibits inhibitory activity against Mycobacterium tuberculosis</p>

<p>Minocycline is a useful organic compound for research related to life sciences. The catalog number is T131626 and the CAS number is 10118-90-8.</p>

<p>Alliacol B is an antibiotic with mild antibacterial and antifungal properties. It can inhibit DNA synthesis in Ehrlich ascites carcinoma cells.</p>

<p>Fosfomycin is an antibiotic that is produced by Streptomyces fradiae.</p>

<p>Antibiotic tan-592B is an antibiotic agent.</p>

<p>Poly(hexamethylenebiguanide) hydrochloride (PHMB HCl) is an antibacterial agent and cationic disinfectant against Gram-negative and Gram-positive bacteria.</p>

<p>FPI-1523 inhibits β-lactamase (Kd: CTX-M-15 = 4 nM, OXA-48 = 34 nM), blocks PBP2 (IC50 = 3.2 μM), and has strong antimicrobial effects.</p>

<p>SDH-IN-9 (compound Ip) serves as a potent Succinate Dehydrogenase inhibitor and exhibits fungicidal properties, effectively targeting Fusarium graminearum Schw</p>

<p>N-acetyl Dapsone is an anti-inflammatory and antimicrobial compound widely used in the treatment of leprosy, malaria, acne and various immune disorders.</p>

<p>Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.</p>

<p>Piscidin-1 (22-42) (TFA) is a highly potent, multi-functional Antimicrobial Peptide (AMP) produced by Orange-spotted grouper (Epinephelus coioides).</p>

<p>Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A.</p>

<p>A-54556B: Natural ADEP antibiotic from S. hawaiiensis, combats Gram-positive and anaerobic bacteria, including penicillin-resistant S. aureus.</p>

<p>HBA(111-142), a C-terminal 32-mer fragment of alpha-hemoglobin, exhibits antibacterial activity against the ESKAPE panel of pathogens, forms amyloid fibrils,</p>

<p>Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics from several Streptomyces that directly inhibit bacterial PGTs.</p>

<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>

<p>Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-</p>

<p>Vitamin K5, a photosensitizer &amp; antimicrobial, inhibits PKM2, PKM1 &amp; PKL, induces apoptosis in colon cells, and preserves food &amp; medicine.</p>

<p>Aurein 3.2 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>