Deuterated Compounds

Applications Labelled Cyanazine (C953500). Selective pre-emergence herbicide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Crayford, J.V., et al.: Pestic. Biochem. Physiol., 2, 295 (1975),

Applications 2-p-Toluenesulfonate 1-Phenyl-d5-1,2-ethanediol is an intermediate in the synthesis of rac Mirabegron-d5 (M364902), which is a potent bladder relaxant and reagent for diabetes remedy.

Applications tert-Butyl-d9 Methyl Ether (CAS# 1219795-06-8) is a useful isotopically labeled research compound.

Applications 1,3-Propane-2,2-d2-diamine 2HCl (CAS# 352438-79-0) is a useful isotopically labeled research compound.

Applications 2,4-Dichlorobenzoic-d3 Acid (CAS# 1398065-99-0) is a useful isotopically labeled research compound.

Applications 1-Bromo-2,3,5-trichlorobenzene-d2 (CAS# 1219803-86-7) is a useful isotopically labeled research compound.

Applications DL-Methionine-2-d1 (CAS# 67866-74-4) is a useful isotopically labeled research compound.

Applications A labelled photodegradation product of Chlorothalonil and Dichlofluanid.
References Al-Ekabi, H., et al.: J. Phys. Chem., 92, 5726 (1988), Pramauro, E., et al.: Environ. Sci. Technol., 27, 1790 (1993),

Applications 4-Biphenylyl Sulfate-d5 Potassium Salt is the isotope labelled analog of 4-Biphenylyl Sulfate Potassium Salt . 4-Biphenylyl Sulfate Potassium Salt is a derivative of 4-Phenylphenol (P336135). 4-Phenylphenol is a reagent used in the synthesis of pyrrolo[1,2-c]imidazole dione derivatives as selective serotonin 5-HT1A receptor agonists with antinociceptive activity.
References Valhondo, M., et al.: J. Med. Chem., 56, 7851 (2013); Nichols, D., et al.: Chem. Rev., 108, 1614 (2008)

Applications N-[(S)-(4-Nitrophenoxy)phenoxylphosphinyl]-1-ethylpropylester-L-Alanine-D4 is a labelled compound form N-[(S)-(4-Nitrophenoxy)phenoxylphosphinyl]-1-ethylpropylester-L-Alanine cas(1884206-50-1)

Applications 2,3,6-Trichlorophenol-4,5-d2 (CAS# 93951-81-6) is a useful isotopically labeled research compound.

Applications 4-Chlorobenzonitrile-d4 (CAS# 1219794-82-7) is a useful isotopically labeled research compound.

Applications 3-Ethyl-d5-toluene is labelled 3-Ethyltoluene which is a useful synthetic intermediate.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications A labelled metabolite of Pantoprazole, an antiulcerative, gastric pump inhibitor.

Applications 2-(4-Nitrophenyl-d4)propane (CAS# 1219803-36-7) is a useful isotopically labeled research compound.

Applications N-[5-[2-[[2-(5-Amino-1,3,4-thiadiazol-2-yl)ethyl]thio]ethyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide-d5 is labelled N-[5-[2-[[2-(5-Amino-1,3,4-thiadiazol-2-yl)ethyl]thio]ethyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide (A630445) which can be used to prepare bis(phenylacetamidothiadiazolyl)ethyl sulfide analogs as glutaminase inhibitors and antitumor agents.
References Shukla, K., et al.: J. Med. Chem., 55, 10551 (2012)

Applications Methyl 5-Hydroxy-3-indoleacetate-d3 is an intermediate in the synthesis of 5-Hydroxyindole-3-acetic Acid-D5 (H953609). 5-Hydroxyindole-3-acetic Acid-D5 is a labelled analogue of 5-Hydroxyindole-3-acetic Acid (H953605). 5-Hydroxyindole-3-acetic Acid is an impurity of Chlorpheniramine (C424300), a histamine H1 receptor antagonist that is used to treat allergy symptoms.
References Popa, V.: CHEST J., 78, 442 (1980); Snyman, J., et al.: Eur. J. Clin. Pharm., 42, 359 (1992); Sowunmi, A., et al.: Trans. Royal Soc. Trop. Med. Hyg., 91, 63 (1997)

Applications 4-Hydroxypiperidine-3,3,4,5,5-d5-N-t-BOC (CAS# 1523606-18-9) is a useful isotopically labeled research compound.

Applications Labelled Isopropylparaben. An antimicrobial agent used in cosmetic products.
References Gilliland, D., et al.: J. Appl. Bacteriol., 72, 258 (1992), Routledge, E., et al.: Toxicol. Appl. Pharmacol., 153, 12 (1998), Miller, C., et al.: J. Biol. Chem., 272, 32824 (1997), Nakagawa, Y., et al.: Biochem. Pharmacol., 55, 1907 (1998),

Applications Bis(4-aminophenyl)-d12 Ether (CAS# 106426-62-4) is a useful isotopically labeled research compound.

Applications D-Alanine-3,3,3-d3-N-t-BOC (CAS# 177614-70-9) is a useful isotopically labeled research compound.

Applications Ethyl-alpha-13C-benzene (CAS# 287399-32-0) is a useful isotopically labeled research compound.

Applications 4-Chlorothiobenzamide-2,3,5,6-d4 (CAS# 1219802-58-0) is a useful isotopically labeled research compound.

Applications trans-9-Octadecenyl phosphocholine-D9 is a labelled analogue of trans-9-Octadecenyl phosphocholine (O235600).

Applications 4-Chlorotoluene-d7 (CAS# 84344-06-9) is a useful isotopically labeled research compound.

Applications N-Propionylglycine-2,2-d2 (CAS# 1256842-51-9) is a useful isotopically labeled research compound.

Applications 1-Bromooctadecane-d37 (CAS# 187826-28-4) is a useful isotopically labeled research compound.

Applications L-Glutamic Acid Dimethyl Ester-13C5 Hydrochloride is an intermediate used in the synthesis of Folic Acid-13C5 (F680303), which is vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.
References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),

Applications Compound has been shown to reversibly block voltage-dependent potassium channels, and is also a common impurity from the synthesis of compounds found in hair dyes
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Williams, D.M., et al.: J. Biol. Chem., 275, 38127 (2000), Munoz-Caro, C., et al.: Biophys. Chem., 96, 1 (2002),

Applications (S)-Carbidopa Methyl-d3 Ester N-cyclohexylidene is the labeled analogue of (S)-Carbidopa Methyl Ester N-cyclohexylidene (C176015), an impurity of Carbidopa (C175915), a prodrug inhibitor of aromatic amino acid decarboxylase.
References Sletzinger, M., et al.: J. Med. Chem., 6, 101 (1963)

Applications 4-Hydroxy-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS# 100326-46-3) is a useful isotopically labeled research compound.

Stability Volatile
Applications Cyclohexene-d10 is a labelled organic solvent. It has also been used in the synthesis of adipic acid.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Reed, S. et al.: J. Chem. Educ. 77, 12 (2000)

Applications Diethyl L-(+)-Tartrate-13C8 is the isotope labelled analog of Diethyl L-(+)-Tartrate. Diethyl L-(+)-Tartrate is used as a chiral reagent in a host of chemical reactions, such as the synthesis of isoquinoline alkaloids and arundic acid, which has been used in acute ischemic stroke therapy.
References Ziolkowski, M. et al.: Tetrahedron Lett., 41, 1963 (2000); Fernandes, R. et al.: Tetrahedron Lett. 50, 5903 (2009);

Applications (±)-1-Phenylethan-1,2,2,2-d4-ol (CAS# 90162-44-0) is a useful isotopically labeled research compound.

Applications Labelled 2-[(Ethylamino)methyl]-4-nitrophenol (E898825). 2-[(Ethylamino)methyl]-4-nitrophenol is used in synthesis of some novel amodiaquine analogs as potential antimalarial and antifilarial compounds.

Applications 1-Bromodecane-d21 (CAS# 98195-39-2) is a useful isotopically labeled research compound.

Applications N2-Acetyl Acyclovir-d4 is the isotope labelled analog of N2-Acetyl Acyclovir (A168015); an impurity of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.
References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)

Applications Sodium Propionate-3,3,3-d3 (CAS# 1210410-35-7) is a useful isotopically labeled research compound. This compound can be used to demonstrate intereactions between ergosterol and amphotericin B in lipid bilayers using NMR spectroscopy to exert antifungal activity.
References Matsumori, N.,et.al., J.Am.Chem.Soc., 131,11855-11860,(2009);

Applications 2-Aminofluorene-d11 (CAS# 347841-44-5) is a useful isotopically labeled research compound.

Applications 21-(3-Carboxy-1-oxopropoxy)-17-hydroxy-pregn-4-ene-3,20-dione-d4 Monosodium Salt is deuterium labelled 21-(3-Carboxy-1-oxopropoxy)-17-hydroxy-pregn-4-ene-3,20-dione Monosodium Salt (a derivative of Cortisol) and exhibits multi-site antiglucocorticoid activity in vivo.
References Duncan, M. R. and Duncan, G. R. J. Steroid Biochem. 10, 245 (1979)

Applications Bis(3-methylpentyl) Phthalate-d4, is the labeled analogue of Bis(3-methylpentyl) Phthalate (B486010), used as a plasticizer to impart softness and flexibility to PVC products.
References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);

Applications Cyclopropane-1,2,2,3,3-d5-carbonyl chloride is a useful building block for organic synthesis

Applications 1-Bromoeicosane-d41 (CAS# 202480-71-5) is a useful isotopically labeled research compound.

Applications Labelled Vanillin. Occurs naturally in a wide variety of foods and plants such as orchids; major commercial source of natural vanillin is from vanilla bean extract. Synthetically produced in-bulk from lignin-based byproduct of paper processes or from guaicol.
References Jenner, P.M., et al.: Food Cosmet. Toxicol., 2, 327 (1964), Clark, G.S., et al.: Perfum. Flavor., 15, 45 (1990),

Applications n-Hexadecyl-d33 Alcohol (CAS# 284474-73-3) is a useful isotopically labeled research compound.

Applications O-Toluoyl Chloride-D7 is the deuterated form of O-Toluoyl Chloride (T536250), which is used in the synthesis if quinolinone compounds as SARS CoV 3CLpro inhibitors. Also used in the synthesis of benzooxaboroles as orally active anti-inflammatory agents.
References Sun, Y. et al.: Chin. J. CHem., 31, 1199 (2013); Akama, T. et al.: Bioorg. Med. Chem. Lett., 23, 5870 (2013);

Applications Ditridecyl Adipate-d8 is the isotope labelled analog of Ditridecyl Adipate (D494195); a compound used as a skin conditioning or fragrance ingredient, plasticizer, solvent or emollient in cosmetics. Also used in combination with other compounds as a finisher for texturing of polyester yarns.
References Fiume, M.M., et al.: Int. J. Toxicol., 31, 5S (2012); Burks, P.P., et al. Finish Composition for Draw-texturing Yarn. US 3859122 A 19750107. Jan 7, 1975

Applications Ethyl-d5 4-Aminobenzoate (CAS# 1219803-76-5) is a useful isotopically labeled research compound.

Applications Propionic Acid (1-13c, 99%) (cas# 6212-69-7) is a useful research chemical.

Applications 5-(4-Hydroxyphenyl)-5-phenyl-d5-hydantoin-15N2 (CAS# 369656-71-3) is a useful isotopically labeled research compound.

Applications 1-Aminonaphthalene-d9 (CAS# 78832-56-1) is a useful isotopically labeled research compound.

Applications n-Dodecyl Alcohol-d26 (CAS# 38086-03-2) is a useful isotopically labeled research compound. It can be used for neutron spin-echo spectroscopy.
References Yamaguchi, T., et.al., J. Phys.Chem.B., 123, 239-246,(2019);

Applications rac Desethyl Phenyl Oxybutynin-d5 is an intermediate in the synthesis of rac Desethyl Oxybutynin-d5 Hydrochloride (D289478), a labelled metabolite of the drug Oxybutynin (D289475). Used in the treatment of incontinence.
References Hughes, K., et al.: Xenobiotica, 22, 859 (1992); Oki, T., et al.: Biol. Pharm. Bull., 24, 491 (2001); Fetscher, C., et al.: Br. J. Pharmacol., 136, 64 (2002); Zobrist, R., et al.: Pharm. Res., 20, 103 (2003)

Applications 1,4-Diethylbenzene-d14 (CAS# 1219803-64-1) is a useful isotopically labeled research compound.

Applications 1-Bromo-3-chloro-5-fluorobenzene-d3 (CAS# 1219805-00-1) is a useful isotopically labeled research compound.

Applications (R)-(-)-Phenylephrine-2,4,6-d3 HCl (CAS# 1276197-50-2) is a useful isotopically labeled research compound.

Applications N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea-d4 is labelled N-4-Hydroxyphenyl-N'-1,2,3-thiadiazol-5-ylurea (H949385) which is a substrate of cytokinin O-glucosyltransferase with position specificity related to receptor recognition. It is a metabolite of Thidiazuron (T344275) which is a non-purine containing urea derivative with cytokinin activity.
References Mok, M., et al.: Plant Physio., 137, 1057(2005); Benezet, H., et al.: Trans. Missouri Academy. Sci., 14, 75 (1980); Orlikowska, T., et al.: Plant Cell Tissue Org. Cult., 59, 95 (1999), Ray, T., et al.: Mol. Biol., 6, 35 (2005), Kanwar, J., et al.: Hort Sci., 2008, 35, 35 (2008),

Applications Pinacol-d12 is an intermediate in the synthesis of Isotope labelled Tebuconazole (T013002), which is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.

Applications 1,2,4,5-Tetramethylbenzene-d14 (CAS# 15502-50-8) is a useful isotopically labeled research compound.

Applications 1-(3,5-Diacetoxyphenyl)-1-bromoethane-13C6, is the labeled analogue of 1-(3,5-Diacetoxyphenyl)-1-bromoethane (D307562), which is an intermediate for the synthesis of Resveratrol (R150000).
References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),

Applications 2,3,6-Trimethylphenol-d11 (CAS# 347841-83-2) is a useful isotopically labeled research compound.

Applications Acetylcholine-1,1,2,2-d4 Bromide is the deuterium labelled form of Acetylcholine Bromide (A172073), which is an endogenous neurotransmitter at cholinergic synapses.
References Kobayashi, M., et al.: Adv. Physiol. Sci., 22, 319 (1981); Hulme, C., et al.: Biophys. J., 91, 2371 (2006);

Applications Phthalic-13C Acid is an isotope labelled version of Phthalic Acid (P384480), an organic reagent used to synthesize phthalates.
References Duchowicz, P.R., et al.: Bioorg. Med. Chem., 16, 7944 (2008);di Luccio, E., et al.: Biochem., 47, 4039 (2008);Lopez, Z., et al.: App. Microbiol. Biotechnol., 78, 739 (2008);Hong, Y., et al.: Toxicol. Lett., 184, 139 (2009)

Applications Isotope labelled Propyl Paraben Sulfate (P838355) is the sulfate conjugate of Propyl Paraben (P838285), an antimicrobial agent used in cosmetic products.
References Kim, D.H., et al.: Biol. Pharma. Bull., 17, 1326 (1994);

Applications It is a stable isotopically labelled analog of Tasimelteon (T007740) which is a novel drug, used in the treatment of non-24 hour sleep-wake disorder. It helps to correct the circadian rhythm disorder often seen in patients who are visually impaired.
References Lahon, J. et al.: World. J. Pharm. Res., 3, 1521 (2014)

Applications Ammonium Formate-d5 (CAS# 65387-23-7) is a useful isotopically labeled research compound.

Applications Benzene-1,2,3,5-d4 (CAS# 14941-52-7) is a useful isotopically labeled research compound.

Applications Iodoacetic Acid-d3 (CAS# 1219799-36-6) is a useful isotopically labeled research compound.

Applications Tetracosanoic-12,12,13,13-d4 Acid (CAS# 1219794-59-8) is a useful isotopically labeled research compound.