Antibacterial

<p>Metallo-β-lactamase-IN-11 (compound 5f), a potent inhibitor of Metallo-β-lactamases (MBLs), demonstrates efficacy against the bacterial metallophyllactamase</p>

<p>Pirlimycin Hydrochloride, a Clindamycin analog, is a semi-synthetic lincosaminide antibiotic.</p>

<p>β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.</p>

<p>EDA-DA is a probe for labeling bacterial cell wall Peptidoglycan, crucial for division and shape.</p>

<p>Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins.</p>

<p>Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.</p>

<p>Altromycin G is a new pluramycin-like antibiotic.</p>

<p>Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.</p>

<p>Viroxocin, a diterpenoid, is isolated from the roots of Salvia viridis L. cvar. Blue Jeans and exhibits weak antibacterial activity [1].</p>

<p>PF 5081090 has a wide range of applications in life science related research.</p>

<p>Julifloricine is an alkaloid isolated from Prosopis juliflora that has antimicrobial activity.</p>

<p>Monocerin, from F. larvarum, combats E. coli, B. megaterium, M. violaceum, C. fusca; kills C. erythrocephala; hinders S. halepense root growth.</p>

<p>Napyradiomycin A1, a fungal compound from C. rubra, has antimicrobial effects (MIC 1.56-12.5 μg/ml) and blocks estrogen receptors and mitochondrial enzymes.</p>

<p>C8-HSL modulates Yersinia pestis virulence, gene expression, metabolism, and is used in cystic fibrosis research.</p>

<p>Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.</p>

<p>8-Methylsulfinyloctyl isothiocyanate: antimicrobial, inhibits plant growth, impairs COX-2 inflammation in macrophages.</p>

<p>Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.</p>

<p>Cephalexin: potent oral antibiotic, broad-spectrum against gram-positive/negative bacteria; treats pneumonia, strep throat, endocarditis.</p>

<p>Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.</p>

<p>Voxvoganan (LTX-109) trihydrochloride, a topical antimicrobial, demonstrates a high efficacy against S.</p>

<p>Antibacterial agent 163 (compound 1), a hydroxyquinoline derivative, potently inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1].</p>

<p>Arylomycin A4 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>c-di-AMP sodium: STING agonist, activates TBK3-IRF3 pathway, boosts type I IFN/TNF, regulates bacterial growth/virulence, and stimulates immune responses.</p>

<p>Wychimicin A, from Actinocrispum wychmicini MI503-AF4, is a potent antibacterial against MRSA and Enterococcus. (IC50=0.125-0.5μg/mL).</p>

<p>Altromycin A is an anticancer agent.</p>

<p>Antibacterial agent 32 fights E. coli (NCTC 13351, M 50, 7 MP) with MICs: 1, 2, 8 mcg/mL.</p>

<p>Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.</p>

<p>Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins</p>

<p>Maximin 5, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Betonicine, an l-alpha-amino acid, is in herbs, spices, pulses, and mainly urine.</p>

<p>Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.</p>

<p>Tetrahydrorhombifoline, a quinolizidine alkaloid found in the aerial parts of Genista vuralii A.</p>

<p>T3SS-IN-3 (compound F-24) serves as an inhibitor specific to the type III secretion system (T3SS), significantly reducing the transcription of the hrpY gene</p>

<p>Dihydrotetrodecamycin, a fungal metabolite extracted from S. nashvillensis, exhibits antibacterial properties. It demonstrates activity against the fish-pathogenic bacterium P. piscicida.</p>

<p>G43 inhibits glucosyltransferase GtfB (Kd 3.7μM) and GtfC (Kd 46.9nM), and fights Streptococcus mutans in caries research.</p>

<p>A-54556B: Natural ADEP antibiotic from S. hawaiiensis, combats Gram-positive and anaerobic bacteria, including penicillin-resistant S. aureus.</p>

<p>Vineomycin A1 (OS-4742 A1) is an antibiotic effective against Gram-positive bacteria, identified in *Streptomyces matensis* subsp. vineus. It has also demonstrated antitumor activity in mice and holds potential for research in skin fibrosis.</p>

<p>Tunicamycin 15:1 is a mixture of tunicamycin structural isomers that contains a 15-carbon N-acyl chain with variable branching patterns.</p>

<p>Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.</p>

<p>MRV03-070, acting as a biosynthetic precursor akin to precolibactin [1], is a colibactin-activating peptidase ClbP inhibitor with an inhibitory concentration (</p>

<p>Cethromycin (ABT-773) is an antibiotic of ketolide.</p>

<p>Xenopsin precursor fragment, an antimicrobial peptide, exhibits both antibacterial/antifungal activity at concentrations ranging from 10 to 500 μg/mL and anti-</p>

<p>Cefluprenam is a a cephalosporin type antibacterial agent.</p>

<p>Vitamin K5, a photosensitizer &amp; antimicrobial, inhibits PKM2, PKM1 &amp; PKL, induces apoptosis in colon cells, and preserves food &amp; medicine.</p>

<p>XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.</p>

<p>Lysobactin (katanosin B) is an antibiotic effective against S. aureus, S. pneumoniae, and blocks PG biosynthesis.</p>

<p>Urechistachykinin I (Uru-TK I) is an invertebrate kalinin-related peptide (TRPs) isolated from thylakoid nematodes.</p>

<p>Aurein 5.2 is an antibiotic antimicrobial peptide [1].</p>

<p>Maximin H2, an antimicrobial peptide originating from the skin secretions of the Chinese red belly toad (Bombina maxima), exhibits inhibitory effects on a range</p>

<p>Amustaline (S-303) dihydrochloride is a nucleic acid alkylator useful for inactivating pathogens in blood with red cells.</p>

<p>Midecamycin acetate is a broad-spectrum antibiotic active against Gram-positive and some Gram-negative strains.</p>

<p>Cefozopran is a fourth-generation cephalosporin.</p>

<p>Maximin 3, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.</p>

<p>Amythiamicin C is an antimicrobial antibiotic effective against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), and also exhibits activity against Plasmodium falciparum (the causative agent of malaria).</p>

<p>ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.</p>

<p>Tylosin lactate: a vet macrolide antibiotic; broad vs. Gram-positive, limited on Gram-negative; from Streptomyces fradiae.</p>

<p>Linearmycin B, a polyene antibiotic from Streptomyces, causes B. subtilis lysis in Streptomyces Mg1 extract.</p>

<p>Cefovecin Sodium(Convenia) is an antibiotic of the cephalosporin class, licensed for the treatment of skin infections in cats and dogs.</p>

<p>Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.</p>

<p>(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).</p>

<p>Antibacterialagent 271 is an antimicrobial compound that significantly inhibits Escherichia coli, with a minimum inhibitory concentration (MIC) of 2.2 μM. It disrupts bacterial membrane integrity, reducing metabolic activity. By binding to DNA grooves, it inhibits replication and induces reactive oxygen species (ROS) accumulation, leading to bacterial death. Antibacterialagent 271 shows considerable potential in combating bacterial infections.</p>

<p>Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.</p>

<p>17-hydroxy Venturicidin A: Streptomyces-derived macrolide with antibiotic and antifungal properties.</p>

<p>Obtusalin, a triterpenoid initially identified in R. dauricum, exhibits UV absorption at 210 nm and possesses antibacterial properties.</p>

<p>Contezolid acefosamil sodium (MRX-4) is an oral antibiotic for drug-resistant Gram-positive cSSTIs, with low myelosuppression and MAOI risks.</p>

<p>Pazufloxacin (T-3761) is a broad-spectrum fluoroquinolone antibiotic effective against various infections, including strains resistant to other quinolones.</p>

<p>Arylomycin B6 is a lipoglycopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>6-C-Methylquercetin-3,4'-dimethyl ether is a flavonol derivative extracted from Bauhinia thonningii Schum leaves, displaying antibacterial effects on Gram-</p>

<p>Maximin H3, an antimicrobial peptide from Chinese red belly toad Bombina maxima skin secretions, exhibits antimicrobial properties against Escherichia coli</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>15-acetoxyscirpenol: ASM that induces apoptosis, inhibits Jurkat T cell growth dose-dependently, and activates caspases other than caspase-3.</p>

<p>Tuberculosis inhibitor 9 (compound 3d), a 3-methoxy-2-phenylimidazo[1,2-b]pyridazine derivative, exhibits potent activity against Mycobacterium tuberculosis and</p>

<p>Cis-β-Terpineol, a monoterpene derived from the aerial parts of Anthemis turcomanica, exhibits antibacterial activity as evidenced by studies on the stems,</p>

<p>D13-9001, an antibiotic, inhibits AcrB and MexB with KDs of 1.15μM in E. coli and 3.57μM in P. aeruginosa.</p>

<p>Ro 09-1428, a parenteral cephalosporin, has high antipseudomonal activity.</p>

<p>Dicloxacillin, a β-Lactam antibiotic, targets beta-lactamase bacteria like Staphylococcus aureus, defeating penicillin resistance.</p>

<p>Sirpefenicol (ZTS-00007928), a phenicol antibacterial for treating animal bacterial infections.</p>

<p>Mycophenolate Mofetil: Non-competitive, selective inhibitor of IMP dehydrogenase I/II, IC50: 39/27 nM.</p>

<p>Flucloxacillin, an antibiotic, effectively combats both gram-positive and gram-negative bacteria [1] [2].</p>

<p>XT17 is an anthrone compound with broad-spectrum antibacterial activity, exerting its effects by disrupting the cell wall and inhibiting DNA synthesis. It demonstrates weak hemolytic activity, low cytotoxicity to mammalian cell lines, and a low rate of resistance development. Additionally, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies confirm that XT17 forms a stable complex with bacterial gyrase. XT17 is suitable for research in the field of anti-infective agents.</p>

<p>Thiomandelic acid is a simple, broad-spectrum and quite potent metallo-β-lactamase inhibitor, an antimicrobial compound.</p>

<p>Melimine, a hybrid antimicrobial peptide derived from Melittin and Protamine, exhibits broad-spectrum activity against various microorganisms, including</p>

<p>Arylomycin A1 is a lipopeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>ChlaDUB1-IN-2 (Compound 27a) serves as an inhibitor of the deubiquitinating enzyme ChlaDUB1 from Chlamydia trachomatis, with an IC50 of 0.97 μM. It also inhibits the formation of Chlamydia trachomatis inclusions, exhibiting an IIC50 of 25.6 μg/mL.</p>

<p>SCH 38519, a fungal metabolite, inhibits thrombin, serotonin in platelets, and bacteria growth.</p>

<p>Compd 3j (Antibacterial agent 149) is a laccase inhibitor that exhibits potent fungicidal activity, particularly useful in researching rice sheath blight [1].</p>

<p>Bryostatin 1, a marine macrolide, permeates CNS and modulates PKC, with strong affinity for Munc13-1 (Ki: 8.07 nM and 0.45 nM).</p>

<p>Psoracorylifol B is a natural product that can be used as a reference standard.</p>

<p>Quinaldopeptin: a quinomycin antibiotic, combats various bacteria, cytotoxic to cells, aids in P388 leukemia mouse survival, intercalates DNA.</p>

<p>Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory</p>

<p>FtsZ-IN-6: strong FtsZ polymerization promoter, GTPase inhibitor, kills bacteria, low resistance and toxicity.</p>

<p>Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.</p>

<p>Ledaborbactam etzadroxil (VNRX-7145) is an orally active inhibitor of Ambler class A, C, and D β-lactamase enzymes.</p>

<p>GSK299423: Antibiotic possibly effective against bacteria with New Delhi metal-β-lactamase, targeting topoisomerases.</p>

<p>RDR 02308 is a TLR4-MyD88 binding inhibitor that inhibits full-length β-lactamase [1] .</p>

<p>Chartreusin is an antibiotic. It also has anticancer activity.</p>

<p>Compound 7a: potent, selective MRSA growth inhibitor; MIC ≤ 0.26 µM; non-cytotoxic, non-hemolytic.</p>