PI3K
PI3K inhibitors are compounds that block the activity of Phosphoinositide 3-Kinases (PI3Ks), a family of enzymes involved in a wide range of cellular processes, including growth, proliferation, survival, and metabolism. The PI3K/Akt/mTOR pathway is often dysregulated in cancer, making PI3K a key target for cancer therapy. PI3K inhibitors are critical tools for studying signal transduction, cancer biology, and the development of targeted therapies. At CymitQuimica, we provide a variety of PI3K inhibitors to support your research in cell signaling, oncology, and therapeutic development.
Found 231 products of "PI3K"
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Sophocarpine monohydrate
CAS:Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formula:C15H22N2OPurity:99.55%Color and Shape:SolidMolecular weight:246.35NSC781406
CAS:NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).Formula:C29H27F2N5O5S2Purity:99.58%Color and Shape:SolidMolecular weight:627.68Ref: TM-T16355
2mg39.00€5mg60.00€1mL*10mM (DMSO)84.00€10mg87.00€25mg159.00€50mg231.00€100mg355.00€200mg505.00€Copanlisib dihydrochloride
CAS:Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.Formula:C23H30Cl2N8O4Purity:99.05% - 99.16%Color and Shape:SolidMolecular weight:553.44Inavolisib
CAS:Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.Formula:C18H19F2N5O4Purity:97.36% - 99.90%Color and Shape:SolidMolecular weight:407.37Ref: TM-T15375
1mg88.00€5mg212.00€10mg373.00€1mL*10mM (DMSO)404.00€25mg635.00€50mg1,035.00€100mg1,691.00€200mg2,262.00€Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formula:C21H27ClN2S2Purity:99.55% - 99.957%Color and Shape:White To Off-White SolidMolecular weight:407.04CGS 15943
CAS:CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Formula:C13H8ClN5OPurity:97.4%Color and Shape:SolidMolecular weight:285.69Ref: TM-T14944
2mg34.00€5mg50.00€1mL*10mM (DMSO)55.00€10mg82.00€25mg147.00€50mg222.00€100mg334.00€200mg494.00€Parsaclisib
CAS:Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
Formula:C20H22ClFN6O2Purity:98.59%Color and Shape:SolidMolecular weight:432.88Recilisib
CAS:Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.Formula:C16H13ClO4SPurity:98.85% - 98.96%Color and Shape:SolidMolecular weight:336.79Ref: TM-T13862
1mg43.00€2mg56.00€5mg93.00€1mL*10mM (DMSO)100.00€10mg113.00€25mg177.00€50mg295.00€100mg477.00€200mg677.00€Pictilisib dimethanesulfonate
CAS:Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) andFormula:C25H35N7O9S4Purity:99.63%Color and Shape:SolidMolecular weight:705.85Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Formula:C23H18FN5O2Purity:99.71%Color and Shape:SolidMolecular weight:415.42Ref: TM-T13119
1mg35.00€2mg50.00€5mg77.00€1mL*10mM (DMSO)84.00€10mg105.00€25mg178.00€50mg289.00€100mg434.00€P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formula:C31H40N8O3SPurity:99.75%Color and Shape:SolidMolecular weight:604.77IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formula:C25H25N7O2Purity:98.00%Color and Shape:SolidMolecular weight:455.51Ref: TM-T15592
1mg44.00€2mg60.00€5mg99.00€1mL*10mM (DMSO)107.00€10mg166.00€25mg323.00€50mg447.00€100mg610.00€PI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formula:C23H25N3O5S2Purity:97.18%Color and Shape:SolidMolecular weight:487.59Ref: TM-T12469
1mg75.00€5mg178.00€1mL*10mM (DMSO)197.00€10mg268.00€25mg485.00€50mg677.00€100mg888.00€Safingol hydrochloride
CAS:Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Formula:C18H40ClNO2Purity:99.39% - 99.71%Color and Shape:SoildMolecular weight:337.969PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formula:C22H25N3O5S2Purity:99.76%Color and Shape:SolidMolecular weight:475.58Ref: TM-T12468
1mg75.00€5mg156.00€1mL*10mM (DMSO)164.00€10mg241.00€25mg399.00€50mg532.00€100mg750.00€200mg1,009.00€D-106669
CAS:D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Formula:C17H18N6OColor and Shape:SolidMolecular weight:322.36PI3K-IN-41
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV lightFormula:C45H39F2N5O12SPurity:98%Color and Shape:SolidMolecular weight:911.88GSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.
Formula:C25H30N6O7SPurity:99.52%Color and Shape:SoildMolecular weight:558.61PITCOIN4
PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivityPurity:98%Color and Shape:Odour SolidPI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formula:C50H46F4N8O8S2Purity:98%Color and Shape:SolidMolecular weight:1027.07IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFormula:C26H21F2N7O3Purity:98%Color and Shape:SolidMolecular weight:517.49GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formula:C29H37FN6O4SPurity:99.8%Color and Shape:SolidMolecular weight:584.71PI5P4Ks-IN-2
CAS:PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.Formula:C22H23N5Purity:98.97% - 99.35%Color and Shape:SoildMolecular weight:357.45Ref: TM-T72032
1mg152.00€5mg319.00€1mL*10mM (DMSO)350.00€10mg477.00€25mg803.00€50mg1,054.00€100mg1,378.00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formula:C20H15Cl2N5O3Purity:98%Color and Shape:SolidMolecular weight:444.27PI3Kδ-IN-14
PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain ofFormula:C26H20ClFN8OPurity:98%Color and Shape:SolidMolecular weight:514.94PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Purity:98%Color and Shape:Odour SolidDuvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formula:C22H18Cl2N6OPurity:99.86% - 99.88%Color and Shape:SoildMolecular weight:453.32Ref: TM-T11129L
1mg296.00€5mg718.00€1mL*10mM (DMSO)895.00€10mg982.00€25mg1,485.00€50mg2,008.00€100mg2,637.00€PI3K-IN-46
CAS:PI3K-IN-46 is a specific inhibitor of PI3Kγ.Formula:C13H9N3OSPurity:97.26%Color and Shape:SoildMolecular weight:255.3Ref: TM-T64392
1mg62.00€1mL*10mM (DMSO)133.00€5mg149.00€10mg213.00€25mg319.00€50mg450.00€100mg605.00€PI3Kα-IN-12
PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values
Formula:C28H36F2N10O5S3Color and Shape:SolidMolecular weight:726.84STX-478
CAS:STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFormula:C16H12F5N5O2Purity:98.31% - 99.78%Color and Shape:SolidMolecular weight:401.29Ref: TM-T78211
1mg84.00€5mg177.00€1mL*10mM (DMSO)195.00€10mg286.00€25mg512.00€50mg772.00€100mg1,153.00€740 Y-P(TFA)
740 Y-P(TFA)(1236188-16-1 free base) (740YPDGFR(TFA)) is a potent and cell-permeable activator of PI3K.Formula:C143H223F3N43O41PS3Purity:99.78%Color and Shape:SolidMolecular weight:3384.73740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formula:C143H226N43O41PS3Purity:99.92%Color and Shape:SoildMolecular weight:3330.79Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formula:C31H24F3N5O3Purity:97.34%Color and Shape:SolidMolecular weight:571.55Ref: TM-T13140
1mg177.00€5mg432.00€1mL*10mM (DMSO)532.00€10mg620.00€25mg1,108.00€50mg1,431.00€100mg1,783.00€PROTAC PI3K/110β degrader-1
CAS:PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Formula:C51H65N9O9SColor and Shape:SolidMolecular weight:980.18PROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Color and Shape:Odour SolidWYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formula:C28H32N8O3Purity:99.93%Color and Shape:SolidMolecular weight:528.61IHMT-PI3Kδ-372 S-isomer
CAS:IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Formula:C26H23F2N7O2Purity:99.97%Color and Shape:SoildMolecular weight:503.5Ref: TM-T60196
1mg109.00€2mg163.00€5mg241.00€1mL*10mM (DMSO)294.00€10mg354.00€25mg532.00€50mg745.00€100mg1,018.00€BAY1082439
CAS:BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Formula:C25H30N6O5Purity:98%Color and Shape:SolidMolecular weight:494.54(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Formula:C27H18F5N5O4SPurity:99.04%Color and Shape:SoildMolecular weight:603.52Ref: TM-T67837
1mg70.00€5mg133.00€1mL*10mM (DMSO)182.00€10mg210.00€25mg371.00€50mg532.00€100mg837.00€PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formula:C21H19ClN4O4Color and Shape:SolidMolecular weight:426.853PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withColor and Shape:Odour SolidRef: TM-L1300
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purity:99.75%Color and Shape:SoildMolecular weight:319.40Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Color and Shape:Odour SolidRef: TM-L1600
1mgTo inquire30μL*10mM (DMSO)To inquire50μL*10mM (DMSO)To inquire100μL*10mM (DMSO)To inquire250μL*10mM (DMSO)To inquireFDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.
Color and Shape:LiquidPI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Color and Shape:Odour SolidIHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Formula:C22H20F2N6O4Color and Shape:SolidMolecular weight:470.43PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formula:C20H25F3N8O4Purity:98.01%Color and Shape:SolidMolecular weight:498.46Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purity:99.66% - 99.74%Color and Shape:SolidMolecular weight:696.82Ref: TM-T5S1982
1mg35.00€5mg77.00€10mg106.00€1mL*10mM (DMSO)107.00€25mg170.00€50mg253.00€100mg375.00€500mg892.00€PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formula:C22H24N2O3Purity:98.92%Color and Shape:SolidMolecular weight:364.44Ref: TM-T28416
1mg40.00€2mg57.00€5mg97.00€1mL*10mM (DMSO)105.00€10mg156.00€25mg255.00€50mg368.00€100mg510.00€200mg700.00€Brevianamide F
CAS:Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.
Formula:C16H17N3O2Purity:97.30% - 98.82%Color and Shape:SolidMolecular weight:283.33
