Antibacterial

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Cyclothialidine is an inhibitor of DNA gyrase.</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.</p>

<p>Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1].</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>

<p>Compound PDK0270, with CAS No. 551-16-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0270 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Lankacidinol A is a metabolite of macrolide antibiotic.</p>

<p>Moenomycin complex is a mixture of moenomycins A, A12, C1, C3 and C4, which are antibiotics from several Streptomyces that directly inhibit bacterial PGTs.</p>

<p>Amythiamicin D is a thiopeptide antibiotic that effectively inhibits the growth of various Gram-positive bacteria, but it is ineffective against Gram-negative bacteria such as Escherichia coli.</p>

<p>Maximin H3, an antimicrobial peptide from Chinese red belly toad Bombina maxima skin secretions, exhibits antimicrobial properties against Escherichia coli</p>

<p>elomycin is a cyclic depsipeptide antibiotic with activity against Gram-positive bacteria.</p>

<p>TP4 (Nile tilapia piscidin) is an orally active piscidin-like antimicrobial peptide that exhibits inhibition of various gram-positive and negative bacterial</p>

<p>Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.</p>

<p>Ceftriaxone: cephalosporin antibiotic, effective against Gram-positive/negative bacteria, with anti-inflammatory/antioxidant properties.</p>

<p>cis-11-Methyl-2-dodecenoic acid: a QS signal, aids microbial communication, regulates virulence, biofilm in pathogens.</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.</p>

<p>Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.</p>

<p>Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.</p>

<p>Atrovenetin is an antibiotic found in Penicillium species (antibiotic). It exhibits inhibitory activity against Bacillus subtilis and Staphylococcus aureus. Atrovenetin is also a potent antioxidant.</p>

<p>DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.</p>

<p>Mycophenolate Mofetil: Non-competitive, selective inhibitor of IMP dehydrogenase I/II, IC50: 39/27 nM.</p>

<p>Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].</p>

<p>'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).</p>

<p>Ceftizoxime, a 3rd-gen cephalosporin, targets PBPs in Gram-positive/negative bacteria, like cefotaxime, but not metabolized.</p>

<p>Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.</p>

<p>Cafamycin is a bioactive chemical.</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.</p>

<p>Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial</p>

<p>Antibacterial agent 139 fights Gram-positive bacteria, including MRSA, VISA, and LRSE, by depolarizing cell membranes.</p>

<p>Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.</p>

<p>Seabream hepcidin, an antimicrobial peptide, exhibits antibacterial (V.</p>

<p>Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.</p>

<p>JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.</p>

<p>Pardaxin P 4 is an antimicrobial peptide found in the secretions of the Red Sea Moses sole (Red Sea Moses sole). It functions as a biolfilm perforating agent, interacting with phospholipid bilayers of varying compositions to induce cytotoxicity and pore formation. Pardaxin P 4 is used in the research of antimicrobial.</p>

<p>Cefquinome is a cephem antibiotic that inhibits Enterobacteriaceae (family [1]).</p>

<p>Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].</p>

<p>LL-C 10037alpha is a gamma-aminoepoxysemiquinone isolated from Streptomyces.</p>

<p>Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.</p>

<p>β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.</p>

<p>Dicresulene diammonium is an impurity found in Policresulen, which is an organic acid possessing hemostatic, antimicrobial, and antiviral properties[1][2].</p>

<p>Psoracorylifol B is a natural product that can be used as a reference standard.</p>

<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>

<p>Isocryptomerin, from Selaginella tamariscina, is an antifungal that depolarizes membranes and has anticancer, antibacterial effects.</p>

<p>Glicophenone, an antibacterial agent, demonstrates minimum inhibitory concentrations (MICs) of 32 μg/mL against multiple strains, including MRSA OM481, MRSA</p>

<p>A 83016A is a kinamycin-type antibiotic.</p>