Deuterated Compounds

<p>Applications Phenylglyoxylic Acid-d5 (cas# 1217089-53-6) is a compound useful in organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications Tris(2-ethylhexyl) Phosphate-d51 is labelled Tris(2-ethylhexyl) Phosphate (T884650) which is used as a phosphorous flame retardant. Tris(2-ethylhexyl) Phosphate (T884650) is also used as a plasticizer in the preparation of a new potentiometric membrane sensor.<br>References Ballesteros-Gomez, A. et al.: Anal. Chem., 85, 9572 {2013); Gholivand, M. et al.: Adv. Sci. Eng. Med., 5, 73 (2013);<br></p>

<p>Applications Labelled Butylparaben. An antimicrobial agent used in cosmetic products.<br>References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),<br></p>

<p>Applications A labelled metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine. An effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.<br>References Loo, T.L. et al.: Cancer Chemother. Pharmacol., 6, 131 (1981); Yuan, B. et al.: ACS Chem. Biol., 5, 1021 (2010); Kroplin, T. et al.: Adv. Exp. Med. Biol., 431, 741 (1998);<br></p>

<p>Applications 1,3,5-Tribromobenzene-d3 (CAS# 52921-77-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 2,3-Butanedione (B690030). 2,3-Butanedione (Diacetyl), the molecule implicated in the disease known as popcorn lung, has now been implicated in amyloid-β peptide toxicity associated with Alzheimer’s disease. Diacetyl accelerates amyloid-β aggregation-a hallmark of Alzheimer’s disease. These preliminary finding raise the possibility of long-term neurological toxicity mediated by DA.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, J., et al.: Exp. Neurol., 158, 328 (1999); Brown, M., et al.: Cell, 100, 391 (2000); Heinitz, K., et al.: J. Neurochem., 98, 1930 (2006); Brody, D., et al.: Science, 321, 1221 (2008); More, S., et al.: J. Med. Chem., 52, 4650 (2009);<br></p>

<p>Applications Pyruvic Acid-13C2 is an intermediate in synthesizing L-Lactic Acid-d3 Sodium Salt (L113503), a labelled sodium salt of L-Lactic Acid (L113500). L-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity. L-(+)-Lactic acid is also present in liver, kidney, thymus gland, human amniotic fluid, and other organs and body fluids.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001); Martinez., et al.: Development, 6, 851 (2002); Nakayama, K., et al.: J. Biochem., 146, 757 (2009); Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009)<br></p>

<p>Applications n-Octacosane-d58 (CAS# 16416-33-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pinoxaden-d3 is a deuterized labeled form of Pinoxaden (P469505), which is derived from Diethylene Glycol Dimethanesulfonate (D444275), an intermediate in the production of alkylating agents.<br>References Wong, I., et al.: J. Med. Chem., 52, 5311 (2009); Muehlebach, M., et al.: Bioorg. Med. Chem., 17, 4241 (2009)<br></p>

<p>Applications A labelled chloropropanol which shows toxic effects.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andersen, H., et al.: Toxicology, 136, 67 (1999), Fry, J., et al.: Food Chem. Toxicol., 37, 351 (1999), Garle, M., et al.: Xenobiotica, 29, 533 (1999),<br></p>

<p>Applications Choline-d13 Chloride (N,N,N-trimethyl-d9; 1,1,2,2-d4) (CAS# 352438-97-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Compound forms a complex with Mefenamic acid increasing its transdermal permeation properties<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fang, L., et al.: J. Pharm. Sci., 93, 144 (2004), Gibellini, F., et al.: Biochem. J., 415, 135 (2008),<br></p>

<p>Applications Isovaleryl L-Carnitine-d3 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications N-Boc-piperazine-d8 is a useful synthetic intermediate for the preparation of labelled compounds.<br></p>

<p>Applications Labelled Fenhexamid (F247650). Hydroxyanilide fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamashita, M., et al.: J. Phys. Chem., 88, 4451 (1984), Kende, A., et al.: Microchem. J., 84, 63 (2006),<br></p>

<p>Applications The labelled analogue of a versatile ethylenediamine derivative used as an intermediate in the organic synthesis of neurochemicals, antitumor agents and other pharmaceutical compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Squires, R.F. et al.: Neurochem. Res., 18, 787 (1993); Murdock, K.C. et al.: J. Med. Chem., 22, 1024 (1974);<br></p>

<p>Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5<br></p>

<p>Applications n-Dotriacontane-d66 (CAS# 62369-68-0) is a useful isotopically labelled research compound. It has been studied as a potential generator to supply charged particles to plastic nuclear track detectors for high-energy neutrons.<br>References Oda, K., et al.: Radiation Measurements, 36, 119 (2003)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled rac 3-Hydroxybutyric Acid (H833020). Optically active 3-hydroxybutyric acids are key intermediates of the biosynthesis and metabolism of fatty acids and exist widely in biological systems.<br>References Freeman, J., et al.: Pediatrics, 102, 1358 (1998), Thio, L., et al.: Neurology, 54, 325 (2000), Rho, J., et al.: Epilepsia, 43, 358 (2002),<br></p>

<p>Applications Ethyl Paraben-d4 is the labeled analogue of Ethyl Paraben (E925475), an antimicrobial agent used in cosmetic products.<br>References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications Isovaleryl L-Carnitine-d9 Chloride is labelled Isovaleryl L-Carnitine Chloride (I917580) which is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications Cyclopropyl-d5-amine is labelled Cyclopopylamine (C989140) which can inactivate major human drug-metabolizing cytochromes P450 enzymes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shaffer C., et al.: J. Am. Chem. Soc., 123, 8502 (2001); Polasek, T., et al.: Brit. J. Clin. Pharmaco., 61, 570 (2006)<br></p>

<p>Applications Labelled TEPA (T776600). Used as insect chemosterilant; in dyeing. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969), Huitema, A., et al.: Br. J. Clin. Pharmacol., 51, 61 (2001), Jinno, H., et al.: Drug Metab. Dispos., 31, 398 (2003),<br></p>

<p>Applications Suberic Acid-d4, is a labeled analogue of Suberic Acid (S688670), which is used in the preparation of reduction-sensitive micelles affecting their cellular uptake. This has potential application in delivery of anticancer drugs. It is also used in the fluorescent detection of amidinium-carboxylate and amidinium formation.<br>References Cui, C. et al.: Biomat., 34, 3858 (2013); Kusukawa, T. et al.: Tetra., 68, 9973 (2012);<br></p>

<p>Applications A labelled metabolite of Theophylline.<br>References ottrup, A., et al.: Pharmacol. Toxicol., 67, 340 (1990), El-Kadi, A., et al.: Drug Metab. Dispos., 28, 1112 (2000), Kim, S., et al.: J. Med. Chem., 45, 2131 ( 2002), Hansel, T., et al.: Drugs Today, 40, 55 (2004),<br></p>

<p>Applications Ethane-d5-thiol (CAS# 61260-03-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled herbicide<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),<br></p>

<p>Applications 4-Dimethylaminosulfotoluidide-d7 is an isotope labelled intermediate in the synthesis of Tolylfluanide (T536730), a polyvalent sulfamide fungicide that is closely related to dichlofluanide.<br>References Wainwright, A. et al.: Bright. Crop Prot. Conf. Pests Dis., 1, 275 (1996)<br></p>

<p>Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (Pyridine)-N-oxide (D293280); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Applications Ethanolamine-13C2 is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);<br></p>

<p>Applications (±)-Fluazifop-d4 is a labeled analogue of (±)-Fluazifop (F407430), a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walker, K.A., et. al.: Biochem. J., 254, 307 (1988); Hajslova, J., et. al.: J. Chrom., 438, 55 (1988)<br></p>

<p>Applications Azoniaspironortropanol-d8 Chloride is the labeled analogue of Azoniaspironortropanol Chloride (A965125), an intermediate used for the synthesis of Trospium Chloride (T892800), an Antispasmodic, used in treatment of urinary incontinence.<br>References Antweiler, H., et al.: Arzneim.-Forsch., 16, 1581 (1966); Lux, G., et al.: Fortschr. Med., 96, 2113 (1978); Madersbacher, H., et al.: Br. J. Urol., 75, 452 (1995); Zinner, N.R., et al.: Expert Opin. Pharmacother., 6, 1409 (2005)<br></p>

<p>Applications A labelled metabolite of Malachite Green in seafood products. A labelled triphenylmethane dye with fungicidal and limited antiseptic activity. The term Malachine green applies to the oxalate as well as the chloride. Harmful if swallowed. Avoid release to the environment.<br>References Carter, S.G., et al.: J. Biochem. Biophys. Methods, 7, 7 (1982), Saikan, S., et al.: J. Chem. Phys., 79, 4154 (1983), Clemmensen, S., et al.: Arch. Toxicol., 56, 43 (1984),<br></p>

<p>Applications A deuterated acyclic nucleotide.<br></p>

<p>Applications Decanoyl-10,10,10,d3-L-carnitine Chloride is the isotope labelled analog of Decanoyl-L-carnitine Chloride (D212580); a metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Eprinomectin-13CD3 is an isotopic analog of Eprinomectin (E590050), a mixture of semi-synthetic Avermectins.<br>References Jones, T.K., et al.: J. Agric. Food Chem., 42, 1786 (1994), Arena, J.P., et al.: J. Parasitol., 81, 286 (1995),<br></p>

<p>Applications Carbetamide-D5 is the labelled analogue of Carbetamide (C178028). Carbetamide is used in the determination of pesticides.<br>References Jia, W., et al.: Journal of Chromatogr. A., 1395, 160-166 (2015)<br></p>

<p>Stability Light and temperature Sensitive<br>Applications 2,2-Dichloroacetic Acid-1-13C is derived from Barium Carbonate-13C (B118672), which is a stable Barium Carbonate isotope used for studies on drug metabolism.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horie, M. et al.: Yakug. Zas., 97, 805 (1977);<br></p>

<p>Applications 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine-d6 (Major) is a labeled analogue of 2,7-Diisopropyl-9,9-dimethyl-9,10-dihydroacridine (D455760), a useful chemical reagent. Also, it is derived from 9,9-Dimethyl-9,10-dihydroacridine (D474300), which are currently being used in the development of thermally activated delayed fluorescence (TADF) molecules which are being researched for their possible efficient deep-​blue TADF emitting potential.<br>References Kwon, D.Y., et al.: J. Nanosci. Nanotechnol., 15, 7828-31 (2015); Wada, Y., et al.: Adv. Mater., 30 (2018).<br></p>

<p>Applications Labelled 4-Nonyl Phenol (N650430). Used in the process for the manufacture of 5-nonyl salicylaldoxime, which is used for the selective purification and concentration of copper ions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Ethylparaben. An antimicrobial agent used in cosmetic products.<br>References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),<br></p>

<p>Applications Dibutyldiethyltin belongs to a class of organotin compounds that are commonly used as pesticides and fungicides and as plastics additives. Diphenyltin Dichloride is an environmental pollutant with potential antitumor activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Khosa, R.L. et al.: Sci. Cult., 35, 637 (1969); Hamasaki, T. et al.: Mutat. Res. Gen. Toxicol. Test., 300, 265 (1993); Peng, J.: Yaox. Xueb., 29, 406 (1994);<br></p>

<p>Applications tert-Butyl Alcohol-d10 is an isotopic analog of Tert-butyl Alcohol (T117540), an organic solvent. It is also used in the synthesis of proteosome inhibitors that are quite potent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kawamura, S. et al.: J. Med. Chem., 56, 3689 (2013); Galy, N. et al.: Tetrahedron Lett., 54, 2703 (2013)<br></p>

<p>Applications 2,6-Dichloroaniline-3,4,5-d3 (CAS# 77435-48-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled active ingredient formulation to prepare agrochemicals and drugs in amorphous form.<br>References Blair, A.M., et al.: J. Agr. Sci., 139, 385 (2002),<br></p>

<p>Applications Post-emergence sulfonylurea herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gubbiga, N.G., et al.: Weed Technol., 9, 574 (1995), Ukrainczyk, L., et al.: J. Agric. Food Chem., 43, 855 (1995)<br></p>

<p>Applications Labelled Trimethylsulfoxonium Iodide (T797500). Used to synthesize methylene-transfer reagents that are used in the preparation of epoxides.<br>References Bravo, P. et al.: Gaz. Chim. Ital., 11, 501 (1986); Okuma, K. et al.: Fuk. Daig. Rig. Shuho, 20, 83 (1990)<br></p>

<p>Applications 4-Aminophenol-15N is an intermediate in the synthesis of Acetaminophen-13C2,15N (A161228), a labelled analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis.<br></p>

<p>Applications Labelled Sodium Formate is used in various organic reactions and syntheses. It is used in the preparation of [3,2b]pyridines as well as the palladium-catalyzed coupling of vinyl triflates with organostannanes.<br>References Mathes, B. et al.: Tetra., 44, 725 (2003); Scott, W. et al.: J. Am. Chem. Soc., 108, 3033 (1986);<br></p>

<p>Applications Isotope labelled Hexadecyltrimethylammonium Bromide (CTAB) (H293860), is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yu, H.-h., et al.: Gongneng Cailiao, 42, 2005 (2011),<br></p>

<p>Applications Bisphenol AF-d4 is the isotope labelled analog of Bisphenol AF (2,2-Bis-(4-hydroxyphenyl)hexafluoropropane). 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane (B447290) acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.<br>References Matsushima, A. et al.: Environ. Health, Perspect. 118, 1267 (2010)<br></p>

<p>Applications Cyclopentanone-2,2,5,5-d4 (CAS# 3997-89-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Ethyl-2-hydroxysuccinimide-d5 is the isotope labelled analog of N-Ethyl-2-hydroxysuccinimide (E919180); a metabolite of N-ethyl-2-pyrollidone (NEP) which is a frequently used industrial solvent shown to be embryotoxic in animal experiments.<br>References Schindler, B.K., et al.: Anal. Chem., 84, 3787 (2012)<br></p>

<p>Applications Hydantoin-5-13C,1-15N (cas# 1189697-61-7) is a compound useful in organic synthesis.<br></p>

<p>Applications PyroPyronaridine-13C2 , d4 Tetraphosphate Salt is the labeled analogue of Pyronaridine (P997640), an antimalarial drug.<br>References Lee, D.W., et. al.: B. Kor. Chem. Soc., 35, 521 (2014)<br></p>

<p>Applications Labelled Morpholine. Morpholines compounds used as selective inhibitors of cytochrome p450 2a13 in treatment of cancer. Salicylate as analgesic; antipyretic; anti-inflammatory.<br> E0<br>References Paladini, D., et al.: Biochem., 48, 5760 (2009), Bard, B., et al.: J. Med. Chem., 52, 3416 (2009),<br></p>

<p>Applications Useful for diagnostic determination of Melamine and related compounds in kidney tissue.<br>References Mast, R., et al.: Food Chem. Toxicol., 21, 807 (1983), Yokley, R., et al.: J. Agric. Food Chem., 48, 3352 (2000), Ehling, S., et al.: Food Addit. Contam., 24, 1319 (2007), Vail, T., et al.: J. Anal. Toxicol., 31, 304 (2007),<br></p>

<p>Applications Labelled Succinic Anhydride is used in the synthesis of propanoyloxy derivatives used as drug absorption modifiers. In addition it is a reagent for novel non-carboxylate inhibitors of AKR1C3<br>References Coufalova, L. et al.: Steroids, 78, 435 (2013); Heinrich, D. et al.: Eur. J. Med. Chem., 62, 738 (2013);<br></p>

<p>Applications Labelled Isonicotinic Acid (I821760). Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>

<p>Applications Nonanal-d18, is the labeled analogue of Nonanal (N649330), a component of essential oils. Nonanal possesses a strong fruity odor. Essential oils have varying effects from antibacterial activity to hypolipidemic activity.<br>References Zorrilla-Fontanesi, Yet al.: Plant. Phys., 159, 851 (2012): Taherkhani, M. et al.: Asian. J. Chem., 24, 1461 (2012); Ahmadvand, H. et al.: Iran. J. Pharm. Res., 11, 1219 (2012);<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications L-Allo-isoleucine-d10 is a derivative compound of L-allo-isoleucine (A548200), which has been suggested to induce epithelial β-defensin expression. In addition, L-allo-isoleucine is utilized in the biosynthesis pathway for coronamic acid.<br>References Fehlbaum, P., et al.: Proc. Natl. Acad. Sci. USA 97, 12723 (2000); Parry, R. J., et al.: J. Am. Chem. Soc. 113, 1849 (1991)<br></p>

<p>Applications 1,4-Naphthoquinone-d6 (CAS# 26473-08-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Propafenone (P757500) impurity.<br>References Kitagawa, S., et al.: Biol. Pharm. Bull., 29, 1 (2006), Boccard, J., et al.: Eur. J. Pharm. Sci., 36, 254 (2009)<br></p>

<p>Applications Isotope labelled 1-Bromobutane (B681830) is used in the synthesis of specifically-deuterated procaine and tetracaine.<br>References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),<br></p>

<p>Applications Isotope labelled Tripropyl phosphate is an organophosphorus flame retardant and plasticizer. Phosphorus Flame Retardant<br>References Bacaloni, A., et al.: Environ. Sci. Technol., 42, 1898 (2008)<br></p>

<p>Applications Labelled Isopropylparaben. An antimicrobial agent used in cosmetic products.<br>References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),<br></p>

<p>Applications Labelled Veratric Acid, a derivative of Protocatechuic Acid. Veratric Acid is a reagent used in the production of antimicrobial agents, antifeedants, and a variety of other biologically active compounds.<br>References Alissandrakis, E. et al.: Eur. Food Res. Technol., 229, 365 (2009); Spaccini, R. et al.: Soil Biol. Biochem., 41, 1164 (2009); Narasimhan, B. et al.: Eur. J. Med. Chem., 44, 689 (2009); Pereira, L. et al.: J. Biotechnol., 139, 68 (2009);<br></p>

<p>Applications Valeric Acid-d9 is the isotope labelled analog of Valeric Acid which is used in biological studies of (D)-β-hydroxybutyrate which inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Taggart, A.K.P., et al.: J. Bio. Chem., 280, 26649 (2005);<br></p>

<p>Applications DL-p-Hydroxyphenyllactic Acid-d3 is the isotope labelled analog of DL-p-Hydroxyphenyllactic Acid (H953665); a reagent in the synthesis of 2-O-(4-coumaroyl)-3-(4-hydroxyphenyl)lactic acid which is an important intermediate of rosmarinic acid biosynthesis.<br>References Matsuno, M., et al.: Chem. Pharm. Bull., 49, 1644 (2001)<br></p>

<p>Applications Labelled Sulfamonomethoxine. Protein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.<br>References Bridges, et al.: Biochem. J., et al.: 96, 829 (1965), Hong, Y.-L., et al.: Antimicrob. Agents Chemother., 39, 1756 (1995)<br></p>

<p>Applications 2,6-Dimethylphenol-d9 (Major) (cas# 1021325-40-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled Mecoprop (M203052). Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gagne, F., et al.: Environ. Res., 103, 238 (2007), LaChapelle, A., et al.: Reprod. Toxicol., 23, 20 (2007),<br></p>

<p>Applications Labelled Coumarin (C755380). Pharmaceutic aid (flavor). Found in tonka beans, levender oil, woodruff, sweet clover.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hazleton, L., et al.: J. Pharmacol. Exp. Ther., 118, 348 (1956), Lake, B., et al.: Food Chem. Toxicol., 37, 423 (1999), Frerot, E., et al.: Flavour Fragrance J., 17, 218 (2002), Yang, Z., et al.: Food Chem., 114, 289 (2009),<br></p>

<p>Applications Isotope labelled Ammelide (A633650), which is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10. 2. Ehling S. et al.: Food Addit. Contam. 2007 Dec;24(12):1319-25.3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>

<p>Applications Nitrogen 15 labelled analogue of Adenosine (A280400), a purine nucleoside that plays an important role in various biochemical processes.<br>References Long, X., et al.: J. Pharmacol. Exper. Ther., 335, 781 (2010); Ham, M., et al.: J. Pharmacol. Exper. Ther., 335, 607 (2010)<br></p>

<p>Applications Benzidine-d8 is involved in the enhancements in ion abundances in high-performance liquid chromatography, thus improving chromatography efficiency and particle-beam process.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bellar, T. A., et al.: J. Am. Soc. Mass. Spectrom., 1, 92-8 (1990)<br></p>

<p>Applications A labelled form of Pirimicarb (P508768) which is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuchiyama, T.; et al.: Journal of Chromatography A, 1524, 233 (2017).<br></p>

<p>Applications Metabolite of Salicylic Acid (S088125).<br>References Jurkowski, W., et al.: Current Drug Metab., 10, 448 (2009), Appeldoorn, M., et al.: J. Agric. Food Chem., 57, 7693 (2009), van Oijen, M., et al.: Pharmacol., 83, 237 (2009),<br></p>

<p>Applications Labelled Benzothiazole. Various benzothiazole-benzamides synthesized were evaluated for their analgesic and antidepressant activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Porsolt, R., et al.: Nature, 266, 730 (1977), Foster, J., et al.: Bioorg. Med. Chem., 7, 2415 (1999), Caliendo, G., et al.: Eur. J. Med. Chem., 36, 517 (2001), Rana, A., et al.: Eur. J. Med. Chem., 43, 1114 (2008),<br></p>

<p>Applications A labelled form of Fenoxycarb (F248870), a carbamate insect growth regulator by preventing immature insects from reaching maturity by mimicking juvenile hormone. Used as a standard for Pesticide detection. Fenoxycarb is also used in cannabis testing kits as a component of pesticide mixes (P698235).<br>References El-Saeid, M.H., et al.: J. Chem., 10, (2013); Coors, A., et al.: Environ. Toxicol. Chem., 31, 1239 (2012);<br></p>

<p>Applications 1,10-Decanedioic-d16 Acid (CAS# 73351-71-0) is a useful isotopically labelled compound for studying saturated fatty acids.<br>References Yamada, T., et al.: Adv. Synth. Catal., 358, 3277 (2016)<br></p>

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4,5-Dimethyl-3-hydroxy-2(5H)-furanone-13C2 is a labelled analogue of 4,5-Dimethyl-3-hydroxy-2(5H)-furanone (D473600). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is a fragrant compound that is a key indicator of maple syrup urine disease, a disorder affecting newborn children that is the result of its inability to properly metabolize Valine (V094205), Leucine (L330110) and Isoleucine (I820175). 4,5-Dimethyl-3-hydroxy-2(5H)-furanone is naturally found in fenugreek seeds, and is an odourant present in sherry wines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Blank, I., et al.: Prog. Flav. Prec. Stud., No vol. given, 103 (1993); Guerra, P. &amp; Yaylayan, V.: J. Agr. Food Chem., 59, 4699 (2011); Mackenzie, D. &amp; Woolf, L.: Brit. Med. J., 1, 90 (1959); Podebrad, F., et al.: J. Inh. Metab. Dis., 22, 107 (1999)<br></p>

<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>

<p>Applications Stearic-D35 Acid is used for preparation of deuterated octadecanethiols. Stearic-D35 Acid is an isotope labeled analog of Stearic Acid (S686495), which is used in the synthesis of surfactants and detergents due to the fatty acid component of its structure.<br>References Badia, A., et al.: J. Am. Chem. Soc., 119, 2682 (1997); Dax, D. et al.: BioRes., 8, 3771 (2013); Ghumare, A. et al.: J. Surf. Deter., 26, 85 (2013);<br></p>

<p>Applications o-Anisidine is a highly toxic environmental pollutant and digestive system carcinogen. It is also a toxin that has been identified to be present in cigarettes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Coggins, C.R.E. et al.: Inhal. Toxicol., 23, 41 (2011); Dracinska, H. et al.: Neuroendorinol. Lett., 27, 9 (2006); Naiman, K. et al.: Neuroendocrinol. Lett., 31, 36 (2010);<br></p>

<p>Applications 1,2,4-Trichlorobenzene-d3 (CAS# 2199-72-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3-Propylene-d6 Thiourea (CAS# 1219802-05-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Fluoro-6-nitroanisole-d3 is a compound useful in organic synthesis.<br></p>

<p>Applications Thiodiglycolic Acid-d4 acts as a reagent for the synthesis of metabolites of S-carboxymethyl-L-cysteine and S-methyl-L-Cysteine and of some isotoically labelled (2H, 13C) analogs.<br>References Meese, C. O., et al.: Archiv der Pharmazie, 323, 957 (1990)<br></p>

<p>Applications Palmitoyl-16,16,16-d3-L-carnitine Hydrochloride is the isotope labelled analog of Palmitoyl-L-carnitine Hydrochloride (P155050); a long-chain fatty ester of carnitine which is accumulated and released into the circulation in fatty-acid oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Thiouracil-13C,15N2 is the labelled version of 2-Thiouracil (T375400), which is a reagent used in the preparation of Antithyroid agents.<br>References Toropov, A., et al.: Eur. J. Med. Chem., 45, 3581 (2010), Daniels, C., et al.: J. Bacteriol., 192, 2169 (2010), Castillo-Garit, J., et al.: Eur. J. Pharm. Sci., 39, 30 (2010),<br></p>

<p>Applications A labelled metabolite of 4-t-nonylphenol<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ye, X., et al.: Drug Metab. Disposition, 35, 1269 (2007), Gabriel, F., et al.: Env. Sci. Technol., 42, 6399 (2008), Liedtke, A., et al.: Env. Toxicol., 23, 59 (2008),<br></p>