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PDK

PDK

PDK (Pyruvate Dehydrogenase Kinase) inhibitors target the PDK enzyme, which regulates the activity of the pyruvate dehydrogenase complex (PDC) and plays a role in metabolic control and apoptosis. By inhibiting PDK, these compounds shift cellular metabolism from glycolysis towards oxidative phosphorylation, which can induce apoptosis in cancer cells that rely on aerobic glycolysis (Warburg effect) for survival. PDK inhibitors are valuable in cancer metabolism research and therapeutic development. At CymitQuimica, we provide high-quality PDK inhibitors to support your research in cancer metabolism, apoptosis, and cellular bioenergetics.

Found 13 products for "PDK".

  • PDKtide
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    PDKtide

    PDKtide is a bioactive peptide. (This peptide serves as a substrate for PDK1 [phosphoinositide-dependent kinase 1].)
    Formula:C212H314N54O66S3
    Molecular weight:4768.20363

    Ref: TM-TP3439

  • 6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
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    6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile

    CAS:
    6-Bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile is a PDK1 inhibitor with anticancer and antiproliferative activity that can be used to study
    Formula:C9H6BrN3O
    Purity:99.81%
    Color and Shape:Solid
    Molecular weight:252.067

    Ref: TM-T77685

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    PDK1-IN-4

    PDK1-IN-4 (Compound R-29) is an inhibitor of PDK1, applicable for lung cancer research.
    Formula:C19H21ClN2O2
    Molecular weight:344.84

    Ref: TM-T205292

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    PDKtide TFA

    PDKtide TFA is a bioactive peptide that serves as a substrate for phosphoinositide-dependent kinase 1 (PDK1).

    Ref: TM-TP4129

  • PDK1-IN-RS2
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    PDK1-IN-RS2

    CAS:
    PDK1-IN-RS2, a PIFtide mimic, selectively inhibits PDK1, blocking S6K1 activation (Kd: 9 μM).
    Formula:C15H9ClN2O2S3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:380.892

    Ref: TM-T16450

  • PS47
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    PS47

    CAS:
    PS-47(PS 47) is an inactive E-isomer of PS48. PS48 is an activator of PDK1.
    Formula:C17H15ClO2
    Purity:99.09%
    Color and Shape:Solid
    Molecular weight:286.753

    Ref: TM-T24677

  • PS 48
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    PS 48

    CAS:
    PS 48 has been shown to be a PKB Kinase (PDK1) activator (Kd: 10.3 μM). This compound selectively binds to the PIF-binding pocket of PKB Kinase (PDK1).
    Formula:C17H15ClO2
    Purity:99.96% - ≥95%
    Color and Shape:Solid
    Molecular weight:286.75

    Ref: TM-T3163

  • PS210
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    PS210

    CAS:
    PS210 selectively activates PDK1 (Kd: 3 μM), doesn't affect PDK1 downstream kinases. Prodrug PS423 inhibits PDK1-mediated S6K phosphorylation.
    Formula:C19H15F3O5
    Purity:99.78%
    Color and Shape:Solid
    Molecular weight:380.3146

    Ref: TM-T16670

  • GSK2334470
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    GSK2334470

    CAS:
    GSK2334470 is a novel PDK1 inhibitor (IC50: ~10 nM, in a cell-free assay), with no inhibitory at other close related AGC-kinases.
    Formula:C25H34N8O
    Purity:99.57% - 99.87%
    Color and Shape:Solid
    Molecular weight:462.59

    Ref: TM-T2348

  • PKD-IN-1 dihydrochloride
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    PKD-IN-1 dihydrochloride

    CAS:
    CRT0066101 dihydrochloride is an inhibitor of PKD.
    Formula:C18H21Cl3N4O
    Purity:99.5%
    Color and Shape:Solid
    Molecular weight:415.75

    Ref: TM-T8957L

  • PDK1-IN-3
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    PDK1-IN-3

    CAS:
    PDK1-IN-3 (Compound C) is a PDK1 inhibitor with an IC50 value of 34 nM.
    Formula:C25H15N5
    Molecular weight:385.42

    Ref: TM-T201162

  • RS1-PDK1 inhibitor
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    RS1-PDK1 inhibitor

    CAS:
    RS1-PDK1 inhibitor (RS 1) is a selective inhibitor of the protein kinase PDK1 that can be used to treat and prevent disease or disorders.
    Formula:C15H9ClN2O2S3
    Purity:97.65%
    Color and Shape:White Solid
    Molecular weight:380.892

    Ref: TM-T24741

  • MP7
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    MP7

    CAS:
    MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
    Formula:C28H22F2N4O4
    Purity:99.89%
    Color and Shape:White Solid
    Molecular weight:516.4955

    Ref: TM-T12398