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ATM/ATR

ATM/ATR

ATM (Ataxia Telangiectasia Mutated) and ATR (ATM and Rad3-related) are key kinases involved in the DNA damage response (DDR) that are activated in response to DNA double-strand breaks and replication stress. ATM/ATR inhibitors target these kinases, disrupting their ability to detect and repair DNA damage. This inhibition can lead to increased genomic instability and cell death, particularly in cancer cells that rely on robust DNA repair mechanisms for survival. ATM/ATR inhibitors are crucial tools in cancer research and therapy, especially in combination with DNA-damaging agents. At CymitQuimica, we provide a wide range of high-quality ATM/ATR inhibitors to support your research in DNA damage response, cancer biology, and therapeutic development.

Found 71 products of "ATM/ATR"

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  • ATR-IN-29
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    ATR-IN-29

    CAS:
    <p>ATR-IN-29, a potent, orally active inhibitor of ATR kinase, exhibits an IC50 of 1 nM and demonstrates antiproliferative activity [1].</p>
    Formula:C19H22N8O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:378.43

    Ref: TM-T79121

  • ATR-IN-13
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    ATR-IN-13

    CAS:
    <p>ATR-IN-13 is a potent inhibitor of ATR kinases (IC50: 2 nM) and can be used to study ATR kinase-mediated diseases (e.g. proliferative diseases, cancer).</p>
    Formula:C24H24FN9O
    Color and Shape:Solid
    Molecular weight:473.51

    Ref: TM-T63066

  • AZ 5704
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    AZ 5704

    CAS:
    <p>ATM kinase inhibitor with 0.6 nM IC50, &gt;600-fold selective, enhances irinotecan effects, oral use.</p>
    Formula:C23H23FN6O2
    Color and Shape:Solid
    Molecular weight:434.47

    Ref: TM-T35942

  • ATR-IN-8
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    ATR-IN-8

    CAS:
    <p>ATR-IN-8 is a potent inhibitor of ATR. ATR-IN-8 has shown potential research value in cancer diseases.</p>
    Formula:C20H22N6O2S
    Color and Shape:Solid
    Molecular weight:410.49

    Ref: TM-T62084

  • ATR-IN-22
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    ATR-IN-22

    CAS:
    <p>ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM and</p>
    Formula:C25H31N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:445.56

    Ref: TM-T79033

  • ATR-IN-20
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    ATR-IN-20

    <p>ATR-IN-20: potent ATR inhibitor, IC50=3nM; inhibits mTOR, IC50=18nM; selective vs PI3Kα, ATM, DNA-PK; good pharmacokinetics; anticancer.</p>
    Formula:C29H31N5O4S
    Color and Shape:Solid
    Molecular weight:545.65

    Ref: TM-T73301

  • ATR-IN-5
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    ATR-IN-5

    CAS:
    <p>ATR-IN-5 is a potent inhibitor of ATR, a member of the PIKK family of proteins involved in genome stability and DNA damage repair.</p>
    Formula:C27H32F3N9O
    Color and Shape:Solid
    Molecular weight:555.6

    Ref: TM-T63923

  • (S)-Ceralasertib
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    (S)-Ceralasertib

    CAS:
    <p>(S)-Ceralasertib: Potent, selective ATR inhibitor with strong preclinical physicochemical and PK profiles.</p>
    Formula:C20H24N6O2S
    Color and Shape:Solid
    Molecular weight:412.51

    Ref: TM-T12795

  • ATR-IN-21
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    ATR-IN-21

    CAS:
    <p>ATR-IN-21, also known as compound 60, is a potent inhibitor of ATR, exhibiting an IC50 of less than 1000 nM [1].</p>
    Formula:C23H27N7O
    Purity:98%
    Color and Shape:Solid
    Molecular weight:417.51

    Ref: TM-T79031

  • ATM-IN-1
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    ATM-IN-1

    CAS:
    <p>ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.</p>
    Formula:C30H36N6O3
    Color and Shape:Solid
    Molecular weight:528.65

    Ref: TM-T63714

  • Camonsertib
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    Camonsertib

    CAS:
    <p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>
    Formula:C21H26N6O3
    Purity:99.6% - 99.93%
    Color and Shape:Solid
    Molecular weight:410.47

    Ref: TM-T62083

  • AZ31
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    AZ31

    CAS:
    <p>AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of &lt;1.2 nM and 46 nM,</p>
    Formula:C24H28N4O3
    Purity:98.01%
    Color and Shape:Solid
    Molecular weight:420.5

    Ref: TM-T19671

  • Lartesertib
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    Lartesertib

    CAS:
    <p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>
    Formula:C23H21FN6O3
    Purity:99.9%
    Color and Shape:Solid
    Molecular weight:448.45

    Ref: TM-T62684

  • ATR-IN-17
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    ATR-IN-17

    CAS:
    <p>ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).</p>
    Formula:C22H28N6O2S
    Color and Shape:Solid
    Molecular weight:440.56

    Ref: TM-T62548

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    ATM Inhibitor-4

    <p>ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.</p>
    Formula:C26H29FN6O3
    Color and Shape:Solid
    Molecular weight:492.55

    Ref: TM-T63317

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    ATM Inhibitor-2

    <p>ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50&lt;1 nM).</p>
    Formula:C26H31N7O3
    Color and Shape:Solid
    Molecular weight:489.57

    Ref: TM-T63279

  • CymitQuimica logo
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    ATM Inhibitor-3

    <p>ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.</p>
    Formula:C25H29FN6O3
    Color and Shape:Solid
    Molecular weight:480.53

    Ref: TM-T63171

  • Decarbamoylmitomycin C
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    Decarbamoylmitomycin C

    CAS:
    <p>Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.</p>
    Formula:C14H17N3O4
    Color and Shape:Solid
    Molecular weight:291.302

    Ref: TM-T206609

  • WSD0628
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    WSD0628

    CAS:
    <p>WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].</p>
    Formula:C23H23F2N5O2
    Color and Shape:Solid
    Molecular weight:439.46

    Ref: TM-T87636

  • ATM Inhibitor-1
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    ATM Inhibitor-1

    CAS:
    <p>ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.</p>
    Formula:C27H36N6O3
    Purity:98%
    Color and Shape:Solid
    Molecular weight:492.61

    Ref: TM-T10396