Cytoskeletal Signaling
Cytoskeletal signaling inhibitors are compounds that disrupt the signaling pathways regulating the cytoskeleton, which is crucial for cell shape, motility, division, and intracellular transport. These inhibitors are used to study the dynamics of cytoskeletal proteins, such as actin and tubulin, and their role in processes like cell migration, adhesion, and cancer metastasis. Cytoskeletal signaling inhibitors are valuable in research on cell biology, cancer, and neurobiology. At CymitQuimica, we offer a comprehensive range of high-quality cytoskeletal signaling inhibitors to support your research in these areas.
Found 1382 products of "Cytoskeletal Signaling"
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Chromeceptin
CAS:<p>Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway.</p>Formula:C19H16F3N3OPurity:99.85%Color and Shape:SoildMolecular weight:359.35SMART1
<p>SMART1 is a CRBN-dependent PROTAC with high specificity that effectively degrades Smurf1. It inhibits tumor growth in xenograft models of colorectal cancer (CRC) with KRAS mutations and blocks the PDK1-Akt signaling pathway in KRAS-mutated colorectal cancer.</p>Formula:C40H35N9O7Color and Shape:SolidMolecular weight:753.76DSPE-PEG1000-iRGD
<p>DSPE-PEG1000-iRGD is a PEG compound made from DSPE and the αv-integrin-targeting peptide (iRGD). The iRGD peptide initially binds to αv-integrins and undergoes proteolytic cleavage within tumors to produce CRGDK/R, which interacts with neuropilin-1, thereby facilitating tumor targeting and penetration. DSPE-PEG1000-iRGD is useful for drug delivery applications.</p>Color and Shape:Odour SolidHypoglycemic agent 3
<p>Compound H26, a derivative of corosolic acid, functions as Hypoglycemic agent 3. It exhibits lipid-lowering and significant blood glucose-reducing properties, making it a potential hypoglycemic drug. Hypoglycemic agent 3 targets MCCC1 to mitigate insulin resistance, and may be useful in researching type 2 diabetes.</p>Formula:C32H51NO5Color and Shape:SolidMolecular weight:529.751NMS-E973
CAS:<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of <10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>Formula:C22H22N4O7Purity:99.84%Color and Shape:SolidMolecular weight:454.43Orbofiban acetate
CAS:<p>Orbofiban Acetate is a compound that serves as an antagonist to the platelet GPIIb/IIIa receptor, effectively inhibiting platelet aggregation when administered</p>Formula:C19H27N5O6Color and Shape:SolidMolecular weight:421.45PDK-IN-1
CAS:<p>PDK-IN-1, a PDK inhibitor, IC50: 0.03μM (PDK1), 0.1μM (HSP90), reduces tumor mass.</p>Formula:C20H16BrN7OColor and Shape:SolidMolecular weight:450.29AKT1-IN-9
<p>AKT1-IN-9 (4) is a selective inhibitor of the AKT1(E17K) mutation, exhibiting EC50 values of 9 nM in LAPC4-CR cells and 995 nM in SkBr3 cells.</p>Formula:C33H25FN6O4Color and Shape:SolidMolecular weight:588.588Davunetide
CAS:<p>Davunetide: neuroprotective 8-amino acid peptide, improves daily function in schizophrenia, boosts memory in mild cognitive impairment.</p>Formula:C36H60N10O12Purity:98%Color and Shape:SolidMolecular weight:824.92Akt1-IN-1
<p>Akt1-IN-1: Potent, selective Akt1 inhibitor, IC50 18.79 nM, non-teratogenic/hepatotoxic/cardiotoxic, useful in cancer research.</p>Formula:C31H34FN5O5S2Color and Shape:SolidMolecular weight:639.76Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Color and Shape:Odour SolidR-BC154 acetate
<p>R-BC154 acetate: selective α9β1 antagonist, high-affinity integrin probe for α9β1/α4β1 activity study.</p>Formula:C56H65N9O14S3Color and Shape:SolidMolecular weight:1184.362119738-71-3
CAS:<p>Compound 2119738-71-3 interacts with the FAK receptor.</p>Formula:C25H29ClFN7O2Purity:98%Color and Shape:SolidMolecular weight:513.99SNIPER(ABL)-050
<p>SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker.</p>Formula:C68H84N12O9Purity:98%Color and Shape:SolidMolecular weight:1213.47FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Color and Shape:LiquidSIAIS100
<p>SIAIS100, a potent BCR-ABL PROTAC degrader, demonstrates a DC50 value of 2.7 nM, highlighting its efficacy.</p>Formula:C44H50ClF2N9O5SColor and Shape:SolidMolecular weight:890.44Besufetamig
CAS:<p>Besufetamig is a bispecific antibody targeting programmed cell death protein 1 (PD-1) and the CD3ε chain. It modulates immune cell activity, exerting both immunosuppressive and antitumor effects. Besufetamig holds promise for cancer research.</p>Color and Shape:LiquidCeratamine A
CAS:<p>Ceratamine A, from Pseudoceratina sponge, is a cytotoxic, microtubule-stabilizing antimitotic alkaloid.</p>Formula:C17H16Br2N4O2Purity:98%Color and Shape:SolidMolecular weight:468.14AKTide-2T
CAS:<p>Peptide substrate for Akt/PKB</p>Formula:C74H114N28O20Purity:98%Color and Shape:SolidMolecular weight:1715.87BCR-ABL-IN-3
CAS:<p>BCR-ABL-IN-3 irreversibly inhibits Bcr-Abl with <100 nM IC50, showing significant anti-cancer effects.</p>Formula:C20H17ClF2N4O3SColor and Shape:SolidMolecular weight:466.89MS15 TFA
<p>MS15 TFA is a potent, selective AKT PROTAC degrader, effectively inhibiting AKT1, AKT2, and AKT3 with IC50 values of 798 nM, 90 nM, and 544 nM, respectively [1</p>Formula:C66H80F3N11O7SPurity:98%Color and Shape:SolidMolecular weight:1228.47Tubulin inhibitor 38
<p>Tubulin Inhibitor 38 (Compound 14), a tetrazole-based agent, demonstrates significant antiproliferative effects by inducing mitotic arrest and blocking the cell</p>Formula:C17H13ClN6OSColor and Shape:SolidMolecular weight:384.84EMD527040
CAS:<p>EMD527040 is a potent αvβ6 antagonist with antifibrotic effects, used in carcinoma and liver fibrosis research.</p>Formula:C29H32Cl2N4O5Color and Shape:SolidMolecular weight:587.5p5 Ligand for Dnak and DnaJ
CAS:<p>P5 is a nonapeptide ligand for DnaK/DnaJ, mimicking the key sites of mitochondrial aspartate aminotransferase presequence.</p>Formula:C44H81N15O11SPurity:98%Color and Shape:SolidMolecular weight:1028.27Box5 TFA
<p>Box5 TFA, a potent Wnt5a antagonist, impedes Wnt5a signaling, restricts Wnt5a-initiated Ca2+ release, and hampers cell migration, showing promise for melanoma</p>Formula:C32H51F3N6O15S2Color and Shape:SolidMolecular weight:880.9Filanesib TFA
CAS:<p>Filanesib (ARRY-520) inhibits KSP, triggering mitotic arrest and cell death in dividing tumor cells.</p>Formula:C22H23F5N4O4SPurity:98%Color and Shape:SolidMolecular weight:534.5MS21
CAS:<p>MS21 is a unique AKT degrader that selectively hampers the proliferation of cancers with mutations in the PI3K/PTEN pathway, alongside wild-type KRAS and BRAF.</p>Formula:C58H79ClN12O6SColor and Shape:SolidMolecular weight:1107.86Anticancer agent 139
<p>Compound 6h (Anticancer Agent 139) exhibits potent anticancer activity, engaging in a π-cationic interaction with Lys352 of Tubulin and demonstrating high</p>Formula:C16H12F3N3OColor and Shape:SolidMolecular weight:319.28MS143
CAS:<p>MS143: potent AKT degrader, DC50=46 nM, GI50=0.8 µM in PC3 cells, degrades AKT via ubiquitin-proteasome, suppresses cancer growth.</p>Formula:C59H81ClN12O6SColor and Shape:SolidMolecular weight:1121.87Echistatin
CAS:<p>Potent αVβ3 integrin blocker, stops osteoclast binding & bone loss, hinders platelet aggregation. Ki=0.27 nM, IC50s: 0.1 nM (bone), 30 nM (platelets).</p>Formula:C217H341N71O74S9Purity:98%Color and Shape:SolidMolecular weight:5417.111H-Benzo[a]carbazole
CAS:<p>11H-Benzo[a]carbazole is a kinesin-like protein KIF11 inhibitor that can inhibit the viability of HeLa cells.</p>Formula:C16H11NPurity:99.14%Color and Shape:SolidMolecular weight:217.27Combretastatin A-1 phosphate tetrasodium
CAS:<p>OXi-4503, a prodrug of Combretastatin A-1, disrupts tubulin, inhibits Wnt/β-catenin and AKT, and has anti-tumor/vascular effects.</p>Formula:C18H18Na4O12P2Color and Shape:SolidMolecular weight:580.24BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formula:C21H16N2O6Color and Shape:SolidMolecular weight:392.36trans-Dehydrocurvularin
CAS:<p>trans-Dehydrocurvularin is a useful organic compound for research related to life sciences. The catalog number is T125357 and the CAS number is 21178-57-4.</p>Formula:C16H18O5Color and Shape:SolidMolecular weight:290.315SNIPER(ABL)-020
<p>SNIPER(ABL)-020, a Dasatinib-Bestatin conjugate via linker, inhibits ABL and targets IAP, reducing BCR-ABL protein.</p>Formula:C44H59ClN10O8SPurity:98%Color and Shape:SolidMolecular weight:923.52Myrtucommulone
CAS:<p>Myrtucommulone is an inhibitor of the chaperonin activity of HSP60, correlating to LRP130 and LONP aggregation.</p>Formula:C38H52O10Purity:98%Color and Shape:SolidMolecular weight:668.81Phosphatidylserines (bovine)
CAS:<p>Phosphatidylserine: a natural phospholipid, 2-10% in mammals, CNS-rich, synthesized in ER, involved in cell signaling, apoptosis marker.</p>Formula:C42H78NO10P(foroleoyl)Color and Shape:SolidMolecular weight:788.1Echistatin TFA
<p>Echistatin TFA: a minimal RGD protein from snake venom; inhibits platelet aggregation and bone resorption; targets αIIbβ3, αvβ3, α5β1.</p>Color and Shape:Odour SolidTubulin polymerization-IN-46
<p>Tubulin polymerization-IN-46 (compound 9q) is a microtubule/tubulin inhibitor that impedes tubulin polymerization, induces apoptosis, and arrests MCF-7 breast</p>Formula:C22H25NO6Color and Shape:SolidMolecular weight:399.44PU-H71 HCl
CAS:<p>PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT.</p>Formula:C18H22ClIN6O2SPurity:98.95%Color and Shape:SoildMolecular weight:548.83Anti-inflammatory agent 60
<p>Anti-inflammatory agent 60 (compound 21) inhibits nitric oxide production, presenting an IC50 of 12.95 μM, and reduces iNOS, phosphorylated p65, and β-catenin</p>Purity:98%Color and Shape:Odour Solid10-Oxo Docetaxel
CAS:<p>10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties.</p>Formula:C43H51NO14Purity:98%Color and Shape:SolidMolecular weight:805.874SNIPER(ABL)-019
<p>SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a</p>Formula:C60H77ClN12O9SPurity:98%Color and Shape:SolidMolecular weight:1177.853-Phenyltoxoflavin
CAS:<p>3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.</p>Formula:C13H11N5O2Purity:99.88%Color and Shape:SolidMolecular weight:269.26Coronaridine
CAS:<p>Coronaridine is a useful organic compound for research related to life sciences. The catalog number is T124824 and the CAS number is 467-77-6.</p>Formula:C21H26N2O2Color and Shape:SolidMolecular weight:338.451MK2-IN-5
CAS:<p>MK2-IN-5, a pseudosubstrate of Mk2 with an inhibition constant (K_i) of 8 μM, selectively targets the protein interaction domain of the MAPK pathway and</p>Formula:C61H113N21O16Purity:98%Color and Shape:SolidMolecular weight:1396.68DynaMin inhibitory peptide, myristoylated
CAS:<p>Cell-permeable dynamin inhibitor; blocks its binding to amphiphysin, hindering endocytosis; curbs NMDA receptor internalization.</p>Formula:C61H107N19O14Purity:98%Color and Shape:SolidMolecular weight:1330.64Blosozumab
CAS:<p>Blosozumab (LY2541546) is a monoclonal antibody targeting sclerostin that promotes bone formation, used in the research of osteoporosis.</p>Purity:98.7% (SEC-HPLC) - 99.53% (SEC-HPLC)Color and Shape:LiquidGamitrinib TPP
CAS:<p>Gamitrinib TPP targets mitochondrial HSP90, inhibiting cancer, and blocks mitochondrial matrix.</p>Formula:C52H65N3O8PPurity:98%Color and Shape:SolidMolecular weight:891.078Catumaxomab
CAS:<p>Catumaxomab is a rat-mouse hybrid lgG2 monoclonal and bispecific antibody that binds to the antigens CD3 and EpCAM for malignant ascites in cancer patients.</p>Purity:95%Color and Shape:Liquid
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