Antibacterial

Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.

Sisomicin is a broad-spectrum aminoglycoside antibiotic isolated from Micromonospora inyoensis. It is highly active against staphylococci.

Cafamycin is a bioactive chemical.

DNA Gyrase-IN-17 (Compound 5C) is an inhibitor of DNA gyrase. It demonstrates significant antimicrobial activity against a range of Gram-positive and Gram-negative strains, including Enterococcus faecium, Escherichia coli, and Pseudomonas aeruginosa, with a MIC value of 62.5 μg/mL. By inhibiting bacterial DNA gyrase, DNA Gyrase-IN-17 disrupts DNA replication. This compound can be useful in the development of antibiotics, particularly for studying resistant strains.

1-Isothiocyanato-6-(methylsulfenyl)-hexane, identified in wasabi (W. japonica), exhibits multifaceted biological activities. This isothiocyanate compound demonstrates antibacterial properties by inhibiting B. subtilis growth in an agar diffusion assay at 25 µmol/disc, and antifungal effectiveness against T. mentagrophytes with a minimum inhibitory concentration (MIC) of 25 µg/ml. Additionally, it acts as a repellent in the blue mussel (M. edulis) assay and shows antifouling capabilities on polyvinyl chloride (PVC) plates at a concentration of 50 µmol/cm^2, underscoring its potential in biotechnological applications.

Brevianamide M (compound 4), a metabolite of the endophytic fungus Aspergillus versicolor isolated from the marine brown alga Sargassum, exhibits antimicrobial

<p>Cefoperazone dihydrate, a semi-synthetic cephalosporin, exhibits a wide range of antibacterial properties.</p>

Bombinin H4 is an antimicrobial peptide originating from the skin of the moth species Bombina variegata.

<p>Avilamycin A: antibiotic, combats C. perfringens and B. hyodysenteriae, lowers mortality in poultry.</p>

<p>Aurein 3.3 is an antimicrobial peptide with antibiotic properties and exhibits anticancer activity [1].</p>

<p>Neamine: antibiotic, anti-angiogenic, battles bacteria, cancer, protects nerves.</p>

Ibezapolstat hydrochloride is an antibacterial agent.

Kipukasin D is a naturally derived nucleoside with antibacterial properties, isolated from Aspergillus versicolor.

Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.

Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.

JAK05 exhibits inhibitory activity against Helicobacter pylori, effectively suppressing strains J63, J196, and J107, with a MIC of 3-5 µg/mL. It shows affinity for binding to H+/K+-ATPase, COX-1/2, TNF-α, and PGE2, and possesses antioxidant and anti-inflammatory properties. In a rat model of ethanol-induced gastric ulcers, JAK05 demonstrates anti-ulcer activity.

Efflux pump-IN-4 inhibits AcrB, enhancing antibiotic potency without harming bacterial membranes or nematodes.

β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.

Dicresulene diammonium is an impurity found in Policresulen, which is an organic acid possessing hemostatic, antimicrobial, and antiviral properties[1][2].

Cephabacin M6 is a new cephem antibiotic isolated from bacterial.