Antibacterial

Compound 1b, also known as Antibacterial agent 145, targets the bacterial iron uptake pathway to exert its effects.

Reltecimod TFA (AB-103 TFA) is a CD28 antagonist and mimetic, inhibiting the stimulation of t-cells thereby attenuating acute inflammation NSTI.

PptT-IN-4 (Compound 3a) is a PptT inhibitor exhibiting an IC50 of 0.71 μM.

Framycetin is an aminoglycoside antibiotic and it also inhibits hammerhead ribozyme (Ki: 13.5 μM).

Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.

Maximin 15, an antimicrobial peptide originating from toad brain, exhibits activity against Staphylococcus aureus, Escherichia coli, and Bacillus subtilis, with

Globomycin: a lipopeptide antibiotic that irreversibly inhibits signal peptidase II, blocking prolipoprotein processing.

SC 28538, a 5-nitroimidazole, matches metronidazole in potency against multiple pathogens in vitro.

Cis-2-dodecenoic acid, identified in Burkholderia cenocepacia, disrupts bacterial quorum sensing, thereby inhibiting biofilm formation and the production of

Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Oritavancin, a semisynthetic antibiotic for skin infections, approved by FDA on August 6, 2014, targets resistant Gram-positive bacteria.

C12-rrw-NH2 (Compound Lip7) is an antimicrobial agent effective against Gram-positive bacteria, particularly demonstrating significant activity against Methicillin-resistant Staphylococcus aureus (MRSA). It induces bacterial cell death by depolarizing the bacterial cell membrane, disrupting membrane integrity, causing nucleic acid and protein leakage, and promoting the generation of Reactive Oxygen Species (ROS). C12-rrw-NH2 is applicable in research focused on developing highly stable antimicrobial peptides.

Salvinolone is a natural product that can be used as a reference standard.

Meloxicillin: a liver-excreted penicillin effective against Gram-negative and some Gram-positive bacteria; treats biliary infections.

Helvolic acid, an antibiotic derived from Xylaria sp., exhibits effectiveness against Gram-positive bacteria.

Aerocyanidin is an antibiotic (antibiotic) that contains an isonitrile group and is primarily effective against Gram-positive bacteria.

Capoamycin is an insotatracine antibiotic investigated for anti tumor properties.

Aurein 2.2, a principal constituent of L.aurea skin secretions, exhibits broad-spectrum antibacterial properties, particularly effective against Gram-positive

LeuRS-IN-1 is a leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity that inhibits M.tb LeuRS.

Bactobolin is a biochemical.

β-Lactamase-IN-4 (WO2013149121A1, compound 708) is a potent β-lactamase inhibitor. It serves as a valuable tool in the investigation of bacterial infections.

Compound 12: a potent anti-MRSA, inhibits S. aureus/E. coli DNA gyrases/topo IV; IC50: 0.185-0.365/0.341-0.059 μM.

NOSO-502: Bacterial translation inhibitor, active against Enterobacteriaceae, safe and effective antibacterial.

(±)-Heraclenol, a coumarin derivative isolated from the fruits of Angelica lucida, exhibits antibacterial properties [1].

Vinclozolin (Ornalin) is a fungicide with anti-androgenic activity, commonly used in agriculture.

PA3552-IN-1: Antibiotic adjuvant, lowers PA3552 expression, resensitizes MDR P. aeruginosa to Polymyxin B.

SPR720 disodium is an orally active and potent phosphate VXc-486 prodrug,has potent bactericidal activities in vivo.

Narasin inhibits dengue virus, treats coccidiosis without harm to cells, and induces cancer cell apoptosis.

Kapurimycin A2 is an antitumor antibiotics.

Compound PDK0095, with CAS No. 1777-82-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0095 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Arylomycin B7 is a lipohexapeptide antibiotic (antibiotic) that specifically targets Gram-positive bacteria.

Gramicidin S (Gramicidin Soviet), a cationic cyclic peptide antibiotic, disrupts the membrane integrity of both Gram-positive and Gram-negative bacteria and

Mafenide, a sulfonamide, inhibits the enzyme carbonic anhydrase and is used as a topical anti-infective drug, especially in burn therapy.

Erythromycin, a macrolide antibiotic, inhibits bacterial protein synthesis, effective against Streptococcus and Staphylococcus, and affects CYP3A4 metabolism.

Albofungin is a xanthone isolated from A. tumemacerans.

Talaromycesone A, from Talaromyces, fights S. epidermidis & MRSA (IC50: 3.7 & 5.48 μM), inhibits AChE (IC50: 7.49 μM).

Antimicrobial agent-40 exhibits antibacterial activity against fungi, Gram-negative, and Gram-positive bacteria. It also shows anticancer properties, displaying significant cytotoxicity towards MCF-7 cells with an IC50 of 33.52 μM.

Allolactose is a disaccharide used as an inducer of the lac operon in Escherichia coli and many other enteric bacteria.

Reltecimod, a CD28 antigen inhibitor, is used potentially for the treatment of necrotizing soft tissue infection.

Antimycobacterial agent-6 (compound 25) effectively inhibits Mycobacterium tuberculosis, including wild-type and fluoroquinolone-resistant strains, by targeting

Antimycobacterial agent-4 (4-nitro-N-[4-(2-pyridyl)thiazol-2-yl]benzamide) has antibacterial activity against Mycobacterium tuberculosis.

UCM53 has a wide range of applications in life science related research.

G43 inhibits glucosyltransferase GtfB (Kd 3.7μM) and GtfC (Kd 46.9nM), and fights Streptococcus mutans in caries research.

Polymyxin B2 is an antibiotic primarily utilized for resistant Gram-negative infections. It is derived from the bacterium Bacillus polymyxa.

Rugulosin (RUG) is a bis-anthraquinoid pigment produced by fungi.

(2E,4E)-Decadienoic acid, an aliphatic anti-oomycete agent, is present in the coculture of Bacillus subtilis and Trichoderma asperellum [1].

ADAM-17 (TACE) and MMP inhibitor; attenuates TNF-α processing. Acts in concert with GM6001 to inhibit Chlamydia trachomatis growth.