PDK
PDK (Pyruvate Dehydrogenase Kinase) inhibitors target the PDK enzyme, which regulates the activity of the pyruvate dehydrogenase complex (PDC) and plays a role in metabolic control and apoptosis. By inhibiting PDK, these compounds shift cellular metabolism from glycolysis towards oxidative phosphorylation, which can induce apoptosis in cancer cells that rely on aerobic glycolysis (Warburg effect) for survival. PDK inhibitors are valuable in cancer metabolism research and therapeutic development. At CymitQuimica, we provide high-quality PDK inhibitors to support your research in cancer metabolism, apoptosis, and cellular bioenergetics.
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PS10
CAS:1564265-82-2
PS10 is a ATP-competitive inhibitor of pan-PDK(PDK2, PDK4, PDK1, and PDK3 with IC50 of 0.8 …
Formula:
C14H13NO6S
Purity:
98%
Color and Shape:
Solid
Molecular weight:
323.32
Ref: TM-T12566
| 1mg | 40.00 € | ||
| 2mg | To inquire |
Estimated delivery in United States, on Monday 2 Dec 2024
![6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile](https://static.cymitquimica.com/products/TM/thumb/T77685.jpg)
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
CAS:1207836-10-9
6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to …
Formula:
C9H6BrN3O
Purity:
98.81%
Color and Shape:
Solid
Molecular weight:
252.07
Ref: TM-T77685
| 100mg | 34.00 € |
Estimated delivery in United States, on Thursday 5 Dec 2024
PDK1-IN-RS2
CAS:1643958-89-7
PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).
Formula:
C15H9ClN2O2S3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
380.89
Ref: TM-T16450
| 1mL*10mM (DMSO) | 173.00 € |
Estimated delivery in United States, on Tuesday 10 Dec 2024
GSK2334470
CAS:1227911-45-6
GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no …
Formula:
C25H34N8O
Purity:
99.04% - 99.87%
Color and Shape:
Solid
Molecular weight:
462.59
Ref: TM-T2348
| 5mg | 52.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 143.00 € | ||
| 50mg | 252.00 € | ||
| 1mL*10mM (DMSO) | 95.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PS47
CAS:1180676-33-8
PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
Formula:
C17H15ClO2
Purity:
99.09%
Color and Shape:
Solid
Molecular weight:
286.75
Ref: TM-T24677
| 5mg | 44.00 € | ||
| 10mg | 63.00 € | ||
| 25mg | 119.00 € | ||
| 50mg | 181.00 € | ||
| 100mg | 299.00 € | ||
| 200mg | 420.00 € | ||
| 1mL*10mM (DMSO) | 63.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
Osu03012
CAS:742112-33-0
Osu03012 (AR-12): oral celecoxib-derived PDK1 inhibitor with anticancer potential.
Formula:
C26H19F3N4O
Purity:
97.95% - 99.22%
Color and Shape:
Solid
Molecular weight:
460.45
Ref: TM-T2466
| 2mg | 37.00 € | ||
| 5mg | 51.00 € | ||
| 10mg | 85.00 € | ||
| 25mg | 141.00 € | ||
| 50mg | 259.00 € | ||
| 100mg | 341.00 € | ||
| 200mg | 445.00 € | ||
| 500mg | 729.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PS 48
CAS:1180676-32-7
PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). …
Formula:
C17H15ClO2
Purity:
98.37% - ≥95%
Color and Shape:
Solid
Molecular weight:
286.75
Ref: TM-T3163
| 5mg | 51.00 € | ||
| 10mg | 70.00 € | ||
| 25mg | 119.00 € | ||
| 50mg | 167.00 € | ||
| 100mg | 252.00 € | ||
| 1mL*10mM (DMSO) | 52.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
PS210
CAS:1221962-86-2
PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits …
Formula:
C19H15F3O5
Purity:
99.65%
Color and Shape:
Solid
Molecular weight:
380.31
Ref: TM-T16670
| 1mg | 37.00 € | ||
| 2mg | 52.00 € | ||
| 5mg | 74.00 € | ||
| 10mg | 106.00 € | ||
| 25mg | 195.00 € | ||
| 50mg | 347.00 € | ||
| 100mg | 515.00 € | ||
| 1mL*10mM (DMSO) | 84.00 € |
Estimated delivery in United States, on Wednesday 11 Dec 2024
M77976
CAS:394237-61-7
M77976 inhibits PDK4 with an IC50 of 648 μM, targeting obesity and diabetes research.
Formula:
C17H16N2O3
Purity:
99.80%
Color and Shape:
Solid
Molecular weight:
296.32
Ref: TM-T15944
| 1mg | 46.00 € | ||
| 5mg | 95.00 € | ||
| 10mg | 141.00 € | ||
| 25mg | 268.00 € | ||
| 50mg | 405.00 € | ||
| 100mg | 637.00 € | ||
| 1mL*10mM (DMSO) | 94.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
RS1-PDK1 inhibitor
CAS:1643958-85-3
RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can …
Formula:
C15H9ClN2O2S3
Purity:
98%
Color and Shape:
Solid
Molecular weight:
380.89
Ref: TM-T24741
| 1mg | 271.00 € | ||
| 5mg | 646.00 € | ||
| 10mg | 912.00 € | ||
| 25mg | 1,340.00 € | ||
| 50mg | 1,808.00 € | ||
| 100mg | 2,464.00 € |
Estimated delivery in United States, on Wednesday 22 Jan 2025
MP7
CAS:1001409-50-2
MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
Formula:
C28H22F2N4O4
Purity:
99.45% - 99.84%
Color and Shape:
Solid
Molecular weight:
516.5
Ref: TM-T12398
| 1mg | 49.00 € | ||
| 5mg | 107.00 € | ||
| 10mg | To inquire | ||
| 50mg | To inquire | ||
| 1mL*10mM (DMSO) | 123.00 € |
Estimated delivery in United States, on Wednesday 5 Feb 2025
