Antibacterial

<p>Antibacterial agent 163 (compound 1), a hydroxyquinoline derivative, potently inhibits methicillin-resistant Staphylococcus aureus (MRSA) [1].</p>

<p>β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.</p>

<p>A unique collection of xnum anti-infective compounds including anti-bacterial, anti-fungi, anti-Human Cytomegalovirus (HCMV), anti-HIV, anti-SARS, anti-</p>

<p>Narasin (sodium salt) (HainanMycin) induces tumor necrosis factor-related apoptosis-induced ligand (TRAIL)-mediated apoptosis by ER stress in glioma cells and</p>

<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>

<p>Maximin 1, an antimicrobial peptide originating from the skin secretions of Bombina maxima, exhibits cytotoxicity against tumor cells and possesses spermicidal</p>

<p>Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.</p>

<p>Racemomycin B is a beta-lysine-rich streptothricin antibiotic.</p>

<p>Flomoxef is an antibiotic in oxacephem group and has excellent activity against various gram-positive bacteria.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.</p>

<p>Rifamycin: Natural antibiotic; blocks prokaryotic RNA synthesis by halting RNA-polymerase.</p>

<p>Methyl quinoline-2-carboxylate (Methyl 2-quinolinecarboxylate) inhibits the binding of Mycobacterium tuberculosis.</p>

<p>Amythiamicin D is a thiopeptide antibiotic that effectively inhibits the growth of various Gram-positive bacteria, but it is ineffective against Gram-negative bacteria such as Escherichia coli.</p>

<p>Doxycycline hydrochloride (Hyclate) is a synthetic tetracycline derivative with similar antimicrobial activity.</p>

<p>Desacetylcefotaxime, a Cefotaxime metabolite, has strong antimicrobial effects against various bacteria.</p>

<p>ROS inducer 8 (Compound 11g) acts as an inhibitor of glutathione (GSH) and promotes the accumulation of reactive oxygen species (ROS) in Enterococcus faecalis, exhibiting antibacterial properties. It is capable of disrupting biofilms and inhibiting S. aureus and E. faecalis with minimum inhibitory concentrations (MICs) of 8 μg/mL and 2 μg/mL, respectively, demonstrating a post-antibiotic effect. Additionally, ROS inducer 8 shows low hemolytic toxicity on sheep red blood cells with an HC50 greater than 1280 μg/mL.</p>

<p>Antibacterial agent 43 from patent WO2013030735A1 shows strong activity against infections and has research potential.</p>

<p>Amythiamicin A is an antibiotic effective against gram-positive bacteria, including Methicillin-resistant Staphylococcus aureus (MRSA), and exhibits activity against Plasmodium falciparum.</p>

<p>Cefpirome: fourth-gen cephalosporin, broad-spectrum, inactivates penicillin-binding proteins in bacteria.</p>