Organosilicon Compounds

Applications (E)-2-(1-Butenyl)-1,3,2-benzodioxaborole (cas# 106094-36-4) is a compound useful in organic synthesis.

Applications Benzothiophene-5-boronic acid

Applications Allylboronic acid pinacol ester
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications 2-tert-Butyldimethylsilyloxyethyl Tosylate is an intermediate in the synthesis of Everolimus (E945400), which is Everolimus Macrolide immunosuppressant; Everolimus is a derivative of Rapamycin. Everolimus inhibits cytokine-mediated lymphocyte proliferation.
References Dumont, F.J., et al.: Curr. Opin. Invest. Drugs, 2, 1220 (2001), Kovarik, J. M., et al.: Clin. Pharmacol. Ther., 69, 48 (2001), Nashan, B., et al.: Ther. Drug Monit., 24, 53 (2002),

Stability Moisture Sensitive
Applications n-Octadecyltrichlorosilane (cas# 112-04-9) is a useful research chemical.
E0

Applications 3-Formylphenylboronic Acid is a reactant in the synthesis of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gosmini, R., et. al.: J. Med. Chem., 57, 8111 (2014)

Applications (5-Formylfuran-2-yl)boronic Acid is a reagent used in Suzuki cross-couplings with deactivated aryl bromides and activated aryl chlorides.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Trinh, T. N., et al.: Org. Biomol. Chem., 12, 9562-9571 (2014);

Applications B-(9-Phenyl-9H-carbazol-3-yl)boronic Acid is used in the synthesis of alkyl-functionalized organic dyes.
References Lee, E. et al.: Bull. Kor. Chem. Soc., 33, 293 (2012);

Applications 4-Ethylsulfonylphenylboronic acid is used in the discovery of small molecular RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis.
References Harris, P. A,, et al.: ACS Med. Chem. Lett., 4, 1238 (2013)

Applications 1-Butenylboronic Acid is a reagent used in the synthesis of polyene natural products.
References Lee, S. J., et al.: J. Am. Chem. Soc., 130, 466-468 (2008)

Applications tert-Butyldiphenylchlorosilane is used to synthesize interphenylene phenyloxazoles, compounds that have antagonistic activity against thromboxane receptors which can be used for treatment of circulatory disorders, angina and stroke.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hadjipavlou–Litina, D. & Kontogiorgis, C.: Int. Elect. J. Mol. Des., 1, 300 (2002); Misra, R., et al.: Bioorg. Med. Chem. Lett., 2, 937 (1992)

Applications Perphenylcyclopentasilane is an intermediate in the synthesis of Cyclopentasilane (C988380), a reagent used for depositing silicon on surfaces for electronics applications.
References Morisaki, Y., et al.: Chem. Lett., 38, 498 (2009);

Applications 4-Acetylphenylboronic acid4-Acetylphenylboronic Acid is used in several metal catalyzed cross-coupling reaction studies.
References Saito, S., et al.: J. Org. Chem., 2, 8024 (1997); Sakai, M., et al.: Organomet., 16, 4229 (1997); Molander, G., et al.: J. Org. Chem., 68, 4302 (2003);

Impurity Paclitaxel - In House Impurity
Applications Protected Baccatin III. Paclitaxel - In House Impurity.

Applications 4-(Cyanophenyl)boronic Acid Pinacol Ester is used to prepare arylparacyclophanes via Suzuki aryl cross-coupling of bromoparacyclophane with arylboronic acid and arylboronates. It’s also used to prepare tyrosine-modified analogs of α4β7 integrin inhibitor biotin-R8ERY.
References Roche, A., et al.: Org. Biomol. Chem.,, 3, 515 (2005); Papst, S., et al.: Bioorg. Med. Chem., 20, 5139 (2012)