Deuterated Compounds

<p>Applications (R)-2,2-Dimethyl-1,3-dioxolan-4-ylmethyl-d2 p-Toluenesulfonate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Applications 5-Chloro-2-methoxy-benzoic Acid Methyl Ester-13C2,d6 (cas# 1794737-29-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Chloro-6-nitrosoresorcinol-13C6 (cas# 953390-33-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled 2-Bromo-1,3-propanediol (B686665). Used for isolating bases by means of Reinecke's salt.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dudley, H., et al.: Biochem. J., 27, 157 (1933),<br></p>

<p>Applications 1-Benzyloxy-2-propanol-d6 is an intermediate in the synthesis of Isotope labelled Propylene Glycol 2-Glucuronide which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds.<br>References Szczepankiewicz, B. et al.: J. Med. Chem., 49, 3563 (2006); Mateus, R. et al.: Int. J. Pharm., 444, 106 (2013);<br></p>

<p>Applications Intermediate for the synthesis of labelled Lercanidipine HCl<br></p>

<p>Applications 4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-[4-[(2-hydroxy-1,1-dimethyl)ethyl]phenyl]butyne (cas# 1189696-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 3-Methyl-2-butenoate-d6 (cas# 53439-15-9) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Trimethylphenylammonium-d9 Iodide (cas# 88278-22-2) is a compound useful in organic synthesis.<br>References Dorweiler, J., et al.: Biochem., 42, 14653 (2003),<br></p>

<p>Applications Isotope labelled Ammonium Chloride is used as a main component and source of nitrogen in fertilizer.<br>References Crill, P. et al.: Soil Biol. Biochem., 26, 1331 (1994); Zaman, M. et al.: Biol. Fert. Soils, 29, 178 (1999);<br></p>

<p>Applications 4-[2-(1-Piperidinyl)ethoxy-d4]benzoic Acid, Hydrochloride Salt (cas# 1246815-60-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Nitisinone intermediate.<br></p>

<p>Applications N-(2-Bromoethyl-d4)phthalimide is the labeled analogue of N-(2-Bromoethyl)phthalimide (B683975), a building block that has been used as a reactant for the preparation of β-Cyclodextrin derivatives. N-(2-Bromoethyl-d4)phthalimide is an intermediate in the synthesis of (E)-Fluvoxamine-d4 Maleate (F603503), the labeled analogue of (E)-Fluvoxamine Maleate (F603500), a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant. Antiobsessional.<br>References Karginov, V.A., et. al.: Bioorg. Med. Chem., 14, 33 (2006); Claassen, V., et al.: Br. J. Pharmacol., 60, 505 (1977); Koran, L.M., et al.: J. Clin. Psychopharmacol., 16, 121 (1996); Ware, M.R., et al.: J. Clin. Psychiatry, 58, Suppl. 5, 15 (1997); Inazu, M., et al.: Neurochem. Int., 39, 39 (2001)<br></p>

<p>Applications 2-Cyano-acetic Acid Sodium Salt-13C2 (cas# 1346598-51-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled Quinoline (Q700380), which is a starting material that may be transformed by bacteria and fungi to produce intermediates useful for the synthesis of drugs. Used in the synthesis of tertiary alcohol modulators of RORγ (1) which appears to have various biological functions. Also derivatives of quinoline have been seen to promote anticancer, antibacterial and antiviral activity, however quinoline itself is often seen as an environmental contaminant (2,3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Kummer, D. et al.: Bioorg. Med. Chem. Lett. 2017 Feb 21.2. Ramirez-Prada, J. et al.: Eur J Med Chem. 2017 Mar 16;131:237-254.3. Mestankova, H. et al.: Water Res. 2016 Apr 15;93:110-20<br></p>

<p>Applications Labelled Resorcinol. A benzene derivative used as keratolytic and antiseborrheic. Also used in veterinary medicine as a topical antipruritic and antiseptic (has been used as intestinal antiseptic).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Cyanoacetylurethane-13C3,15N2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications Labelled analogue of N-Methyl-N,N-bis(2-pyridylethyl)amine, a reagent in the preparation of copper pyridylmethylethylenediamine dicyanamido polymeric complexes.<br>References Mautner, F.A. et al.: Inorg. Chim. Acta, 362, 4073 (2009);<br></p>

<p>Applications Labelled 2-Nitro-p-anisidine (N491800). Toxic to some wild and domestic birds and mice. Molluscicidal activity<br>References De Abreu, F. et al.; Bioorg. Med. Chem. 9, 659 (2001); Schafer, E.W. et al.; Arch. Environ. Con. Tox. 14, 111 (1985); Schafer, E.W. et al.; Arch. Environ. Con. Tox. 12, 355 (1983)<br></p>

<p>Applications N-[2-(S)-Methyl-d3-butyryl]-4-(S)-phenylmethyl-2-oxazolidinone (cas# 1073232-99-1) is a compound useful in organic synthesis.<br></p>

<p>Stability Temperature Sensitive<br>Applications This compound contains 10-20% of the alpha isomer. The exact amount has not been quantified.<br></p>

<p>Applications 2-Naphthalenecarboxylic Acid-13C6 (cas# 1346602-42-3) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-1-Nitrosopiperidin-3-ol-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.<br>References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)<br></p>

<p>Applications N-Nitro-S-methylisothiourea-13C is an intermediate used in the synthesis of Clothianidin-d3, 13C1 (C588502), which is the isotope labelled analog of Clothianidin. Clothianidin is a neonicotinoid insecticide for use in food crops.<br>References Kamel, A., et al.: J. Agric. Food Chem., 58, 5926 (2010), Lynd, L., et al.: Energy Environ. Sci., 3, 1150 (2010), Cresswell, J., et al.: Ecotoxicology, 20, 149 (2011),<br></p>

<p>Applications 2-Phosphono-3-(methylbutyric Acid) Triethyl Ester-d7 is an isotope labelled intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.<br>References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);<br></p>

<p>Applications 4-Nitrobenzonitrile-d4 (CAS# 1219798-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 5,6-Diamino-2,4-dihydroxypyrimidine-13C2 Bisulfite Salt is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(tert-Butyldimethylsilyloxy)-1-ethynyl-cyclopropane-d4 (cas# 1246817-59-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled 2-Bromo-5-picoline (B685570). Used for preparation of [[(triazolylmethyl)pyridyl]phenyl]tetrazoles and related compounds as cardiovascular agents.<br>References Behforouz, M., et al.: J. Med. Chem., 46, 5773 (2003), Behforouz, M., et al.: Bioorg. Med. Chem., 15, 495 (2007),<br></p>

<p>Applications (2-Carboxyethyl)dimethyl-d6-sulfonium Chloride is an intermediate in the synthesis of Dimethylsulfonioproprionate-d6 (D479362), a labelled metabolite produced primarily by marine phytoplankton and is the main precursor to the climatically important gas dimethylsulfide (DMS). Dimethylsulfonioproprionate along with DMS is a primary source of sulfur aerosol in the earth’s atmosphere and may have an influence on global temperature.<br>References Reisch, C.R. et al.: Front. Microb. Physiol. Metab., 1, 172 (2011); Matrai, P.A/ et al.: Marine Biol., 119, 61 (1994); Gabric, A.J. et al.: Tel. Ser. B Chem. Phys. Meteorol., 57B, 391 (2005):<br></p>

<p>Applications N-Isopropyl-N-methylamine-d7 Hydrochloride is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.<br>References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)<br></p>

<p>Applications (R)-(-)-4-Benzyl-3-propionyl-2-oxazolidinone-D3 is an intermediate in the synthesis of (S)-3-Hydroxy-2-methylpropanoic Acid-d3 sodium salt (H997291), which is the labelled version of 3-hydroxy-2-methyl-Propanoic acid sodium salt (CAS# 1893416-17-5), a useful building block used in the synthesis of aminotriazine derivatives.<br>References Du, Z.; et al.: WO 2016049211 (2016).<br></p>

<p>Applications 5-Bromo-6-chlorobenzene-1,2,3,4-d4 is the isotope labelled compound of (B682312) which is a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT2C agonists.<br>References Conway, R.J., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012)<br></p>

<p>Applications 1-Cyclohexyl-1-(4-benzyloxycyclohexyl)-2-(2-pyridinyl)ethanol-d11_x000D_(Mixture of Diastereomers) (cas# 1189891-05-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl 5-Oxohexanoate-1,4,5-13C3 (cas# 1185166-61-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Labelled Doxylamine intermediate.<br>References Rennison, D., et al.: Bioorg. Med. Chem., 15, 2963 (2007),<br></p>

<p>Applications (-)-(2S,3S)-Viridifloric Acid Acetonide-d7 is the isotope labelled intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.<br>References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);<br></p>

<p>Applications O-Demethyl Pyraclostrobin-d3 is an intermediate used in the synthesis of Pyraclostrobin-d6 (P840402), which is an isotope labelled Pyraclostrobin is a fungicide for use in seed grass and food crops.<br>References Gyldenkaerne, S., et al.: Pestic Sci., 55, 1210 (1999), Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007),<br></p>

<p>Applications Intermediate in the preparation of labelled Cycloserine (C988802).<br></p>

<p>Applications D-Aspartic Acid-d3 L-Alanine Copper(II) Complex is an intermediate in the synthesis of D-Aspartic-2,3,3-d3 Acid (A790019) which is derived from D-Asparatic Acid (A790020), which is a non-essential amino acid found in food sources. Its conjugate base D-aspartate has potential use as an therapeutic agent in the treatment of schizophrenia-related symptoms.<br>References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);<br></p>

<p>Applications Protected, labelled Guanine.<br>References Hakimelahi, G., et al.: J. Med. Chem., 44, 3710 (2001),<br></p>

<p>Applications Reagent used in the addition of labelled cyclopropane.<br>References Cave, C., et al.: Eur. J. Med. Chem., 25, 75 (1990), Kiyama, R., et al.: Chem. Pharm. Bull., 43, 960 (1995), Humphries, P., et al.: Bioorg. Med. Chem. Lett., 16, 6120 (2006)<br></p>

<p>Applications An intermediate of Rosuvastatin (R700500).<br></p>

<p>Applications Ethyl Cyanoacetate-13C2 (cas# 93664-96-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Dimethyl-d6-(tetrahydro-3,3-diphenyl-2-furylidene)ammonium Bromide is a compound useful in organic synthesis.<br></p>

<p>Applications Used in the preparation of piperazine-1-carboxamide derivatives as fatty acid amide hydrolase (FAAH) inhibitors.<br>References Glorius, F., et al.: Org. Biomol. Chem., 3, 4171 (2005),<br></p>

<p>Applications α,α-Diphenyl-1-azabicyclo[2.2.2]octane-4-methanol-d10 is an intermediate in the synthesis of Umeclidinium Bromide-d5, which is considered as a potentially long-acting antimuscarinic agent.<br>References Cazzola, M., et al.: Pharmacol., Rev., 64, 450 (2012); Laine, D., et al.: J. Med. Chem., 52, 2493 (2009)<br></p>

<p>Applications 4-Chloro-N-[2-(4-hydroxyphenyl)ethyl]benzamide-d4 (cas# 1189464-84-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Reagent used in the preparation of labelled cyclopropane derivatives.<br>References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),<br></p>

<p>Applications Chemical building block used in the synthesis of more complex structures.<br></p>

<p>Applications 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-1-propanol-d6 is a compound useful in organic synthesis.<br></p>

<p>Applications Propane-1,3-diylbis((3-acetamidopropyl)carbamic Acid) di-tert-Butyl Ester-d6 is an isotope labelled intermediate in the synthesis of derivatives of Spermine (S680510) which is a biogenic polyamine formed from Spermidine (S680400) that occurs in almost all tissues.<br>References Theoharides, T.C., et al.: Life Sci., 27, 703 (1980); Horn, Y., et al.: Cancer Res., 42, 3248 (1982)<br></p>

<p>Applications A labelled antibacterial agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Piipari, R., et al.: Clin. Exp. Allergy, 28, 358 (1998), Kanerva, L., et al.: Contact Dermatitis, 44, 193 (2001), Frauen, M., et al.: J. Pharm. Biomed. Anal., 25, 965 (2001),<br></p>

<p>Applications Ethyl (5-Ethyl-2-pyridinyl)-1,1-d2-acetate (cas# 1189654-25-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Tributyl(vinyl)tin-d3 is an intermediate for the synthesis of Protoporphyrin IX Dimethyl Ester-d6 (P839127), which is the labelled version of Protoporphyrin IX P(P838900). Protoporphyrin IX (PPIX) is ubiquitously present in all living cells in small amounts as a precursor of heme and PPIX-based strategies have been used for cancer diagnosis and treatment. It can be used in biological study for role of protoporphyrin IX in skin photosensitivity, biliary stones, hepatobiliary damage, liver failure and cancer diagnosis and treatment in human.<br>References Sachar, M., et al.: J. Pharmacol. Exp. Ther., 356, 267-275 (2016)<br></p>

<p>Applications Ethyl-d5 2-Methylbutyrate is the labeled analogue of Ethyl 2-Methylbutyrate (E923200), an ester that has a sweet, apple-like aroma. Ethyl 2-methylbutyrate is naturally found in apples, cherries and orange juice.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cho, I., et al.: J. Agr. Food Chem., 54, 6332 (2006); Mattheis, J., et al.: J. Agr. Food Chem., 45, 212 (1997); Moshonas, M. &amp; Shaw, P.: J. Agr. Food Chem., 35, 161 (1987); Willaert, G., et al.: J. Agr. Food Chem., 31, 809 (1983)<br></p>

<p>Applications Monomethyl Glutarate-1,5-13C2 (cas# 1189708-76-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Glycine-13C2,15N p-Toluenesulfonate is a by-product of an intermediate during the synthesis of m-Hydroxyhippuric Acid-13C2, 15N (H943127), a labelled m-Hydroxyhippuric Acid (H943125) which is a metabolite of caffeic and chlorogenic acids in human.<br>References Booth, A., et al.: J. Biol. Chem., 229, 51 (1957); Gonthier, M., et al.: Biomed. Pharmacother., 60, 536 (2006)<br></p>

<p>Applications 1,1-Dimethylethyl 4-(2-Hydroxyethyl)piperazine-1-carboxylate-d4 is an isotope labelled intermediate in the synthesis of labelled Flupentixol.<br>References Panteleev, J., et al.: Synlett., 26, 953 (2015); Liang, Y.K., et al.: Euro. J. Med. Chem., 84, 505 (2014);<br></p>

<p>Applications An intermediate in the synthesis of the Daspone metabolite.<br></p>

<p>Applications Reactant used in the preparation of labelled Camptothecin derivatives.<br></p>

<p>Applications 4-Chlorophenyl-1,2-epoxybutane-d5 (cas# 1189717-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the preparation of labelled α-Carboline derivatives<br></p>

<p>Applications Cyanoacetic Acid-13C2 is an intermediate for the synthesis of Diclazuril-13C3,15N2 (D436202), which is the labelled analogue of Diclazuril (D436200). Diclazuril is a nucleotide analogue with broad-spectrum anticoccidial activity and a coccidiostat.<br>References Maes, L., et al.: J. Parasitol., 74, 931 (1988)<br></p>

<p>Applications Diethyl Cromoglycate-D5 is an intermediate used in the synthesis of Cromolyn-d5 Disodium Salt (C815002), which is a chromone complex which blocks mast cell degranulation.<br>References Ashton, M.J., et al.: Toxicol. Appl. Pharmacol., 26, 319 (1973), Friday, G.A., et al.: Am. J. Ophthalmol., 95, 169 (1983)<br></p>

<p>Applications Dimethyl-d6 Carbonate is the labeled analogue of Dimethyl Carbonate (D446705), which is used in the synthesis of phosphine-boranes in the preparation of new bidentate ligands. Also used in the synthesis of flavonoid analogs.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Imamoto, T. et al.: J. Am. Chem. Soc., 112, 5244 (1990); Cushman, M. et al.: J. Med. Chem., 34, 798 (1991)<br></p>

<p>Applications Isotope labelled Methanol (M276585), which is a common chemical reagent in organic synthesis participating in a variety of reactions. Used to prepare novel triazole-polyphenol hybrid compounds as FabG4 (Rv0242c) enzyme inhibitors for the treatment of Mycobacterium Tuberculosis (1). Also used in the synthesis of prodelphinidin B1/B2/B4 which display antitumor activities against prostate cancer cells.Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Banerjee, D. et al.: Org. Biomol. Chem. 2014 Jan 7;12(1):73-85.<br></p>

<p>Applications Ethyl 3-(4-Fluorophenyl)-2-(2-methylpropionyl)propenoate-d6 (cas# 1185241-64-8) is a compound useful in organic synthesis.<br></p>

<p>Applications rac 10-Hydroxy-1-undecen-6-one-d6 (cas# 1246818-57-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 5H-Pyrido[1,2,3-de]-1,4-benzoxazine-D3 Boron Derivative is an intermediate in the synthesis of (R)-Ofloxacin-d3 (O245742), which is a labelled fluorinated quinolone antibacterial. An enantiomer of Levofloxacin (L360000).<br>References Hwangbo, H.J. et al.: Eur. J. Pharmac. Sci., 18, 197 (203); Gascon, A.R. et al.: J. Clin. Pharmacol, 40, 869 (2000); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990);<br></p>

<p>Applications 1’-Hydroxy N-Trityl Medetomidine-d3 is an intermediate in the synthesis of Dexmedetomidine-d4 L-Tartrate (d4-Major) (D299006). Dexmedetomidine-d4 L-Tartrate is the labeled salt analogue of Dexmedetomidine (D299000), an α2-Adrenergic agonist; (+)-isomer of Medetomidine; sedative; analgesic.<br>References Rajala, R., et al.: Eur. J. Pharm. Sci., 1, 219 (1994); Jalonen, J., et al.: Anesthesiology, 86, 331 (1997); Talke, P., et al.: Anesth. Analg., 85, 1136 (1997); Bhana, N., et al.: Drugs, 59, 263 (2000)<br></p>

<p>Applications Rabeprazole-D4 Sulfide is an intermediate in the synthesis of Rabeprazole-d4 (R070492). Rabeprazole-D4 Sulfide is an isotope-labeled analogue of Rabeprazole Sulfide (Rabeprazole EP Impurity B), which is a metabolite of Rabeprazole (R070500).<br>References Morii, M., and Takeguchi, N.: J. Biol. Chem., 268, 21553 (1993); Yasuda, S., et al.: Int. J. Clin. Pharmacol. Ther., 32, 466 (1994); Cloud, M.L., et al.: Dig. Dis. Sci., 43, 993 (1998)<br></p>

<p>Applications (-)-(2S,3S)-Viridifloric Acid Ethyl Ester is an intermediate in the synthesis of (+)-amabiline, an unsaturated pyrrolizidine alkaloid from Cynoglossum amabile.<br>References Senter, T. J., et al.: Org. Lett., 14, 1869 (2012);<br></p>

<p>Applications Labelled Dapsone intermediate.<br>References Tingle, M., et al.: Brit. J. Clin. Pharmacol., 30, 829 (1990), Vage, C., et al.: Toxicol. App. Pharmacol., 129, 309 (1994),<br></p>

<p>Applications 1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2 is a labelled imidazole (I350202) derivative, used in the preparation of Histamine H3 Receptor Agonists and druglike angiotensin II compounds with affinity for the AT2 receptor.<br>References Wijtmans, M. et al.: J. Med. Chem., 51, 2944 (2008); Georgsson, J. et al.: J. Med. Chem., 50, 1711 (2007)<br></p>

<p>Applications Intermediate for the preparation of Isotope Labelled Tolmetin.<br></p>

<p>Applications 1-Bromobutane-2,2,3,3,4,4,4-d7 (CAS# 223487-53-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Furan-3-methanol. Furan-3-methanol is used in the synthesis of potentially prebiotic RNA precursors: adenine and uracil derivatives.<br>References Pavey, J.B.J., et al.: Tetrahedr. Lett., 36, 2657 (1995),<br></p>

<p>Applications 2-(Cyclopropylmethoxy-d4)-acetic Acid (cas# 1346602-05-8) is a compound useful in organic synthesis.<br></p>

<p>Applications Aniline-13C6 Hydrochloride is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications 1-Ethoxyethanimine-D3 Hydrochloride is an intermediate in the synthesis of Secnidazole-d3 (S225003), which is a labelled Secnidazole (S225000). Analog of Metronidazole. Antiamebic. Antiprotozoal (Trichomonas).<br>References Cosar, C., et al.: Arzneim.-Forsch., 16, 23 (1966), Videau, D., et al.: Br. J. Vener. Dis., 54, 77 (1978), Symonds, J., et al.: J. Antimicrob. Chemother., 5, 484 (1979),<br></p>

<p>Applications Can be used in the preparation of substances for treatment of dermatological conditions and skin protection.<br></p>

<p>Applications A labelled substituted piperidine as pesticide.<br></p>

<p>Applications Lapatinib-d7 Sulfoxide Dihydrochloride is a by-product during the synthesis of Lapatinib-d7 Dihydrochloride (L175807), a labeled Lapatinib (L175800), a reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003); Wood, E.R., et al.: Cancer Res., 64, 6652 (2004); Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005)<br></p>

<p>Applications 2-(Benzyloxy)-1-propanol-d6 is an intermediate in the synthesis of Isotope labelled Propylene Glycol 2-Glucuronide which is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds.<br>References Szczepankiewicz, B. et al.: J. Med. Chem., 49, 3563 (2006); Mateus, R. et al.: Int. J. Pharm., 444, 106 (2013);<br></p>

<p>Applications (R)-2-Hydroxy-3-(benzoyloxy)propyl-1,1-d2 4-Toluenesulfonate is an intermediate used in the synthesis of (S)-PA 824-d4 (P122502), which is a labelled novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Applications 2,2-Difluoroethylamine-d2 Hydrochloride is an intermediate used in the synthesis of Flupyradifurone-d5 (F598616), which is the labeled form of Flupyradifurone (F598615), can be used as an insecticide.<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications n-Dipropylamine-d4 Hydrochloride (cas# 1329834-71-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-Hydroxy-6-methyl-4-[[(4-methylphenyl)imino]methyl]-3-pyridinemethanol-d5 is an intermediate in the synthesis of labelled Pyridoxal phosphate.<br>References Sharif, S., et al.: J. Am. Chem. Soc., 129, 4440 (2007);<br></p>

<p>Applications 1-Bromobenzene-13C6 is the isotope labelled analog of 1-Bromobenzene, which is used as a general reagent in palladium-catalyzed reactions and in the synthesis of Grignard reagents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Miyaura, N. et al.: Synth. Commun., 11, 513 (1981); Nahm, S. et al.: Tetra. Lett., 22, 3815 (1981);<br></p>

<p>Applications Labelled Cyanazine (C953500). Selective pre-emergence herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Crayford, J.V., et al.: Pestic. Biochem. Physiol., 2, 295 (1975),<br></p>

<p>Applications Pyrimidine with the ability to form complexes with heavy metal ions.<br>References Iltzsch, M., et al.: Biochem. Pharmacol., 48, 781 (1994),<br></p>

<p>Applications A labelled reactant used in the preparation of inhibitors for treatment of neurodegenerative diseases.<br></p>