Antibacterial

Ertapenem: injectable carbapenem with broad antimicrobial spectrum, resistant to many beta-lactamases.

CjGlmU, a sugar nucleotidyltransferase, uses UTP and GlcNAc-1-P to make UDP-GlcNAc, and has antimicrobial research potential.

Penicillin G Benzathine Tetrahydrate (Benzathine Benzylpenicillin Tetrahydrate) serves as an antibiotic effective against numerous bacterial infections [1].

Lactoferricin H, Lactotransferrin (37-61), human, is a bioactive peptide with antimicrobial properties, derived from the amino acid residues 37-61 of human

AIP-II is a macrocyclic peptide signaling molecule produced by Staphylococcus aureus for quorum sensing. It binds to the AgrC-II receptor, regulating the expression of virulence genes within Staphylococcus aureus. Additionally, AIP-II acts as an antagonist to the AgrC-I receptor.

Esculentin 1A, a potent antimicrobial peptide (AMP) derived from frog skin, demonstrates significant in vitro activity against Pseudomonas [1].

Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.

Cefpimizole is a broad-spectrum caphalosporin antibiotic with limited side effects and high efficacy.

PF 5081090 has a wide range of applications in life science related research.

Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .

Pelagiomicin A is used as an anticancer antibiotic produced by the marine bacterium Pelagiobacter variabilis.

Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.

Monocerin, from F. larvarum, combats E. coli, B. megaterium, M. violaceum, C. fusca; kills C. erythrocephala; hinders S. halepense root growth.

Altromycin A is an anticancer agent.

Antibacterial agent 55 (example 21) is a antibacterial agent.

ChlaDUB1-IN-2 (Compound 27a) serves as an inhibitor of the deubiquitinating enzyme ChlaDUB1 from Chlamydia trachomatis, with an IC50 of 0.97 μM. It also inhibits the formation of Chlamydia trachomatis inclusions, exhibiting an IIC50 of 25.6 μg/mL.

TP2 inhibits Pks13, halting mycolic acid production and killing mycobacteria, with a 1 μM MIC against Mycobacterium tuberculosis.

Pks13-IN-1 (Compound 44) is an orally active inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13). It inhibits the M. tuberculosis H37Rv strain with a minimum inhibitory concentration (MIC) of 0.07 μM. In mouse models, Pks13-IN-1 demonstrates antibacterial activity.

Cefoperazone dihydrate, a semi-synthetic cephalosporin, exhibits a wide range of antibacterial properties.

Pexiganan, a synthetic magainin 2 analog, is a broad-spectrum antimicrobial peptide for researching infections like diabetic foot ulcers.

8-Methylsulfinyloctyl isothiocyanate: antimicrobial, inhibits plant growth, impairs COX-2 inflammation in macrophages.

Nybomycin, a fungal metabolite from Streptomyces sp. A717, has antibacterial properties; effective against various bacteria including M. tuberculosis.

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It disrupts bacterial cell membranes, causing leakage of cellular contents and demonstrating broad-spectrum antibacterial activity. Additionally, Antimicrobial agent-39 targets organic cation transporters (OCT) and accumulates in infected kidneys, improving pyelonephritis in mouse models.

Clindamycin phosphate HCl: prodrug, becomes active clindamycin in vivo; used for acne, bacterial vaginosis research.

Agent 138: soluble benzothiazole, inhibits DNA gyrase/topoisomerase IV, targets Gram+ & Gram- bacteria, binds plasma proteins.

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

(E/Z)-Eltrombopag 13C4 is a mix of E/Z isotopologues, both 13C-labeled TPO receptor agonists for thrombocytopenia.

Flurithromycin is an orally active, broad-spectrum antibiotic for bacterial infection research.

Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.

Angustifoline HCl, from Lupinus angustifolius, has antimicrobial effects on S. aureus, B. subtilis, E. coli, P. aeruginosa, B. thuringiensis.

Fortimicin C is a bioactive chemical.

"Ribostamycin (Vistamycin) is a broad-spectrum antibiotic, effective against many bacteria and inhibits PDI."

NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.

Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.

Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.

1-Methyl-2-tridecenylquinolinone fights H. pylori (MIC50: 22 µM, MIC90: 50 µM); may research ulcers.

K4 peptide exhibits potent antimicrobial properties, effectively targeting both Gram-positive and Gram-negative bacteria, particularly pathogenic strains like

Antibacterial agent 165 (compound 3), a hydroxyquinoline derivative, effectively inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1], demonstrating

Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.

Maximin 5, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal

Batzelladine D inhibits Pdr5p, with IC50 of 7.1 µM, and exhibits antifungal, antiparasitic, antiviral, antibacterial, and antitumor properties.

Roquefortine C is a fungal cyclopeptide isolated from Penicillium roquefortii, activates P-gp and also inhibits P450-3A and other haemoproteins

DNA gyrase/Topo IV-IN-1 (Compound 27) is an inhibitor of DNA gyrase and topoisomerase IV with antibacterial properties. It exhibits IC50 values of 11 and 17 nM against the DNA gyrase of Escherichia coli and methicillin-resistant Staphylococcus aureus, respectively, and IC50 values of 83 and 21 nM against topoisomerase IV of the same organisms. DNA gyrase/Topo IV-IN-1 is applicable in anti-infective research.

Antistaphylococcal agent 3 is an antistaphylococcal therapeutic agent.

Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.

Ceftiofur hydrochloride (U-67279A) is a stable, broad-spectrum 3rd-gen cephalosporin with antibacterial properties.

Betonicine, an l-alpha-amino acid, is in herbs, spices, pulses, and mainly urine.

Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.

Valclavam is a biochemical.

Compound 1h (Antibacterial agent 108) is a potent antibacterial agent, demonstrating a minimum inhibitory concentration (MIC) of 3 μM against both MRSA and

Apigravin, a potent antibacterial compound, demonstrates activity against Bacillus subtilis, exhibiting a minimum inhibitory concentration (MIC) value of 61 μM

Emeguisin A, a depsidone from E. unguis, fights S. aureus, MRSA, C. neoformans (MIC 0.5 μg/ml), and P. falciparum (IC50 2.2 μM).

Kyotorphin is a Morphine-like dipeptide.

Mtb-IN-5 (compound (-)17j) is an isoxazole exhibiting anti-Mycobacterium tuberculosis (Mtb) activity.

Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.

Dalbavancin HCl (MDL-63397 HCl), a semi-synthetic antibiotic, targets Gram-positive bacteria with low MICs for S. aureus and B. anthracis.

A-54556B: Natural ADEP antibiotic from S. hawaiiensis, combats Gram-positive and anaerobic bacteria, including penicillin-resistant S. aureus.

LL-BM123γ2 is an antimicrobial agent that exhibits activity against various microorganisms. It is utilized in research related to antimicrobial properties.

Pyrindamycin B is an antibiotic,and actives against gram-positive and gram-negative bacterias

Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).

BING is an antimicrobial peptide isolated from Japanese medaka fish. It exhibits broad-spectrum toxicity against pathogenic bacteria, including resistant strains. BING disrupts the periplasmic peptidyl-prolyl isomerase in Gram-negative bacteria and reduces RNA levels of cpxR, which plays a crucial role in the development of antibiotic resistance.

Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.

(-)-cis-Myrtanol, a terpenoid compound derived from Artemisia dracunculus, exhibits effective antimicrobial activity against harmful gut bacteria such as Bifidobacterium bifidum.

Psoracorylifol C is a useful organic compound for research related to life sciences and the catalog number is T124015.

Murrayanol is a useful organic compound for research related to life sciences and the catalog number is T125851.

MRV03-070, acting as a biosynthetic precursor akin to precolibactin [1], is a colibactin-activating peptidase ClbP inhibitor with an inhibitory concentration (

KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2, with an IC50 value of 8.3 nM. KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems, leading to significant bacterial resistance to carbapenem antibiotics.

A 83016A is a kinamycin-type antibiotic.

Ecteinascidin-Analog-1, a tetrahydroisoquinoline, is key for synthesizing ecteinascidin analogs with antitumor and antimicrobial properties.

Netropsin: polypeptide from Streptomyces, with antibiotic/antiviral properties, binds to A-T DNA regions, effective on Gram-positive/negative bacteria.

Gallichrome: an active peptide that interacts with siderophore hydroxamate; used in iron uptake research in gram-positive/negative bacteria.

Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.

FPR2 antagonist; blocks NADPH oxidase, no FPR1 effect; hinders cell movement; antiviral against influenza.

MRV03-037 inhibits ClbP, blocking colibactin's genotoxic impact on cells, and stops gut bacterial genotoxin production.

BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae

JSF-4898 is an orally bioactive inhibitor of Mycobacterium tuberculosis MenG enzyme. It exhibits a minimum inhibitory concentration (MIC) of 0.78 μM against Mycobacterium tuberculosis H37Rv. Additionally, JSF-4898 enhances the efficacy of rifampicin in a subacute infection model of Mycobacterium tuberculosis in mice.

XMP-629, an endotoxin inhibitor, is used potentially for the treatment of impetigo and acne rosacea.

Aurein 5.2 is an antibiotic antimicrobial peptide [1].

Anti gram-positive/negative bacteria agent 1 is an antibiotic linked with a synthetic MECAM-based siderophore, serving as a conjugate aimed at combating gram-

Ficellomycin is an aziridine antibiotic produced by Streptomyces ficellus. Which shows high in vitro activity against Gram-positive bacteria.

6'-Hydroxy-3,4,2',3',4'-pentamethoxychalcone is an alkenylphenol from Piper obliquum with antiinflammatory and antibacterial activities.

Paldimycin B is a semi-synthetic antibiotic.

Antibacterial agent 40 is an antibacterial agent.

Hodgkinsine, a pyrrolidinoindoline alkaloid with analgesic properties, found in P. colorata, increases pain tolerance in mice at 5 mg/kg.

Lysolipin I is a bioactive chemical.

Nyssoside, an ellagic acid derivative, exhibits notable antioxidant and antibacterial properties against a variety of pathogenic bacteria.

Cefotetan Sodium: a 2nd-gen cephamycin antibiotic effective against various aerobic/anaerobic, gram+/- bacteria, inhibits cell wall synthesis.

Ro 25-0534 is an antipseudomonal dual-action drug with antimicrobial activity.

Antimicrobial agent-12 serves as a powerful antibacterial compound that also exhibits inhibitory activity against SARS-CoV-2 [1].

Calcium lactate (Conclyte) fortifies juice with calcium and aids soybean sprout growth and phytic acid breakdown.

(E)-Aztreonam (SQ-28429) is a monocyclic beta-lactam antibiotic active against gram-negative pathogens, useful for studying resistant infections.

Secnidazole hemihydrate is an oral azole antibiotic for treating amoebiasis, giardiasis, and bacterial vaginitis. It inhibits P. aeruginosa and S. marcescens.

Antibacterial agent 54 (example 20) is a antibacterial agent.

Antibacterial agent 56 (example 22) is a antibacterial agent.

Ilicicolin F is a useful organic compound for research related to life sciences. The catalog number is T125283 and the CAS number is 22738-98-3.

BABX inhibits FAS-II, affecting fatty acid production in S. aureus/E. coli, and blocks LXRα agonist binding. IC50: 11.4/35.3 μg/ml. MIC: 0.2-0.4 μg/ml.

Biotin protein ligase-IN-1 (Compound Bio-9) is an inhibitor of biotin protein ligase (BPL) with a Kd of 7 nM. This compound exhibits antimicrobial activity, with minimum inhibitory concentration (MIC) values of 0.2 μM against Staphylococcus aureus (including MRSA and MSSA) and 20 μM against Mycobacterium tuberculosis.

Parvodicin C2, a glycopeptide antibiotic derived from A. parvosata and part of the parvodicin complex, serves as a component of the A40926 antibiotic complex utilized as a precursor for synthesizing dalbavancin. It exhibits activity against methicillin-sensitive and methicillin-resistant strains of S. aureus, S. epidermidis, S. saprophyticus, S. hemolyticus, and E. faecalis.

BO-1, a benzoate ester, exhibits antibacterial properties, effectively inhibiting multidrug-resistant Staphylococcus aureus.

6-Deoxy-8-O-methylrabelomycin is a useful organic compound for research related to life sciences.

3'-Hydroxyxanthyletin is a useful organic compound for research related to life sciences and the catalog number is T125640.

ML338 is a potent inhibitor of dormant M. tuberculosis with IC90 of 1 μM and IC99 of 4 μM, aiding in tuberculosis research.

(R)-Eucomol, a flavonoid derivative, exhibits slight antibacterial properties and demonstrates cytotoxic activity against KB and P-388 cells [1].

Baquiloprim: an antibiotic that inhibits bacterial dihydrofolate reductases; fights Gram-negative and Gram-positive bacteria.

Vecantoxatug is a humanized monoclonal antibody designed to target Clostridium tetani toxin (TeNT, a neurotoxin). It specifically binds to the tetanus toxin, preventing the toxin from interacting with cell receptors and thus exhibits antitoxin activity. Vecantoxatug holds potential for tetanus research.

Faropenem daloxate (Faropenem medoxil) is useful for penem and antibiotics.

Elf18 is an N-terminal segment of the bacterial elongation factor Tu. In Arabidopsis, it acts as a pathogen-associated molecular pattern (PAMP) recognized by pattern recognition receptors (PRR), thereby triggering an immune response.