Antibacterial

Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.

Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.

Compound PDK0095, with CAS No. 1777-82-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0095 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Urease-IN-18 (compound 13a) is a non-competitive urease inhibitor with an IC50 value of 1.6 μM. Urease plays a role in maintaining an alkaline environment that supports the survival and proliferation of certain pathogens within the host.

Laidlomycin, a polyether, polycyclic, monocarboxylic acid, possesses inhibitory activity against various Mycoplasma species, especially Acholeplasma laidlawii.

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

'10'-Desmethoxystreptonigrin antibiotic derived from streptonigrin combats various bacteria and cancer cells, and inhibits p21ras farnesylation (IC50 = 21 nM).

Bottromycin A2, an antibiotic from Streptomyces, halts protein synthesis and targets MRSA, VRE (MIC: 1, 0.5 μg/ml).

Polybia-MP1 is an antimicrobial mastoparan peptide [1] .

Antimicrobial agent-26 is a powerful antimicrobial that has demonstrated the ability to counteract antibiotic resistance in vitro [1].

Cefotiam (SCE-963), a parenteral cephalosporin antibiotic, exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria [1] [2].

Bio-AMS (TFA) inhibits bacterial biotin protein ligase, targets M. tuberculosis, and stops fatty acid/lipid synthesis.

Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.

Atrovenetin is an antibiotic found in Penicillium species (antibiotic). It exhibits inhibitory activity against Bacillus subtilis and Staphylococcus aureus. Atrovenetin is also a potent antioxidant.

Antimicrobial agent-37 (compound 6a) is a potent broad-spectrum antibacterial agent that disrupts bacterial biofilms by targeting and lysing the bacterial membrane.

Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.

InhA-IN-9 (compound 7h) is an inhibitor of the Mycobacterium tuberculosis enzyme InhA (an enoyl ACP reductase). It has the ability to bind with InhA and demonstrates anti-tuberculosis activity with a MIC value of 2 μg/mL.

Cafamycin is a bioactive chemical.

Esculentin 1A, a potent antimicrobial peptide (AMP) derived from frog skin, demonstrates significant in vitro activity against Pseudomonas [1].

Efrotomycin: an oral antibiotic from Streptomyces Lactamdurans; minimal effect on Salmonella in pigs.

Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial

Zelkovamycin, a cyclic peptide antibiotic, blocks X. oryzae, P. oryzae, S. aureus, A. laidlawii growth at 0.01-300 μg/ml concentration.

A 201A is a nucleoside antibiotic, it is isolated from Streptomyces capreolus.

Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].

Prodigiosin hydrochloride is a bioactive red pigment from bacteria with antibacterial, antifungal, anticancer properties, and inhibits Wnt/β-catenin.

JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.

Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.

Viomycin: tuberactinomycin antibiotic, halts prokaryotic protein synthesis and group I intron splicing, arrests bacterial ribosomes.

Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.

Tryptophanase, a bacterial enzyme, catalyzes the degradation of tryptophan into indole, pyruvate, and ammonia [1].

Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.

β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.

Dicresulene diammonium is an impurity found in Policresulen, which is an organic acid possessing hemostatic, antimicrobial, and antiviral properties[1][2].

ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.

Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.

Altromycin A is an anticancer agent.

Isouvaretin demonstrates potent antibacterial activity against B. subtilis and S. epidermidis.

Homo-BacPROTAC7, a ClpC1 NTD BacPROTAC degrader, targets ClpC2 and efficiently kills M. tuberculosis [1].

Aurein 2.6, an antibiotic antimicrobial peptide, exhibits activity against various Gram-positive bacteria with minimum inhibitory concentrations (MIC) of 25, 25

Kapurimycin A3 is an antitumor antibiotics.

G43 inhibits glucosyltransferase GtfB (Kd 3.7μM) and GtfC (Kd 46.9nM), and fights Streptococcus mutans in caries research.

Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.

Lugdunin is an antibiotic peptide that disrupts membrane potential in bacteria, demonstrating activity against Gram-positive species including S.

Pks13-IN-1 (Compound 44) is an orally active inhibitor of Mycobacterium tuberculosis polyketide synthase 13 (Pks13). It inhibits the M. tuberculosis H37Rv strain with a minimum inhibitory concentration (MIC) of 0.07 μM. In mouse models, Pks13-IN-1 demonstrates antibacterial activity.

SPR741, a cationic peptide from polymyxin B, is being developed to treat serious Gram-negative infections.

2-Phenoxyphenol has antibacterial against Staphylococcus aureus, Staphylococcus aureus, Escherichia coli, Burkholderia pseudomallei, etc.

Loloatin B 10 is a bioactive chemical.

JH-LPH-28, a sulfonyl piperazine, inhibits LpxH with strong antibiotic activity, MIC of 0.83 μg/mL.

Obtusalin, a triterpenoid initially identified in R. dauricum, exhibits UV absorption at 210 nm and possesses antibacterial properties.